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14 条记录 (耗时 0.037 秒)

    Cyclosporin compositions
    1.
    发明授权
    Cyclosporin compositions 失效
    环孢菌素组合物

    公开(公告)号：US06582718B2

    公开(公告)日：2003-06-24

    申请号：US09939967

    申请日：2001-08-27

    申请人： Yoichi Kawashima ,  Mitsuaki Kuwano

    发明人： Yoichi Kawashima ,  Mitsuaki Kuwano

    IPC分类号： A61F200

    CPC分类号： A61K38/13 ,  A61K9/0048 ,  Y02A50/465 ,  Y10S514/885

    摘要： An ophthalmic composition particularly in the form of eye-drops suitable for the treatment of diseases of the eye and surrounding areas. The composition contains a cyclosporin and a surfactant selected from polyoxyethylene fatty acid esters, polyoxyethylene alkylphenyl ethers and polyoxyethylene alkyl ethers, or mixtures thereof.

    摘要翻译： 一种眼用组合物，特别是适用于治疗眼睛和周围区域疾病的眼药水。 该组合物含有环孢菌素和选自聚氧乙烯脂肪酸酯，聚氧乙烯烷基苯基醚和聚氧乙烯烷基醚的表面活性剂，或其混合物。

    Drug delivery system using subconjunctival depot
    5.
    发明申请
    Drug delivery system using subconjunctival depot 审中-公开
    药物输送系统使用结膜库

    公开(公告)号：US20060039979A1

    公开(公告)日：2006-02-23

    申请号：US10537453

    申请日：2003-12-03

    申请人： Kazuhito Yamada ,  Mitsuaki Kuwano

    发明人： Kazuhito Yamada ,  Mitsuaki Kuwano

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0048 ,  A61K9/0051 ,  A61K9/1647 ,  A61K31/573 ,  A61K47/10 ,  A61K47/12 ,  A61K47/36 ,  A61K47/38

    摘要： The present invention provides a drug delivery system to a posterior segment wherein a pharmaceutical composition comprising a drug and a vehicle is administered subconjunctivally to form a depot out of the vehicle, and thereby the drug is gradually released from the depot to enable an effective concentration of the drug to be maintained, the pharmaceutical composition comprising the vehicle which is in the form of gel subconjunctivally and the drug suspended in the vehicle.

    摘要翻译： 本发明提供了一种向后段施用药物递送系统，其中包含药物和载体的药物组合物经结膜下给药以形成车辆外的贮库，从而使药物逐渐从贮库释放， 待维持的药物，包含结膜凝胶形式的载体的药物组合物和悬浮在载体中的药物。

    Process for producing microparticles
    6.
    发明授权
    Process for producing microparticles 有权
    微粒生产方法

    公开(公告)号：US07923034B2

    公开(公告)日：2011-04-12

    申请号：US10559173

    申请日：2004-06-03

    申请人： Kazuhito Yamada ,  Yasumasa Sasaki ,  Fumitaka Tasaka ,  Mitsuaki Kuwano

    发明人： Kazuhito Yamada ,  Yasumasa Sasaki ,  Fumitaka Tasaka ,  Mitsuaki Kuwano

    IPC分类号： A61K9/50

    CPC分类号： A61K31/573 ,  A61K9/1647 ,  A61K31/58

    摘要： An object of the present invention is to provide a solvent which is able to produce microparticles where content of the drug is still high and no initial burst takes place even when a drug having a low solubility in a halogenated hydrocarbon solvent is used. The present invention provides a process for production by a solvent-evaporation microencapsulation method, of microparticles which are composed of biodegradable polymer and contain a drug having a low solubility in a halogenated hydrocarbon, which is characterized in that the drug and the biodegradable polymer are dissolved in a mixed solvent comprising a first solvent: halogenated hydrocarbon, and a second solvent: a water-immiscible organic solvent in which solubility of the above-mentioned drug is 0.3% (w/v) or more.

    摘要翻译： 本发明的目的在于提供即使使用在卤代烃类溶剂中溶解性低的药物，也能够产生药物含量仍然很高而不发生初始爆发的微粒的溶剂。 本发明提供了一种通过溶剂蒸发微胶囊化方法生产由生物可降解聚合物组成并含有在卤代烃中具有低溶解度的药物的微粒的方法，其特征在于药物和可生物降解聚合物溶解 在包含第一溶剂：卤代烃和第二溶剂的混合溶剂中：上述药物的溶解度为0.3％（w / v）以上的与水不混溶的有机溶剂。

    Drug delivery system using subconjunctival depot
    7.
    发明申请
    Drug delivery system using subconjunctival depot 审中-公开

    公开(公告)号：US20060013859A1

    公开(公告)日：2006-01-19

    申请号：US11146252

    申请日：2005-06-06

    申请人： Kazuhito Yamada ,  Mitsuaki Kuwano

    发明人： Kazuhito Yamada ,  Mitsuaki Kuwano

    IPC分类号： A61F2/00

    CPC分类号： A61F9/0008 ,  A61K9/0048

    摘要： The present invention provides a drug delivery system to a posterior segment wherein a pharmaceutical composition comprising a drug and a vehicle is administered subconjunctivally to form a depot out of the vehicle, and thereby the drug is gradually released from the depot to enable an effective concentration of the drug to be maintained, the pharmaceutical composition comprising the vehicle which is in the form of gel subconjunctivally and the drug suspended in the vehicle.

    Eyedrops containing particulate agar
    8.
    发明申请
    Eyedrops containing particulate agar 审中-公开
    含有颗粒状琼脂的滴眼液

    公开(公告)号：US20080199524A1

    公开(公告)日：2008-08-21

    申请号：US11810524

    申请日：2007-06-06

    申请人： Masahiro Inohara ,  Masahito Yoshikawa ,  Takashi Taniguchi ,  Mitsuru Yokota ,  Naoki Shimoyama ,  Masaki Ue ,  Miho Araki ,  Yukiko Sugihara ,  Yoshihide Horibe ,  Mitsuaki Kuwano

    发明人： Masahiro Inohara ,  Masahito Yoshikawa ,  Takashi Taniguchi ,  Mitsuru Yokota ,  Naoki Shimoyama ,  Masaki Ue ,  Miho Araki ,  Yukiko Sugihara ,  Yoshihide Horibe ,  Mitsuaki Kuwano

    IPC分类号： A61K9/14

    CPC分类号： A61K9/0048 ,  A61K9/08

    摘要： It is intended to prepare a composition which contains polysaccharide at a high concentration and yet remains in the state of a liquid having low viscosity to thereby provide drugs, eyedrops, foods, cosmetics, toiletry products having a novel texture or function. The composition in the state of a liquid having low viscosity is obtained by heating polysaccharide at a high concentration in a water-containing liquid and then cooling under applying a shear force, which enables the provision of the above-described drugs. The composition is usable as an aqueous drug vehicle which is free from gelling due to temperature changes during storage and easily applied without pouring and/or streaming down. Eyedrops containing agar have an effect of enhancing ocular drug penetration. Eyedrops containing particulate agar maintain a low viscosity and, achieve easy instillation and impart a favorable feel in instillation.

    摘要翻译： 本发明的目的在于制备含有高浓度多糖但仍具有低粘度的液体状态的组合物，从而提供具有新颖的质地或功能的药物，滴眼剂，食品，化妆品，化妆品等。 通过在含水液体中以高浓度加热多糖，然后在施加剪切力的条件下冷却，得到具有低粘度的液体状态的组合物，从而能够提供上述药物。 该组合物可用作水性药物载体，其由于储存期间的温度变化而没有胶凝，并且容易施用而没有倾倒和/或流下。 含有琼脂的滴眼液具有增强眼药物渗透的作用。 含有颗粒状琼脂的喷雾剂保持低粘度，并且实现容易滴注并赋予滴注有利的感觉。

    Delivering substance and drug delivery system using the same
    9.
    发明授权
    Delivering substance and drug delivery system using the same 失效
    使用相同的物质和药物输送系统

    公开(公告)号：US07455855B2

    公开(公告)日：2008-11-25

    申请号：US10240438

    申请日：2001-04-03

    申请人： Mitsuaki Kuwano ,  Masaki Nakagawa ,  Hiroshi Suhara

    发明人： Mitsuaki Kuwano ,  Masaki Nakagawa ,  Hiroshi Suhara

    IPC分类号： A61F2/00

    CPC分类号： A61K9/1271 ,  A61K47/544 ,  A61K47/60

    摘要： An object of the present invention is to prepare substances which are excellent in delivery and enable drugs to be retained in a body effectively over a long period and to construct a drug delivery system using the substances. When the delivering substance which is obtained by reacting polyalkylene glycol or a reactive derivative thereof, a phospholipid and a drug with each other to form covalent bonds is administered systemically or topically, the substance is retained at a target site in a body for a long period, thereby making it possible to sustain drug efficacy over a long period by a single administration.

    摘要翻译： 本发明的目的在于制备输送性优异的物质，能够长时间地有效地保持体内的药物，构成使用该物质的药物输送系统。 当通过使聚亚烷基二醇或其活性衍生物，磷脂和药物彼此反应以形成共价键而获得的递送物质被全身或局部施用时，该物质长时间保留在体内的靶位点 ，从而可以通过单次给药长时间维持药物功效。

    Aqueous preparation of lactoferrin having improved stability
    10.
    发明授权
    Aqueous preparation of lactoferrin having improved stability 失效
    具有改善的稳定性的乳铁蛋白的水性制剂

    公开(公告)号：US06479627B1

    公开(公告)日：2002-11-12

    申请号：US09463773

    申请日：2000-01-31

    申请人： Atsutoshi Ota ,  Mitsuaki Kuwano ,  Hiroyuki Asada

    发明人： Atsutoshi Ota ,  Mitsuaki Kuwano ,  Hiroyuki Asada

    IPC分类号： C07K1400

    CPC分类号： A61K47/12 ,  A61K9/0048 ,  A61K38/40 ,  Y10S530/832

    摘要： An object of the present invention is to provide an aqueous solution of lactoferrin which can be preserved for a long period of time. The aqueous preparation according to the present invention is an aqueous preparation which is characterized by containing a polyvalent inorganic or organic acid or a salt thereof whereby stability of lactoferrin is improved and is an aqueous preparation in which concentration of the polyvalent inorganic or organic acid or a salt thereof is 0.005% (w/v) or more. In the case of ophthalmic solutions, for example, the polyvalent inorganic or organic acid or a salt thereof is preferably 0.01-3.0% (w/v), particularly preferably 0.1-1.0% (w/v).

    摘要翻译： 本发明的一个目的是提供一种长时间保存的乳铁蛋白水溶液。 本发明的水性制剂是含有多价无机或有机酸或其盐的水性制剂，其中乳铁蛋白的稳定性得到改善，并且是多价无机酸或有机酸的浓度或 其盐为0.005％（w / v）以上。 在眼用溶​​液的情况下，例如，多价无机或有机酸或其盐优选为0.01-3.0％（w / v），特别优选为0.1〜1.0％（w / v）。