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公开(公告)号：US11692216B2
公开(公告)日：2023-07-04
申请号：US16788406
申请日：2020-02-12
发明人： Masaaki Oka , Shoichi Hazama , Ryouichi Tsunedomi
IPC分类号： C12Q1/6886 , C12Q1/6827 , C12Q1/68 , C12Q1/6809 , C12Q1/6876 , G01N33/50
CPC分类号： C12Q1/6827 , C12Q1/68 , C12Q1/6809 , C12Q1/6876 , G01N33/5014 , C12Q2600/106 , C12Q2600/118 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158
摘要： An object of the present invention is to provide a simple and efficient device for predicting a risk of occurrence of a side effect of irinotecan by analyzing a single nucleotide polymorphism in a region encoding a specific gene. The prediction of the risk of the occurrence of a side effect of irinotecan is assisted by analyzing a single nucleotide polymorphism in a region encoding the APCDD1L gene, the R3HCC1 gene, the OR51I2 gene, the MKKS gene, the EDEM3 gene, or the ACOX1 gene which are present on genomic DNA in a biological sample collected from a test subject; or a single nucleotide polymorphism which is in linkage disequilibrium with or genetically linked to the single nucleotide polymorphism, and determining whether the single nucleotide polymorphism is homozygous for a variant type, heterozygous, or homozygous for a wild-type.
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公开(公告)号：US10450601B2
公开(公告)日：2019-10-22
申请号：US15024392
申请日：2014-09-01
IPC分类号： C12Q1/68 , C07H21/00 , C12Q1/6837 , C12N15/09 , C12Q1/6816 , C12Q1/6832
摘要： A buffer composition for hybridization of a target nucleic acid is provided. The nucleic acid can include a nucleotide to be detected with a nucleic acid probe. The probe can contain a nucleotide sequence complementary to the target nucleic acid. The buffer can include a blocking nucleic acid having a nucleotide sequence complementary to a non-target nucleic acid having a nucleotide not to be detected corresponding to the nucleotide to be detected. The buffer composition can suppress non-specific hybridization to the nucleic acid probe even when a non-target nucleic acid is present. The use of the buffer composition can achieve excellent detection efficiency of the target nucleic acid.
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公开(公告)号：US20200172966A1
公开(公告)日：2020-06-04
申请号：US16788406
申请日：2020-02-12
发明人： Masaaki Oka , Shoichi Hazama , Ryouichi Tsunedomi
IPC分类号： C12Q1/6827 , G01N33/50 , C12Q1/6876 , C12Q1/6809 , C12Q1/68
摘要： An object of the present invention is to provide a simple and efficient device for predicting a risk of occurrence of a side effect of irinotecan by analyzing a single nucleotide polymorphism in a region encoding a specific gene. The prediction of the risk of the occurrence of a side effect of irinotecan is assisted by analyzing a single nucleotide polymorphism in a region encoding the APCDD1L gene, the R3HCC1 gene, the OR5112 gene, the MKKS gene, the EDEM3 gene, or the ACOX1 gene which are present on genomic DNA in a biological sample collected from a test subject; or a single nucleotide polymorphism which is in linkage disequilibrium with or genetically linked to the single nucleotide polymorphism, and determining whether the single nucleotide polymorphism is homozygous for a variant type, heterozygous, or homozygous for a wild-type.
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公开(公告)号：US20180237833A1
公开(公告)日：2018-08-23
申请号：US15549823
申请日：2016-02-16
发明人： Masaaki Oka , Shoichi Hazama , Ryouichi Tsunedomi
IPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6876 , G01N33/50
CPC分类号： C12Q1/6827 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/142 , C12Q2600/156 , C12Q2600/158 , G01N33/5014
摘要： An object of the present invention is to provide a simple and efficient device for predicting a risk of occurrence of a side effect of irinotecan by analyzing a single nucleotide polymorphism in a region encoding a specific gene. The prediction of the risk of the occurrence of a side effect of irinotecan is assisted by analyzing a single nucleotide polymorphism in a region encoding the APCDD1L gene, the R3HCC1 gene, the OR5112 gene, the MKKS gene, the EDEM3 gene, or the ACOX1 gene which are present on genomic DNA in a biological sample collected from a test subject; or a single nucleotide polymorphism which is in linkage disequilibrium with or genetically linked to the single nucleotide polymorphism, and determining whether the single nucleotide polymorphism is homozygous for a variant type, heterozygous, or homozygous for a wild-type.
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5.发明授权公开(公告)号：US11461598B2
公开(公告)日：2022-10-04
申请号：US16079835
申请日：2016-12-26
申请人： Yamaguchi University
摘要： An information processor can logically support prediction based on past statistical information even though the information contains qualitative or non-numerical data. The processor determines whether an input pattern corresponding to an input object (a determination target) belongs to a specific class among multiple classes, based on feature subsets of any combination of a plurality of features, each feature comprises multiple categories. The processor includes a storage storing the input pattern corresponding to the input object and samples corresponding to respective sample objects and a classification determiner determining whether the input pattern belongs to the specific class. The classification determiner calculates a first conditional probability and a second conditional probability based on the number of the samples belonging to each category of the respective features, the first conditional probability is a probability that the data of the input pattern belong to categories corresponding to the respective feature for the specific class, the second conditional probability is a probability that the data of the input pattern belong to categories corresponding to the respective features for a non-specific class which is a class other than the specific class among classes, and the number of the samples is counted for each class based on the feature information on the samples and the class label information on the samples, and determines whether the input pattern belongs to the specific class based on the feature information on the input pattern, the first conditional probability and the second conditional probability.
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