公开(公告)号：US20070014742A1

公开(公告)日：2007-01-18

申请号：US11531583

申请日：2006-09-13

申请人： Yoshinari Kumagai ,  Toshiyuki Yoneda ,  Russell Blacher ,  Motoyoshi Nomizu

发明人： Yoshinari Kumagai ,  Toshiyuki Yoneda ,  Russell Blacher ,  Motoyoshi Nomizu

IPC分类号： A61K38/10 ,  A61K38/06 ,  A61K8/66

CPC分类号： A61K8/64 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K38/16 ,  A61K38/1709 ,  A61Q11/00 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4728 ,  C07K14/705 ,  C07K14/78

摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.

摘要翻译： 公开了包含10至50个氨基酸的肽序列。 序列的特征在于含有整合素结合基序如RGD序列，糖胺聚糖结合基序和钙结合基序中的至少一种，并且与基质细胞外磷酸糖蛋白中的RGD序列连续的氨基酸的其余部分。 这些序列可以配制用于注射或分散在牙膏或漱口剂或牙龈贴片中并且被施用以增强骨/牙齿生长和/或减少体内过量的尿中磷酸盐的损失。

公开(公告)号：US20050163728A1

公开(公告)日：2005-07-28

申请号：US11042492

申请日：2005-01-24

申请人： Yoshinari Kumagai ,  Toshiyuki Yoneda ,  Russell Blacher

发明人： Yoshinari Kumagai ,  Toshiyuki Yoneda ,  Russell Blacher

IPC分类号： A61K9/08 ,  A61K8/00 ,  A61K8/64 ,  A61K9/70 ,  A61K38/00 ,  A61K47/04 ,  A61P3/00 ,  A61P19/08 ,  A61P19/10 ,  A61Q11/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/705 ,  C07K14/78 ,  A61K38/10 ,  A61K7/28 ,  A61K38/08

CPC分类号： A61K8/64 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K38/16 ,  A61K38/1709 ,  A61Q11/00 ,  C07K14/47 ,  C07K14/4705 ,  C07K14/4728 ,  C07K14/705 ,  C07K14/78

摘要： Peptide sequences comprising 10 to 50 amino acids are disclosed. The sequences are characterized by containing at least one of an integrin binding motif such as an RGD sequence, a glycosaminoglycan binding motif, and a calcium binding motif, and the remainder of amino acids contiguous with the RGD sequence in matrix extracellular phosphoglycoprotein. The sequences may be formulated for injection or dispersed in toothpaste or a mouthwash or gum patch and administered to enhance bone/tooth growth and/or reduce excessive urinary phosphate loss from the body.

公开(公告)号：US20060104974A1

公开(公告)日：2006-05-18

申请号：US09784950

申请日：2001-02-15

申请人： C. Davis ,  Russell Blacher ,  Jose Corvalan ,  Alan Culwell ,  Larry Green ,  Joanne Hales ,  Nancy Havrilla ,  Vladimir Ivanov ,  John Lipani ,  Qiang Liu ,  Richard Weber ,  Xiao-Dong Yang

发明人： C. Davis ,  Russell Blacher ,  Jose Corvalan ,  Alan Culwell ,  Larry Green ,  Joanne Hales ,  Nancy Havrilla ,  Vladimir Ivanov ,  John Lipani ,  Qiang Liu ,  Richard Weber ,  Xiao-Dong Yang

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K14/70596 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

摘要： In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

摘要翻译： 根据本发明，我们发现在诸如T细胞，B细胞和/或单核细胞的某些细胞上表达的分子CD147可用于治疗各种疾病。 特别地，我们已经证明，结合CD147并导致这种细胞的杀伤，例如通过补体结合的抗体在治疗疾病中是有效的。 这种治疗显示有效的疾病包括但不限于：移植物抗宿主病（GVHD），器官移植排斥疾病（包括但不限于肾移植，眼部移植等），癌症（包括但不限于： 血液（即白血病和淋巴瘤），胰腺等），自身免疫疾病，炎性疾病等。

公开(公告)号：US20070048305A1

公开(公告)日：2007-03-01

申请号：US11366003

申请日：2006-02-28

申请人： C. Davis ,  Russell Blacher ,  Jose Corvalan ,  Alan Culwell ,  Larry Green ,  Joanna Hales ,  Nancy Havrilla ,  Vladimir Ivanov ,  John Lipani ,  Qiang Liu ,  Richard Weber ,  Xiao-Dong Yang

发明人： C. Davis ,  Russell Blacher ,  Jose Corvalan ,  Alan Culwell ,  Larry Green ,  Joanna Hales ,  Nancy Havrilla ,  Vladimir Ivanov ,  John Lipani ,  Qiang Liu ,  Richard Weber ,  Xiao-Dong Yang

IPC分类号： A61K39/395 ,  C07K16/28

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K14/70596 ,  C07K16/2896 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30

摘要： In accordance with the present invention, we have discovered that the molecule CD147 as expressed on certain cells, such as T-cells, B-cells, and/or monocytes, can be utilized for the treatment of a variety of diseases. In particular, we have demonstrated that antibodies that bind to CD147 and that result in the killing of such cells, for example, through the binding of complement, is efficacious in the treatment of diseases. Diseases in which such treatment appears efficacious include, without limitation: graft versus host disease (GVHD), organ transplant rejection diseases (including, without limitation, renal transplant, ocular transplant, and others), cancers (including, without limitation, cancers of the blood (i.e., leukemias and lymphomas), pancreatic, and others), autoimmune diseases, inflammatory diseases, and others.

摘要翻译： 根据本发明，我们发现在诸如T细胞，B细胞和/或单核细胞的某些细胞上表达的分子CD147可用于治疗各种疾病。 特别地，我们已经证明，结合CD147并导致这种细胞的杀伤，例如通过补体结合的抗体在治疗疾病中是有效的。 这种治疗显示有效的疾病包括但不限于：移植物抗宿主病（GVHD），器官移植排斥疾病（包括但不限于肾移植，眼部移植等），癌症（包括但不限于： 血液（即白血病和淋巴瘤），胰腺等），自身免疫疾病，炎性疾病等。