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1.发明授权公开(公告)号：US07790428B2
公开(公告)日：2010-09-07
申请号：US11726434
申请日：2007-03-22
申请人： Ying-Kai Wang , Mengping Liu , Brian A. Dougherty , Matthew D. Healy , Daniel B. Davison , Charles E. Mazzucco , Trina Maurice
发明人： Ying-Kai Wang , Mengping Liu , Brian A. Dougherty , Matthew D. Healy , Daniel B. Davison , Charles E. Mazzucco , Trina Maurice
CPC分类号： C07K14/395 , C07K14/38 , C07K14/40 , C07K2299/00
摘要： The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.
摘要翻译： 本发明提供必需的真菌多核苷酸及其编码的多肽，其同系物及其用途。 另外，本发明提供了用于鉴定可用于药物筛选的必需多核苷酸和真菌菌株的方法。
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公开(公告)号：US07442532B2
公开(公告)日：2008-10-28
申请号：US11725755
申请日：2007-03-20
申请人： Ying-Kai Wang , Mengping Liu , Brian A. Dougherty , Matthew D. Healy , Daniel B. Davison , Charles E. Mazzucco , Trina Maurice
发明人： Ying-Kai Wang , Mengping Liu , Brian A. Dougherty , Matthew D. Healy , Daniel B. Davison , Charles E. Mazzucco , Trina Maurice
CPC分类号： C07K14/395 , C07K14/38 , C07K14/40 , C07K2299/00
摘要： The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.
摘要翻译： 本发明提供必需的真菌多核苷酸及其编码的多肽，其同系物及其用途。 另外，本发明提供了用于鉴定可用于药物筛选的必需多核苷酸和真菌菌株的方法。
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公开(公告)号：US07465568B2
公开(公告)日：2008-12-16
申请号：US10424324
申请日：2003-04-25
申请人： Ying-Kai Wang , Mengping Liu , Brian A. Dougherty , Matthew D. Healy , Daniel B. Davison , Charles E. Mazzucco , Trina C. Maurice
发明人： Ying-Kai Wang , Mengping Liu , Brian A. Dougherty , Matthew D. Healy , Daniel B. Davison , Charles E. Mazzucco , Trina C. Maurice
CPC分类号： C07K14/395 , C07K14/38 , C07K14/40 , C07K2299/00
摘要： The presnt invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the identification of essential polynucleotides and fungal strains which may be used for drug screening.
摘要翻译： 本发明提供必需的真菌多核苷酸及其编码的多肽，其同系物及其用途。 另外，本发明提供了用于鉴定可用于药物筛选的必需多核苷酸和真菌菌株的方法。
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公开(公告)号：US07141418B2
公开(公告)日：2006-11-28
申请号：US10158844
申请日：2002-06-03
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
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5.发明授权Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds 失效用于改变紫杉烷类和紫杉烷类化合物生物合成的组合物和方法公开(公告)号：US07273755B2
公开(公告)日：2007-09-25
申请号：US10361290
申请日：2003-02-10
申请人： Christopher L. Steele , Yijun Chen , Brian A. Dougherty , Sandra Hofstead , Kin S. Lam , Wenying Li , Zizhuo Xing
发明人： Christopher L. Steele , Yijun Chen , Brian A. Dougherty , Sandra Hofstead , Kin S. Lam , Wenying Li , Zizhuo Xing
CPC分类号： C12N5/0025 , C12N9/90 , C12P17/02
摘要： Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.
摘要翻译： 提供了用于苯丙氨酸氨基变位酶的分离的核酸和氨基酸序列以及用于纯化该酶的方法。 还提供了用于改变植物细胞培养物中化合物的生物合成的方法。 特别地，提供了用于改变紫杉烷类和紫杉烷类化合物生产的方法。
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公开(公告)号：US08168205B2
公开(公告)日：2012-05-01
申请号：US12635794
申请日：2009-12-11
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US20100221287A1
公开(公告)日：2010-09-02
申请号：US12635794
申请日：2009-12-11
申请人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick J. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
IPC分类号： A61K39/02 , C07H21/00 , C12N15/74 , C12N5/10 , C07K2/00 , A61K38/02 , C07K16/00 , C12P21/00 , A61P37/04 , A61P31/04
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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公开(公告)号：US06420135B1
公开(公告)日：2002-07-16
申请号：US08961527
申请日：1997-10-30
申请人： Charles A. Kunsch , Gil H. Choi , Patrick S. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
发明人： Charles A. Kunsch , Gil H. Choi , Patrick S. Dillon , Craig A. Rosen , Steven C. Barash , Michael R. Fannon , Brian A. Dougherty
IPC分类号： C12P2106
CPC分类号： C07K14/3156 , A61K38/00 , A61K39/00 , C07K14/315
摘要： The present invention provides polynucleotide sequences of the genome of Streptococcus pneumoniae, polypeptide sequences encoded by the polynucleotide sequences, corresponding polynucleotides and polypeptides, vectors and hosts comprising the polynucleotides, and assays and other uses thereof. The present invention further provides polynucleotide and polypeptide sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use.
摘要翻译： 本发明提供了肺炎链球菌基因组的多核苷酸序列，由多核苷酸序列编码的多肽序列，相应的多核苷酸和多肽，载体和包含多核苷酸的宿主，以及其测定和其它用途。 本发明还提供了存储在计算机可读介质上的多核苷酸和多肽序列信息，以及便于其使用的基于计算机的系统和方法。
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