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1.发明申请Micro-reactor, dissociation constant measuring apparatus, dissociation constant measuring method, and dissociation constant measuring program 审中-公开微反应器，解离常数测量装置，解离常数测量方法和解离常数测量程序公开(公告)号：US20060172409A1
公开(公告)日：2006-08-03
申请号：US11341746
申请日：2006-01-27
申请人： Yoko Shinohara , Minao Yamamoto , Masataka Shinogi , Fumio Kimura , Haruki Kato
发明人： Yoko Shinohara , Minao Yamamoto , Masataka Shinogi , Fumio Kimura , Haruki Kato
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00824 , B01J2219/00831 , B01J2219/00833 , B01J2219/00853 , B01J2219/0086 , B01J2219/00957 , B01L3/5027 , G01G3/13 , G01N27/221 , G01N29/022 , G01N29/222 , G01N33/557 , G01N2291/0224 , G01N2291/0256 , G01N2291/02809 , G01N2291/02863 , G01N2291/0423 , G01N2291/0426
摘要： In order to make it possible to predict a dissociation constant at an initial stage of reaction, a concentration sensor for a sample is provided on a downstream side of a mass sensor. This makes it possible to learn concentration of a sample solution at the time when a mass is detected by the mass sensor. When the concentration and the mass are substituted in a predetermined logical expression, it is possible to obtain a predicted value of a dissociation constant. The concentration sensor is a capacitor constituted by electrodes opposed to each other. Since a dielectric constant changes when analytes are present between the electrodes, it is possible to detect analyte concentration according to the dielectric constant. Since it is possible to reduce a size of the capacitor, it is possible to keep a size of a micro-reactor small. Note that the mass sensor outputs a resonance frequency of a quartz resonator. A measuring apparatus can calculate a mass from transition of this frequency.
摘要翻译： 为了能够在反应的初始阶段预测解离常数，在质量传感器的下游侧设置有用于样品的浓度传感器。 这使得可以在通过质量传感器检测质量时学习样品溶液的浓度。 当以预定的逻辑表达式代替浓度和质量时，可以获得解离常数的预测值。 浓度传感器是由彼此相对的电极构成的电容器。 由于当电极之间存在分析物时介电常数发生变化，因此可以根据介电常数检测分析物浓度。 由于可以减小电容器的尺寸，因此可以保持微反应器的尺寸小。 注意，质量传感器输出石英谐振器的谐振频率。 测量装置可以计算从该频率的转变中的质量。
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2.发明授权Reactor, micro-reactor chip, micro-reactor system, and method for manufacturing the reactor 有权反应器，微反应器芯片，微反应器系统以及反应器的制造方法公开(公告)号：US08828321B2
公开(公告)日：2014-09-09
申请号：US11338293
申请日：2006-01-24
申请人： Yoko Shinohara , Minao Yamamoto , Masataka Shinogi , Haruki Kato
发明人： Yoko Shinohara , Minao Yamamoto , Masataka Shinogi , Haruki Kato
IPC分类号： G01N27/00
CPC分类号： G01N29/036 , G01N2291/0256
摘要： A reactor comprises a main body having a flow path substrate and a crystal substrate chemically bonded to the flow path substrate to form a flow path for running a sample to be measured and a reactor tank connected to the flow path. An adsorption film is disposed in the reactor tank for adsorbing a specific substance contained in the sample to be measured. A measuring device measures a physical quantity of the specific substance contained in the sample and adsorbed by the adsorption film.
摘要翻译： 反应器包括主体，其具有流路基板和化学键合到流路基板的晶体基板，以形成用于使待测样品运行的流路和连接到流路的反应器罐。 吸附膜设置在反应槽中，用于吸附待测样品中所含的特定物质。 测量装置测量样品中所含特定物质的物理量并被吸附膜吸附。
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3.发明申请Reactor, a microchip, and a micro reactor system as well as a method for manufacturing the reactor 有权反应器，微芯片和微反应器系统以及制造反应器的方法公开(公告)号：US20060169045A1
公开(公告)日：2006-08-03
申请号：US11338293
申请日：2006-01-24
申请人： Yoko Shinohara , Minao Yamamoto , Masataka Shinogi , Haruki Kato
发明人： Yoko Shinohara , Minao Yamamoto , Masataka Shinogi , Haruki Kato
IPC分类号： B01J19/00
CPC分类号： G01N29/036 , G01N2291/0256
摘要： In order to provide a reactor, a micro reactor chip, and a micro reactor system which can maintain high sensitivity without residual stresses on a crystal oscillator and unwanted oscillation modes, both surfaces of an AT-cut crystal plate 100 is deposited or sputtered with gold to prepare a detection electrode 601, an opposite electrode 602, and wiring to both electrodes. A resist is then formed on a cleaned silicon wafer. Polydimethylsiloxane (PDMS) is then poured onto the silicon wafer and allowed to cure. The PDMS is then peeled from the silicon wafer to form a groove 500 in the PDMS. The PDMS is then laid on the crystal plate. When the crystal substrate side is then irradiate with ultraviolet light the silicon-carbon bond between the crystal and the PDMS is cut, thus causing the crystal and the PDMS to bond to each other by means of a siloxane bond. The liquid introduction port and the liquid discharge port are then cut to form the reactor. A micro reactor chip and a micro reactor system are configured through the application of the construction of the reactor.
摘要翻译： 为了提供一种反应堆，微反应堆芯片和微反应器系统，其可以在晶体振荡器和不期望的振荡模式下保持高灵敏度而没有残余应力，AT切割晶体板100的两个表面被沉积或溅射金 以准备检测电极601，相对电极602和与两电极的布线。 然后在清洁的硅晶片上形成抗蚀剂。 然后将聚二甲基硅氧烷（PDMS）倒入硅晶片上并使其固化。 然后PDMS从硅晶片剥离，以在PDMS中形成凹槽500。 然后将PDMS放置在晶体板上。 当晶体衬底侧用紫外光照射时，晶体和PDMS之间的硅 - 碳键被切割，从而通过硅氧烷键使晶体和PDMS彼此结合。 然后将液体导入口和液体排出口切割成反应器。 微反应器芯片和微反应器系统通过应用反应器的结构来构造。
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公开(公告)号：US07413545B2
公开(公告)日：2008-08-19
申请号：US10405128
申请日：2003-04-02
CPC分类号： A61B5/026 , A61B5/02241 , A61B8/06 , G06F19/00
摘要： In a method of calculating circulation dynamics of a living body, a resistance component corresponding to a shape of a blood vessel in the living body is derived using previously obtained values of viscosity, pressure and flow rate of blood flowing in the blood vessel. Information corresponding to the viscosity of the blood is calculated using the derived resistance component.
摘要翻译： 在计算生物体的循环动力学的方法中，使用先前获得的血液中流动的血液的粘度，压力和流量的值，得出与生物体的血管形状对应的阻力成分。 使用得到的电阻成分计算与血液粘度相对应的信息。
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5.发明授权Microchip for analysis, analysis system having the same, and analysis method 有权Microchip分析，分析系统具有相同的分析方法公开(公告)号：US07842240B2
公开(公告)日：2010-11-30
申请号：US11121321
申请日：2005-05-03
申请人： Minao Yamamoto , Masataka Shinogi
发明人： Minao Yamamoto , Masataka Shinogi
CPC分类号： B82Y30/00 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2200/0684 , B01L2200/10 , B01L2200/141 , B01L2300/0816 , B01L2300/1805 , B01L2400/0487 , B01L2400/0655
摘要： A microchip has a substrate on which there are formed a reaction bath section, a first flow channel to which are connected a supply channel that supplies a buffer solution and the reaction bath section, a second flow channel to which are connected a supply channel that supplies a sample solution containing a first substance and a channel that discharges the sample and buffer solutions to an exterior of the substrate, and a connecting channel connecting the first flow channel to the second flow channel. The reaction bath section receives the first and second substances so that the first and second substances react in the reaction bath section. The first and second flow channels are provided with valves disposed relative to the connecting channel such that selective opening and closing of the valves causes the buffer solution to flow first into the reaction bath section at a preselected speed and the sample solution to flow second into the reaction bath section at the preselected speed to cause the first and second substances to react in the reaction bath section.
摘要翻译： 微芯片具有在其上形成有反应槽部的基板，连接有供给缓冲溶液的供给通道的第一流路和反应槽部，与供给通道的供给通路连接的第二流路 包含将样品和溶液排出到基板的外部的第一物质和通道的样品溶液以及将第一流动通道连接到第二流动通道的连接通道。 反应槽段接收第一和第二物质，使得第一和第二物质在反应槽部分中反应。 第一和第二流动通道设置有相对于连接通道设置的阀，使得阀的选择性打开和关闭使得缓冲溶液以预先选择的速度首先流入反应槽部分，并将样品溶液流入第 反应槽部分以预先选择的速度使第一和第二物质在反应浴部分中反应。
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公开(公告)号：US20070191720A1
公开(公告)日：2007-08-16
申请号：US11602374
申请日：2006-11-20
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/681 , A61B5/6826 , A61B5/6838 , A61B5/7257 , A61B8/06
摘要： To provide a noninvasive type blood rheology measuring apparatus capable of simply and conveniently measuring blood rheology information without sampling blood from a subject in measuring the blood rheology and a small-sized and portable apparatus, a blood rheology measuring apparatus of the invention is on a basis of a constitution including means form on invasively detecting a flow velocity of the blood flowing in the blood vessel as a Doppler shift signal by transmitting and receiving a wave from the face of the skin and means for analyzing blood rheology by a temporal change of the flow velocity value of the blood detected by the means.
摘要翻译： 本发明的血液流变学测定装置为了提供能够简便且方便地测定血液流变学信息的无创型血液流变学测定装置，在测定血液流变学和来自受试者的血液的情况下， 包括通过从皮肤表面发射和接收波而将在血管中流动的血液的流速入侵地检测为多普勒频移信号的装置，以及用于通过流动的时间变化来分析血液流变学的装置 通过手段检测血液的速度值。
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公开(公告)号：US20060281995A1
公开(公告)日：2006-12-14
申请号：US11416051
申请日：2006-05-02
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/681 , A61B5/6826 , A61B5/6838 , A61B5/7257 , A61B8/06
摘要： A blood rheology measuring apparatus has a measuring portion for measuring a flow velocity of the blood flowing in a blood vessel of a person in a mode of a Doppler shift signal by transmitting and receiving a wave to and from a surface of the person's skin. An information processing portion calculates an intensity at each of frequency components of the Doppler shift signal, extracts a maximum frequency in a signal at an intensity level equal to or larger than a threshold in the histogram or a maximum frequency when an integrated value from a low frequency component reaches a predetermined rate of a total thereof in the histogram, and provides a temporal change waveform of the extracted frequency. The blood rheology is analyzed based on the maximum frequency in the frequency waveform.
摘要翻译： 血液流变学测量装置具有测量部分，用于以多普勒频移信号的模式测量在人的血管中流动的血液的流速，通过向人的皮肤表面发送和接收波。 信息处理部分计算多普勒频移信号的每个频率分量的强度，提取在直方图中等于或大于阈值的强度级别的信号中的最大频率，或者当从低频的积分值 频率分量在直方图中达到其总共的预定速率，并且提供所提取的频率的时间变化波形。 基于频率波形中的最大频率分析血液流变学。
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公开(公告)号：US08277388B2
公开(公告)日：2012-10-02
申请号：US11602374
申请日：2006-11-20
CPC分类号： A61B5/022 , A61B5/681 , A61B5/6826 , A61B5/6838 , A61B5/7257 , A61B8/06
摘要： A blood rheology measuring apparatus has a measuring portion for measuring a flow velocity of the blood flowing in a blood vessel of a person in a mode of a Doppler shift signal by transmitting and receiving a wave to and from a surface of the person's skin. An information processing portion calculates an intensity at each of frequency components of the Doppler shift signal, extracts a maximum frequency in a signal at an intensity level equal to or larger than a threshold in the histogram or a maximum frequency when an integrated value from a low frequency component reaches a predetermined rate of a total thereof in the histogram, and provides a temporal change waveform of the extracted frequency. The blood rheology is analyzed by an area value of a portion at and above a line connecting a minimum value of one pulse waveform and a minimum value of a successive pulse waveform of the frequency waveform.
摘要翻译： 血液流变学测量装置具有测量部分，用于以多普勒频移信号的模式测量在人的血管中流动的血液的流速，通过向人的皮肤表面发送和接收波。 信息处理部分计算多普勒频移信号的每个频率分量的强度，提取在直方图中等于或大于阈值的强度级别的信号中的最大频率，或者当从低频的积分值 频率分量在直方图中达到其总共的预定速率，并且提供所提取的频率的时间变化波形。 通过连接一个脉搏波形的最小值和频率波形的连续脉搏波形的最小值的线路以上的部分的面积值来分析血液流变学。
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公开(公告)号：US07959575B2
公开(公告)日：2011-06-14
申请号：US11416051
申请日：2006-05-02
CPC分类号： A61B5/022 , A61B5/681 , A61B5/6826 , A61B5/6838 , A61B5/7257 , A61B8/06
摘要： A blood rheology measuring apparatus has a measuring portion for measuring a flow velocity of the blood flowing in a blood vessel of a person in a mode of a Doppler shift signal by transmitting and receiving a wave to and from a surface of the person's skin. An information processing portion calculates an intensity at each of frequency components of the Doppler shift signal, extracts a maximum frequency in a signal at an intensity level equal to or larger than a threshold in the histogram or a maximum frequency when an integrated value from a low frequency component reaches a predetermined rate of a total thereof in the histogram, and provides a temporal change waveform of the extracted frequency. The blood rheology is analyzed based on the maximum frequency in the frequency waveform.
摘要翻译： 血液流变学测量装置具有测量部分，用于以多普勒频移信号的模式测量在人的血管中流动的血液的流速，通过向人的皮肤表面发送和接收波。 信息处理部分计算多普勒频移信号的每个频率分量的强度，在直方图中的等于或大于阈值的强度级别的信号中提取最大频率，或者当从低的积分值 频率分量在直方图中达到其总共的预定速率，并且提供所提取的频率的时间变化波形。 基于频率波形中的最大频率分析血液流变学。
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公开(公告)号：US07147602B2
公开(公告)日：2006-12-12
申请号：US10190783
申请日：2002-07-08
CPC分类号： A61B5/022 , A61B5/681 , A61B5/6826 , A61B5/6838 , A61B5/7257 , A61B8/06
摘要： A blood rheology measuring apparatus has a measuring portion for measuring blood circulation information inside of a living body from outside of the living body. The blood circulation information is a maximum blood flow velocity for one pulse. An information processing portion processes the measured information from the measuring portion to obtain information concerning a blood rheology of the living body.
摘要翻译： 血液流变学测量装置具有用于从生物体外部测量生物体内部的血液循环信息的测量部分。 血液循环信息是一个脉冲的最大血流速度。 信息处理部分处理来自测量部分的测量信息以获得关于生物体的血液流变学的信息。
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