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    Systems and methods for using electrical impedance for neuro cardiac therapy
    4.
    发明授权
    Systems and methods for using electrical impedance for neuro cardiac therapy 有权
    使用电阻抗进行神经心脏治疗的系统和方法

    公开(公告)号：US09393415B2

    公开(公告)日：2016-07-19

    申请号：US13309320

    申请日：2011-12-01

    申请人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  John D. Hatlestad

    发明人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  John D. Hatlestad

    IPC分类号： A61B5/02 ,  A61N1/36 ,  A61B5/053 ,  A61N1/365

    CPC分类号： A61N1/36053 ,  A61B5/0538 ,  A61N1/36117 ,  A61N1/36135 ,  A61N1/36521

    摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

    摘要翻译： 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。 阻抗传感器被配置为产生感测的阻抗值。 阻抗分析器被配置为分析由传感器产生的感测阻抗值。 分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。

    Cardiac resynchronization therapy optimization using cardiac activation sequence information
    5.
    发明申请
    Cardiac resynchronization therapy optimization using cardiac activation sequence information 有权
    心脏再同步治疗优化使用心脏激活序列信息

    公开(公告)号：US20080119903A1

    公开(公告)日：2008-05-22

    申请号：US11601216

    申请日：2006-11-17

    申请人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

    发明人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

    IPC分类号： A61N1/365

    CPC分类号： A61N1/3627 ,  A61B5/04011 ,  A61B5/0452 ,  A61N1/365 ,  A61N1/36535 ,  A61N1/36542

    摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.

    摘要翻译： 系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。 调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。 响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。 可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

    Cardiac resynchronization therapy optimization using cardiac activation sequence information
    6.
    发明授权
    Cardiac resynchronization therapy optimization using cardiac activation sequence information 有权
    心脏再同步治疗优化使用心脏激活序列信息

    公开(公告)号：US08725255B2

    公开(公告)日：2014-05-13

    申请号：US11601216

    申请日：2006-11-17

    申请人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

    发明人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  Jiang Ding ,  Yinghong Yu ,  Yanting Dong

    IPC分类号： A61N1/365 ,  A61N1/362

    CPC分类号： A61N1/3627 ,  A61B5/04011 ,  A61B5/0452 ,  A61N1/365 ,  A61N1/36535 ,  A61N1/36542

    摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.

    摘要翻译： 系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。 调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。 响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。 可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

    SYSTEMS AND METHODS FOR USING ELECTRICAL IMPEDANCE FOR NEURO CARDIAC THERAPY
    7.
    发明申请
    SYSTEMS AND METHODS FOR USING ELECTRICAL IMPEDANCE FOR NEURO CARDIAC THERAPY 有权
    用于神经心脏治疗的电阻抗系统和方法

    公开(公告)号：US20120172742A1

    公开(公告)日：2012-07-05

    申请号：US13309320

    申请日：2011-12-01

    申请人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  John D. Hatlestad

    发明人： Shantha Arcot-Krishnamurthy ,  Yi Zhang ,  John D. Hatlestad

    IPC分类号： A61N1/372 ,  A61B5/085 ,  A61N1/365

    CPC分类号： A61N1/36053 ,  A61B5/0538 ,  A61N1/36117 ,  A61N1/36135 ,  A61N1/36521

    摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.

    摘要翻译： 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。 阻抗传感器被配置为产生感测的阻抗值。 阻抗分析器被配置为分析由传感器产生的感测阻抗值。 分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。