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1.发明授权Compositions and methods for altering biosynthesis of taxanes and taxane-related compounds 失效用于改变紫杉烷类和紫杉烷类化合物生物合成的组合物和方法公开(公告)号：US07273755B2
公开(公告)日：2007-09-25
申请号：US10361290
申请日：2003-02-10
申请人： Christopher L. Steele , Yijun Chen , Brian A. Dougherty , Sandra Hofstead , Kin S. Lam , Wenying Li , Zizhuo Xing
发明人： Christopher L. Steele , Yijun Chen , Brian A. Dougherty , Sandra Hofstead , Kin S. Lam , Wenying Li , Zizhuo Xing
CPC分类号： C12N5/0025 , C12N9/90 , C12P17/02
摘要： Isolated nucleic acid and amino acid sequences for phenylalanine aminomutase enzyme and methods for purifying this enzyme are provided. Methods for altering biosynthesis of compounds in plant cell cultures are also provided. In particular, methods for altering production of taxanes and taxane-related compounds are provided.
摘要翻译： 提供了用于苯丙氨酸氨基变位酶的分离的核酸和氨基酸序列以及用于纯化该酶的方法。 还提供了用于改变植物细胞培养物中化合物的生物合成的方法。 特别地，提供了用于改变紫杉烷类和紫杉烷类化合物生产的方法。
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公开(公告)号：US06218398B1
公开(公告)日：2001-04-17
申请号：US09351791
申请日：1999-07-13
申请人： John E. Leet , Helen A. Ax , Donald R. Gustavson , Daniel M. Brown , Laura Turner , Kimberly Brown , Wenying Li , Kin S. Lam
发明人： John E. Leet , Helen A. Ax , Donald R. Gustavson , Daniel M. Brown , Laura Turner , Kimberly Brown , Wenying Li , Kin S. Lam
IPC分类号： C07D51522
CPC分类号： C07K5/06139 , A61K31/4353 , A61K38/00 , C12R1/365
摘要： Novel thiazolyl peptide antibiotic compounds, including nocathiacin I, II and III, are disclosed. Also, novel microorganism ATCC-202099 is disclosed.
摘要翻译： 公开了新的噻唑基肽抗生素化合物，包括nocathiacin I，II和III。 另外，公开了新的微生物ATCC-202099。
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公开(公告)号：US06287827B1
公开(公告)日：2001-09-11
申请号：US09562388
申请日：2000-05-01
申请人： Wenying Li , John E. Leet , Kin S. Lam
发明人： Wenying Li , John E. Leet , Kin S. Lam
IPC分类号： C12P1700
摘要： Fermentation of Nocardia sp. ATCC-202099 in the presence of a halogen- or hydroxy-substituted tryptophan precursor yields a novel corresponding halogen- or hydroxy-substituted nocathiacin compound which has broad spectrum antibiotic activity against Gram-positive bacteria and has in vivo efficacy in animals.
摘要翻译： 诺卡氏菌发酵 ATCC-202099在卤素或羟基取代的色氨酸前体的存在下产生一种新的相应的卤素或羟基取代的硫酸合成化合物，其对革兰氏阳性细菌具有广谱抗生素活性，并具有动物体内功效。
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4.发明授权Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权稠合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂公开(公告)号：US07655689B2
公开(公告)日：2010-02-02
申请号：US11338587
申请日：2006-03-20
申请人： Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
发明人： Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC分类号： C07D209/00 , A01N43/38
CPC分类号： C07D487/18
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译： 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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5.发明授权Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效稠合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂公开(公告)号：US07517904B2
公开(公告)日：2009-04-14
申请号：US11176810
申请日：2005-07-07
申请人： Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
发明人： Mark E. Salvati , James Aaron Balog , Dacia A. Pickering , Sören Giese , Aberra Fura , Wenying Li , Ramesh N. Patel , Ronald L. Hanson , Toomas Mitt , Jacques Y. Roberge , James R. Corte , Steven H. Spergel , Richard A. Rampulla , Raj N. Misra , Hai-Yun Xiao
IPC分类号： A61K31/407 , A61K31/34 , C07D491/08
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译： 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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!['N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites](/abs-image/US/2006/09/21/US20060211705A1/abs.jpg.150x150.jpg)
6.发明申请'N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites 有权'N-（2-氯-6-甲基苯基）-2 - [[6- [4-（2-羟乙基）-1-哌嗪基] -2-甲基-4-嘧啶基]氨基] -5-噻唑甲酰胺代谢物公开(公告)号：US20060211705A1
公开(公告)日：2006-09-21
申请号：US11376665
申请日：2006-03-15
申请人： Vinod Arora , Lisa Christopher , Donghui Cui , Wenying Li
发明人： Vinod Arora , Lisa Christopher , Donghui Cui , Wenying Li
IPC分类号： A61K31/506 , C07D417/14
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention is directed to metabolites of ′N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, the compound of formula (I), pharmaceutical compositions thereof, and to methods of using the metabolites and the pharmaceutical compositions in the treatment of oncological and immunological disorders.
摘要翻译： 本发明涉及“N-（2-氯-6-甲基苯基）-2 - [[6- [4-（2-羟乙基）-1-哌嗪基] -2-甲基-4-嘧啶基]氨基 ] -5-噻唑甲酰胺，式（I）化合物，其药物组合物，以及使用代谢物和药物组合物治疗肿瘤学和免疫学疾病的方法。
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7.发明申请公开(公告)号：US20070184533A1
公开(公告)日：2007-08-09
申请号：US11697363
申请日：2007-04-06
申请人： Wenying Li , James Matson , Xiaohua Huang , Kin Lam , Grace McClure
发明人： Wenying Li , James Matson , Xiaohua Huang , Kin Lam , Grace McClure
IPC分类号： C12P17/00 , C07D417/02
CPC分类号： C07D493/04 , C12P17/08 , C12P17/10 , C12P17/18 , C12P17/181 , C12P17/182 , C12P17/185
摘要： A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
摘要翻译： 一种用于制备含有末端羟烷基的埃坡霉素的微生物方法，包括使至少一种具有末端烷基的埃坡霉素与能够催化所述烷基的选择性羟基化为羟基烷基的酶或微生物接触，并进行所述羟基化 。
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!['N-(2-chloro-6-methylphenyl)-2-[[(6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites](/abs-image/US/2009/11/24/US07622473B2/abs.jpg.150x150.jpg)
8.发明授权'N-(2-chloro-6-methylphenyl)-2-[[(6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites 有权'N-（2-氯-6-甲基苯基）-2 - [[（6- [4-（2-羟基乙基）-1-哌嗪基] -2-甲基-4-嘧啶基]氨基] -5-噻唑甲酰胺代谢物公开(公告)号：US07622473B2
公开(公告)日：2009-11-24
申请号：US11376665
申请日：2006-03-15
IPC分类号： A61K31/497 , C07D403/00
CPC分类号： C07D417/12 , C07D417/14
摘要： The present invention is directed to metabolites of ′N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, the compound of formula (I), pharmaceutical compositions thereof, and to methods of using the metabolites and the pharmaceutical compositions in the treatment of oncological and immunological disorders.
摘要翻译： 本发明涉及“N-（2-氯-6-甲基苯基）-2 - [[6- [4-（2-羟乙基）-1-哌嗪基] -2-甲基-4-嘧啶基]氨基 ] -5-噻唑甲酰胺，式（I）化合物，其药物组合物，以及使用代谢物和药物组合物治疗肿瘤学和免疫学疾病的方法。
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9.发明申请Fused Heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 失效融合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂公开(公告)号：US20050272799A1
公开(公告)日：2005-12-08
申请号：US11176810
申请日：2005-07-07
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译： 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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10.发明申请Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权稠合的杂环琥珀酰亚胺化合物及其类似物，核激素受体功能的调节剂公开(公告)号：US20050192253A1
公开(公告)日：2005-09-01
申请号：US10974049
申请日：2004-10-25
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07D471/18 , C07D487/08 , C07D487/18 , C07D491/18 , C07D491/22 , C07D495/18 , C07D519/00 , C07D487/14
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
摘要翻译： 稠合的环状化合物，使用这些化合物治疗核激素受体相关病症如癌症和免疫疾病的方法，以及含有这些化合物的药物组合物。
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