公开(公告)号：US5329010A

公开(公告)日：1994-07-12

申请号：US840862

申请日：1992-02-25

申请人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Tetsuya Kawahara ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Koukichi Harada ,  Kaname Miyamoto ,  Koichi Abe

发明人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Tetsuya Kawahara ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Koukichi Harada ,  Kaname Miyamoto ,  Koichi Abe

IPC分类号： A61K31/44 ,  A61K31/122 ,  A61K31/4164 ,  A61K31/4406 ,  A61K31/4418 ,  A61K31/5377 ,  A61P1/16 ,  A61P11/06 ,  A61P11/08 ,  A61P43/00 ,  C07C50/06 ,  C07D213/28 ,  C07D213/50 ,  C07D213/55 ,  C07D213/56 ,  C07D233/54 ,  C07D233/64

CPC分类号： C07D213/56 ,  C07D213/55

摘要： The present invention is a quinone derivative which exhibits excellent therapeutic activity represented by the general formula (I) or a pharmacologically acceptable salt thereof: ##STR1## wherein A stands for a group represented by the formula: ##STR2## (wherein R.sup.3, R.sup.4 and R.sup.5 is the same or different from each other and each stand for a hydrogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxy group, an alkoxyalkyl group, an alkoxyalkoxy group, a cycloalkylalkoxy group, a thiol group or a thioalkyl group, with the proviso that R.sup.3 and R.sup.4 are each a lower alkoxy groupR.sup.1 stands for a heteroarylalkyl group; andB stands for a carboxyl group or a protected carboxyl group.

摘要翻译： 本发明是由通式（I）表示的优异的治疗活性或其药理学上可接受的盐的醌衍生物：其中A表示由下式表示的基团：（其中R 3 R 4和R 5彼此相同或不同，分别表示氢原子，羟基，低级烷基，低级烷氧基，烷氧基烷基，烷氧基烷氧基，环烷基烷氧基，硫醇基或 硫烷基，条件是R 3和R 4各自为低级烷氧基，R 1表示杂芳基烷基; B表示羧基或被保护的羧基。

公开(公告)号：US5635519A

公开(公告)日：1997-06-03

申请号：US388813

申请日：1995-02-15

申请人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Manabu Murakami ,  Kiyoshi Oketani ,  Takashi Inoue ,  Takashi Yamanaka ,  Isao Yamatsu

发明人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Manabu Murakami ,  Kiyoshi Oketani ,  Takashi Inoue ,  Takashi Yamanaka ,  Isao Yamatsu

IPC分类号： C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D401/02 ,  A61K31/44

CPC分类号： C07D417/06 ,  C07D277/82 ,  C07D417/12 ,  Y02P20/55

摘要： A benzothiazole derivative or a pharmacologically acceptable salt thereof of the following formula, as defined in the claims, which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective: ##STR1##

摘要翻译： 可用作抑制白细胞三烯和血栓素生成功能的疾病有效的预防或治疗剂的权利要求中所定义的下式的苯并噻唑衍生物或其药理学上可接受的盐：

公开(公告)号：US5420144A

公开(公告)日：1995-05-30

申请号：US148914

申请日：1993-11-05

申请人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Manabu Murakami ,  Kiyoshi Oketani ,  Takashi Inoue ,  Takashi Yamanaka ,  Isao Yamatsu

发明人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Manabu Murakami ,  Kiyoshi Oketani ,  Takashi Inoue ,  Takashi Yamanaka ,  Isao Yamatsu

IPC分类号： C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D417/04 ,  A61K31/41

CPC分类号： C07D417/06 ,  C07D277/82 ,  C07D417/12 ,  Y02P20/55

摘要： A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.A benzothiazole derivative represented by the following general formula (I): ##STR1##

摘要翻译： 可用作抑制白细胞三烯和血栓素生成功能有效的疾病的预防或治疗剂的苯并噻唑衍生物或其药理学上可接受的盐。 由以下通式（I）表示的苯并噻唑衍生物：（I）

公开(公告)号：US5300518A

公开(公告)日：1994-04-05

申请号：US861379

申请日：1992-03-31

申请人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Manabu Murakami ,  Kiyoshi Oketani ,  Takashi Inoue ,  Takashi Yamanaka ,  Isao Yamatsu

发明人： Yasushi Okamoto ,  Katsuya Tagami ,  Shigeki Hibi ,  Hirotoshi Numata ,  Naoki Kobayashi ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Manabu Murakami ,  Kiyoshi Oketani ,  Takashi Inoue ,  Takashi Yamanaka ,  Isao Yamatsu

IPC分类号： C07D277/82 ,  C07D417/06 ,  C07D417/12 ,  C07D277/62 ,  A61K31/41

CPC分类号： C07D417/06 ,  C07D277/82 ,  C07D417/12 ,  Y02P20/55

摘要： A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective.A benzothiazole derivative represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.3 are either the same or different and represents a hydrogen atom, a lower alkyl group or a lower alkoxy group; R.sup.4 represents a group represented by the formula --(CH.sub.x)--.sub.q wherein q is a integer of from 1 to 4;R.sup.2 represents a hydrogen atom and;R.sup.5 and R.sup.6 are the same or different and each represent a hydrogen atom or a lower alkyl group; or a pharmacologically acceptable salt thereof.

摘要翻译： 可用作抑制白细胞三烯和血栓素生成功能有效的疾病的预防或治疗剂的苯并噻唑衍生物或其药理学上可接受的盐。 由以下通式（I）表示的苯并噻唑衍生物：（*化学结构*）（I）其中R 1和R 3相同或不同，表示氢原子，低级烷基或低级烷氧基; R 4表示由式 - （CH x）-q表示的基团，其中q为1至4的整数; R2表示氢原子， R 5和R 6相同或不同，各自表示氢原子或低级烷基; 或其药理学上可接受的盐。

公开(公告)号：US20090215795A1

公开(公告)日：2009-08-27

申请号：US12175015

申请日：2008-07-17

申请人： Shuichi Suzuki ,  Makoto Kotake ,  Mitsuaki Miyamoto ,  Tetsuya Kawahara ,  Akiharu Kajiwara ,  Ieharu Hishinuma ,  Kazuo Okano ,  Syuhei Miyazawa ,  Richard Clark ,  Fumihiro Ozaki ,  Nobuaki Sato ,  Masanobu Shinoda ,  Atsushi Kamada ,  Itaru Tsukada ,  Fumiyoshi Matsuura ,  Yoshimitsu Naoe ,  Taro Terauchi ,  Yoshiaki Oohashi ,  Osamu Ito ,  Hiroshi Tanaka ,  Takashi Musha ,  Motoji Kogushi ,  Tsutomu Kawata ,  Toshiyuki Matsuoka ,  Hiroko Kobayashi ,  Ken-ichi Chiba ,  Akifumi Kimura ,  Naoto Ono

发明人： Shuichi Suzuki ,  Makoto Kotake ,  Mitsuaki Miyamoto ,  Tetsuya Kawahara ,  Akiharu Kajiwara ,  Ieharu Hishinuma ,  Kazuo Okano ,  Syuhei Miyazawa ,  Richard Clark ,  Fumihiro Ozaki ,  Nobuaki Sato ,  Masanobu Shinoda ,  Atsushi Kamada ,  Itaru Tsukada ,  Fumiyoshi Matsuura ,  Yoshimitsu Naoe ,  Taro Terauchi ,  Yoshiaki Oohashi ,  Osamu Ito ,  Hiroshi Tanaka ,  Takashi Musha ,  Motoji Kogushi ,  Tsutomu Kawata ,  Toshiyuki Matsuoka ,  Hiroko Kobayashi ,  Ken-ichi Chiba ,  Akifumi Kimura ,  Naoto Ono

IPC分类号： A61K31/496 ,  C07D207/04 ,  A61K31/40 ,  C07D209/96 ,  C07D401/02 ,  A61K31/454 ,  C07D209/52 ,  A61K31/403 ,  A61P35/00 ,  A61P25/00 ,  A61P11/00 ,  A61P9/00 ,  C07D277/20 ,  A61K31/426 ,  C07D213/02 ,  A61K31/4439 ,  C07D233/54 ,  A61K31/4178 ,  C07D403/02

CPC分类号： C07D209/44

摘要： A cyclic amidine derivative represented by the formula: [wherein R1, R2 and R3 represent hydrogen, C1-6 alkyl, aryl-C1-6 alkyl, etc.; R4, R5 and R7 represent hydrogen, C1-6 alkyl, etc.; Z represents 0 or 1; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; n represents 1 or 2; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; Ar represents hydrogen, a group represented by the formula: [wherein R10-R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc., and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocycle], etc.] or a salt thereof.

摘要翻译： 由下式表示的环状脒衍生物[其中R 1，R 2和R 3表示氢，C 1-6烷基，芳基-C 1-6烷基等; R4，R5和R7代表氢，C1-6烷基等; Z表示0或1; R6表示氢，C1-6烷基，C1-6烷氧基羰基等; n表示1或2; Y1表示单键，-CH2-等; Y2表示单键，-CO-等; Ar表示氢，由下式表示的基团：[其中R 10 -R 14表示氢，C 1-6烷基，羟基，C 1-6烷氧基等，R 11和R 12或R 12和R 13可以键合在一起形成5- 至8-元杂环]等]或其盐。

公开(公告)号：US20090203911A1

公开(公告)日：2009-08-13

申请号：US12189590

申请日：2008-08-11

申请人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei MIYAZAWA ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： C07D405/14 ,  C07D401/12

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： A novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases is provided, which has an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

摘要翻译： 提供了可用作酸性相关疾病的治疗或预防剂的新型化合物，其对胃酸分泌具有优异的抑制作用，保持对胃酸分泌的抑制作用的优异效果，从而保持胃内pH高 长时间，具有更多的安全性和适当的物理化学稳定性。 提供一种化合物，其中R 1和R 3可以相同或不同，各自表示氢原子或C 1 -C 6烷基; R2代表（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9-三氧杂螺[5.5]十一烷-3 - 甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R4，R5，R6和R7表示氢原子，卤素原子，C1-C6烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; W1表示单键，亚甲基或亚乙基，它们的盐或它们的溶剂合物。

公开(公告)号：US07244730B2

公开(公告)日：2007-07-17

申请号：US10475188

申请日：2002-04-19

申请人： Shuichi Suzuki ,  Makoto Kotake ,  Mitsuaki Miyamoto ,  Tetsuya Kawahara ,  Akiharu Kajiwara ,  Ieharu Hishinuma ,  Kazuo Okano ,  Syuhei Miyazawa ,  Richard Clark ,  Fumihiro Ozaki ,  Nobuaki Sato ,  Masanobu Shinoda ,  Atsushi Kamada ,  Itaru Tsukada ,  Fumiyoshi Matsuura ,  Yoshimitsu Naoe ,  Taro Terauchi ,  Yoshiaki Oohashi ,  Osamu Ito ,  Hiroshi Tanaka ,  Takashi Musya ,  Motoji Kogushi ,  Tsutomu Kawada ,  Toshiyuki Matsuoka ,  Hiroko Kobayashi ,  Ken-ichi Chiba ,  Akifumi Kimura ,  Naoto Ono

发明人： Shuichi Suzuki ,  Makoto Kotake ,  Mitsuaki Miyamoto ,  Tetsuya Kawahara ,  Akiharu Kajiwara ,  Ieharu Hishinuma ,  Kazuo Okano ,  Syuhei Miyazawa ,  Richard Clark ,  Fumihiro Ozaki ,  Nobuaki Sato ,  Masanobu Shinoda ,  Atsushi Kamada ,  Itaru Tsukada ,  Fumiyoshi Matsuura ,  Yoshimitsu Naoe ,  Taro Terauchi ,  Yoshiaki Oohashi ,  Osamu Ito ,  Hiroshi Tanaka ,  Takashi Musya ,  Motoji Kogushi ,  Tsutomu Kawada ,  Toshiyuki Matsuoka ,  Hiroko Kobayashi ,  Ken-ichi Chiba ,  Akifumi Kimura ,  Naoto Ono

IPC分类号： A61K31/535 ,  A61K31/40 ,  C07D265/30 ,  C07D241/04 ,  C07D209/44

CPC分类号： C07D209/44

摘要： A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R101–R103 represent hydrogen, halogen, C1-6 alkyl, etc.; R5 represents hydrogen, C1-6 alkyl, C1-6 alkoxy-C1-6 alkyl, etc.; R6 represents hydrogen, C1-6 alkyl, C1-6 alkyloxycarbonyl, etc.; Y1 represents a single bond, —CH2—, etc.; Y2 represents a single bond, —CO—, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R10—R14 represent hydrogen, C1-6 alkyl, hydroxyl, C1-6 alkoxy, etc.; and R11 and R12 or R12 and R13 may bond together to form a 5- to 8-membered heterocyclic ring], etc.}, or a salt thereof.

摘要翻译： 由下式表示的2-亚氨基吡咯烷衍生物：其中环B表示苯环，吡啶环等; R 101为-O-，卤素，C 1-6烷基等; R 5表示氢，C 1-6烷基，C 1-6烷氧基-C 1-6烷基 等等 R 6表示氢，C 1-6烷基，C 1-6烷氧基羰基等; Y 1表示单键，-CH 2 - 等; Y 2表示单键，-CO-等; 和Ar表示氢，由下式表示的基团：其中R 10 -R 14表示氢，C 1-6烷基，羟基 C 1-6烷氧基等; 并且R 11和R 12或R 12和R 13可以键合在一起形成5-8个 - 杂环]等，或其盐。

公开(公告)号：US07425634B2

公开(公告)日：2008-09-16

申请号：US11520838

申请日：2006-09-14

申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： C07D401/12

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability.Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。

公开(公告)号：US20070015782A1

公开(公告)日：2007-01-18

申请号：US11403815

申请日：2006-04-14

申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： A61K31/4747 ,  A61K31/4439 ,  C07D491/14

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

公开(公告)号：US20070010542A1

公开(公告)日：2007-01-11

申请号：US11520838

申请日：2006-09-14

申请人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

发明人： Shuhei Miyazawa ,  Masanobu Shinoda ,  Tetsuya Kawahara ,  Nobuhisa Watanabe ,  Hitoshi Harada ,  Daisuke Iida ,  Hiroki Terauchi ,  Junichi Nagakawa ,  Hideaki Fujisaki ,  Atsuhiko Kubota ,  Masato Ueda

IPC分类号： A61K31/4747 ,  A61K31/4439 ,  C07D405/14

CPC分类号： C07D491/04 ,  C07D405/14 ,  C07D493/08 ,  C07D493/10

摘要： An object of the present invention is to provide a novel chemical compound useful as a therapeutic or prophylactic agent for acid-related diseases, having an excellent inhibitory effect against gastric acid secretion, an excellent effect of maintaining the inhibitory effect against gastric acid secretion, thereby maintaining intragastric pH high for a long time, and having more safety and appropriate physicochemical stability. Provided is a compound represented by where R1 and R3 may be the same or different and each represent a hydrogen atom or a C1-C6 alkyl group; R2 represents (5,5-dimethyl-1,3-dioxan-2-yl)methoxy group, 5,7-dioxaspiro[2.5]oct-6-ylmethoxy group, 1,5,9-trioxaspiro[5.5]undec-3-ylmethoxy group, or (2,2-dimethyl-1,3-dioxan-5-yl)methoxy group; R4, R5, R6 and R7 represent a hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 haloalkyl group, C1-C6 alkoxy group or C1-C6 haloalkoxy group; and W1 represents a single bond, methylene or ethylene group, a salt thereof or a solvate of these.

摘要翻译： 本发明的目的是提供一种新颖的化合物，其可用作酸性相关疾病的治疗或预防剂，对胃酸分泌具有优异的抑制作用，具有保持对胃酸分泌的抑制作用的优异效果，从而 长时间保持胃内pH高，并具有更多的安全性和适当的物理化学稳定性。 其中R 1和R 3可以相同或不同，表示氢原子或C1-C6烷基; R 5表示（5,5-二甲基-1,3-二恶烷-2-基）甲氧基，5,7-二氧杂螺[2.5]辛-6-基甲氧基，1,5,9 - 三氧杂螺[5.5]十一烷-3-基甲氧基或（2,2-二甲基-1,3-二恶烷-5-基）甲氧基; R 4，R 5，R 6和R 7表示氢原子，卤素原子，C 1 -C 6 烷基，C1-C6卤代烷基，C1-C6烷氧基或C1-C6卤代烷氧基; 和W 1表示单键，亚甲基或亚乙基，其盐或它们的溶剂合物。