摘要:
A variety of organic materials susceptible to fungal attack (especially wood and wood-based materials) can be protected from such attack and fungi growing on such materials can be eradicated by treating them, e.g. by applying to the surfaces or impregnating, with one or more compounds of formula (I): ##STR1## (wherein X represents a halogen atom and R represents a hydroxy group, an alkoxy gorup, a substituted or unsubstituted phenoxy group, an amino group, a mono- or di- alkylamino group, a phenylamino or benzylamino group which is unsubstituted or has one or two substituents on the benzene ring of the phenyl or benzyl moiety, or a 3-halo-2,3-diiodoallyloxy group). An anti-fungal composition contains one or more of these compounds in admixture with a carrier or adjuvant.
摘要:
Iodopropargyl derivatives of formula:IC.tbd.CCH.sub.2 OR[wherein R represents an alkanoyl group (which may be unsubstituted or have one or more halogen, cyano, substituted or unsubstituted .alpha.-phenoxy or phenyl substituents) an alkenoyl group (optionally phenyl-substituted), a substituted or unsubstitutd alkoxycarbonyl group, a cycloalkanoyl group, a substituted or unsubstituted benzoyl group, a substituted or unsubstituted phenoxycarbonyl group, a substituted or unsubstituted benzyloxycarbonyl group, a heterocyclic carbonyl group, an alkylsulphonyl group, a substituted or unsubstituted benzenesulphonyl group, a naphthyloxycarbonyl group, an iodopropargyloxycarbonyl group, a substituted or unsubstituted cycloalkoxycarbonyl group, a heterocyclic methoxycarbonyl group, a 3-pyridyloxycarbonyl group (which may be unsubstituted or have one or more halogen substituents) or an alkenyloxycarbonyl group] are, except where R represents an acetyl or an unsubstituted benzoyl group, new compounds and are useful for the preservation of a variety or organic materials, including the protection of these materials against fungal or insect attack. The derivatives may be prepared by reacting 3-hydroxy-1-iodo-1-propyne with a compound of formula RX (in which R is as defined above and X represents a halogen atom) or, where R in the desired compound contains an oxycarbonyl group, reacting the 3-hydroxy-1-iodo-1-propyne with phosgene and then reacting the product with an appropriate hydroxy-containing compound.
摘要:
1,1,2-Triiodo-1-propene and 1-bromo-1,2-diiodo-1-propene derivatives having a formyloxy, alkanoyloxy, alkoxycarbonyloxy, alkoxycarbonylalkoxy, phenoxycarbonylalkoxy or benzyloxycarbonylalkoxy group at the 3-position are valuable anti-fungal and preservative agents having good heat and light stability.
摘要:
Compounds of formula (I): ##STR1## [in which: R.sup.1 is heterocyclic group having 5 or 6 ring atoms, or --NR.sup.7 R.sup.8, where R.sup.7 is alkyl and R.sup.8 is optionally substituted phenyl, optionally substituted phenylalkyl or cycloalkyl; R.sup.2 is optionally substituted phenyl or naphthyl; R.sup.3 is thiazolyl; R.sup.4 is cyclohexyl or isopropyl; R.sup.5 is alkyl; and R.sup.6 is alkyl] and salts thereof have renin-inhibitory and, hence, hypotensive activities and are of value in the diagnosis and treatment of hypertension induced by failures in the renin-angiotensin system. They may be prepared by reacting together appropriate amino acids or derivatives thereof.
摘要:
Oligopeptides of formula (I): ##STR1## where R.sup.1 -R.sup.5 are various organic groups, and A represents a group of formula --NH-- or --(CH.sub.2).sub.n --, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.
摘要:
Pyridine derivatives having the formula ##STR1## wherein R.sub.1 represents hydrogen atom, amino group or a group ##STR2## in which R.sub.5 and R.sub.6 may be the same or different and each represents an alkyl group of 1 to 4 carbon atoms or R.sub.5 is hydrogen atom and R.sub.6 represents an alkyl group of 1 to 4 carbon atoms, an alkenyl group of 3 or 4 carbon atoms or a benzyl group optionally substituted with halogen, cyano, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms;R.sub.2 represents nitro group, amino group or an alkylamino group of 1 to 3 carbon atoms;R.sub.3 and R.sub.4 individually represent hydrogen atom, an alkyl group of 1 to 4 carbon atoms, an alkoxyalkyl group which has 1 to 4 carbon atoms in the alkoxy moiety and 2 to 4 carbon atoms in the alkyl moiety, an alkenyl group of 3 or 4 carbon atoms, an alkanoyl group of 1 to 18 carbon atoms or a benzyl group optionally substituted with halogen, cyano, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms; provided that when R.sub.1 is hydrogen atom and R.sub.2 is nitro group, R.sub.3 and R.sub.4 may be the same or different and each represents said alkyl group or said alkoxyalkyl group or R.sub.3 is hydrogen atom and R.sub.4 is hydrogen atom, said alkyl group, said alkoxyalkyl group, said alkenyl group, said alkanoyl group or said benzyl group, when R.sub.1 is hydrogen atom and R.sub.2 is amino group or said alkylamino group, R.sub.3 and R.sub.4 individually is hydrogen atom or they may be the same or different and each represents said alkyl group, when R.sub.1 is amino group and R.sub.2 is nitro group, R.sub.3 and R.sub.4 may be the same or different and each represents said alkyl group or R.sub. 3 is hydrogen atom and R.sub.4 is said alkyl group or said alkenyl group, and when R.sub.1 is said group ##STR3## and R.sub.2 is nitro group, R.sub.3 and R.sub.4 are the same as defined above with respect to the R.sub.5 and R.sub.6.They are highly effective in the treatment of coccidiosis, especially that caused by the protozoa belonging to the species Eimeria tenella or E. necatrix.
摘要:
Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms.They are highly effective in the treatment of coccidiosis.
摘要:
An anticoccidial composition which comprises a compound of the formula ##SPC1##Intimately dispersed in an inert edible carrier, wherein R.sub.1 and R.sub.2 are each hydrogen, an aliphatic acyl group, an aromatic acyl group or a heterocyclic acyl group, and at least R.sub.1 and R.sub.2 is said heterocyclic acyl group; or a salt thereof.The composition is a preventive and curative anticoccidial agent for poultry and domestic animals. Particularly, it shows a significant activity against chronic coccidiosis caused by Eimeria acervulina.The composition is less toxic for animals, besides it has an advantage that it is also effective for coccidiosis caused by coccidia resistant to the known anticoccidial agents.
摘要:
Compounds of formula (I): ##STR1## (in which: R.sup.1 is hydrogen or alkl; R.sup.2 is a variety of groups or atoms; R.sup.3 is optionally substituted hydroxy or --(NH).sub.n --NR.sup.5 R.sup.6, wherein R.sup.5 and R.sup.6 are a variety of groups or atoms, preferably alkyl substituted by heterocyclic, and n is 0 or 1; Q is oxygen or sulfur; and A is a C.sub.1 -C.sub.6 alkylene group) have valuable cardiotionic activity and may be used for the treatment of cardiac disorders. They may be prepared from corresponding compounds containing a benzene ring with a group --QH at the 1-position and a group --CO--CHR.sup.1 --NH--COOR.sup.7 at the 4-position by ring closure and introduction of the group of formula --A--CO--R.sup.3 in any order.
摘要翻译:式(I)化合物:其中:R 1是氢或烷基; R 2是各种基团或基团; R 3是任选取代的羟基或 - (NH)n -NR 5 R 6,其中R 5和R 6 是各种基团或原子,优选被杂环取代的烷基,n为0或1; Q为氧或硫; A为C1-C6亚烷基)具有有价值的心血管活性,可用于治疗心脏 疾病 它们可以由相应的化合物制备,所述化合物含有1-环基团-QH的苯环和通过闭环在4-位上的-CO-CHR1-NH-COOR7基团,并引入式-A- CO-R3以任何顺序。
摘要:
Pyridine derivatives having the formula ##STR1## wherein R.sub.1 is an alkyl group having 1 to 3 carbon atoms; R.sub.2 is hydrogen atom or an alkyl group having 1 to 3 carbon atoms; R.sub.3 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkenyl group having 3 or 4 carbon atoms, an alkyl group having 1 or 2 carbon atoms and hydroxy as a substituent, an alkanoyl group having 1 to 18 carbon atoms, an alkenoyl group having 3 to 11 carbon atoms, an aromatic acyl group having 6 or 10 carbon atoms in the aromatic ring and optionally alkyl, alkoxy, acetylamino, cyano or halogen as a substituent, a heterocyclic acyl group, an alkylcarbamoyl group having 1 to 4 carbon atoms in the alkyl moiety, an allylcarbamoyl group or hydroxy group; n is an integer of 0 to 2 inclusive; and, when n is 2, R.sub.1 's may be the same or different; provided that when R.sub.2 is said alkyl group having 1 to 3 carbon atoms, R.sub.3 is said alkyl group having 1 to 4 carbon atoms.They are highly effective in the treatment of coccidiosis.