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公开(公告)号:US07189322B2
公开(公告)日:2007-03-13
申请号:US11042512
申请日:2005-01-26
申请人: Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
发明人: Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
CPC分类号: B01D69/02 , A61L2/0017 , B01D67/0009 , B01D71/38 , B01D71/82 , B01D2323/30 , B01D2325/14 , B01D2325/16 , B01D2325/36 , Y10T436/255
摘要: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.
摘要翻译: 本发明提供了一种亲水性带电微孔膜,其包含多孔疏水性底物和包含电荷提供剂的涂层。 本发明还提供了一种亲水性带电膜,其包含多孔疏水性底物和分布在基材内的亲水性电荷提供剂。 本发明还提供一种过滤器以及包括本发明的亲水带电膜的过滤装置。 本发明还提供了一种用于处理含有细菌污染物如内毒素的流体的方法,包括使膜与流体接触以提供细菌污染物耗尽的流体。
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公开(公告)号:US06849185B1
公开(公告)日:2005-02-01
申请号:US09959882
申请日:2000-05-12
申请人: Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
发明人: Xiaosong Wu , Joe L. Kinsey, Jr. , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
CPC分类号: B01D69/02 , A61L2/0017 , B01D67/0009 , B01D71/38 , B01D71/82 , B01D2323/30 , B01D2325/14 , B01D2325/16 , B01D2325/36 , Y10T436/255
摘要: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.
摘要翻译: 本发明提供了一种亲水性带电微孔膜,其包含多孔疏水性底物和包含电荷提供剂的涂层。 本发明还提供了一种亲水性带电膜,其包含多孔疏水性底物和分布在基材内的亲水性电荷提供剂。 本发明还提供一种过滤器以及包括本发明的亲水带电膜的过滤装置。 本发明还提供了一种用于处理含有细菌污染物如内毒素的流体的方法,包括使膜与流体接触以提供细菌污染物耗尽的流体。
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公开(公告)号:US20060151374A1
公开(公告)日:2006-07-13
申请号:US11042512
申请日:2005-01-26
申请人: Xiaosong Wu , Joe Kinsey , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
发明人: Xiaosong Wu , Joe Kinsey , Michael Ishee , Peter Konstantin , Joel Shertok , Yujing Yang
IPC分类号: B01D63/00
CPC分类号: B01D69/02 , A61L2/0017 , B01D67/0009 , B01D71/38 , B01D71/82 , B01D2323/30 , B01D2325/14 , B01D2325/16 , B01D2325/36 , Y10T436/255
摘要: The present invention provides a hydrophilic charged microporous membrane comprising a porous hydrophobic substrate and a coating comprising a charge-providing agent. The present invention further provides a hydrophilic charged membrane comprising a porous hydrophobic substrate and a hydrophilic charge-providing agent distributed within the substrate. The present invention further provides a filter as well as a filter device comprising the inventive hydrophilic charged membrane. The present invention further provides a process for treating a fluid containing bacterial contaminants such as endotoxins comprising contacting the membrane with the fluid to provide a bacterial contaminant depleted fluid.
摘要翻译: 本发明提供了一种亲水性带电微孔膜,其包含多孔疏水性底物和包含电荷提供剂的涂层。 本发明还提供了一种亲水性带电膜,其包含多孔疏水性底物和分布在基材内的亲水性电荷提供剂。 本发明还提供一种过滤器以及包括本发明的亲水带电膜的过滤装置。 本发明还提供了一种用于处理含有细菌污染物如内毒素的流体的方法,包括使膜与流体接触以提供细菌污染物耗尽的流体。
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公开(公告)号:US07223341B2
公开(公告)日:2007-05-29
申请号:US11480977
申请日:2006-07-06
申请人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
CPC分类号: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
摘要翻译: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜,其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜,其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用,包括离子交换层析,大分子转移,以及生物分子如蛋白质,核酸,内毒素等的检测,过滤和纯化。
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公开(公告)号:US06851561B2
公开(公告)日:2005-02-08
申请号:US10891098
申请日:2004-07-15
申请人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC分类号: B01D15/36 , B01D61/00 , B01D61/14 , B01D63/14 , B01D67/00 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01J20/28 , B01J41/12 , B01J41/20 , B01J47/12 , B01D63/06 , B01D71/56
CPC分类号: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
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公开(公告)号:US07094347B2
公开(公告)日:2006-08-22
申请号:US11035950
申请日:2005-01-18
申请人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
CPC分类号: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
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公开(公告)号:US20060249445A1
公开(公告)日:2006-11-09
申请号:US11480977
申请日:2006-07-06
申请人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC分类号: B01D71/06
CPC分类号: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
摘要翻译: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜,其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜,其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用,包括离子交换层析,大分子转移,以及生物分子如蛋白质,核酸,内毒素等的检测,过滤和纯化。
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公开(公告)号:US06780327B1
公开(公告)日:2004-08-24
申请号:US09914163
申请日:2001-12-12
申请人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC分类号: B01D6114
CPC分类号: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要: The present invention provides a positively charged microporous membrane having a protein binding capacity about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
摘要翻译: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微孔膜,其包含亲水性多孔基质和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜,其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用,包括离子交换层析,大分子转移,以及生物分子如蛋白质,核酸,内毒素等的检测,过滤和纯化。
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公开(公告)号:US07396465B2
公开(公告)日:2008-07-08
申请号:US11742749
申请日:2007-05-01
申请人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
CPC分类号: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
摘要翻译: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜,其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜,其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用,包括离子交换层析,大分子转移,以及生物分子如蛋白质,核酸,内毒素等的检测,过滤和纯化。
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公开(公告)号:US20050211621A1
公开(公告)日:2005-09-29
申请号:US11035950
申请日:2005-01-18
申请人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC分类号: B01D15/36 , B01D61/00 , B01D61/14 , B01D63/14 , B01D67/00 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01J20/28 , B01J41/12 , B01J41/20 , B01J47/12
CPC分类号: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
摘要翻译: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜,其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜,其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用,包括离子交换层析,大分子转移,以及生物分子如蛋白质,核酸,内毒素等的检测,过滤和纯化。
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