公开(公告)号：US20070243546A1

公开(公告)日：2007-10-18

申请号：US11695599

申请日：2007-04-02

申请人： Yanxiang Cao ,  Shivani Nautiyal ,  Charles Miyada ,  Christopher Davies ,  Gangwu Mei ,  Alan Williams ,  Eric Schell ,  John Blume

发明人： Yanxiang Cao ,  Shivani Nautiyal ,  Charles Miyada ,  Christopher Davies ,  Gangwu Mei ,  Alan Williams ,  Eric Schell ,  John Blume

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q2600/154 ,  C12Q2523/125

摘要： Arrays for genome-wide analysis of methylation are disclosed. In a preferred aspect arrays comprising a plurality of probes complementary to a plurality of identified CpG islands in the human, mouse and rat genome are disclosed. The arrays may be used to detect methylation within CpG islands in samples from human, mouse and rat genomes.

摘要翻译： 公开了用于甲基化的全基因组分析的阵列。 在优选的方面，公开了包含与人，小鼠和大鼠基因组中的多个鉴定的CpG岛互补的多个探针的阵列。 阵列可用于检测来自人，小鼠和大鼠基因组的样品中CpG岛内的甲基化。

公开(公告)号：US20050272080A1

公开(公告)日：2005-12-08

申请号：US11121849

申请日：2005-05-03

申请人： John Palma ,  Eric Schell ,  Alan Williams

发明人： John Palma ,  Eric Schell ,  Alan Williams

IPC分类号： C12M1/34 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/158 ,  C12Q2600/166

摘要： The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these compromised samples. Arrays are disclosed in which the probe selection region used to select probes for the array is the 300 bases of the target MRNA that are immediately upstream of the start of the poly(A) tail of the mRNA. The probes selected for the array are more biased toward the 3′ end of the mRNA than other arrays that are currently available.

摘要翻译： 本发明提供用于分析受损核酸样品的阵列，例如从福尔马林固定石蜡包埋样品获得的核酸和分析这些受损样品的方法。 公开了阵列，其中用于选择阵列的探针的探针选择区是目标MRNA的300个碱基，其紧邻mRNA的poly（A）尾的起始位置的上游。 针对阵列选择的探针比目前可用的其他阵列更偏向mRNA的3'末端。

公开(公告)号：US20070148667A1

公开(公告)日：2007-06-28

申请号：US11538054

申请日：2006-10-02

申请人： Alan Williams ,  Simon Cawley ,  John Blume ,  Hui Wang ,  Tyson Clark

发明人： Alan Williams ,  Simon Cawley ,  John Blume ,  Hui Wang ,  Tyson Clark

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： G06F19/20

摘要： Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.

摘要翻译： 公开了用于分析可选拼接的方法和软件产品。 一般来说，这些方法涉及将探针组或外显子强度标准化为基因的表达水平测量。 该方法可用于鉴定组织特异性选择性剪接事件。

公开(公告)号：US20050244851A1

公开(公告)日：2005-11-03

申请号：US11036498

申请日：2005-01-13

申请人： John Blume ,  Alan Williams

发明人： John Blume ,  Alan Williams

IPC分类号： C12M1/34 ,  C12Q1/68

CPC分类号： C12Q1/6876 ,  C12Q1/6837 ,  C12Q2600/158 ,  C12Q2600/166

摘要： The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of human exons. The invention provides the sequences in such a way as to make them available for a variety of analyses including analysis of alternative splicing events. In one embodiment the nucleic acid sequences provided are present as an array of probes that may be used to measure gene expression of at least 5,000 alternatively spliced human genes. As such, the invention relates to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, pharmacology and medical diagnostics.

摘要翻译： 本发明提供在一个实施方案中与各种各样的人外显子互补的核酸序列。 本发明以这样的方式提供了序列，使得它们可用于各种分析，包括可变剪接事件的分析。 在一个实施方案中，提供的核酸序列作为可用于测量至少5,000个可变剪接的人基因的基因表达的探针阵列存在。 因此，本发明涉及受分子相互作用性质影响的不同领域，包括化学，生物学，医学，药理学和医学诊断。

公开(公告)号：US20050214823A1

公开(公告)日：2005-09-29

申请号：US11036317

申请日：2005-01-13

申请人： John Blume ,  Alan Williams

发明人： John Blume ,  Alan Williams

IPC分类号： C12M1/34 ,  C12Q1/68

CPC分类号： C12Q1/6876 ,  C12Q2600/158 ,  C12Q2600/166

摘要： The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of mouse genes. The invention provides the sequences in such a way as to make them available for a variety of analyses. In one embodiment the nucleic acid sequences provided are present as an array of probes that may be used to measure gene expression of different mature RNA isoforms from at least 5,000 alternatively spliced mouse genes. As such, the invention relates to diverse fields impacted by the nature of molecular interaction, including chemistry, biology, medicine, pharmacology and medical diagnostics.

摘要翻译： 本发明提供在一个实施方案中与多种小鼠基因互补的核酸序列。 本发明提供了这样的顺序，使得它们可用于各种分析。 在一个实施方案中，提供的核酸序列作为探针阵列存在，其可用于从至少5,000个可变剪接的小鼠基因测量不同成熟RNA同种型的基因表达。 因此，本发明涉及受分子相互作用性质影响的不同领域，包括化学，生物学，医学，药理学和医学诊断。

公开(公告)号：US10241075B2

公开(公告)日：2019-03-26

申请号：US13340490

申请日：2011-12-29

申请人： Melville Davey ,  Simon Cawley ,  Alan Williams

发明人： Melville Davey ,  Simon Cawley ,  Alan Williams

IPC分类号： G01N27/414 ,  G06F19/22 ,  G01N27/27

摘要： A method for nucleic acid sequencing includes receiving a plurality of signals indicative of a parameter measured for a plurality of defined spaces, at least some of the defined spaces including one or more sample nucleic acids, the signals being responsive to a plurality of nucleotide flows introducing nucleotides to the defined spaces; determining, for at least some of the defined spaces, whether the defined space includes a sample nucleic acid; processing, for at least some of the defined spaces determined to include a sample nucleic acid, the received signals to improve a quality of the received signals; and predicting a plurality of nucleotide sequences corresponding to respective sample nucleic acids for the defined spaces based on the processed signals and the nucleotide flows.

公开(公告)号：US07497238B2

公开(公告)日：2009-03-03

申请号：US11218323

申请日：2005-09-01

申请人： Alan Williams

发明人： Alan Williams

IPC分类号： B27C5/00

CPC分类号： B27D1/10 ,  B27G5/02 ,  B27M3/002 ,  Y10T83/7627

摘要： Apparatus and method for use with a power saw or router in cutting workpieces to form a lap joint or a routed groove, involves at least one channel-forming member forming an elongated channel having an open side to receive at least one workpiece and having a cutter-receiving opening, and one or more guides on the channel-forming member and extending in a direction transverse to the channel so as to guide a saw or router in a manner that a cutter thereof is guided to cut across the workpiece residing in the channel.

摘要翻译： 用于切割工件以形成搭接接头或布线槽的动力锯或路由器的装置和方法涉及形成具有开口侧的细长通道的至少一个通道形成构件，以容纳至少一个工件并具有切割器 以及一个或多个在通道形成构件上的引导件，并且在横向于通道的方向上延伸，以便引导锯或路由器，使得其切割器被引导穿过驻留在通道中的工件 。

公开(公告)号：US20060027288A1

公开(公告)日：2006-02-09

申请号：US10914346

申请日：2004-08-09

申请人： Alan Williams

发明人： Alan Williams

IPC分类号： B27C5/00

CPC分类号： B27D1/10 ,  B27G5/02 ,  B27M3/002

摘要： Apparatus and method for use with a power saw in cutting workpieces to form a lap joint, involves at least one channel-forming member forming an elongated channel having an open side to receive overlapped regions of first an second workpieces and having a saw blade-receiving opening, and one or more saw guides on the channel-forming member and extending in a direction transverse to the channel so as to guide a saw in a manner that a cutting blade thereof is guided to cut across the overlapped regions residing in the channel.

摘要翻译： 用于切割工件以形成搭接接头的动力锯的装置和方法涉及至少一个通道形成构件，其形成具有敞开侧的细长通道，以接收第一和第二工件的重叠区域并具有锯片接收 开口和一个或多个锯条引导件，并且在横向于通道的方向上延伸，以便引导锯，使其切割刀片被引导穿过位于通道中的重叠区域。

公开(公告)号：US06350500B1

公开(公告)日：2002-02-26

申请号：US09385901

申请日：1999-08-30

申请人： Mike Drummond ,  Alan Williams ,  Gerald Gainey

发明人： Mike Drummond ,  Alan Williams ,  Gerald Gainey

IPC分类号： B65D304

CPC分类号： B29C53/60 ,  B29C53/607 ,  B29C2053/8025 ,  B31C3/00 ,  B31C3/04 ,  B65D3/22 ,  Y10S206/803 ,  Y10S206/83 ,  Y10T156/1739 ,  Y10T428/1303 ,  Y10T428/1352 ,  Y10T428/2826

摘要： A tubular composite container includes a paperboard body ply wrapped into a tubular shape, and a polymer film liner ply wrapped into a tubular shape and adhered to the inner surface of the body ply. The liner strip includes a heat seal layer facing the body ply that is formed of a heat-sealable material, and the inner surface of the liner ply that contacts the mandrel is formed of a hard polymer material whose melting temperature is substantially higher than the sealing temperature at which the heat-sealable material softens and seals to itself. One edge portion of the liner ply is folded inward toward the mandrel, the liner ply is wrapped onto the mandrel such that the folded edge portion overlaps an opposite edge portion of the liner ply, and the heat seal layer on the folded edge portion is heat sealed to the opposite edge portion.

摘要翻译： 管状复合容器包括被包裹成管状的纸板本体层和被包裹成管状的聚合物膜衬垫层，并且粘合到主体帘布层的内表面。 衬垫条包括面向主体层的热封层，其由可热封材料形成，并且与心轴接触的衬垫层的内表面由熔融温度明显高于密封件的硬质聚合物材料形成 可热封材料软化并密封到其自身的温度。 衬垫层的一个边缘部分朝向心轴向内折叠，衬垫层被包裹在心轴上，使得折叠边缘部分与衬垫层的相对边缘部分重叠，并且折叠边缘部分上的热封层是热的 密封到相对边缘部分。

公开(公告)号：US08596403B2

公开(公告)日：2013-12-03

申请号：US13426716

申请日：2012-03-22

申请人： James Dennis Cunningham ,  Taichi Yamashita ,  Alan Williams

发明人： James Dennis Cunningham ,  Taichi Yamashita ,  Alan Williams

IPC分类号： B60K1/00

CPC分类号： B60K1/00 ,  B62D25/082 ,  Y10T29/49826

摘要： An electric vehicle includes a right side member and a left side member with a motor compartment disposed therebetween, a motor compartment cross member extending transversely across the motor compartment, the motor compartment cross member coupled to the left side member and the right side member, a front cross member extending transversely across the motor compartment, wherein the front cross member is spaced apart from the motor compartment cross member in a vertical direction, and a motor mount member extending between the front cross member and the motor compartment cross member, wherein the motor mount member is coupled to the front cross member and the motor compartment cross member, the motor mount member comprising an attachment point for receiving a corresponding coupler of an electric motor.

摘要翻译： 一种电动车辆包括右侧构件和左侧构件，其间设置有电动机室，横向延伸穿过电动机室的电动机室横向构件，联接到左侧构件和右侧构件的电动机室横向构件， 所述前横梁横向延伸穿过所述马达室，其中所述前横向构件在垂直方向上与所述马达室横向构件间隔开;以及马达安装构件，其在所述前横梁和所述马达室横向构件之间延伸，其中所述马达 安装构件联接到前横向构件和马达室横向构件，马达安装构件包括用于接收电动机的对应联接器的附接点。