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公开(公告)号：US20120137635A1
公开(公告)日：2012-06-07
申请号：US13303186
申请日：2011-11-23
IPC分类号： B65B31/00
CPC分类号： B29D11/00038 , B29D11/00865
摘要： The invention provides a method of coating and thereby affecting the surface properties of a substrate such as a contact lens or other ophthalmic device. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a substrate surface.
摘要翻译： 本发明提供一种涂覆方法，从而影响诸如隐形眼镜或其它眼科装置的基底的表面性质。 该方法包括以下步骤：从工作气体产生大气等离子体流，并用发电机控制大气等离子体流的连续性，以及将大气等离子体流引入衬底表面。
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公开(公告)号：US09156213B2
公开(公告)日：2015-10-13
申请号：US13303186
申请日：2011-11-23
IPC分类号： B29D11/00
CPC分类号： B29D11/00038 , B29D11/00865
摘要： The invention provides a method of coating and thereby affecting the surface properties of a substrate such as a contact lens or other ophthalmic device. The method comprises the steps of generating an atmospheric plasma flow from a working gas and controlling the continuity of the atmospheric plasma flow with a power generator, and, introducing the atmospheric plasma flow to a substrate surface.
摘要翻译： 本发明提供一种涂覆方法，从而影响诸如隐形眼镜或其它眼科装置的基底的表面性质。 该方法包括以下步骤：从工作气体产生大气等离子体流，并用发电机控制大气等离子体流的连续性，以及将大气等离子体流引入衬底表面。
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公开(公告)号：US08529057B2
公开(公告)日：2013-09-10
申请号：US13193651
申请日：2011-07-29
申请人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
IPC分类号： G02C7/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
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公开(公告)号：US20120026457A1
公开(公告)日：2012-02-02
申请号：US13193651
申请日：2011-07-29
申请人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
发明人： Yongxing Qiu , Newton T. Samuel , John Dallas Pruitt , Chandana Kolluru , Arturo N. Medina , Lynn Cook Winterton , Daqing Wu , Xinming Qian , Jared Nelson
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a cost-effective method for making a silicone hydrogel contact lens having a crosslinked hydrophilic coating thereon. A method of the invention involves heating a silicone hydrogel contact lens in an aqueous solution in the presence of a water-soluble, highly branched, thermally-crosslinkable hydrophilic polymeric material having positively-charged azetidinium groups, to and at a temperature from about 40° C. to about 140° C. for a period of time sufficient to covalently attach the thermally-crosslinkable hydrophilic polymeric material onto the surface of the silicone hydrogel contact lens through covalent linkages each formed between one azetidinium group and one of the reactive functional groups on and/or near the surface of the silicone hydrogel contact lens, thereby forming a crosslinked hydrophilic coating on the silicone hydrogel contact lens. Such method can be advantageously implemented directly in a sealed lens package during autoclave.
摘要翻译： 本发明涉及制备其上具有交联亲水性涂层的硅氧水凝胶隐形眼镜的成本有效的方法。 本发明的方法涉及在具有带正电荷的氮杂环丁烷基团的水溶性，高度支化，热交联的亲水性聚合物材料存在下，在约40℃的温度下，在水溶液中加热硅酮水凝胶隐形眼镜 在约140℃下进行足够的时间以将可热交联的亲水聚合物材料共价连接到硅氧烷水凝胶隐形眼镜的表面上，通过共价连接，每个共价键在一个氮杂环丁烷基团和一个反应性官能团之间形成， 和/或靠近硅酮水凝胶隐形眼镜的表面，从而在硅氧水凝胶隐形眼镜上形成交联的亲水涂层。 这种方法可以有利地在高压釜中直接在密封的透镜包装中实现。
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公开(公告)号：US20120026458A1
公开(公告)日：2012-02-02
申请号：US13193653
申请日：2011-07-29
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
摘要翻译： 本发明涉及具有层状结构构型的水合硅氧水凝胶隐形眼镜：完全被完全或基本上不含有硅酮的较高水含量水凝胶层覆盖的较低水含量的硅氧烷水凝胶核（或本体材料）。 本发明的水合硅氧水凝胶隐形眼镜具有高的透氧性，用于维持角膜健康和柔软，富水，润滑的表面，用于穿戴舒适。
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公开(公告)号：US08480227B2
公开(公告)日：2013-07-09
申请号：US13193653
申请日：2011-07-29
IPC分类号： G02C7/00
CPC分类号： C09D177/06 , B29D11/00067 , C08G77/388 , C08J5/00 , C08J7/042 , C08J2383/04 , C08J2383/08 , C08J2433/02 , C08J2433/26 , C08J2487/00 , C08L83/04 , C09D5/1637 , C09D5/1681 , C09D133/02 , C09D133/14 , C09D133/26 , C09D171/02 , G02B1/043 , G02B1/10 , G02B1/18 , G02C7/049 , G02C2202/06 , G02C2202/16 , C08L101/14
摘要： The invention is related to a hydrated silicone hydrogel contact lens having a layered structural configuration: a lower water content silicone hydrogel core (or bulk material) completely covered with a layer of a higher water content hydrogel totally or substantially free of silicone. A hydrated silicone hydrogel contact lens of the invention possesses high oxygen permeability for maintaining the corneal health and a soft, water-rich, lubricious surface for wearing comfort.
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公开(公告)号：US20120139138A1
公开(公告)日：2012-06-07
申请号：US13309654
申请日：2011-12-02
申请人： Newton T. Samuel , Horngyih Huang , Daqing Wu , Uwe Haken , John Dallas Pruitt , Angelika Maria Domschke , Yasuo Matsuzawa
发明人： Newton T. Samuel , Horngyih Huang , Daqing Wu , Uwe Haken , John Dallas Pruitt , Angelika Maria Domschke , Yasuo Matsuzawa
IPC分类号： B29D11/02
CPC分类号： B29D11/00153 , B08B9/00 , G02B1/043 , C08L83/04 , C08L101/14
摘要： The invention provides a method for washing, with a water-based system, reusable molds for making silicone hydrogel contact lenses. The water-based washing system comprises an ethoxylated silicone polyether surfactant. The water-based system of the invention can effectively wash away silicone-containing components and other components of a lens formulation left behind on the molding surfaces of a reusable mold, after removing a silicone hydrogel contact lens cast molded in the reusable mold.
摘要翻译： 本发明提供了一种用水洗系统清洗可重复使用的模具以制造硅酮水凝胶隐形眼镜的方法。 水基洗涤系统包括乙氧基化硅氧烷聚醚表面活性剂。 在去除在可重复使用的模具中铸造的硅酮水凝胶隐形眼镜之后，本发明的水基系统可以有效地洗掉留在可重复使用的模具的模制表面上的透镜制剂的含硅酮组分和其它组分。
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公开(公告)号：US09156215B2
公开(公告)日：2015-10-13
申请号：US13309654
申请日：2011-12-02
申请人： Newton T. Samuel , Horngyih Huang , Daqing Wu , Uwe Haken , John Dallas Pruitt , Angelika Maria Domschke , Yasuo Matsuzawa
发明人： Newton T. Samuel , Horngyih Huang , Daqing Wu , Uwe Haken , John Dallas Pruitt , Angelika Maria Domschke , Yasuo Matsuzawa
CPC分类号： B29D11/00153 , B08B9/00 , G02B1/043 , C08L83/04 , C08L101/14
摘要： The invention provides a method for washing, with a water-based system, reusable molds for making silicone hydrogel contact lenses. The water-based washing system comprises an ethoxylated silicone polyether surfactant. The water-based system of the invention can effectively wash away silicone-containing components and other components of a lens formulation left behind on the molding surfaces of a reusable mold, after removing a silicone hydrogel contact lens cast molded in the reusable mold.
摘要翻译： 本发明提供了一种用水洗系统清洗可重复使用的模具以制造硅酮水凝胶隐形眼镜的方法。 水基洗涤系统包括乙氧基化硅氧烷聚醚表面活性剂。 在去除在可重复使用的模具中铸造的硅酮水凝胶隐形眼镜之后，本发明的水基系统可以有效地洗掉留在可重复使用的模具的模制表面上的透镜制剂的含硅酮组分和其它组分。
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公开(公告)号：US09052439B2
公开(公告)日：2015-06-09
申请号：US13186616
申请日：2011-07-20
申请人： Newton T. Samuel , John Dallas Pruitt , Daqing Wu , Selma Kuyu
发明人： Newton T. Samuel , John Dallas Pruitt , Daqing Wu , Selma Kuyu
CPC分类号： G02B1/043 , B29D11/00038 , B29D11/00048 , G02C7/04 , G02C7/049 , C08L101/14
摘要： Described herein is a cost-effective and time-efficient method for making UV-absorbing contact lenses. In contrast to the conventional method for making UV-absorbing contact lenses which involves copolymerizing a lens forming composition including a UV-absorbing vinylic monomer, a method of the invention involves covalent attachment of a UV-absorbing compound having a second reactive functional group to a preformed contact lens having a first reactive functional group therein and/or thereon.
摘要翻译： 本文描述了制造紫外线吸收隐形眼镜的成本效益和时间有效的方法。 与使紫外线吸收性隐形眼镜相关的常规方法与包含紫外线吸收性乙烯基单体的透镜形成组合物共聚，本发明的方法涉及将具有第二反应性官能团的紫外线吸收性化合物与 其中和/或其上具有第一反应性官能团的预成型隐形眼镜。
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公开(公告)号：US10155349B2
公开(公告)日：2018-12-18
申请号：US12629913
申请日：2009-12-03
摘要： The invention relates to a soft hydrogel contact lens, especially a silicone hydrogel contact lens, which has a capability of delivering a hydrophobic comfort agent into the eye of a wearer. The hydrophobic comfort agent includes without limitation a monoglyceride, a diglyceride, a triglyceride, a glycolipid, a glyceroglycolipid, a sphingolipid, a sphingo-glycolipid, a phospholipid, a fatty acid, a fatty alcohol, a hydrocarbon having a C12-C28 chain in length, a mineral oil, a silicone oil, or a mixture thereof. It can be released from the soft hydrogel contact lens into the eye of a wearer when being worn so as to strengthen and stabilize the tear film lipid layer and alleviate the dryness of the eye.
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