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1.发明授权公开(公告)号：US09393415B2
公开(公告)日：2016-07-19
申请号：US13309320
申请日：2011-12-01
CPC分类号： A61N1/36053 , A61B5/0538 , A61N1/36117 , A61N1/36135 , A61N1/36521
摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.
摘要翻译： 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。 阻抗传感器被配置为产生感测的阻抗值。 阻抗分析器被配置为分析由传感器产生的感测阻抗值。 分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。
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2.发明申请公开(公告)号：US20120172742A1
公开(公告)日：2012-07-05
申请号：US13309320
申请日：2011-12-01
CPC分类号： A61N1/36053 , A61B5/0538 , A61N1/36117 , A61N1/36135 , A61N1/36521
摘要： A device embodiment is configured to deliver vagal stimulation therapy (VST) to a vagus nerve of a patient. The device embodiment includes a neural stimulator, an implantable impedance sensor and an impedance analyzer. The neural stimulator is configured to deliver the VST to the vagus nerve in a cervical region of the patient. The implantable impedance sensor is configured to detect impedance changes in a cervical region of the patient caused by laryngeal vibrations. The impedance sensor is configured to generate sensed impedance values. The impedance analyzer is configured to analyze the sensed impedance values generated by the sensor. The analyzer is configured to detect laryngeal vibrations or cough from the sensed impedance values.
摘要翻译： 设备实施例被配置为将迷走神经刺激治疗（VST）递送到患者的迷走神经。 装置实施例包括神经刺激器，可植入阻抗传感器和阻抗分析器。 神经刺激器被配置成将VST输送到患者的颈部区域中的迷走神经。 可植入阻抗传感器被配置为检测由喉部振动引起的患者的颈部区域中的阻抗变化。 阻抗传感器被配置为产生感测的阻抗值。 阻抗分析器被配置为分析由传感器产生的感测阻抗值。 分析器被配置为检测来自感测的阻抗值的喉部振动或咳嗽。
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公开(公告)号：US08936556B2
公开(公告)日：2015-01-20
申请号：US12564741
申请日：2009-09-22
申请人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
发明人： Kent Lee , Yi Zhang , Paul F. Emerson , Jesse W. Hartley , John D. Hatlestad , Jonathan T. Kwok , Weiguang Shao
IPC分类号： A61B5/02 , G06N5/02 , A61B5/08 , A61B5/00 , A61B5/091 , A61B5/04 , A61B5/0488 , A61B5/0476 , A61B5/0402 , A61B5/029 , A61B5/11
CPC分类号： A61B5/0809 , A61B5/029 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/091 , A61B5/11 , A61B5/4818
摘要： A respiration pattern of a number of respiration cycles is detected and breath intervals (BI) and tidal volume (TVOL) measurements of each of the respiration cycles are respectively determined. An unevenly sampled instantaneous minute ventilation (iMV) signal is produced using the BI and TVOL measurements, and an evenly sampled iMV signal (resampled iMV signal) is produced using the unevenly sampled iMV signal. Disordered breathing is detected based on a comparison between a baseline threshold and the resampled iMV signal.
摘要翻译： 检测多个呼吸周期的呼吸模式，分别确定每个呼吸周期的呼吸间隔（BI）和潮气量（TVOL）测量值。 使用BI和TVOL测量产生不均匀采样的瞬时分钟通气（iMV）信号，并且使用不均匀采样的iMV信号产生均匀采样的iMV信号（重新采样的iMV信号）。 基于基线阈值和重新采样的iMV信号之间的比较来检测呼吸紊乱。
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4.发明授权Monitoring projections along principal components of multiple sensors as an indicator of worsening heart failure 有权根据多个传感器的主要组件监测预测作为心力衰竭恶化的指标公开(公告)号：US08858448B2
公开(公告)日：2014-10-14
申请号：US13325120
申请日：2011-12-14
申请人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
发明人： Pramodsingh Hirasingh Thakur , Abhilash Patangay , Ramesh Wariar , John D. Hatlestad , Yi Zhang
IPC分类号： A61B5/02 , A61B5/11 , A61B5/0205 , A61B5/042 , A61B5/00 , A61B7/02 , A61B5/08 , A61N1/362 , A61B7/04 , A61N1/37 , A61B5/053
CPC分类号： A61B5/042 , A61B5/0205 , A61B5/053 , A61B5/0809 , A61B5/1107 , A61B5/6869 , A61B5/7253 , A61B7/023 , A61B7/04 , A61B2562/0219 , A61N1/3627 , A61N1/37
摘要： A device can include at least a first physiologic sensor circuit configured to provide a first physiologic signal, a second physiologic sensor circuit configured to provide a second physiologic signal, and a processor circuit. The processor circuit includes a principal component analysis circuit configured to represent data determined from the at least first and second physiologic sensor circuits as at least first and second axes, respectively, in a multidimensional space, determine one or more principal components in the multidimensional space, determine a quantitative attribute of the first and the second physiologic signals using at least one of the determined principal components or a projection of the data along the at least one determined principal component, and provide an indication of heart failure status according to the quantitative attribute to at least one of a user or a process.
摘要翻译： 装置可以包括至少第一生理传感器电路，其被配置为提供第一生理信号，被配置为提供第二生理信号的第二生理传感器电路和处理器电路。 处理器电路包括主分量分析电路，其被配置为将表示从至少第一和第二生理传感器电路确定的数据分别表示为多维空间中的至少第一和第二轴，确定多维空间中的一个或多个主要分量， 使用确定的主成分中的至少一个或沿着至少一个确定的主成分的数据的投影来确定第一和第二生理信号的定量属性，并且根据定量属性提供心力衰竭状态的指示 至少一个用户或进程。
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公开(公告)号：US10596381B2
公开(公告)日：2020-03-24
申请号：US13325354
申请日：2011-12-14
申请人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
发明人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.
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公开(公告)号：US20120157798A1
公开(公告)日：2012-06-21
申请号：US13325354
申请日：2011-12-14
申请人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
发明人： Viktoria A. Averina , John D. Hatlestad , Abhilash Patangay , Pramodsingh Hirasingh Thakur , Yi Zhang , Kenneth C. Beck
IPC分类号： A61B5/11 , A61B5/08 , A61B5/053 , A61B5/00 , A61B5/0205
CPC分类号： A61N1/36542 , A61B5/0205 , A61B5/0538 , A61B5/0809 , A61B5/1116 , A61B5/686 , A61B5/6869 , A61B7/04
摘要： An implantable or other ambulatory medical apparatus comprises a posture sensing circuit, a physiologic sensing circuit that senses a time varying physiologic signal, and a processor circuit. The processor circuit includes a posture calculation circuit and a measurement circuit. The posture calculation circuit determines a posture of the subject using posture data obtained using the posture signal and determines when the posture of the subject is steady state. The measurement circuit derives a physiologic measurement using physiologic data extracted from the physiologic signal during at least one time period when posture is determined to be steady state and provides the physiologic measurement to at least one of a user and a process in association with the determined steady state posture.
摘要翻译： 植入式或其他动态医疗装置包括姿势感测电路，感测时变生理信号的生理感测电路和处理器电路。 处理器电路包括姿势计算电路和测量电路。 姿势计算电路使用姿势信号获得的姿势数据来确定对象的姿势，并且确定被摄体的姿势何时处于稳定状态。 测量电路使用在至少一个时间段内从生理信号中提取的生理数据进行生理测量，当姿势被确定为稳态时，并且将生理测量结果与所确定的稳定性相关联地向用户和过程中的至少一个提供生理测量 状态。
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7.发明授权Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权使用一个或多个可植入装置监测疾病和药物管理的计时生理节律公开(公告)号：US08005540B2
公开(公告)日：2011-08-23
申请号：US12836441
申请日：2010-07-14
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61N1/02
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评估或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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8.发明申请Rapid Shallow Breathing Detection for use in Congestive Heart Failure Status Determination 有权快速浅呼吸检测用于充血性心力衰竭状态测定公开(公告)号：US20100298732A1
公开(公告)日：2010-11-25
申请号：US12847645
申请日：2010-07-30
IPC分类号： A61B5/08
CPC分类号： A61B5/091 , A61B5/053 , A61B5/0816 , A61B5/411 , A61B2562/0219 , A61N1/3627 , A61N1/36521
摘要： Systems and methods involve use of a medical device comprising sensing circuitry. One or more respiratory parameters are detected using the device. Patient baseline weight is provided, and an output signal indicative of a patient's congestive heart failure status is generated based on a change in the one or more respiratory parameters and a change in the patient's measured weight or predicted weight relative to the patient baseline weight. The respiratory parameters may include one or more of respiration rate, relative tidal volume, an index indicative of rapid shallow breathing by the patient, an index derived by computing a respiration rate and a tidal volume for each patient breath, and an index indicative of dyspnea, for example.
摘要翻译： 系统和方法涉及使用包括感测电路的医疗装置。 使用该装置检测一个或多个呼吸参数。 提供患者基线重量，并且基于一个或多个呼吸参数的变化和患者相对于患者基线重量的测量重量或预测体重的变化来生成指示患者充血性心力衰竭状态的输出信号。 呼吸参数可以包括呼吸速率，相对潮气量，指示患者快速浅呼吸的指标，通过计算呼吸速率导出的指数和每个患者呼吸的潮气量以及指示呼吸困难的指数中的一个或多个 ， 例如。
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9.发明授权Monitoring of chronobiological rhythms for disease and drug management using one or more implantable device 有权使用一个或多个可植入装置监测疾病和药物管理的计时生理节律公开(公告)号：US07764996B2
公开(公告)日：2010-07-27
申请号：US11554986
申请日：2006-10-31
申请人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
发明人： Yi Zhang , John D. Hatlestad , Gerrard M. Carlson , Yousufali Dalal , Marina V. Brockway , Kent Lee , Richard O. Kuenzler , Carlos Haro , Krzysztof Z. Siejko , Abhilash Patangay
IPC分类号： A61B5/00
CPC分类号： A61M5/1723 , A61B5/02055 , A61B5/0215 , A61B5/024 , A61B5/02405 , A61B5/053 , A61B5/0816 , A61B5/1116 , A61B5/686 , A61B5/7275 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/365 , A61N1/36585 , G06F19/00
摘要： The health state of a subject is automatically evaluated or predicted using at least one implantable device. In varying examples, the health state is determined by sensing or receiving information about at least one physiological process having a circadian rhythm whose presence, absence, or baseline change is associated with impending disease, and comparing such rhythm to baseline circadian rhythm prediction criteria. Other chronobiological rhythms beside circadian may also be used. The baseline prediction criteria may be derived using one or more past physiological process observation of the subject or population of subjects in a non-disease health state. The prediction processing may be performed by the at least one implantable device or by an external device in communication with the implantable device. Systems and methods for invoking a therapy in response to the health state, such as to prevent or minimize the consequences of predicted impending heart failure, are also discussed.
摘要翻译： 使用至少一个可植入装置自动评价或预测受试者的健康状况。 在不同的实施例中，通过感测或接收关于至少一个具有昼夜节律的生理过程的信息来确定健康状况，所述生理过程的存在，不存在或基线变化与即将发生的疾病相关联，并将该节律与基线昼夜节律预测标准进行比较。 也可以使用昼夜节律以外的其他时间生理节律。 可以使用在非疾病健康状态下的受试者或受试者群体的一个或多个过去的生理过程观察来导出基线预测标准。 预测处理可以由至少一个可植入装置或与可植入装置通信的外部装置执行。 还讨论了响应于健康状态调用疗法的系统和方法，例如预防或最小化预期的即将到来的心力衰竭的后果。
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公开(公告)号：US20090198139A1
公开(公告)日：2009-08-06
申请号：US12384271
申请日：2009-04-02
申请人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
发明人： Aaron Lewicke , Yi Zhang , John D. Hatlestad
IPC分类号： A61B5/0205
CPC分类号： A61B5/0816 , A61B5/0205 , A61B5/1116 , A61B5/7264 , G06F19/00
摘要： A device and method can monitor or trend a patient's respiration rate measurements according to the time of day. The device, which may be implantable or external, collects and classifies respiration rate measurements over time. The trended information about particular classes of respiration rate measurements is then communicated to a remote external device, which in turn provides an indication of heart failure decompensation. Examples of classes of respiration rate measurements include a daily maximum respiration rate value, a daily minimum respiration rate value, a daily maximum respiration rate variability value, a daily minimum respiration rate variability value, and a daily central respiration rate value. These respiration rate measurements can be further classified into daytime or nighttime respiration rate measurements.
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