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    Electrochemical test sensor
    1.
    发明授权
    Electrochemical test sensor 有权
    电化学测试传感器

    公开(公告)号：US07122110B2

    公开(公告)日：2006-10-17

    申请号：US10992593

    申请日：2004-11-18

    申请人： Yingping Deng ,  Sherry J. Jamison ,  Andrew J. Edelbrock

    发明人： Yingping Deng ,  Sherry J. Jamison ,  Andrew J. Edelbrock

    IPC分类号： G01N27/327 ,  B05D3/00

    CPC分类号： C12Q1/54 ,  C12Q1/004

    摘要： Disclosed is an improved electrochemical sensor for the detection of an analyte in a fluid test sample. The electrochemical sensor is of the type in which the fluid test sample is drawn into a capillary space and the improvement to the sensor involves an arrangement where a portion of the sensor's counter electrode is placed on the edge of the capillary space in a relationship to the sensor's working electrode such that if the capillary space is not completely filled there will be generated only a very weak current. When the sensor is connected to a properly programmed current detector, the weak current caused by the underfilling of the capillary space will be detected as an error and will notify the user of the sensor that the test should not be continued.

    摘要翻译： 公开了用于检测流体测试样品中的分析物的改进的电化学传感器。 电化学传感器是将流体测试样品吸入毛细管空间的类型，并且对传感器的改进涉及将传感器的对电极的一部分放置在与毛细管空间的边缘相关的布置 传感器的工作电极，使得如果毛细管空间未完全填充，则仅产生非常弱的电流。 当传感器连接到正确编程的电流检测器时，由毛细管空间不足引起的弱电流将被检测为错误，并将通知用户传感器不应继续测试。

    Methods for performing hematocrit adjustment in glucose assays and devices for same
    2.
    发明授权
    Methods for performing hematocrit adjustment in glucose assays and devices for same 有权
    用于在葡萄糖测定中进行血细胞比容调节的方法及其装置

    公开(公告)号：US07972861B2

    公开(公告)日：2011-07-05

    申请号：US11596401

    申请日：2005-05-13

    申请人： Yingping Deng ,  Sherry J. Jamison

    发明人： Yingping Deng ,  Sherry J. Jamison

    IPC分类号： G01N33/66 ,  G01N33/50 ,  G01N27/06

    CPC分类号： G01N27/3274 ,  Y10T436/144444

    摘要： Methods and devices for performing in situ hematocrit adjustments during glucose testing using glucose-monitoring products and using those adjusted values to estimate the hematocrit value of blood samples to reduce or eliminate the assay bias caused by the different hematocrit levels of blood samples. One method involves measuring the glucose value, Glum, of the blood sample; measuring the resistance of the blood sample (Rcell) using a biosensor reagent; measuring the resistance of plasma (Rplasma) using the biosensor reagent; determining the calculated resistance of red blood cells, RRBC, of the blood sample according to the relationship RRBC=Rcell−Rplasma; calculating the percent hematocrit, % Hctc, of the blood sample; determining whether to adjust the glucose value, Glum, to an adjusted glucose value, Gluadj; and using the percent hematocrit, % Hctc, and either the glucose value, Glum, or the adjusted glucose value, Gluadj, to adjust for any bias of the biosensor reagent.

    摘要翻译： 使用葡萄糖监测产品在葡萄糖测试期间进行原位血细胞比容调整的方法和装置，并使用这些调整值来估计血液样品的血细胞比容值，以减少或消除由血液样品的不同血细胞比容水平引起的测定偏差。 一种方法包括测量血液样品的葡萄糖值Glum; 使用生物传感器试剂测量血液样品（Rcell）的电阻; 使用生物传感器试剂测量血浆（Rplasma）的电阻; 根据RRBC = Rcell-Rplasma的关系确定血液样本的红血细胞计数电阻RRBC; 计算血液样品的血细胞比容百分比％Hctc; 确定是否将葡萄糖值Glum调节至调节的葡萄糖值Gluadj; 并且使用百分比血细胞比容％Hctc和葡萄糖值Glum或调节的葡萄糖值Gluadj来调整生物传感器试剂的任何偏差。

    Electrochemical sensor
    5.
    发明申请
    Electrochemical sensor 有权

    公开(公告)号：US20060037870A1

    公开(公告)日：2006-02-23

    申请号：US10992593

    申请日：2004-11-18

    申请人： Yingping Deng ,  Sherry Jamison ,  Andrew Edelbrock

    发明人： Yingping Deng ,  Sherry Jamison ,  Andrew Edelbrock

    IPC分类号： G01N27/26 ,  C12Q1/00

    CPC分类号： C12Q1/54 ,  C12Q1/004

    摘要： Disclosed is an improved electrochemical sensor for the detection of an analyte in a fluid test sample. The electrochemical sensor is of the type in which the fluid test sample is drawn into a capillary space and the improvement to the sensor involves an arrangement where a portion of the sensor's counter electrode is placed on the edge of the capillary space in a relationship to the sensor's working electrode such that if the capillary space is not completely filled there will be generated only a very weak current. When the sensor is connected to a properly programmed current detector, the weak current caused by the underfilling of the capillary space will be detected as an error and will notify the user of the sensor that the test should not be continued.

    Methods for Performing Hematocrit Adjustment in Glucose Assays and Devices for Same
    6.
    发明申请
    Methods for Performing Hematocrit Adjustment in Glucose Assays and Devices for Same 有权
    在葡萄糖测定和相关设备中进行血细胞比容调整的方法

    公开(公告)号：US20070231914A1

    公开(公告)日：2007-10-04

    申请号：US11596401

    申请日：2005-05-13

    申请人： Yingping Deng ,  Sherry Jamison

    发明人： Yingping Deng ,  Sherry Jamison

    IPC分类号： G01N27/416 ,  C12M1/34 ,  G01N33/50

    CPC分类号： G01N27/3274 ,  Y10T436/144444

    摘要： Methods and devices for performing in situ hematocrit adjustments during glucose testing using glucose-monitoring products and using those adjusted values to estimate the hematocrit value of blood samples to reduce or eliminate the assay bias caused by the different hematocrit levels of blood samples. One method involves measuring the glucose value, Glum, of the blood sample; measuring the resistance of the blood sample (Rcell) using a biosensor reagent; measuring the resistance of plasma (Rplasma) using the biosensor reagent; determining the calculated resistance of red blood cells, RRBC, of the blood sample according to the relationship RRBC=Rcell−Rplasma; calculating the percent hematocrit, % Hctc, of the blood sample; determining whether to adjust the glucose value, Glum, to an adjusted glucose value, Gluadj; and using the percent hematocrit, % Hctc, and either the glucose value, Glum, or the adjusted glucose value, Gluadj, to adjust for any bias of the biosensor reagent.

    摘要翻译： 使用葡萄糖监测产品在葡萄糖测试期间进行原位血细胞比容调整的方法和装置，并使用这些调整值来估计血液样品的血细胞比容值，以减少或消除由血液样品的不同血细胞比容水平引起的测定偏差。 一种方法包括测量血液样品的葡萄糖值，Glu <！ - SIPO < 使用生物传感器试剂测量血液样品（R细胞）的电阻; 使用生物传感器试剂测量血浆（R>等离子体）的电阻; 根据关系式<？in-line-formula description =“In-Line Formulas”end =“lead”？> R，确定血液样本的红血细胞计算电阻RBC RBC = R 等离子体; <？in-line-formula description =“在线公式”end =“tail”？>计算血液样本的百分比血细胞比容％Hct 确定是否将葡萄糖值Glu 调节至调节的葡萄糖值Glu。 并使用百分比血细胞比容％Hct ，将葡萄糖值，Glu /或调整的葡萄糖值Glu调整至 调整生物传感器试剂的任何偏差。

    Methods of determining the concentration of an analyte in a fluid test sample
    7.
    发明授权
    Methods of determining the concentration of an analyte in a fluid test sample 有权
    确定流体测试样品中分析物浓度的方法

    公开(公告)号：US07132041B2

    公开(公告)日：2006-11-07

    申请号：US10770199

    申请日：2004-02-02

    申请人： Yingping Deng ,  Amy H. Chu

    发明人： Yingping Deng ,  Amy H. Chu

    IPC分类号： G01N27/26 ,  G01N33/50 ,  C12Q1/26

    CPC分类号： C12Q1/006 ,  G01N27/3274

    摘要： A method of determining the concentration of an analyte in a fluid test sample that includes providing an electrochemical sensor adapted to measure the analyte in the test sample. The test sample sufficiently covers a counter and working electrode of the electrochemical sensor. A first potential is applied between the counter and working electrodes for a first predetermined time period and the current is measured and the time is recorded. After the first potential is removed or substantially reduced, a second potential is applied between the counter and working electrodes and the current is measured. The concentration of the analyte is determined in the test sample as a function of the current measured. An index is calculated and compared to at least one predetermined parameter to identify when a bias, if any, exceeds a threshold. An error signal or analyte concentration is displayed depending on the comparison.

    摘要翻译： 确定流体测试样品中分析物浓度的方法，其包括提供适于测量测试样品中的分析物的电化学传感器。 测试样品充分覆盖电化学传感器的计数器和工作电极。 在第一预定时间段内在计数器和工作电极之间施加第一电位，并且测量电流并记录时间。 在去除或显着减小第一电位之后，在计数器和工作电极之间施加第二电位，并测量电流。 在测试样品中测定分析物的浓度作为测量电流的函数。 计算索引并将其与至少一个预定参数进行比较，以识别偏差（如果有的话）何时超过阈值。 根据比较显示错误信号或分析物浓度。