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公开(公告)号：US20060057661A1
公开(公告)日：2006-03-16
申请号：US10881316
申请日：2004-06-30
申请人： Xuedong Song , Shu-Ping Yang , Rosann Kaylor
发明人： Xuedong Song , Shu-Ping Yang , Rosann Kaylor
CPC分类号： G01N33/558 , C12Q1/04 , G01N33/543 , G01N33/54326 , G01N33/58 , G01N33/68
摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.
摘要翻译： 提供了用于检测酶或酶抑制剂的存在或数量的诊断测试试剂盒。 诊断试剂盒利用反应性配合物来促进酶或酶抑制剂的检测。 反应性配合物包括与报告物和磁性物质连接（例如共价键合，物理吸附等）的底物。 在一个实施方案中，例如，将肽，蛋白质或糖蛋白底物连接到报告物（例如，染色的胶乳颗粒）和磁性颗粒。 在该实施方案中，底物提供蛋白水解酶的切割靶。 具体地，当与反应性配合物接触时，蛋白水解酶切割底物并释放报告物和/或磁性颗粒。 由释放的记者展示的信号可以用于指示测试样品中酶或酶抑制剂的存在或数量。
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公开(公告)号：US20060068500A1
公开(公告)日：2006-03-30
申请号：US10951367
申请日：2004-09-28
申请人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
发明人： Ning Wei , Shu-Ping Yang , Rosann Kaylor
IPC分类号： G01N33/558
CPC分类号： G01N33/558 , G01N2333/40
摘要： There is provided a lateral flow assay device for detecting the presence or quantity of an analyte residing in a test sample where the lateral flow assay device has a porous membrane in liquid communication with a conjugate pad and a wicking pad. The conjugate pad has a gold colloid-containing detection probe. The porous membrane has a detection zone where an immobilized first capture reagent configured to bind to at least a portion of the analyte and analyte-conjugate complexes to generate a detection signal. The control zone is located downstream from the detection zone on the porous membrane and has a second capture reagent immobilized within the control zone. The conjugate pad is located upstream from the detection zone, and has detection probes with specific binding members for the analyte. A sample containing an analyte is deposited on the conjugate pad, interacts with the detection probes, and moves toward the control zone for detection.
摘要翻译： 提供了一种侧流测定装置，用于检测驻留在测试样品中的分析物的存在或数量，其中侧流测定装置具有与结合垫和芯吸垫液体连通的多孔膜。 共轭垫具有含金胶体的检测探针。 多孔膜具有检测区，其中固定的第一捕获试剂被配置为结合至少一部分分析物和分析物 - 共轭复合物以产生检测信号。 控制区位于多孔膜上的检测区的下游，并且具有固定在控制区内的第二捕获试剂。 缀合垫位于检测区的上游，并具有用于分析物的具有特异性结合构件的检测探针。 将含有分析物的样品沉积在共轭垫上，与检测探针相互作用，并朝向控制区移动进行检测。
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公开(公告)号：US07094528B2
公开(公告)日：2006-08-22
申请号：US10881316
申请日：2004-06-30
IPC分类号： C12Q1/00
CPC分类号： G01N33/558 , C12Q1/04 , G01N33/543 , G01N33/54326 , G01N33/58 , G01N33/68
摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.
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公开(公告)号：USD673595S1
公开(公告)日：2013-01-01
申请号：US29422979
申请日：2012-05-25
申请人： Ming-Hsien Cho , Shu-Ping Yang , Chen-Chia Chen
设计人： Ming-Hsien Cho , Shu-Ping Yang , Chen-Chia Chen
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公开(公告)号：US07795225B2
公开(公告)日：2010-09-14
申请号：US11609816
申请日：2006-12-12
申请人： Shu-Ping Yang , Stephen Quirk
发明人： Shu-Ping Yang , Stephen Quirk
摘要： The invention provides inhibitors of chondrosarcoma cell growth that are useful as anti-cancer and anti-tumor agents. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases and that can inhibit the activity of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams and wound dressings.
摘要翻译： 本发明提供了可用作抗癌剂和抗肿瘤剂的软骨肉瘤细胞生长抑制剂。 抑制剂是具有与基质金属蛋白酶的酶原形式的切割区相关的序列并且可以抑制基质金属蛋白酶的活性的肽。 本发明的肽抑制剂可以配制成治疗组合物，洗剂，霜剂和伤口敷料。
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公开(公告)号：US07786176B2
公开(公告)日：2010-08-31
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
发明人： Stephanie M. Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Linda Greene , Kelly Arehart , Curtis Sayre , Robert B. Johnson
IPC分类号： A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译： 提供了一种当与阴离子粘膜天然存在的单价或多价阳离子（例如钠（Na +）和钙（Ca 2+））阳离子接触时，迅速形成凝胶的阴道治疗组合物。 凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。 除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。 另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。 以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。 例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。
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公开(公告)号：US07658947B2
公开(公告)日：2010-02-09
申请号：US10877855
申请日：2004-06-25
申请人： Yanbin Huang , Shu-Ping Yang , Sharon Linda Greene
发明人： Yanbin Huang , Shu-Ping Yang , Sharon Linda Greene
IPC分类号： A61K9/14
CPC分类号： A61K9/0024 , A61K8/042 , A61K8/365 , A61K8/731 , A61K47/12 , A61K47/38 , A61K2800/5422 , A61Q19/00
摘要： There is provided a new thermo-gelling composition made with methylcellulose and citric acid. This composition may also have an effective amount of a treating agent, which may be a medicinal agent, cosmetic agent, moisturizer, adjuvant, nutritional agent, other ingredients and combinations thereof. The composition is useful in delivering moisturizers or pharmaceutically active agents to the user in a controlled release manner through the mucosal tissues in a body cavity, or on body surfaces, or as a subcutaneously injected medicament. The composition may also be used as a replacement for the soft tissues of the body as in, for example, the foot cushion and cartilage repair.
摘要翻译： 提供了由甲基纤维素和柠檬酸制成的新的热凝胶组合物。 该组合物还可以具有有效量的处理剂，其可以是药剂，化妆品，保湿剂，佐剂，营养剂，其它成分及其组合。 该组合物可用于通过体腔或身体表面的粘膜组织或皮下注射的药物以控制释放的方式向使用者输送保湿剂或药物活性剂。 该组合物还可以用作身体的软组织的替代物，例如在脚垫和软骨修复中。
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8.发明申请Therapeutic article including a personal care composition and methods of making the therapeutic article 有权包括个人护理组合物和制备治疗用品的方法的治疗用品公开(公告)号：US20070135777A1
公开(公告)日：2007-06-14
申请号：US11300601
申请日：2005-12-14
申请人： Sharon Greene , Kaiyuan Yang , Shu-Ping Yang , Ning Wei , Jai Kyung , Jeffrey Fish
发明人： Sharon Greene , Kaiyuan Yang , Shu-Ping Yang , Ning Wei , Jai Kyung , Jeffrey Fish
IPC分类号： A61F13/00
CPC分类号： A61K9/70 , A61F2013/00646 , A61F2013/00727 , A61M35/00
摘要： A therapeutic article includes a skin contact layer having a plurality of fibers forming a plurality of point-bearing surfaces configured for wear against a user's skin; a personal care composition disposed proximate the fibers; an external layer attached to the skin contact layer; and an intermediate layer interposed between the skin contact layer and the external layer, the intermediate layer being configured to activate the personal care composition, the external layer being configured to direct the activated personal care composition through the skin contact layer to treat the user.
摘要翻译： 治疗用品包括皮肤接触层，所述皮肤接触层具有多个纤维，所述多个纤维形成用于对使用者的皮肤的磨损的多个点支承表面; 设置在纤维附近的个人护理组合物; 附着于皮肤接触层的外层; 以及介于皮肤接触层和外层之间的中间层，所述中间层被配置为激活个人护理组合物，所述外层被配置为引导所述活化的个人护理组合物通过所述皮肤接触层以治疗所述使用者。
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公开(公告)号：US20070078090A1
公开(公告)日：2007-04-05
申请号：US11609816
申请日：2006-12-12
申请人： Shu-Ping Yang , Stephen Quirk
发明人： Shu-Ping Yang , Stephen Quirk
IPC分类号： A61K38/10
摘要： The invention provides inhibitors of chondrosarcoma cell growth that are useful as anti-cancer and anti-tumor agents. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases and that can inhibit the activity of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams and wound dressings.
摘要翻译： 本发明提供了可用作抗癌剂和抗肿瘤剂的软骨肉瘤细胞生长抑制剂。 抑制剂是具有与基质金属蛋白酶的酶原形式的切割区相关的序列并且可以抑制基质金属蛋白酶的活性的肽。 本发明的肽抑制剂可以配制成治疗组合物，洗剂，霜剂和伤口敷料。
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公开(公告)号：US08399012B2
公开(公告)日：2013-03-19
申请号：US11405262
申请日：2006-04-17
申请人： Molly K. Smith , Kelly D. Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
发明人： Molly K. Smith , Kelly D. Arehart , Lei Huang , Shu-Ping Yang , Yanbin Huang
CPC分类号： A61K47/34 , A61F6/08 , A61K9/0036 , A61K31/00 , A61K31/19 , A61M31/002 , C08G63/12 , C08G63/16 , C08G63/914
摘要： A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.
摘要翻译： 公开了一种可生物降解的生物输送装置。 生物输送装置由包含多元醇和多元酸的反应产物的聚合物形成。 当暴露于水时，聚合物通过水解降解。 特别有利的是，聚合物可以形成为具有弹性和柔性。 在一个实施方案中，聚合物形成阴道插入物。 当聚合物降解时，聚合物将酸释放到阴道环境中以降低环境的pH。
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