-
公开(公告)号：US08048992B2
公开(公告)日：2011-11-01
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/00
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译： 旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。 通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。 基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。
-
公开(公告)号：US20090053243A1
公开(公告)日：2009-02-26
申请号：US11885245
申请日：2006-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsustumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , A61P31/00 , C12N5/06 , G01N33/574
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译： 旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。 通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。 基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。
-
公开(公告)号：US20120046451A1
公开(公告)日：2012-02-23
申请号：US13238096
申请日：2011-09-21
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Nobuhiro Takahashi , Atsushi Sugioka , Nobuhiro Hayashi , Akihiko Takasaki , Kazuhiro Suzuki , Miwa Morita , Gene Kurosawa , Sari Fujiyama , Susumu Tsutsumi , Keiko Ogawa , Kazuki Matsuda , Chiho Muramatsu , Yoshitaka Iba , Mariko Sumitomo , Masachika Azuma , Yoshinori Ukai , Kazuhiro Morishita
IPC分类号： C07K16/42
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/2803 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/732 , C07K2319/00 , G01N33/57426 , G01N33/57438
摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressed in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treating cancer, etc.
摘要翻译： 旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。 通过用抗体处理被鉴定为特异性表达于肺癌细胞中的分子的IgSF4，并施加ADCC活性。 基于该发现，提供了抗IgSF4抗体作为治疗癌症等的手段。
-
公开(公告)号：US08101553B1
公开(公告)日：2012-01-24
申请号：US10204773
申请日：2001-02-22
申请人： Yoshikazu Kurosawa , Yasushi Akahori , Yoshitaka Iba , Kazuhiko Morino , Midori Shinohara , Motohide Takahashi , Yoshinobu Okuno , Kimiyasu Shiraki
发明人： Yoshikazu Kurosawa , Yasushi Akahori , Yoshitaka Iba , Kazuhiko Morino , Midori Shinohara , Motohide Takahashi , Yoshinobu Okuno , Kimiyasu Shiraki
IPC分类号： C40B50/06
CPC分类号： C12N15/10 , C07K16/00 , C07K2317/50 , C07K2317/56
摘要： An antibody library is prepared by selecting a light chain variable region capable of binding to the variable region of heavy chain to reproduce an active conformation and using the same. Because of being capable of maintaining the diversity of the heavy chain variable region at a high ratio in vitro, the antibody library of the present invention is expected as enabling the acquisition of antibodies with various binding activities.
摘要翻译： 通过选择能够结合重链可变区的轻链可变区以再现活性构象并使用它们来制备抗体文库。 由于能够在体外以高比例保持重链可变区的多样性，本发明的抗体文库预期能够获得具有各种结合活性的抗体。
-
公开(公告)号：US09534042B2
公开(公告)日：2017-01-03
申请号：US13198147
申请日：2011-08-04
CPC分类号： C07K16/1018 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2319/00
摘要： Provided is an anti-influenza virus antibody that exhibits neutralizing activity beyond the barrier of the two groups of influenza viruses categorized according to the conservativeness of hemagglutinin amino acids, a method of producing the same, and a test method for determining whether the subject carries the neutralizing antibody.
摘要翻译： 本发明提供了抗血清病毒抗体，其表现出根据血凝素氨基酸的保守性分类的两组流感病毒的屏障之外的中和活性，其生产方法，以及用于确定受试者是否携带 中和抗体。
-
-
-
-
搜索结果
5 条记录 (耗时 0.057 秒)
