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公开(公告)号：US06656971B2
公开(公告)日：2003-12-02
申请号：US10057203
申请日：2002-01-25
申请人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
发明人： Yong-Qian Wu , Sergei Belyakov , Gregory S. Hamilton , David Limburg , Joseph P. Steiner , Mark Vaal , Ling Wei , Douglas Wilkinson
IPC分类号： A61K31166
CPC分类号： C07D209/48 , A61K31/325 , C07C233/29 , C07C233/66 , C07C233/75 , C07C233/76 , C07C235/42 , C07C235/56 , C07C243/38 , C07C255/54 , C07C275/42 , C07C311/46 , C07C311/48 , C07C335/18 , C07C335/36 , C07C337/06 , C07C2602/10 , C07D213/56 , C07D213/74 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/135 , Y02A50/409 , Y02A50/411 , Y02A50/421 , Y02A50/422 , Y02A50/423
摘要： The present invention relates to novel, non-peptidic small organic compounds having an affinity for cyclophilin (CyP)-type immunophilin proteins, and to pharmaceutical compositions comprising one or more of the said compounds. The invention further relates to the uses of these compounds and compositions for binding CyP-type proteins, inhibiting their peptidyl-prolyl isomerase activity, and for research, development, and therapeutic applications in a variety of medical disorders.
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公开(公告)号：US06677376B1
公开(公告)日：2004-01-13
申请号：US09656898
申请日：2000-09-07
申请人： Gregory S. Hamilton , Joseph P. Steiner , Mark J. Vaal , Chi Choi , Ling Wei
发明人： Gregory S. Hamilton , Joseph P. Steiner , Mark J. Vaal , Chi Choi , Ling Wei
IPC分类号： A61K3118
CPC分类号： C07C275/28 , A61K31/17 , C07C275/30 , C07C275/40 , C07C275/42 , C07C311/21 , C07C323/62 , C07C2601/14
摘要： The invention relates to non-peptidic compounds that possess bioactive properties, such as the ability to protect neuronal cells from otherwise lethal treatments or the ability to promote the growth or regeneration of neuronal cells. In part, the invention provides compounds that interact with or bind to a cyclophilin and compounds that have activity towards neuronal cells. Methods for using the compounds, such as administering them to cells or animals or using them to treat neurodegenerative conditions, are specifically included.
摘要翻译： 本发明涉及具有生物活性的非肽类化合物，例如保护神经细胞免受其他致死性治疗或促进神经元细胞生长或再生的能力。 部分地，本发明提供了与亲环蛋白相互作用或结合的化合物和对神经元细胞具有活性的化合物。 具体包括使用化合物的方法，例如将其施用于细胞或动物或用于治疗神经变性病症。
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公开(公告)号：US07153883B2
公开(公告)日：2006-12-26
申请号：US09920017
申请日：2001-08-02
IPC分类号： A61K31/40 , C07D207/10
CPC分类号： C07D403/04 , A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/445 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/55 , C07D207/09 , C07D207/12 , C07D207/16 , C07D211/34 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/04
摘要： This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.
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公开(公告)号：US07253169B2
公开(公告)日：2007-08-07
申请号：US09835523
申请日：2001-04-17
申请人： Yong-Qian Wu , Wei Huang , Gregory S. Hamilton
发明人： Yong-Qian Wu , Wei Huang , Gregory S. Hamilton
IPC分类号： A61K31/50 , A61K31/501 , A61K31/551 , A61K31/675 , C07D413/02 , C07D43/02
CPC分类号： C07D231/04 , C07D237/04 , C07D401/06 , C07D401/12 , C07D487/04
摘要： The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
摘要翻译： 本发明涉及N-取代的环状氮杂化合物，包含这些化合物的药物组合物及其用于实现神经元活性的方法。
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公开(公告)号：US06417189B1
公开(公告)日：2002-07-09
申请号：US09551618
申请日：2000-04-17
申请人： Yong-Qian Wu , Wei Huang , Gregory S. Hamilton
发明人： Yong-Qian Wu , Wei Huang , Gregory S. Hamilton
IPC分类号： A61K31495
CPC分类号： C07D401/06 , C07D231/04 , C07D237/04 , C07D401/12 , C07D487/04
摘要： The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
摘要翻译： 本发明涉及N-取代的环状氮杂化合物，包含这些化合物的药物组合物及其用于实现神经元活性的方法。
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公开(公告)号：US07078424B2
公开(公告)日：2006-07-18
申请号：US10601607
申请日：2003-06-24
IPC分类号： A61K31/41 , C07D403/04
CPC分类号： C07D207/08 , A61K8/4913 , A61Q7/00 , C07D207/16 , C07D403/04
摘要： This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.
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7.发明授权N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres 失效N-杂环羧酸或羧酸异构体的N-连接磺酰胺公开(公告)号：US07459473B2
公开(公告)日：2008-12-02
申请号：US09204236
申请日：1998-12-03
CPC分类号： C07D207/08 , A61K8/4913 , A61Q7/00 , C07D207/16 , C07D403/04
摘要： This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.
摘要翻译： 本发明涉及N-杂环羧酸和羧酸异构体的新型N-连接磺酰胺及其制备方法，以及用于治疗神经系统疾病，包括物理损伤的神经和神经变性疾病，以及治疗脱发和促进毛发生长的用途。
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8.发明授权公开(公告)号：US06331537B1
公开(公告)日：2001-12-18
申请号：US09453571
申请日：1999-12-02
IPC分类号： A01N4346
CPC分类号： C07D403/04 , A61K31/401 , A61K31/4025 , A61K31/41 , A61K31/445 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/55 , C07D207/09 , C07D207/12 , C07D207/16 , C07D211/34 , C07D403/06 , C07D405/12 , C07D409/12 , C07D413/04
摘要： This invention relates to novel N-heteorocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodengenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.
摘要翻译： 本发明涉及新型N-单环素羧酸和羧酸等体积，它们的制备和用途，用于治疗神经系统疾病，包括物理损伤的神经和神经再生疾病，用于治疗脱发和促进毛发生长，用于治疗视力障碍和/或改善视力，以及 用于通过施用这些化合物来治疗记忆障碍和/或增强记忆性能。
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9.发明授权公开(公告)号：US06429215B1
公开(公告)日：2002-08-06
申请号：US09893568
申请日：2001-06-29
IPC分类号： A61K3144
CPC分类号： A61K8/4926 , A61K8/49 , A61K8/4913 , A61K8/492 , A61K31/4439 , A61K31/47 , A61K31/4709 , A61Q7/00 , Y10S514/88
摘要： This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.
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公开(公告)号：US06395758B1
公开(公告)日：2002-05-28
申请号：US09134475
申请日：1998-08-14
IPC分类号： A61K31445
CPC分类号： A61K31/401 , A61K31/17 , A61K31/27 , A61K31/4439
摘要： This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using small molecule carbamates and ureas.
摘要翻译： 本发明涉及用于治疗视力障碍，改善视力，治疗记忆障碍或使用小分子氨基甲酸酯和脲增强记忆性能的药物组合物和方法。
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