公开(公告)号：US07488805B2

公开(公告)日：2009-02-10

申请号：US11739267

申请日：2007-04-24

申请人： Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Wen Yu

发明人： Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Wen Yu

IPC分类号： C07K16/00

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及新的凋亡多肽，例如参与调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定调节Apop1，Apop2和Apop3的生物学活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。

公开(公告)号：US07223850B1

公开(公告)日：2007-05-29

申请号：US09762491

申请日：1999-08-06

申请人： Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Wen Yu

发明人： Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Wen Yu

IPC分类号： C12N15/11 ,  C07K14/00

CPC分类号： C12N9/12

摘要： The present invention is directed to novel apoptosis polypeptides such as the Apop1, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided here are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及新的凋亡多肽，例如涉及调节凋亡的Apop1和Apop3蛋白和相关分子以及编码那些多肽的核酸分子。 此处还提供了包含这些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明进一步提供了用于鉴定调节Apop1，Apop2和Apop3的生物活性的新组合物的方法，以及这些组合物在诊断和治疗疾病中的用途。

公开(公告)号：US20060228761A1

公开(公告)日：2006-10-12

申请号：US11295841

申请日：2005-12-06

申请人： Ying Luo ,  Pei Yu ,  Mary Shen ,  Betty Huang

发明人： Ying Luo ,  Pei Yu ,  Mary Shen ,  Betty Huang

IPC分类号： G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C40B30/06 ,  C07K14/82 ,  C07K16/30

CPC分类号： C12N9/1205 ,  C07K14/4738 ,  C07K16/18

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

公开(公告)号：US07420045B1

公开(公告)日：2008-09-02

申请号：US10130555

申请日：2000-11-17

申请人： Ying Luo ,  Xiang Xu ,  Cindy Leo ,  Betty Huang ,  Mary Shen

发明人： Ying Luo ,  Xiang Xu ,  Cindy Leo ,  Betty Huang ,  Mary Shen

IPC分类号： C07H21/02 ,  C12P21/06 ,  C12P1/00 ,  C12N1/20

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also, provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 此外，本文提供的是包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及用于产生本发明多肽的方法 本发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US07001732B2

公开(公告)日：2006-02-21

申请号：US10165696

申请日：2002-06-07

申请人： Ying Luo ,  PeiWen Yu ,  Mary Shen ,  Betty Huang

发明人： Ying Luo ,  PeiWen Yu ,  Mary Shen ,  Betty Huang

IPC分类号： G01N33/53 ,  C07K14/475

CPC分类号： C12N9/1205 ,  C07K14/4738 ,  C07K16/18

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US06737232B1

公开(公告)日：2004-05-18

申请号：US09442013

申请日：1999-11-17

申请人： Ying Luo ,  Xiang Xu ,  Cindy Leo ,  Betty Huang ,  Mary Shen

发明人： Ying Luo ,  Xiang Xu ,  Cindy Leo ,  Betty Huang ,  Mary Shen

IPC分类号： C12Q100

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US07423118B1

公开(公告)日：2008-09-09

申请号：US09715725

申请日：2000-11-16

申请人： Ying Luo ,  Xiang Xu ,  Cindy Leo ,  Betty Huang ,  Mary Shen

发明人： Ying Luo ,  Xiang Xu ,  Cindy Leo ,  Betty Huang ,  Mary Shen

IPC分类号： C07K14/00

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US20080021202A1

公开(公告)日：2008-01-24

申请号：US11739267

申请日：2007-04-24

申请人： Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Yu

发明人： Ying Luo ,  Betty Huang ,  Mary Shen ,  Pei Yu

IPC分类号： C07K16/18

CPC分类号： C07K14/4747 ,  A61K38/00

摘要： The present invention is directed to novel apoptosis polypeptides such as the Apop1, Apop2, and Apop3 proteins and related molecules which are involved in modulating apoptosis and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are method for identifying novel compositions which modulate the biological activity of Apop1, Apop2, and Apop3, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及新的凋亡多肽，例如参与调节凋亡的Apop1，Apop2和Apop3蛋白和相关分子以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定调节Apop1，Apop2和Apop3的生物学活性的新组合物的方法，以及这些组合物在疾病诊断和治疗中的用途。

公开(公告)号：US06428980B1

公开(公告)日：2002-08-06

申请号：US09441039

申请日：1999-11-16

申请人： Ying Luo ,  PeiWen Yu ,  Mary Shen ,  Betty Huang

发明人： Ying Luo ,  PeiWen Yu ,  Mary Shen ,  Betty Huang

IPC分类号： C12N510

CPC分类号： C12N9/1205 ,  C07K14/4738 ,  C07K16/18

摘要： The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.

摘要翻译： 本发明涉及对细胞周期有影响或与细胞周期有关的新型多肽，核酸和相关分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本发明还提供了鉴定介导细胞周期生物活性的新型组合物的方法，以及这些组合物在疾病诊断和治疗中的应用。

公开(公告)号：US6114111A

公开(公告)日：2000-09-05

申请号：US50863

申请日：1998-03-30

申请人： Ying Luo ,  Betty Huang ,  Donald Payan

发明人： Ying Luo ,  Betty Huang ,  Donald Payan

IPC分类号： C12N15/10 ,  C12N15/12 ,  C12Q1/70

CPC分类号： C12N15/1055 ,  C12Q2565/201

摘要： The present invention is directed to compositions and methods for a genetic system of detecting protein--protein interactions in a mammalian host cell. Two fusion proteins are made in the host cell. The first fusion protein contains a DNA binding domain which is fused to a so-called bait protein. The second fusion protein consists of a transcriptional activation domain fused to a so-called test protein. The transcriptional activation domain is recruited to the promoter through the functional interaction between the bait protein and the test protein. Subsequently the transcriptional activation domain interacts with the basal transcription machinery to activate expression of one or more reporter genes which can be identified and characterized. The individual compositions are useful for analyzing protein--protein interactions between known proteins and to isolate, clone and characterize unknown proteins. The individual compositions can be used to express the fusion proteins either transiently or stably.

摘要翻译： 本发明涉及用于在哺乳动物宿主细胞中检测蛋白质 - 蛋白质相互作用的遗传系统的组合物和方法。 在宿主细胞中制备两种融合蛋白。 第一个融合蛋白含有与所谓诱饵蛋白融合的DNA结合结构域。 第二种融合蛋白由与所谓的测试蛋白融合的转录激活结构域组成。 通过诱饵蛋白质和测试蛋白质之间的功能相互作用将转录激活结构域引入启动子。 随后，转录激活结构域与基础转录机制相互作用以激活一种或多种可鉴定和表征的报告基因的表达。 单独的组合物可用于分析已知蛋白质之间的蛋白质 - 蛋白质相互作用并分离，克隆和表征未知蛋白质。 单独的组合物可用于瞬时或稳定地表达融合蛋白。