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公开(公告)号：US20070237794A1
公开(公告)日：2007-10-11
申请号：US11733440
申请日：2007-04-10
申请人： Yasuyuki Goto , Steven Reed
发明人： Yasuyuki Goto , Steven Reed
CPC分类号： G01N33/56905 , G01N33/5008 , G01N33/5023 , G01N33/5091 , G01N33/6854 , G01N2500/00
摘要： Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.
摘要翻译： 提供了用于诊断，预防，治疗和检测利什曼病感染和刺激患者免疫应答的化合物和方法。 所公开的化合物包括含有一种或多种利什曼原虫抗原或其变体的至少一种免疫原性部分的多肽和融合蛋白。 另外，公开了筛选具有免疫原性的串联重复蛋白的筛选文库的方法。 描述了可用于预防和治疗利什曼病以及利什曼病感染检测的包含多核苷酸，多肽，融合蛋白及其变体的疫苗和药物组合物。
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2.发明授权Leishmania sterol 24-c-methyltransferase compositions for the prevention, treatment and diagnosis of leishmaniasis 有权利什曼原虫甾醇24-C-甲基转移酶组合物，用于预防，治疗和诊断利什曼病公开(公告)号：US08916168B2
公开(公告)日：2014-12-23
申请号：US12171729
申请日：2008-07-11
申请人： Steven Reed , Yasuyuki Goto
发明人： Steven Reed , Yasuyuki Goto
IPC分类号： A61K39/008 , C07H21/04 , A61K38/45 , A61K39/00
CPC分类号： A61K38/45 , A61K39/008 , A61K2039/55572 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise Leishmania sterol 24-c-methyltransferase (SMT) polypeptides, portions, variants and/or fusions, as well as polynucleotides encoding SMT polypeptides, portions, variants and/or fusions.
摘要翻译： 公开了用于预防，治疗和检测利什曼病的组合物和方法。 组合物通常包含利什曼原虫甾醇24-C-甲基转移酶（SMT）多肽，部分，变体和/或融合物，以及编码SMT多肽，部分，变体和/或融合物的多核苷酸。
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3.发明申请LEISHMANIA STEROL 24-C-METHYLTRANSFERASE COMPOSITIONS FOR THE PREVENTION, TREATMENT AND DIAGNOSIS OF LEISHMANIASIS 有权LEISHMANIA STEROL用于预防，治疗和诊断淋巴细胞的24-C-甲基衍生物组合物公开(公告)号：US20090041798A1
公开(公告)日：2009-02-12
申请号：US12171729
申请日：2008-07-11
申请人： Steven Reed , Yasuyuki Goto
发明人： Steven Reed , Yasuyuki Goto
IPC分类号： A61K39/00 , A61K39/008 , A61P37/04
CPC分类号： A61K38/45 , A61K39/008 , A61K2039/55572 , Y02A50/41
摘要： Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise Leishmania sterol 24-c-methyltransferase (SMT) polypeptides, portions, variants and/or fusions, as well as polynucleotides encoding SMT polypeptides, portions, variants and/or fusions.
摘要翻译： 公开了用于预防，治疗和检测利什曼病的组合物和方法。 组合物通常包含利什曼原虫甾醇24-C-甲基转移酶（SMT）多肽，部分，变体和/或融合物，以及编码SMT多肽，部分，变体和/或融合物的多核苷酸。
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公开(公告)号：US08110200B2
公开(公告)日：2012-02-07
申请号：US12698893
申请日：2010-02-02
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US08071747B2
公开(公告)日：2011-12-06
申请号：US12490272
申请日：2009-06-23
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
CPC分类号： C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US08067016B2
公开(公告)日：2011-11-29
申请号：US12490984
申请日：2009-06-24
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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公开(公告)号：US20100183677A1
公开(公告)日：2010-07-22
申请号：US12698976
申请日：2010-02-02
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
IPC分类号： A61K39/04 , A61K31/7088 , A61P31/06 , A61K45/00
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US20100172927A1
公开(公告)日：2010-07-08
申请号：US12442538
申请日：2007-10-03
申请人： Mark Alderson , Rhea Coler , Yves Lobet , Jean-Francois L. Maisonneuve , Pascal Mettens , Peter Probst , Steven Reed
发明人： Mark Alderson , Rhea Coler , Yves Lobet , Jean-Francois L. Maisonneuve , Pascal Mettens , Peter Probst , Steven Reed
IPC分类号： A61K39/118 , A61P31/04 , A61P27/00 , C07K14/295
CPC分类号： A61K39/118 , A61K2039/53 , A61K2039/54 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577
摘要： Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.
摘要翻译： 用于治疗或预防眼沙眼衣原体感染的方法和组合物。 组合物包含一种或多种沙眼衣原体蛋白，其免疫原性片段或编码这种蛋白质或片段的多核苷酸。
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公开(公告)号：US07691993B2
公开(公告)日：2010-04-06
申请号：US11982179
申请日：2007-10-31
申请人： Yasir Skeiky , Jeff Guderian , Steven Reed
发明人： Yasir Skeiky , Jeff Guderian , Steven Reed
CPC分类号： C07K14/35 , A61K39/00 , A61K2039/53 , A61K2039/55566 , A61K2039/55577 , C07K2319/02
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US07311922B1
公开(公告)日：2007-12-25
申请号：US09688672
申请日：2000-10-10
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
IPC分类号： A61K39/08 , A61K39/02 , A61K39/40 , A61K39/395
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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