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公开(公告)号：US20100172927A1
公开(公告)日：2010-07-08
申请号：US12442538
申请日：2007-10-03
申请人： Mark Alderson , Rhea Coler , Yves Lobet , Jean-Francois L. Maisonneuve , Pascal Mettens , Peter Probst , Steven Reed
发明人： Mark Alderson , Rhea Coler , Yves Lobet , Jean-Francois L. Maisonneuve , Pascal Mettens , Peter Probst , Steven Reed
IPC分类号： A61K39/118 , A61P31/04 , A61P27/00 , C07K14/295
CPC分类号： A61K39/118 , A61K2039/53 , A61K2039/54 , A61K2039/55555 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577
摘要： Methods and compositions for the treatment or prevention of ocular Chlamydia trachomatis infection. Compositions comprise one or more Chlamydia trachomatis proteins, immunogenic fragments thereof or polynucleotides encoding such proteins or fragments.
摘要翻译： 用于治疗或预防眼沙眼衣原体感染的方法和组合物。 组合物包含一种或多种沙眼衣原体蛋白，其免疫原性片段或编码这种蛋白质或片段的多核苷酸。
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公开(公告)号：US20090022755A1
公开(公告)日：2009-01-22
申请号：US11909992
申请日：2006-03-24
申请人： Brenda Barth , Ajay Bhatia , Mark Alderson , Jean-Francois L. Maisonneuve , Yves Lobet , Florence Bernadette Nozay , Martine Marchand , Pascal Mettens , Yasir A. Skeiky , Peter Probst
发明人： Brenda Barth , Ajay Bhatia , Mark Alderson , Jean-Francois L. Maisonneuve , Yves Lobet , Florence Bernadette Nozay , Martine Marchand , Pascal Mettens , Yasir A. Skeiky , Peter Probst
CPC分类号： A61K39/118 , A61K2039/55572 , A61K2039/55577 , C07K14/295
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
摘要翻译： 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。
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公开(公告)号：US08541007B2
公开(公告)日：2013-09-24
申请号：US12974428
申请日：2010-12-21
申请人： Mark Alderson , Ajay Bhatia , Yves Lobet , Brenda Maisonneuve , Jean-Francois L Maisonneuve , Martine Marchand , Pascal Mettens , Florence Bernadette Nozay , Peter Probst , Samira H Skeiky
发明人： Mark Alderson , Ajay Bhatia , Yves Lobet , Brenda Maisonneuve , Jean-Francois L Maisonneuve , Martine Marchand , Pascal Mettens , Florence Bernadette Nozay , Peter Probst , Yasir A Skeiky
IPC分类号： A61K39/118
CPC分类号： A61K39/118 , A61K2039/55555 , A61K2039/55572 , A61K2039/55577 , G01N33/56927
摘要： The present invention relates to compositions comprising proteins or polynucleotides of Chlamydia sp., in particular combinations of proteins or polynucleotides encoding them, and methods for the use of the proteins or polynucleotides in the treatment, prevention and diagnosis of Chlamydia infection.
摘要翻译： 本发明涉及包含衣原体属的蛋白质或多核苷酸的组合物，特别是编码它们的蛋白质或多核苷酸的组合，以及用于治疗，预防和诊断衣原体感染的蛋白质或多核苷酸的方法。
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公开(公告)号：US20090123491A1
公开(公告)日：2009-05-14
申请号：US11912730
申请日：2006-04-27
申请人： Rhea Coler , Yves Lobet , Steven Reed
发明人： Rhea Coler , Yves Lobet , Steven Reed
IPC分类号： A61K39/04 , A61K31/7088 , A61P37/04
CPC分类号： A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35
摘要： The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.
摘要翻译： 本发明涉及通过施用包含编码Mtb72f融合蛋白或Mtb72f融合蛋白或其免疫原性片段的核酸的药物组合物，例如与佐剂一起施用来防止活性和潜伏性结核分枝杆菌感染的再活化的方法 。 Mtb72f核酸或融合蛋白可以与一种或多种对结核分枝杆菌感染有效的化学治疗剂一起施用。 所述方法还提供了缩短化疗方案针对结核分枝杆菌感染的时间过程。
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公开(公告)号：US08470338B2
公开(公告)日：2013-06-25
申请号：US11912730
申请日：2006-04-27
申请人： Rhea Coler , Yves Lobet , Steven Reed
发明人： Rhea Coler , Yves Lobet , Steven Reed
CPC分类号： A61K39/04 , A61K31/4409 , A61K31/496 , A61K2039/523 , A61K2039/53 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577 , A61K2039/575 , C07K14/35
摘要： The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.
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公开(公告)号：US20090191234A1
公开(公告)日：2009-07-30
申请号：US12343145
申请日：2008-12-23
申请人： Lauren Bakaletz , Joseph Cohen , Guy Dequesne , Yves Lobet
发明人： Lauren Bakaletz , Joseph Cohen , Guy Dequesne , Yves Lobet
IPC分类号： A61K39/145 , C07K14/11 , C07K7/08 , C07K19/00 , C07H21/04 , C07H21/02 , C12N15/63 , C12N1/21 , C12P21/02 , C07K16/08 , C12Q1/70
CPC分类号： C07K16/1242 , A61K39/00 , C07K14/285 , C07K2319/00 , G01N33/56911
摘要： This invention relates to three newly-identified, distinct groups of antigenic peptides [LB1(f) peptides] from the same region of the P5-like fimbrin protein discovered using sequence data from the fimbrin protein of many Haemophilus influenzae strains. The invention additionally provides chimeric polypeptides that carry one or more representatives of such peptides from different groups and which induce an immunogenic response in animals to Haemophilus influenzae. The peptides and polypeptides of the invention will be useful in vaccine compositions which provide protection against a wide range of H. influenzae strains.
摘要翻译： 本发明涉及使用来自许多流感嗜血杆菌菌株的fimbrin蛋白的序列数据发现的来自P5样fimbrin蛋白的相同区域的三种新鉴定的不同组的抗原肽[LB1（f）肽]。 本发明另外提供了携带来自不同群体的这种肽的一种或多种代表并且在动物中对流感嗜血杆菌诱导免疫原性应答的嵌合多肽。 本发明的肽和多肽可用于提供针对广泛的流感嗜血杆菌菌株的保护的疫苗组合物中。
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公开(公告)号：US20080081050A1
公开(公告)日：2008-04-03
申请号：US11745006
申请日：2007-05-07
申请人： Philippe Hermand , Craig Laferriere , Yves Lobet , Jan Poolman
发明人： Philippe Hermand , Craig Laferriere , Yves Lobet , Jan Poolman
CPC分类号： A61K39/092 , A61K39/0208 , A61K39/095 , A61K39/102 , A61K39/13 , A61K39/292 , A61K2039/55 , A61K2039/55572 , A61K2039/6068 , Y02A50/396 , Y02A50/466
摘要： The present invention relates to a combination of 2 or more S pneumoniae proteins, their manufacture and use in medicine as a vaccine. Such combinations are particularly useful for the protection of infants and elderly against streptococcal infection.
摘要翻译： 本发明涉及2种或更多种肺炎衣原体蛋白的组合，其在药物中的制造和用途作为疫苗。 这种组合对于保护婴幼儿免受链球菌感染特别有用。
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公开(公告)号：US20050281847A1
公开(公告)日：2005-12-22
申请号：US11103957
申请日：2005-04-12
IPC分类号： C12N15/09 , A61K39/00 , A61K39/095 , A61K39/118 , A61P31/04 , C07K14/295 , C12N1/21
CPC分类号： C07K14/295 , A61K39/00 , A61K39/118
摘要： The present invention relates to the field of Gram-negative bacterial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to the field of useful Gram-negative bacterial outer membrane vesicle (or bleb) compositions comprising heterologously expressed Chlamydia antigens, and advantageous methods of rendering these compositions more effective and safer as a vaccine.
摘要翻译： 本发明涉及革兰氏阴性细菌疫苗组合物的领域，它们的制造以及这些组合物在医药中的用途。 更具体地说，涉及包含异源表达的衣原体抗原的有用的革兰氏阴性细菌外膜囊泡（或泡沫）组合物的领域，以及使这些组合物作为疫苗更有效和更安全的有利方法。
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9.发明授权Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines 失效Osp一种布氏疏螺旋体亚群的蛋白质，编码基因和疫苗
公开(公告)号：US6113914A
公开(公告)日：2000-09-05
申请号：US193159
申请日：1994-07-05
申请人： Yves Lobet , Markus Simon , Ulrich Schaible , Reinhard Wallich , Michael Kramer
发明人： Yves Lobet , Markus Simon , Ulrich Schaible , Reinhard Wallich , Michael Kramer
IPC分类号： A61K38/00 , A61K39/00 , A61K39/02 , A61P31/04 , C07K14/11 , C07K14/20 , C07K16/00 , C07K16/12 , C07K19/00 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/32 , C12N15/44 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/01 , C12R1/19 , A61K39/116 , G01N33/554
CPC分类号： C07K16/1207 , C07K14/005 , C07K14/20 , C12Q1/689 , C12R1/01 , A61K38/00 , A61K39/00 , C07K2319/40 , C12N2760/16022 , Y10S530/806 , Y10S530/82 , Y10S530/825
摘要： The invention relates to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borrelia groups are also disclosed.
摘要翻译： PCT No.PCT / EP92 / 01827 Sec。 371日期：1994年7月5日 102（e）日期1994年7月5日PCT提交1992年8月11日PCT公布。 公开号WO93 / 04175 日期1993年3月4日本发明涉及由其衍生的新型疏螺旋体和OspA抗原。 这些抗原与已知的OspA显示出很小的同源性，因此可用作疫苗和诊断试剂。 还公开了基于来自不同Borrelia组的OspA的多组分疫苗。
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10.发明申请VACCINES COMPRISING OUTER MEMBRANE VESICLES FROM GRAM NEGATIVE BACTERIA 审中-公开包含来自GRAM Negative BACTERIA的外膜的疫苗公开(公告)号：US20090117147A1
公开(公告)日：2009-05-07
申请号：US11949071
申请日：2007-12-03
申请人： Francois-Xavier Jacques BERTHET , Wilfried L J. Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Nathalie Garcon , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
发明人： Francois-Xavier Jacques BERTHET , Wilfried L J. Dalemans , Philippe Denoel , Guy Dequesne , Christiane Feron , Nathalie Garcon , Yves Lobet , Jan Poolman , Georges Thiry , Joelle Thonnard , Pierre Voet
IPC分类号： A61K39/02
CPC分类号： A61K39/02 , A61K39/092 , A61K39/102 , A61K39/39 , A61K2039/55555 , A61K2039/55572 , A61K2039/55594 , A61K2039/6068
摘要： The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
摘要翻译： 本发明涉及疫苗制剂领域，特别涉及包含外膜囊泡（或泡沫）的新型佐剂组合物领域，以及使这些组合物解毒的有利方法以及使用这些佐剂的有利方法。
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