公开(公告)号：US20150004207A1

公开(公告)日：2015-01-01

申请号：US14348815

申请日：2012-01-17

申请人： Xu Cai ,  Dadong Zhang ,  Yan Hu ,  Peng Huang ,  Junfei Li ,  Chengyun Yue ,  Zhirong Tang ,  Qiyi Luo

发明人： Xu Cai ,  Dadong Zhang ,  Yan Hu ,  Peng Huang ,  Junfei Li ,  Chengyun Yue ,  Zhirong Tang ,  Qiyi Luo

IPC分类号： A61L31/10 ,  B05B17/06 ,  B05D1/02 ,  B05D1/18 ,  A61L31/16 ,  A61L31/14

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2002/0086 ,  A61F2240/00 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2400/00 ,  A61L2420/02 ,  A61L2420/06 ,  B05B17/06 ,  B05D1/02 ,  B05D1/18

摘要： An interventional medical device and manufacturing method thereof, the interventional medical device comprising a stent body (1); the stent body (1) is provided with a drug releasing structure on the surface, the drug in the drug releasing structure being a drug for inhibiting adventitial fibroblast proliferation. When the interventional medical device is implanted into a human body, the drug for inhibiting the adventitial fibroblast proliferation can be slowly released into vessel wall cells in contact with the stent body (1), thus inhibiting the proliferation of the adventitial fibroblasts, promoting vascular compensatory expansion, and reducing the incidence rate of instent restenosis.

摘要翻译： 一种介入医疗装置及其制造方法，所述介入医疗装置包括支架主体（1）; 支架体（1）在表面设置有药物释放结构，药物释放结构中的药物是用于抑制外膜成纤维细胞增殖的药物。 当将介入医疗器械植入人体内时，用于抑制外膜成纤维细胞增殖的药物可以缓慢释放到与支架体（1）接触的血管壁细胞中，从而抑制外膜成纤维细胞的增殖，促进血管补偿 扩张，并减少局限性再狭窄的发生率。

公开(公告)号：US09433709B2

公开(公告)日：2016-09-06

申请号：US14677741

申请日：2015-04-02

申请人： Dadong Zhang ,  Xu Cai ,  Chengyun Yue ,  Junfei Li ,  Yan Hu ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo

发明人： Dadong Zhang ,  Xu Cai ,  Chengyun Yue ,  Junfei Li ,  Yan Hu ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo

IPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61F2/82

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  C08L75/04 ,  C08L67/04 ,  C08L89/00 ,  C08L33/10 ,  C08L5/08

摘要： An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.

摘要翻译： 介入医疗装置及其制造方法。 介入医疗装置包括：支架主体（1）; 支架体（1）的表面设有药物释放结构（3），药物释放结构（3）中的药物是抑制外膜成纤维细胞增殖的药物和抑制内膜和/或平滑增生的药物 肌肉细胞。 在使用中，将介入医疗装置植入人体后，用于抑制携带的外膜成纤维细胞增殖的药物可以促进血管的代偿性扩张，并且抑制其上承载的内膜细胞和/或平滑肌细胞增殖的药物 可以抑制血管的内膜增殖。 两种药物的组合大大降低了支架内再狭窄的发生率。

公开(公告)号：US20140248327A1

公开(公告)日：2014-09-04

申请号：US14348857

申请日：2012-01-16

申请人： Dadong Zhang ,  Xu Cai ,  Chengyun Yue ,  Junfei Li ,  Yan Hu ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo

发明人： Dadong Zhang ,  Xu Cai ,  Chengyun Yue ,  Junfei Li ,  Yan Hu ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo

IPC分类号： A61L31/16 ,  A61L31/10 ,  A61L31/14

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  C08L75/04 ,  C08L67/04 ,  C08L89/00 ,  C08L33/10 ,  C08L5/08

摘要： An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.

摘要翻译： 介入医疗装置及其制造方法。 介入医疗装置包括：支架主体（1）; 支架体（1）的表面设有药物释放结构（3），药物释放结构（3）中的药物是抑制外膜成纤维细胞增殖的药物和抑制内膜和/或平滑增生的药物 肌肉细胞。 在使用中，将介入医疗装置植入人体后，用于抑制携带的外膜成纤维细胞增殖的药物可以促进血管的代偿性扩张，并且抑制其上承载的内膜细胞和/或平滑肌细胞增殖的药物 可以抑制血管的内膜增殖。 两种药物的组合大大降低了支架内再狭窄的发生率。

公开(公告)号：US20130296806A1

公开(公告)日：2013-11-07

申请号：US13703855

申请日：2011-06-13

申请人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

发明人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

IPC分类号： A61L27/34

CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/42

摘要： The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.

摘要翻译： 本发明公开了一种介入医疗装置及其制造方法。 至少一个涂层设置在介入医疗装置的外表面上，涂层的最外层的材料是含磺酸基的聚合物。 在本发明中，介入医疗装置的最外层的材料是含磺酸基的聚合物。 由于存在磺酸盐基，除了适当的亲水性之外，聚合物具有与肝素相同的表面性质。 在将介入医疗装置植入人体后，在介入医疗装置的外表面上形成亲水性表面，其也在体液中带负电。 因此，由于细胞相容性的增强，细胞可以容易地附着和生长在其外表面上。 此外，由于与肝素相同的表面特性，具有优异的抗凝血性，能够抑制血栓形成，降低手术后并发症的发生率。

公开(公告)号：US09226994B2

公开(公告)日：2016-01-05

申请号：US13703855

申请日：2011-06-13

申请人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

发明人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

IPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16

CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/42

摘要： The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.

摘要翻译： 本发明公开了一种介入医疗装置及其制造方法。 至少一个涂层设置在介入医疗装置的外表面上，涂层的最外层的材料是含磺酸基的聚合物。 在本发明中，介入医疗装置的最外层的材料是含磺酸基的聚合物。 由于存在磺酸盐基，除了适当的亲水性之外，聚合物具有与肝素相同的表面性质。 在将介入医疗装置植入人体后，在介入医疗装置的外表面上形成亲水性表面，其也在体液中带负电。 因此，由于细胞相容性的增强，细胞可以容易地附着和生长在其外表面上。 此外，由于与肝素相同的表面特性，具有优异的抗凝血性，能够抑制血栓形成，降低手术后并发症的发生率。

公开(公告)号：US20120316642A1

公开(公告)日：2012-12-13

申请号：US13519930

申请日：2010-12-30

申请人： Qifeng Yu ,  Xiang Liu ,  Yunlei Wang ,  Chengyun Yue ,  Qiyi Luo

发明人： Qifeng Yu ,  Xiang Liu ,  Yunlei Wang ,  Chengyun Yue ,  Qiyi Luo

IPC分类号： A61F2/24

CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2002/3021 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2220/0075 ,  A61F2230/0021 ,  A61F2230/0023 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039

摘要： An invasive cardiac valve comprises a tubular stent (1) and a valve (2). One end of the tubular stent (1) is of a frusto-conical structure, the other end is wide open, and the diameter of the open end is greater than the diameter of the frusto-conical end. The valve (2) is attached to the frusto-conical end of the tubular stent (1); and a delivery and retrieval hole (4) of the cardiac valve is provided at the top of the open end of the tubular stent (1). Because the diameter of the open end is greater than the diameter of the frusto-conical end, the cardiac valve can be effectively fixed in a position of aortic annulus to prevent the cardiac valve displacement caused by the impact of the blood flow. Because the valve (2) is attached to the frusto-conical end of the tubular stent (1), the valve (2) can totally avoid the left and right coronary ostia and does not affect the haemodynamics of the coronary artery. Because a delivery and retrieval hole (4) of the cardiac valve is provided at the top of the open end of the tubular stent (1), the cardiac valve can be retrieved and reset at any time by handle control if it is found to be placed in an improper position during the release process.

摘要翻译： 侵入式心脏瓣膜包括管状支架（1）和阀（2）。 管状支架（1）的一端具有截头圆锥形结构，另一端敞开，开口端的直径大于截头圆锥端的直径。 阀（2）连接到管状支架（1）的截头圆锥端; 并且所述心脏瓣膜的输送和取出孔（4）设置在所述管状支架（1）的开口端的顶部。 因为开口端的直径大于截头圆锥端的直径，所以心脏瓣膜可以有效地固定在主动脉瓣环的位置，以防止由血液流动引起的心脏瓣膜位移。 因为阀（2）附接到管状支架（1）的截头圆锥端，所以阀（2）可以完全避免左冠状动脉和右冠状动脉，并且不影响冠状动脉的血流动力学。 因为心脏瓣膜的输送和取出孔（4）设置在管状支架（1）的开口端的顶部，所以如果发现心脏瓣膜被发现是可以通过手柄控制随时取出和重新设置心脏瓣膜 在释放过程中处于不正确的位置。

公开(公告)号：US09095431B2

公开(公告)日：2015-08-04

申请号：US13519930

申请日：2010-12-30

申请人： Qifeng Yu ,  Xiang Liu ,  Yunlei Wang ,  Chengyun Yue ,  Qiyi Luo

发明人： Qifeng Yu ,  Xiang Liu ,  Yunlei Wang ,  Chengyun Yue ,  Qiyi Luo

IPC分类号： A61F2/06 ,  A61F2/24 ,  A61F2/30

CPC分类号： A61F2/2412 ,  A61F2/2415 ,  A61F2/2418 ,  A61F2002/3021 ,  A61F2002/9528 ,  A61F2002/9534 ,  A61F2220/0075 ,  A61F2230/0021 ,  A61F2230/0023 ,  A61F2230/0054 ,  A61F2230/0067 ,  A61F2230/008 ,  A61F2250/0039

摘要： An invasive cardiac valve comprises a tubular stent (1) and a valve (2). One end of the tubular stent (1) is of a frusto-conical structure, the other end is wide open, and the diameter of the open end is greater than the diameter of the frusto-conical end. The valve (2) is attached to the frusto-conical end of the tubular stent (1); and a delivery and retrieval hole (4) of the cardiac valve is provided at the top of the open end of the tubular stent (1). Because the diameter of the open end is greater than the diameter of the frusto-conical end, the cardiac valve can be effectively fixed in a position of aortic annulus to prevent the cardiac valve displacement caused by the impact of the blood flow. Because the valve (2) is attached to the frusto-conical end of the tubular stent (1), the valve (2) can totally avoid the left and right coronary ostia and does not affect the haemodynamics of the coronary artery. Because a delivery and retrieval hole (4) of the cardiac valve is provided at the top of the open end of the tubular stent (1), the cardiac valve can be retrieved and reset at any time by handle control if it is found to be placed in an improper position during the release process.

摘要翻译： 侵入式心脏瓣膜包括管状支架（1）和阀（2）。 管状支架（1）的一端具有截头圆锥形结构，另一端敞开，开口端的直径大于截头圆锥端的直径。 阀（2）连接到管状支架（1）的截头圆锥端; 并且所述心脏瓣膜的输送和取出孔（4）设置在所述管状支架（1）的开口端的顶部。 因为开口端的直径大于截头圆锥端的直径，所以心脏瓣膜可以有效地固定在主动脉瓣环的位置，以防止由血液流动引起的心脏瓣膜位移。 因为阀（2）附接到管状支架（1）的截头圆锥端，所以阀（2）可以完全避免左冠状动脉和右冠状动脉，并且不影响冠状动脉的血流动力学。 因为心脏瓣膜的输送和取出孔（4）设置在管状支架（1）的开口端的顶部，所以如果发现心脏瓣膜被发现是可以通过手柄控制随时取出和重新设置心脏瓣膜 在释放过程中处于不正确的位置。

公开(公告)号：US07427415B2

公开(公告)日：2008-09-23

申请号：US10684859

申请日：2003-10-14

申请人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

发明人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

IPC分类号： A61K9/16

CPC分类号： C12N11/08 ,  A61K9/0024 ,  A61K9/5031 ,  A61K9/5036 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/30 ,  C12N2533/74

摘要： The present invention relates to compositions and methods of treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. This invention provides for the placement of biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials. Several methods are presented to accomplish coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. This invention also provides methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

摘要翻译： 本发明涉及通过将包封的生物材料植入需要治疗的患者中来治疗疾病如糖尿病的组合物和方法。 本发明提供了使用光聚合在生物材料周围放置生物相容性涂层材料，同时保持生物材料的预包封状态。 提出了几种方法来完成涂覆几种不同类型的生物材料。 涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。 产生涂层的聚合反应的组分可以包括天然和合成聚合物，大分子单体，促进剂，助催化剂，光引发剂和辐射。 本发明还提供了利用这些封装的生物材料通过将它们植入包括皮下部位在内的身体的若干区域来治疗不同的人和动物疾病或病症的方法。 可以操作涂层材料以提供不同程度的生物相容性，蛋白质扩散性特征，强度和生物降解性，以优化从包封的植入物到宿主受体的生物材料递送，同时保护封装的生物材料免受宿主炎症和免疫的破坏 不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。

公开(公告)号：US20090004238A1

公开(公告)日：2009-01-01

申请号：US12197040

申请日：2008-08-22

申请人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

发明人： David Scharp ,  Paul Latta ,  Chengyun Yue ,  Xiaojie Yu ,  Jeffrey Alan Hubbell

IPC分类号： A61K45/00 ,  A61P25/00 ,  A61P9/00 ,  A61P17/00 ,  A61P3/00 ,  A61P37/00 ,  A61K9/48

CPC分类号： C12N11/08 ,  A61K9/0024 ,  A61K9/5031 ,  A61K9/5036 ,  A61K2035/126 ,  C12N5/0012 ,  C12N5/0677 ,  C12N11/04 ,  C12N2533/30 ,  C12N2533/74

摘要： Methods of applying biocompatible coating materials around biological materials using photopolymerization while maintaining the pre-encapsulation status of the biological materials are disclosed. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. Methods of utilizing these encapsulated biological materials to treat different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site are also disclosed. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.

摘要翻译： 公开了在保持生物材料的预包封状态的同时使用光聚合在生物材料周围应用生物相容性涂层材料的方法。 涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。 产生涂层的聚合反应的组分可以包括天然和合成聚合物，大分子单体，促进剂，助催化剂，光引发剂和辐射。 还公开了利用这些包封的生物材料通过将它们植入体内包括皮下部位的几个区域来治疗不同的人和动物疾病或病症的方法。 可以操作涂层材料以提供不同程度的生物相容性，蛋白质扩散性特征，强度和生物降解性，以优化从包封的植入物到宿主受体的生物材料递送，同时保护封装的生物材料免受宿主炎症和免疫的破坏 不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。