公开(公告)号：US20060134073A1

公开(公告)日：2006-06-22

申请号：US11173537

申请日：2005-07-01

申请人： Yoshifumi Naka ,  David Pinsky ,  David Stern

发明人： Yoshifumi Naka ,  David Pinsky ,  David Stern

IPC分类号： C12N5/08 ,  A61K35/14 ,  A61K31/7076 ,  A61K31/52

CPC分类号： A61K35/44 ,  C12N5/0691 ,  Y02A50/395

摘要： The present invention relates to ex vivo methods for preserving/maintaining blood vessels that are to be used as vascular grafts. The present invention also relates to compositions comprising an analogue of cAMP and/or an analogue of cGMP for use in the methods of the invention, which compositions are free of: (i) an inhibitor of Type I phosphodiesterase, (ii) an inhibitor of Type II phosphodiesterase, (iii) an inhibitor of Type III phosphodiesterase, (iv) an inhibitor of Type IV phosphodiesterase, and (v) an inhibitor of TNF-α.

摘要翻译： 本发明涉及用于保存/维持用作血管移植物的血管的离体方法。 本发明还涉及包含用于本发明方法的cAMP类似物和/或cGMP类似物的组合物，该组合物不含：（i）I型磷酸二酯酶抑制剂，（ii） II型磷酸二酯酶，（iii）III型磷酸二酯酶抑制剂，（iv）IV型磷酸二酯酶抑制剂，和（v）TNF-α抑制剂。

公开(公告)号：US20050250688A1

公开(公告)日：2005-11-10

申请号：US10692439

申请日：2003-10-22

申请人： David Pinsky ,  David Stern ,  Ann Schmidt ,  Eric Rose ,  Robert Solomon

发明人： David Pinsky ,  David Stern ,  Ann Schmidt ,  Eric Rose ,  Robert Solomon

IPC分类号： A61K38/37 ,  A61K38/48 ,  A61K39/395 ,  A61K48/00

CPC分类号： A61K38/4846

摘要： The present invention provides for a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable Factor IXa compound in a sufficient amount over a sufficient time period so as to treat the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of inactivated Factor IXa in a sufficient amount over a sufficient period of time to inhibit coagulation so as to treat the ischemic disorder in the subject.

摘要翻译： 本发明提供一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内向受试者施用足够量的药学上可接受的因子IXa化合物，以治疗受试者的缺血性疾病。 本发明还提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内以足够的时间向受试者施用药学上可接受的形式的灭活因子IXa以抑制凝血，以便治疗缺血性疾病 学科。

公开(公告)号：US20050048133A1

公开(公告)日：2005-03-03

申请号：US10679135

申请日：2003-10-03

申请人： David Pinsky ,  David Stern ,  Charles Prestigiacome

发明人： David Pinsky ,  David Stern ,  Charles Prestigiacome

IPC分类号： A61K38/00 ,  A61K38/48 ,  C07K14/705 ,  C07K16/28 ,  C12N9/64 ,  A61K33/00

CPC分类号： C12N9/644 ,  A61K38/4846 ,  C07K14/70564 ,  C07K16/2854 ,  C12Y304/21022

摘要： The present invention provides for a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of a selectin antagonist in a sufficient amount over a sufficient time period to prevent white blood cell accumulation so as to treat the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject carbon monoxide gas in a sufficient amount over a sufficient period of time thereby treating the ischemic disorder in the subject. The invention further provides a method for treating an ischemic disorder in a subject which comprises administering to the subject a pharmaceutically acceptable form of inactivated Factor IX in a sufficient amount over a sufficient period of time to inhibit coagulation so as to treat the ischemic disorder in the subject.

摘要翻译： 本发明提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内以足够量的时间向所述受试者施用药学上可接受的形式的选择素拮抗剂，以防止白血细胞积聚，从而治疗缺血性 主题无序。 本发明进一步提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内向受试者施用足够量的一氧化碳气体，从而治疗受试者的缺血性疾病。 本发明进一步提供了一种治疗受试者的缺血性疾病的方法，其包括在足够的时间内以足够的时间向受试者施用药学上可接受的形式的灭活因子IX以抑制凝血，以便治疗缺血性障碍 学科。

公开(公告)号：US20130018938A1

公开(公告)日：2013-01-17

申请号：US13180375

申请日：2011-07-11

申请人： Anthony WOOD ,  David Stern ,  David Westerhoff ,  Bill Ataras ,  Mark Goodwin ,  Aaron Graham ,  Matt Emerson ,  Kevin Phillips

发明人： Anthony WOOD ,  David Stern ,  David Westerhoff ,  Bill Ataras ,  Mark Goodwin ,  Aaron Graham ,  Matt Emerson ,  Kevin Phillips

IPC分类号： G06F15/16

CPC分类号： H04L65/4069 ,  H04L65/1063 ,  H04L65/4076

摘要： A method for a computer system includes receiving an identifier associated with a client streaming player, determining one or more attributes associated with the identifier from a data structure in response to the identifier, determining available channels from a plurality of channels that are to be made available to the client streaming player in response to the identifier, wherein available channels comprises a first channel, but not the second channel, determining a first graphical identifier associated with the first channel, providing the first graphical identifier to the client streaming player, receiving a user selection of the first graphical identifier indicating a user request to associate the first channel with the computer system, and providing an indicator of a server network address associated with the first channel to the client streaming player.

摘要翻译： 一种用于计算机系统的方法包括：接收与客户端流播放器相关联的标识符，响应于所述标识符从数据结构确定与所述标识符相关联的一个或多个属性，从多个信道中确定可用信道 响应于所述标识符到所述客户端流播放器，其中可用信道包括第一信道而不是所述第二信道，确定与所述第一信道相关联的第一图形标识符，向所述客户端流播放器提供所述第一图形标识符，接收用户 选择第一图形标识符，指示用户请求将第一频道与计算机系统相关联，以及向客户端流播放器提供与第一频道相关联的服务器网络地址的指示符。

公开(公告)号：US20100296727A1

公开(公告)日：2010-11-25

申请号：US12780825

申请日：2010-05-14

申请人： David Stern ,  Chuan Gao ,  Melvin Yamamoto ,  Devin Nguyen

发明人： David Stern ,  Chuan Gao ,  Melvin Yamamoto ,  Devin Nguyen

IPC分类号： G06K9/00 ,  B23P11/00

CPC分类号： G06K9/00134 ,  G01N21/6452 ,  G02B21/0076 ,  G02B21/008 ,  G02B21/16 ,  G02B21/361 ,  Y10T29/49826

摘要： In one embodiment of the invention, a method to image a probe array is described that includes focusing on a plurality of fiducials on a surface of an array. The method utilizes obtaining the best z position of the fiducials and using a surface fitting algorithm to produce a surface fit profile. One or more surface non-flatness parameters can be adjusted to improve the flatness image of the array surface to be imaged.

摘要翻译： 在本发明的一个实施例中，描述了一种对探针阵列成像的方法，其包括聚焦在阵列表面上的多个基准点上。 该方法利用获得基准的最佳z位置并使用表面拟合算法来产生表面拟合曲线。 可以调整一个或多个表面非平坦度参数以改善待成像的阵列表面的平坦度图像。

公开(公告)号：US07481771B2

公开(公告)日：2009-01-27

申请号：US10886829

申请日：2004-07-07

申请人： Michael Fonseca ,  Mark Allen ,  David Stern ,  Jason White ,  Jason Kroh

发明人： Michael Fonseca ,  Mark Allen ,  David Stern ,  Jason White ,  Jason Kroh

IPC分类号： A61B5/0215

CPC分类号： A61B5/0031 ,  A61B5/0215

摘要： The progress of a endovascular cardiac repair can be monitored by inserting a pressure transducer sensor using a catheter into a chamber of the heart during endovascular repair and then using a small, hand-held read out device to measure pressure easily, safely, inexpensively and accurately. In one aspect a sensor is introduced into the body by the steps of folding or rolling the sensor into a cylinder, loading it into a catheter, and deploying into the heart chamber by allowing it to unroll or unfold, either by itself or facilitated by the incorporation of a super-elastic alloy component.

摘要翻译： 可以通过在血管内修复期间使用导管将压力换能器传感器插入心脏腔室来监测血管内心脏修复的进展，然后使用小的手持式读出装置来容易地，安全地，低成本地和准确地测量压力 。 在一个方面，传感器通过将传感器折叠或滚动到圆筒中，将其装入导管中并通过允许其自身展开或展开而部署到心室中的步骤被引入到体内， 掺入超弹性合金成分。

公开(公告)号：US20080004096A1

公开(公告)日：2008-01-03

申请号：US11421913

申请日：2006-06-02

申请人： Thore K. H. Graepel ,  Ralf Herbrich ,  David Stern

发明人： Thore K. H. Graepel ,  Ralf Herbrich ,  David Stern

IPC分类号： A63F9/24

CPC分类号： A63F3/022 ,  A63F3/04 ,  G09B19/22

摘要： We describe an apparatus for learning to predict moves in games such as chess, Go and the like, from historical game records. We obtain a probability distribution over legal moves in a given board configuration. This enables us to provide an automated game playing system, a training tool for players and a move selector/sorter for input to a game tree search system. We use a pattern extraction system to select patterns from historical game records. Our learning algorithm learns a distribution over the values of a move given a board position based on local pattern context. In another embodiment we use an Independent Bernoulli model whereby we assume each moved is played independently of other available moves.

摘要翻译： 我们描述一种从历史游戏记录中学习来预测诸如象棋，Go等游戏中的移动的装置。 在给定的电路板配置中，我们获得了合法移动的概率分布。 这使我们能够提供一种自动游戏系统，用于玩家的训练工具和用于输入到游戏树搜索系统的移动选择器/分选器。 我们使用模式提取系统从历史游戏记录中选择模式。 我们的学习算法基于局部模式上下文学习一个给定一个董事会职位的动作值的分布。 在另一个实施例中，我们使用独立的伯努利模型，由此我们假设每个移动都是独立于其他可用移动进行的。

公开(公告)号：US07255710B2

公开(公告)日：2007-08-14

申请号：US10636323

申请日：2003-08-06

申请人： Jason White ,  David Stern ,  Mark Allen ,  David O'Brien

发明人： Jason White ,  David Stern ,  Mark Allen ,  David O'Brien

IPC分类号： A61F2/06

CPC分类号： A61F2/88 ,  A61F2/90

摘要： A stent constructed using elements containing micro-mechanical latching mechanisms is disclosed. The micro-mechanical latching elements allow sliding motion between two surfaces in one direction, and restrict sliding motion in the opposite direction. The micro-mechanical latch surface features are formed using microelectronic mechanical systems (MEMS) manufacturing methods. The male surface of the latching components contains an array of ridges or protrusions, and the receiving surface contains a matching array of recesses. The array of ridges or protrusions and the corresponding recesses have uniformly dissimilar slopes that result in a substantially greater frictional force in one direction than in the opposite direction. The separation distance between the two surfaces is such that the male latch surface is engaged with the receiving surface recesses in the low stress “locked” state, preventing motion in the undesired direction.

摘要翻译： 公开了使用包含微机械闭锁机构的元件构造的支架。 微机械闭锁元件允许在一个方向上的两个表面之间的滑动运动，并且在相反方向上限制滑动运动。 使用微电子机械系统（MEMS）制造方法形成微机械闩锁表面特征。 闩锁部件的阳表面包含脊或突起的阵列，并且接收表面包含匹配的凹槽阵列。 脊或突起的阵列和相应的凹槽具有均匀不相似的斜面，其在一个方向上产生比在相反方向上显着更大的摩擦力。 两个表面之间的分隔距离使得阳锁闩表面在低应力“锁定”状态下与接收表面凹部接合，从而防止在不期望的方向上的运动。

公开(公告)号：US20050281708A1

公开(公告)日：2005-12-22

申请号：US11178087

申请日：2005-07-07

申请人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

发明人： Mark Trulson ,  James Winkler ,  Maureen Cronin ,  David Stern

IPC分类号： C12M1/34 ,  G01J1/20 ,  G01N21/64 ,  G01T1/10

CPC分类号： G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/6417 ,  G01N2021/6423

摘要： In accordance with various embodiments of the invention, an apparatus is provided for hybridizing a nucleic acid microarray immobilized on a surface of a solid substrate. The apparatus comprises at least one assembly for securing the solid substrate during hybridization, the assembly comprising a carrier and a cover having a surface facing the carrier. The carrier and the cover can be dimensioned to receive the solid substrate between the carrier and the surface of the cover so that the surfaces of the cover and the solid substrate define a cavity. In some embodiments, the apparatus can include a fluid control module comprising a manifold, at least one liquid reservoir, at least one waste container, and a vacuum source in fluid communication with the waste container. The manifold can provide fluid communication between the liquid reservoir and the cavity and between the cavity and the waste container, and the vacuum source can provide a pressure difference between the liquid reservoir and the waste container. The apparatus can further include at least one thermal management module for controlling temperature of the nucleic acid microarray immobilized on the surface of the solid substrate, and the thermal management module thermally can contact the assembly; and a pulse valve in fluid communication with the cavity, the pulse valve adapted to agitate fluid within the cavity.

公开(公告)号：US20050269246A1

公开(公告)日：2005-12-08

申请号：US11106289

申请日：2005-04-14

申请人： William Wachter ,  Stephen McCarthy ,  Jeffrey Beck ,  David Stern

发明人： William Wachter ,  Stephen McCarthy ,  Jeffrey Beck ,  David Stern

IPC分类号： C10G11/02 ,  C10G11/04 ,  C10G11/05

CPC分类号： C10G11/04 ,  C10G11/05

摘要： This invention relates to a FCC process using a mesoporous catalytic cracking catalyst. The mesoporous fluidized catalytic cracking catalyst is selective for minimizing the production of coke and light gas. The catalyst comprises at least one amorphous, porous matrix, each matrix having pores ranging in diameter from about 1 Å to about 10 Å and pores ranging in diameter from about 40 Å to about 500 Å, wherein in the pore range from 50 Å to 250 Å, there is a single maximum in differential pore volume distribution over the 50 Å to 250 Å range.

摘要翻译： 本发明涉及使用中孔催化裂化催化剂的FCC方法。 中孔流化催化裂化催化剂是选择性地使焦炭和轻质气体的生产最小化。 催化剂包含至少一种无定形多孔基质，每个基质的孔直径约为约至约10埃，孔径范围为约40至约500，其中孔径范围为50埃至250埃 Å，在50Å至250Å范围内，微分孔体积分布有单一最大值。