Drug delivery system using subconjunctival depot
    4.
    发明申请
    Drug delivery system using subconjunctival depot 审中-公开
    药物输送系统使用结膜库

    公开(公告)号:US20060039979A1

    公开(公告)日:2006-02-23

    申请号:US10537453

    申请日:2003-12-03

    Abstract: The present invention provides a drug delivery system to a posterior segment wherein a pharmaceutical composition comprising a drug and a vehicle is administered subconjunctivally to form a depot out of the vehicle, and thereby the drug is gradually released from the depot to enable an effective concentration of the drug to be maintained, the pharmaceutical composition comprising the vehicle which is in the form of gel subconjunctivally and the drug suspended in the vehicle.

    Abstract translation: 本发明提供了一种向后段施用药物递送系统,其中包含药物和载体的药物组合物经结膜下给药以形成车辆外的贮库,从而使药物逐渐从贮库释放, 待维持的药物,包含结膜凝胶形式的载体的药物组合物和悬浮在载体中的药物。

    Process for producing microparticles
    6.
    发明授权
    Process for producing microparticles 有权
    微粒生产方法

    公开(公告)号:US07923034B2

    公开(公告)日:2011-04-12

    申请号:US10559173

    申请日:2004-06-03

    CPC classification number: A61K31/573 A61K9/1647 A61K31/58

    Abstract: An object of the present invention is to provide a solvent which is able to produce microparticles where content of the drug is still high and no initial burst takes place even when a drug having a low solubility in a halogenated hydrocarbon solvent is used. The present invention provides a process for production by a solvent-evaporation microencapsulation method, of microparticles which are composed of biodegradable polymer and contain a drug having a low solubility in a halogenated hydrocarbon, which is characterized in that the drug and the biodegradable polymer are dissolved in a mixed solvent comprising a first solvent: halogenated hydrocarbon, and a second solvent: a water-immiscible organic solvent in which solubility of the above-mentioned drug is 0.3% (w/v) or more.

    Abstract translation: 本发明的目的在于提供即使使用在卤代烃类溶剂中溶解性低的药物,也能够产生药物含量仍然很高而不发生初始爆发的微粒的溶剂。 本发明提供了一种通过溶剂蒸发微胶囊化方法生产由生物可降解聚合物组成并含有在卤代烃中具有低溶解度的药物的微粒的方法,其特征在于药物和可生物降解聚合物溶解 在包含第一溶剂:卤代烃和第二溶剂的混合溶剂中:上述药物的溶解度为0.3%(w / v)以上的与水不混溶的有机溶剂。

    Drug delivery system using subconjunctival depot

    公开(公告)号:US20060013859A1

    公开(公告)日:2006-01-19

    申请号:US11146252

    申请日:2005-06-06

    CPC classification number: A61F9/0008 A61K9/0048

    Abstract: The present invention provides a drug delivery system to a posterior segment wherein a pharmaceutical composition comprising a drug and a vehicle is administered subconjunctivally to form a depot out of the vehicle, and thereby the drug is gradually released from the depot to enable an effective concentration of the drug to be maintained, the pharmaceutical composition comprising the vehicle which is in the form of gel subconjunctivally and the drug suspended in the vehicle.

    Slip control system
    10.
    发明授权
    Slip control system 失效
    滑动控制系统

    公开(公告)号:US5954618A

    公开(公告)日:1999-09-21

    申请号:US926431

    申请日:1997-09-10

    CPC classification number: F16H61/143 Y10T477/65 Y10T477/75 Y10T477/755

    Abstract: A slip control system for an automatic transmission includes a fluid coupling including a release side oil chamber, an apply side oil chamber and a lockup clutch unit that is applied and released on an basis of the oil pressure that is fed to at least one of the release side oil chamber and the apply side oil chamber; an oil pressure generating unit for generating the oil pressure; a vehicular running state detecting unit for a detecting vehicular running state; an electronic control unit for determining whether a slip control is to be made, on the basis of a determination upon whether the present vehicular running state, as detected by the vehicular running state detecting unit, belongs to a predetermined slip control region; and an oil pressure regulating unit for regulating the oil pressure in response to a signal coming from the electronic control unit, to make the slip control by sliding the lockup clutch unit. The electronic control unit determines the state of a heat, as generated according to the slip control; and changes the slip control region on the basis of the heat state.

    Abstract translation: 用于自动变速器的滑动控制系统包括:流体联接器,其包括释放侧油室,应用侧油室和锁定离合器单元,其基于供给至至少一个的油压的油压被施加和释放 释放侧油室和应用侧油室; 用于产生油压的油压发生单元; 用于检测车辆行驶状态的车辆行驶状态检测单元; 基于由车辆行驶状态检测单元检测到的当前车辆行驶状态是否属于预定的滑动控制区域,确定是否进行滑行控制的电子控制单元; 以及油压调节单元,用于响应于来自电子控制单元的信号调节油压,以通过滑动锁止离合器单元进行滑动控制。 电子控制单元确定根据滑动控制产生的热量状态; 并基于加热状态改变滑移控制区域。

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