公开(公告)号：US07402138B2

公开(公告)日：2008-07-22

申请号：US11094228

申请日：2005-03-31

申请人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

发明人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

IPC分类号： A61B5/02

CPC分类号： A61B5/029 ,  A61B5/0245 ,  A61B5/0285

摘要： A first member is adapted to measure an electrocardiogram of a patient. A second member is adapted to measure a peripheral pulse wave of the patient. A first calculator calculates a pulse wave propagation time (PWTT) and a heart rate (HR) of the patient based on the electrocardiogram and the peripheral pulse wave. A second calculator calculates a cardiac output (CO) of the patient with an equation of CO=(αK·PWTT+βK)·HR, where α, β and K are coefficients inherent to the patient.

摘要翻译： 第一构件适于测量患者的心电图。 第二构件适于测量患者的外周脉搏波。 第一计算器基于心电图和外周脉搏波计算患者的脉搏波传播时间（PWTT）和心率（HR）。 第二计算器用CO =（αK.PWTT+βK）·HR等式计算患者的心输出量（CO），其中α，β和K是患者固有的系数。

公开(公告)号：US20070167852A1

公开(公告)日：2007-07-19

申请号：US11694657

申请日：2007-03-30

申请人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

发明人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

IPC分类号： A61B5/04

CPC分类号： A61B5/029 ,  A61B5/0245 ,  A61B5/0285

摘要： A first member is adapted to measure an electrocardiogram of a patient. A second member is adapted to measure a peripheral pulse wave of the patient. A first calculator calculates a pulse wave propagation time (PWTT) and a heart rate (HR) of the patient based on the electrocardiogram and the peripheral pulse wave. A second calculator calculates a cardiac output (CO) of the patient with an equation of CO=(αK·PWTT+βK)·HR, where α, β and K are coefficients inherent to the patient.

摘要翻译： 第一构件适于测量患者的心电图。 第二构件适于测量患者的外周脉搏波。 第一计算器基于心电图和外周脉搏波计算患者的脉搏波传播时间（PWTT）和心率（HR）。 第二计算器用CO =（αK.PWTT+βK）·HR等式计算患者的心输出量（CO），其中α，β和K是患者固有的系数。

公开(公告)号：US20050222514A1

公开(公告)日：2005-10-06

申请号：US11094228

申请日：2005-03-31

申请人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

发明人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

IPC分类号： A61B5/02 ,  A61B5/0245 ,  A61B5/0285 ,  A61B5/029 ,  A61B5/04

CPC分类号： A61B5/029 ,  A61B5/0245 ,  A61B5/0285

摘要： A first member is adapted to measure an electrocardiogram of a patient. A second member is adapted to measure a peripheral pulse wave of the patient. A first calculator calculates a pulse wave propagation time (PWTT) and a heart rate (HR) of the patient based on the electrocardiogram and the peripheral pulse wave. A second calculator calculates a cardiac output (CO) of the patient with an equation of CO=(αK·PWTT+βK)·HR, where α, β and K are coefficients inherent to the patient.

摘要翻译： 第一构件适于测量患者的心电图。 第二构件适于测量患者的外周脉搏波。 第一计算器基于心电图和外周脉搏波计算患者的脉搏波传播时间（PWTT）和心率（HR）。 第二计算器用CO =（αK.PWTT+βK）·HR等式计算患者的心输出量（CO），其中α，β和K是患者固有的系数。

公开(公告)号：US07615011B2

公开(公告)日：2009-11-10

申请号：US11694657

申请日：2007-03-30

申请人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

发明人： Yoshihiro Sugo ,  Takeshi Akiyama ,  Keisuke Uchida ,  Sunao Takeda

IPC分类号： A61B5/02

CPC分类号： A61B5/029 ,  A61B5/0245 ,  A61B5/0285

摘要： A first member is adapted to measure an electrocardiogram of a patient. A second member is adapted to measure a peripheral pulse wave of the patient. A first calculator calculates a pulse wave propagation time (PWTT) and a heart rate (HR) of the patient based on the electrocardiogram and the peripheral pulse wave. A second calculator calculates a cardiac output (CO) of the patient with an equation of CO=(αK·PWTT+βK)·HR, where α, β and K are coefficients inherent to the patient.

摘要翻译： 第一构件适于测量患者的心电图。 第二构件适于测量患者的外周脉搏波。 第一计算器基于心电图和外周脉搏波计算患者的脉搏波传播时间（PWTT）和心率（HR）。 第二计算器用CO =（αK.PWTT+βK）·HR等式计算患者的心输出量（CO），其中α，β和K是患者固有的系数。

公开(公告)号：US08649837B2

公开(公告)日：2014-02-11

申请号：US12175413

申请日：2008-07-17

申请人： Yoshihiro Sugo ,  Naoki Kobayashi ,  Sunao Takeda

发明人： Yoshihiro Sugo ,  Naoki Kobayashi ,  Sunao Takeda

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/02416 ,  A61B5/7257

摘要： In order to measure a pulse rate and an oxygen saturation of a subject who is in an exercised state, each of two pulse wave signals obtained from the subject is separated into a signal component and a noise component. A frequency spectrum of the signal component and a frequency spectrum of the noise component are obtained. It is judged whether a body motion of the subject is occurred based on the frequency spectrum of the signal component and the frequency spectrum of the noise component. A pulsation frequency is determined based on the judgment as to the body motion. The pulse rate is calculated based on the pulsation frequency. The oxygen saturation is calculated based on a ratio of spectra of the two pulse wave signals corresponding to the pulsation frequency.

摘要翻译： 为了测量处于锻炼状态的受试者的脉搏率和氧饱和度，从被检体获得的两个脉搏波信号中的每一个被分离为信号分量和噪声分量。 获得信号分量的频谱和噪声分量的频谱。 基于信号分量的频谱和噪声分量的频谱，判断是否发生被检体的体动。 基于关于身体运动的判断来确定脉动频率。 脉搏频率基于脉动频率计算。 基于对应于脉动频率的两个脉波信号的频谱比计算氧饱和度。

公开(公告)号：US09304088B2

公开(公告)日：2016-04-05

申请号：US13400106

申请日：2012-02-19

申请人： Mitsuhiro Oura ,  Teruo Okano ,  Tatsuya Shimizu ,  Hirotsugu Kubo ,  Sunao Takeda ,  Shinji Yamamori

发明人： Mitsuhiro Oura ,  Teruo Okano ,  Tatsuya Shimizu ,  Hirotsugu Kubo ,  Sunao Takeda ,  Shinji Yamamori

IPC分类号： G01N21/80 ,  G01N31/22 ,  G01N21/31 ,  C12M1/34

CPC分类号： G01N21/80 ,  C12M41/26 ,  G01N21/3151 ,  G01N31/221 ,  G01N2201/0627 ,  G01N2201/1211

摘要： A method of measuring a pH of a solution includes: emitting light beams of two wavelengths from one side of a measuring region of a solution into which an indicator is mixed, while pulsating the solution in the measuring region; receiving at least one of transmitted light beams and reflected light beams of the emitted light beams on the other side of the measuring region, while pulsating the solution in the measuring region; obtaining absorbances of the two wavelengths based on the received at least one of the transmitted light beams and the reflected light beams; obtaining an absorbance ratio from the obtained absorbances; and calculating a pH value of the solution based on the obtained absorbance ratio and an absorbance ratio/pH value correspondence database which is previously stored.

摘要翻译： 测量溶液的pH的方法包括：在测量区域中的溶液脉动的同时，从混合有指示剂的溶液的测量区域的一侧发射两个波长的光束; 在所述测量区域中的所述溶液脉动的同时，在所述测量区域的另一侧上接收所发射的光束的透射光束和反射光束中的至少一个; 基于所接收的所述透射光束和所述反射光束中的至少一个，获得所述两个波长的吸光度; 从所获得的吸光度获得吸光度比; 并且基于所获得的吸光度比和预先存储的吸光度比/ pH值对应数据库来计算溶液的pH值。

公开(公告)号：US08420028B2

公开(公告)日：2013-04-16

申请号：US13214774

申请日：2011-08-22

申请人： Akane Suzuki ,  Takahiro Shioyama ,  Sunao Takeda

发明人： Akane Suzuki ,  Takahiro Shioyama ,  Sunao Takeda

IPC分类号： A61B10/00

CPC分类号： G01N1/286 ,  G01N1/38 ,  G01N15/14 ,  G01N2001/085 ,  G01N2001/2866

摘要： A cell isolation apparatus includes: a cylinder member that is inserted into a container into which a reagent is to be introduced; a net which is stretched over the cylinder member; a tissue acquiring unit that is projected from the cylinder member; and a bottom lid portion that is configured by a bottomed pipe in which a first hole that communicates an interior with an exterior is formed, and that is fitted to a bottom portion of the cylinder member in a state where the net and the tissue acquiring unit are accommodated.

摘要翻译： 细胞隔离装置包括：插入到待引入试剂的容器中的圆筒构件; 在气缸构件上拉伸的网; 组织获取单元，其从所述圆筒构件突出; 以及底盖部，其由形成有与内部连通的第一孔的有底管构成，并且在所述网和所述组织获取单元的状态下嵌合到所述筒构件的底部， 被容纳。

公开(公告)号：US07713197B2

公开(公告)日：2010-05-11

申请号：US11578910

申请日：2005-03-18

申请人： Makoto Nakai ,  Sunao Takeda ,  Akihiko Uchiyama ,  Kenji Yanashima ,  Akihiro Fujita ,  Itaru Yoshizawa

发明人： Makoto Nakai ,  Sunao Takeda ,  Akihiko Uchiyama ,  Kenji Yanashima ,  Akihiro Fujita ,  Itaru Yoshizawa

IPC分类号： A61B3/16 ,  G01L7/00 ,  G01L9/00 ,  G01L11/00 ,  G01L13/00 ,  G01L15/00 ,  G01L17/00 ,  G01L19/00 ,  G01L21/00 ,  G01L21/02

CPC分类号： G01L9/0022 ,  A61B3/16 ,  A61B5/0051 ,  G01L9/008

摘要： A tonometry device includes a contact device for contacting the object, means for vibrating the contact device and the object, means for applying a voltage to the vibration means, means for measuring a current flowing through the vibration means, and an information processing means. The information processing means determines two resonance points of the device and the measured object by measuring current through the system at a plurality of vibrational frequencies. The information processing means then determines the internal pressure of the object by determining that a first pressure is higher than a second pressure by determining that the first pressure has a lower measured current than the second pressure at frequencies outside of the range of frequencies between the resonance points, and that the first pressure has a higher measured current than the second pressure at frequencies within the range of frequencies between the resonance points.

摘要翻译： 测压装置包括用于接触物体的接触装置，用于振动接触装置和物体的装置，用于向振动装置施加电压的装置，用于测量流过振动装置的电流的装置，以及信息处理装置。 信息处理装置通过以多个振动频率测量通过系统的电流来确定装置和被测物体的两个共振点。 信息处理装置然后通过确定第一压力高于第二压力来确定对象的内部压力，通过确定第一压力具有比谐振频率范围之外的频率处的第二压力低的测量电流 并且第一压力在谐振点之间的频率范围内的频率处具有比第二压力更高的测量电流。

公开(公告)号：US6008239A

公开(公告)日：1999-12-28

申请号：US135163

申请日：1998-08-17

申请人： Yasushi Kaneko ,  Sunao Takeda ,  Minoru Tokizawa ,  Hiromichi Eto ,  Kazuya Ishida ,  Kazunori Maebashi ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Susumu Sato

发明人： Yasushi Kaneko ,  Sunao Takeda ,  Minoru Tokizawa ,  Hiromichi Eto ,  Kazuya Ishida ,  Kazunori Maebashi ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Susumu Sato

IPC分类号： A01N43/653 ,  C07D249/08 ,  C07D521/00 ,  A61K31/505

CPC分类号： C07D231/12 ,  A01N43/653 ,  C07D233/56 ,  C07D249/08

摘要： Described is a triazole derivative represented by the formula (1): ##STR1## wherein R.sup.1 represents a lower alkyl group or an aralkyl group, R.sup.2 represents a hydrogen atom, a lower alkyl group, an aralkyl group or an acyl group, X.sup.1 and X.sup.2 are the same or different and each independently represents a hydrogen atom, a halogen atom or a trifluoromethyl group, n stands for an integer of 0 to 2 and m stands for an integer of 1 to 5, or salt thereof; and also a pharmaceutical comprising the derivative or salt thereof as an effective ingredient. The compound as described above has a high antimycotic activity and is useful for the prevention and treatment of mammalian mycotic infections.

摘要翻译： 描述了由式（1）表示的三唑衍生物：其中R1表示低级烷基或芳烷基，R2表示氢原子，低级烷基，芳烷基或酰基，X1和X2相同 或不同，各自独立地表示氢原子，卤素原子或三氟甲基，n表示0〜2的整数，m表示1〜5的整数，或其盐。 以及包含其衍生物或其盐作为有效成分的药物。 如上所述的化合物具有高的抗真菌活性，并且可用于预防和治疗哺乳动物真菌感染。

公开(公告)号：US5430028A

公开(公告)日：1995-07-04

申请号：US185898

申请日：1994-01-26

申请人： Terumitsu Kaihoh ,  Sunao Takeda ,  Fujiko Konno ,  Akihiro Shibata ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tadayuki Kuraishi

发明人： Terumitsu Kaihoh ,  Sunao Takeda ,  Fujiko Konno ,  Akihiro Shibata ,  Masaru Matsumoto ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tadayuki Kuraishi

IPC分类号： A61K31/47 ,  A61K31/495 ,  C07D215/56 ,  C07D401/04 ,  A61K31/55 ,  A61K31/505 ,  C07D243/00 ,  C07D243/08

CPC分类号： C07D215/56 ,  A61K31/47 ,  A61K31/495 ,  C07D401/04

摘要： A 5-aminoquinolone carboxylic acid derivative represented by the following general formula (1): ##STR1## wherein R.sup.1 means a hydrogen atom, an amino group, a linear or branched alkyl group having 1-5 carbon atoms and an alkylamino group containing a linear or branched alkyl group having 1-5 carbon atoms, R.sup.2 denotes a hydrogen atom or a linear or branched alkyl group having 1-5 carbon atoms, X stands for a halogen atom, Y means CH.sub.2, NH, CHR.sup.3 NR.sup.3, (R.sup.3 denoting a linear or branched alkyl group having 1-5 carbon atoms) or an oxygen atom, and Z stands for an oxygen atom or 2 hydrogen atoms, or a salt thereof, and an antibacterial agent containing such a derivative or salt as an active ingredient.The derivative or salt thereof exhibits strong anti-bacterial activities against Grampositive bacteria including tolerant bacteria, and is satisfactorily absorbed in a living body.

摘要翻译： PCT No.PCT / JP93 / 00694 Sec。 371日期1994年1月26日 102（e）日期1994年1月26日PCT提交1993年5月25日PCT公布。 出版物WO93 / 24460 PCT 日期：1993年12月9日，下列通式（1）表示的5-氨基喹诺酮羧酸衍生物：其中R 1表示氢原子，氨基，直链或支链烷基， 5个碳原子和含有1-5个碳原子的直链或支链烷基的烷基氨基，R2表示氢原子或具有1-5个碳原子的直链或支链烷基，X表示卤素原子，Y表示CH2 ，NH，CHR 3 NR 3，（R3表示具有1-5个碳原子的直链或支链烷基）或氧原子，Z表示氧原子或2个氢原子，或其盐，以及含有这些的抗菌剂 衍生物或盐作为活性成分。 其衍生物或盐对包括耐受性细菌的细菌性细菌表现出强的抗菌活性，并且令人满意地吸收在生物体内。