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    Methods and apparatuses for detection of myocardial ischemia upon exertion
    1.
    发明授权
    Methods and apparatuses for detection of myocardial ischemia upon exertion 有权
    用于检测心肌缺血的方法和装置

    公开(公告)号：US08321003B2

    公开(公告)日：2012-11-27

    申请号：US12508398

    申请日：2009-07-23

    申请人： Yi Zhang ,  Kenneth C. Beck ,  Aaron Lewicke ,  Yunlong Zhang

    发明人： Yi Zhang ,  Kenneth C. Beck ,  Aaron Lewicke ,  Yunlong Zhang

    IPC分类号： A61B5/04

    CPC分类号： A61B5/0205 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/03 ,  A61B5/4519

    摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.

    摘要翻译： 本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段 一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度水平相关联的心脏反应信息进行比较， 以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

    Methods and Apparatuses for Detection of Myocardial Ischemia Upon Exertion
    2.
    发明申请
    Methods and Apparatuses for Detection of Myocardial Ischemia Upon Exertion 有权
    用于检测心肌缺血的方法和装置

    公开(公告)号：US20100030090A1

    公开(公告)日：2010-02-04

    申请号：US12508398

    申请日：2009-07-23

    申请人： YI ZHANG ,  Kenneth C. Beck ,  AARON LEWICKE ,  YUNLONG ZHANG

    发明人： YI ZHANG ,  Kenneth C. Beck ,  AARON LEWICKE ,  YUNLONG ZHANG

    IPC分类号： A61B5/02

    CPC分类号： A61B5/0205 ,  A61B5/02055 ,  A61B5/0215 ,  A61B5/03 ,  A61B5/4519

    摘要： Various method embodiments of the present invention concern sensing patient-internal pressure measurements indicative of physiological exertion, identifying one or more steady state periods of physiological exertion based on the patient-internal pressure measurements, sensing extra-cardiac response data and cardiac response data corresponding to the one or more physiological exertion steady state periods, respectively comparing the extra-cardiac response data and the cardiac response data to extra-cardiac response information and cardiac response information associated with equivalent levels of physiological exertion intensity of the one or more steady state periods, and determining the likelihood that myocardial ischemia occurred during the one or more steady state periods based on the comparison of the extra-cardiac response data to the extra-cardiac response information and the cardiac response data to the cardiac response information.

    摘要翻译： 本发明的各种方法实施例涉及感测指示生理消耗的患者 - 内部压力测量，基于患者内部的压力测量，感测心脏外的心脏反应数据和对应于心脏的心脏反应数据来识别生理消耗的一个或多个稳定状态时段 一个或多个生理活动稳态时段，分别将心外反应数据和心脏响应数据与心脏外反应信息和与一个或多个稳态周期的等效生理消耗强度的等效水平相关联的心脏反应信息进行比较， 以及基于心外反应数据与心外反应信息和对心脏反应信息的心脏反应数据的比较，确定在一个或多个稳态期间发生心肌缺血的可能性。

    Systems and methods for monitoring pulmonary edema dynamics
    3.
    发明授权
    Systems and methods for monitoring pulmonary edema dynamics 有权
    用于监测肺水肿动态的系统和方法

    公开(公告)号：US08417463B2

    公开(公告)日：2013-04-09

    申请号：US12505926

    申请日：2009-07-20

    申请人： Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

    发明人： Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

    IPC分类号： A61B5/00 ,  A61B5/08 ,  A61B5/02 ,  A61B5/04 ,  A61N1/00 ,  G01N33/48 ,  G01N33/50

    CPC分类号： A61B5/03 ,  A61B5/021 ,  A61B5/0537 ,  A61B5/4878

    摘要： This document discusses, among other things, systems and methods for measuring the dynamics of pulmonary congestion in heart failure subjects over time to monitor the subjects susceptibility to pulmonary edema, including sensing and receiving information indicative of a bodily pressure and information indicative of pulmonary fluid, and using the transient responses of these measurements to compute parameters related to the dynamics of thoracic fluid accumulation, such as a critical pressure (Pc), a critical time (Tc), or a filtration index (Kfi).

    摘要翻译： 本文件尤其讨论了随着时间的推移，测量心力衰竭受试者的肺充血动力学的系统和方法，以监测受试者对肺水肿的易感性，包括感测和接收指示身体压力的信息和指示肺动脉的信息， 并且使用这些测量的瞬态响应来计算与胸腔积液的动力学相关的参数，例如临界压力（Pc），临界时间（Tc）或过滤指数（Kfi）。

    SYSTEMS AND METHODS FOR MONITORING PULMONARY EDEMA DYNAMICS
    4.
    发明申请
    SYSTEMS AND METHODS FOR MONITORING PULMONARY EDEMA DYNAMICS 有权
    用于监测脉冲EDEMA动力学的系统和方法

    公开(公告)号：US20100022911A1

    公开(公告)日：2010-01-28

    申请号：US12505926

    申请日：2009-07-20

    申请人： Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

    发明人： Ramesh Wariar ,  John D. Hatlestad ,  Kenneth C. Beck ,  Aaron Lewicke

    IPC分类号： A61B5/00

    CPC分类号： A61B5/03 ,  A61B5/021 ,  A61B5/0537 ,  A61B5/4878

    摘要： This document discusses, among other things, systems and methods for measuring the dynamics of pulmonary congestion in heart failure subjects over time to monitor the subjects susceptibility to pulmonary edema, including sensing and receiving information indicative of a bodily pressure and information indicative of pulmonary fluid, and using the transient responses of these measurements to compute parameters related to the dynamics of thoracic fluid accumulation, such as a critical pressure (Pc), a critical time (Tc), or a filtration index (Kfi).

    摘要翻译： 本文件尤其讨论了随着时间的推移，测量心力衰竭受试者的肺充血动力学的系统和方法，以监测受试者对肺水肿的易感性，包括感测和接收指示身体压力的信息和指示肺动脉的信息， 并且使用这些测量的瞬态响应来计算与胸腔积液的动力学相关的参数，例如临界压力（Pc），临界时间（Tc）或过滤指数（Kfi）。

    NEURAL CONTROL OF CENTRAL SLEEP APNEA
    7.
    发明申请
    NEURAL CONTROL OF CENTRAL SLEEP APNEA 有权
    中央休眠APNEA的神经控制

    公开(公告)号：US20130079842A1

    公开(公告)日：2013-03-28

    申请号：US13626399

    申请日：2012-09-25

    申请人： Eric A. Mokelke ,  Yi Zhang ,  John D. Hatlestad ,  Kenneth C. Beck ,  Viktoria A. Averina ,  Jon Peterson ,  Kent Lee

    发明人： Eric A. Mokelke ,  Yi Zhang ,  John D. Hatlestad ,  Kenneth C. Beck ,  Viktoria A. Averina ,  Jon Peterson ,  Kent Lee

    IPC分类号： A61N1/36

    CPC分类号： A61N1/3611 ,  A61N1/36053

    摘要： An apparatus comprises a physiologic sensing circuit and a control circuit. The physiologic sensing circuit is configured to sense an electrical respiration signal representative of respiration of a subject. The control circuit includes a respiration monitor circuit and a therapy circuit. The respiration monitor circuit is configured to extract a respiration parameter from the respiration signal and detect that a value of the respiration parameter is outside of a target value range for the respiration parameter. The therapy circuit is configured to deliver neural stimulation to the carotid sinus of the subject to stimulate respiration and to adjust respiration to maintain the value of the respiration parameter within the target value range.

    摘要翻译： 一种装置包括生理感测电路和控制电路。 生理感测电路被配置为感测代表受试者呼吸的电呼吸信号。 控制电路包括呼吸监测电路和治疗电路。 呼吸监视器电路被配置为从呼吸信号中提取呼吸参数，并且检测呼吸参数的值在呼吸参数的目标值范围之外。 治疗电路被配置为将神经刺激递送到受试者的颈动脉窦以刺激呼吸并调节呼吸以将呼吸参数的值保持在目标值范围内。

    PHYSIOLOGIC RESPONSE TO POSTURE
    10.
    发明申请
    PHYSIOLOGIC RESPONSE TO POSTURE 审中-公开
    生理反应

    公开(公告)号：US20120157798A1

    公开(公告)日：2012-06-21

    申请号：US13325354

    申请日：2011-12-14

    申请人： Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

    发明人： Viktoria A. Averina ,  John D. Hatlestad ,  Abhilash Patangay ,  Pramodsingh Hirasingh Thakur ,  Yi Zhang ,  Kenneth C. Beck

    IPC分类号： A61B5/11 ,  A61B5/08 ,  A61B5/053 ,  A61B5/00 ,  A61B5/0205

    CPC分类号： A61N1/36542 ,  A61B5/0205 ,  A61B5/0538 ,  A61B5/0809 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/6869 ,  A61B7/04

    摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.

    摘要翻译： 植入式或其他动态医疗装置包括姿势感测电路，感测时变生理信号的生理感测电路和处理器电路。 处理器电路包括姿势计算电路和测量电路。 姿势计算电路使用姿势信号获得的姿势数据来确定对象的姿势，并且确定被摄体的姿势何时处于稳定状态。 测量电路使用在至少一个时间段内从生理信号中提取的生理数据进行生理测量，当姿势被确定为稳态时，并且将生理测量结果与所确定的稳定性相关联地向用户和过程中的至少一个提供生理测量 状态。