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1.发明授权DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia 有权DOT1组蛋白甲基转移酶作为鉴定白血病治疗剂的靶标公开(公告)号：US07442685B2
公开(公告)日：2008-10-28
申请号：US10866908
申请日：2004-06-14
申请人： Yi Zhang , Qin Feng , Yuki Okada , Guoliang Xu
发明人： Yi Zhang , Qin Feng , Yuki Okada , Guoliang Xu
IPC分类号： C07K1/00
CPC分类号： C12Q1/6886 , C07H21/04 , C12N9/1007 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/53 , G01N33/6893 , G01N2440/12
摘要： The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.
摘要翻译： 本发明提供具有组蛋白H3赖氨酸79甲基转移酶活性的多肽以及编码其的核酸。 还提供了使用本发明的多肽和核酸在筛选测定中鉴定目的化合物的方法。 还提供了用于预测受试者疾病进程的白血病和预后方法的诊断方法。
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2.发明申请DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia 有权DOT1组蛋白甲基转移酶作为鉴定白血病治疗剂的靶标公开(公告)号：US20050048634A1
公开(公告)日：2005-03-03
申请号：US10866908
申请日：2004-06-14
申请人： Yi Zhang , Qin Feng , Yuki Okada , Guoliang Xu
发明人： Yi Zhang , Qin Feng , Yuki Okada , Guoliang Xu
CPC分类号： C12Q1/6886 , C07H21/04 , C12N9/1007 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/53 , G01N33/6893 , G01N2440/12
摘要： The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.
摘要翻译： 本发明提供具有组蛋白H3赖氨酸79甲基转移酶活性的多肽以及编码其的核酸。 还提供了使用本发明的多肽和核酸在筛选测定中鉴定目的化合物的方法。 还提供了用于预测受试者疾病进程的白血病和预后方法的诊断方法。
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3.发明授权DOT1 histone methyltransferases as a target for identifying therapeutic agents for leukemia 有权DOT1组蛋白甲基转移酶作为鉴定白血病治疗剂的靶标公开(公告)号：US08901286B2
公开(公告)日：2014-12-02
申请号：US12251037
申请日：2008-10-14
CPC分类号： C12Q1/6886 , C07H21/04 , C12N9/1007 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/53 , G01N33/6893 , G01N2440/12
摘要： The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.
摘要翻译： 本发明提供具有组蛋白H3赖氨酸79甲基转移酶活性的多肽以及编码其的核酸。 还提供了使用本发明的多肽和核酸在筛选测定中鉴定目的化合物的方法。 还提供了用于预测受试者疾病进程的白血病和预后方法的诊断方法。
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4.发明授权公开(公告)号：US08911933B2
公开(公告)日：2014-12-16
申请号：US12251078
申请日：2008-10-14
CPC分类号： C12Q1/6886 , C07H21/04 , C12N9/1007 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/53 , G01N33/6893 , G01N2440/12
摘要： The present invention provides polypeptides with histone H3 lysine 79 methyltransferase activity as well as nucleic acids encoding the same. Also provided are methods of using the polypeptides and nucleic acids of the invention in screening assays to identify compounds of interest. Further provided are diagnostic methods for leukemia and prognostic methods to predict the course of the disease in a subject.
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公开(公告)号：US08377883B2
公开(公告)日：2013-02-19
申请号：US12443684
申请日：2007-09-29
申请人： Chengchao Shou , Yahui Su , Qin Feng
发明人： Chengchao Shou , Yahui Su , Qin Feng
摘要： The present invention relates to a peptide for anti-angiogenesis and use thereof, in particular, to a peptide useful for treating angiogenesis diseases; a polynucleotide coding the peptide; a vector and a cell comprising the polynucleotide; a pharmaceutical composition comprising the peptide, the fused peptide or the fused protein, the polynucleotide, the vector and/or the cell. The peptide, the fused peptide or the fused protein, the polynucleotide, the vector, the cell and/or the pharmaceutical composition can be used for treatment of associated diseases such as tumor by anti-angiogenesis.
摘要翻译： 本发明涉及用于抗血管发生的肽及其用途，特别涉及可用于治疗血管发生疾病的肽; 编码该肽的多核苷酸; 载体和包含所述多核苷酸的细胞; 包含肽，融合肽或融合蛋白，多核苷酸，载体和/或细胞的药物组合物。 肽，融合肽或融合蛋白，多核苷酸，载体，细胞和/或药物组合物可用于通过抗血管生成治疗相关疾病如肿瘤。
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