Heat-sensitive record material
    4.
    发明授权
    Heat-sensitive record material 失效
    热敏记录材料

    公开(公告)号:US4228222A

    公开(公告)日:1980-10-14

    申请号:US22866

    申请日:1979-03-21

    IPC分类号: B41M5/337 B32B27/00 B41M5/18

    摘要: The heat-sensitive record material comprises a base sheet and a color developing layer formed on at least one surface of said base sheet, said color developing layer comprising electron donating color forming material and acceptor reactive with said color forming material to develop a color, said color developing layer further including as a binder water soluble resinous material having carboxyl radicals, partly in the form of magnesium salt and partly in the form of another salt.

    摘要翻译: 热敏记录材料包括基片和形成在所述基片的至少一个表面上的彩色显影层,所述彩色显影层包括给电子成色材料和与所述成色材料反应以形成颜色的受体,所述颜色显影层 彩色显影层还包括具有羧基的粘合剂水溶性树脂材料,部分为镁盐形式,部分为其它盐形式。

    Hyaluronic acid modification products and drug carriers using them
    5.
    发明授权
    Hyaluronic acid modification products and drug carriers using them 有权
    透明质酸改性产品和使用它们的药物载体

    公开(公告)号:US07767806B2

    公开(公告)日:2010-08-03

    申请号:US10571005

    申请日:2004-09-08

    IPC分类号: C07H5/04 C07H1/00 A61K31/728

    摘要: A hyaluronic acid modification product includes a polymer bonded to hyaluronic acid, the polymer being polylactic acid, polyglycolic acid or lactic acid-glycolic acid copolymer, providing a drug carrier which efficiently encapsulates low molecular weight drugs and provides sustained-release over a long term, control of blood residence, is well dispersible in an aqueous solution, and has excellent biocompatibility.

    摘要翻译: 透明质酸改性产品包括与透明质酸结合的聚合物,聚合物是聚乳酸,聚乙醇酸或乳酸 - 乙醇酸共聚物,提供有效地包封低分子量药物并长期持续释放的药物载体, 血液停留的控制在水溶液中分散性良好,生物相容性优异。

    CONJUGATE OF WATER-SOLUBLE HYALURONIC ACID MODIFICATION PRODUCT WITH GLP-A ANALOGUE
    7.
    发明申请
    CONJUGATE OF WATER-SOLUBLE HYALURONIC ACID MODIFICATION PRODUCT WITH GLP-A ANALOGUE 审中-公开
    具有GLP-A类似物的水溶性羟尿酸改性产品的结合

    公开(公告)号:US20090082266A1

    公开(公告)日:2009-03-26

    申请号:US11908278

    申请日:2006-03-08

    IPC分类号: A61K38/17 A61P3/00

    摘要: To provide a GLP-1 analogue long-acting prophylactic or therapeutic agent for diabetes, diabetic complications and/or obesity due to diabetes which provides an extended half-life of a GLP-1 analogue in the blood to prevent frequent administration, and is biodegradable and safe.The present invention provides a conjugate obtained by binding, to a GLP-1 analogue into which a mercapto group is incorporated, water soluble hyaluronic acid modification product obtained by incorporating a substituent via an amide bond to the carboxyl group of glucuronic acid portion of hyaluronic acid as a derivative thereof, using a specific condensing agent in an aprotic polar solvent; and a prophylactic or therapeutic agent having a durable blood glucose lowering effect for diabetes, diabetic complications or obesity.

    摘要翻译: 提供GLP-1类似物长效预防或治疗糖尿病,由于糖尿病导致的糖尿病并发症和/或肥胖症,其提供血液中GLP-1类似物的延长半衰期以防止频繁施用,并且是可生物降解的 安全。 本发明提供了通过与其中引入巯基的GLP-1类似物结合获得的缀合物,其通过将酰胺键引入到透明质酸的葡萄糖醛酸部分的羧基而获得的水溶性透明质酸改性产物 作为其衍生物,在非质子极性溶剂中使用特定的缩合剂; 以及对糖尿病,糖尿病并发症或肥胖具有持久的血糖降低作用的预防或治疗剂。

    Hyaluronic acid modification products and drug carrier therefrom
    8.
    发明申请
    Hyaluronic acid modification products and drug carrier therefrom 有权
    透明质酸改性产品和药物载体

    公开(公告)号:US20070031503A1

    公开(公告)日:2007-02-08

    申请号:US10571005

    申请日:2004-09-08

    摘要: There is provided a drug carrier which has solved the problems of conventional drug carriers, which can encapsulate a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which has high dispersibility in an aqueous solution, and which is not problematical in safety. A drug carrier, which comprises injectable fine particles minimal in agglomeration between the particles, and which has excellent biocompatibility, is also provided. A hyaluronic acid modification product comprising hyaluronic acid or its derivative, and a polymer bonded together, the polymer being selected from polylactic acid, polyglycolic acid and lactic acid-glycolic acid copolymer, according to the present invention, provides a drug carrier which encapsulates a low molecular drug efficiently, which can control a sustained release period for a long term, which can control blood residence, which is well dispersible in an aqueous solution, and which is not problematical in safety. The hyaluronic acid modification product of the present invention also provides a drug carrier comprising injectable fine particles minimal in agglomeration between the particles, and having excellent biocompatibility.

    摘要翻译: 提供了能够有效地包封低分子药物的常规药物载体的问题的药物载体,其可以长期控制持续释放时间,其可以控制血液存留,其在水性中具有高分散性 解决方案,这在安全性上没有问题。 还提供了一种药物载体,其包含颗粒之间附聚最少的可注射的微粒,并且其具有优异的生物相容性。 根据本发明的包含透明质酸或其衍生物的透明质酸改性产品和结合在一起的聚合物,聚合物选自聚乳酸,聚乙醇酸和乳酸 - 乙醇酸共聚物,提供了一种药物载体,其包封低 分子药物有效地控制长期的持续释放期,其可以控制在水溶液中良好分散的血液停留,并且这在安全性方面没有问题。 本发明的透明质酸改性产品还提供了一种药物载体,其包含颗粒之间最少聚集的可注射的微粒,并且具有优异的生物相容性。

    Method of manufacturing gloss paper
    9.
    发明授权
    Method of manufacturing gloss paper 失效
    光泽纸的制造方法

    公开(公告)号:US5030325A

    公开(公告)日:1991-07-09

    申请号:US369631

    申请日:1989-06-21

    摘要: A method of manufacturing gloss coated paper by applying a coating composition containing a pigment and an adhesive on base paper. The pigment contains 5 to 40% by weight of satin white with an average particle diameter of 0.8 .mu.m or below and an organic pigment with an average particle diameter of 0.1 to 1.0 .mu.m and a glass transition point (Tg) of 40.degree. C. or above. The weight ratio of the satin white to the organic pigment is from 0.2/1 to 5/1. The coating composition provides a coated paper with excellent gloss and smoothness.

    摘要翻译: 通过在基纸上涂布含有颜料和粘合剂的涂料组合物来制造光泽涂布纸的方法。 颜料含有5〜40重量%的平均粒径为0.8μm以下的缎白,平均粒径为0.1〜1.0μm,玻璃化转变点(Tg)为40℃的有机颜料 或以上。 缎白与有机颜料的重量比为0.2 / 1至5/1。 涂料组合物提供具有优异光泽和光滑度的涂布纸。

    Vane compressor with vane back pressure adjustment
    10.
    发明授权
    Vane compressor with vane back pressure adjustment 失效
    叶片压缩机带叶片背压调节

    公开(公告)号:US4717321A

    公开(公告)日:1988-01-05

    申请号:US874555

    申请日:1986-06-16

    CPC分类号: F01C21/0872

    摘要: A vane compressor has a vane back pressure adjustment device including back-pressure chambers defined in a vane-supporting rotor and surrounded by vanes and side blocks secured to axial ends of a cylinder. The back-pressure chamber has axial ends disposed to follow a path against each of the side blocks when the rotor rotates. The path is divided into at least one high-pressure zone in which the vanes move across a pump outlet defined in the cylinder, and at least one normal-pressure zone which is the remainder of the path. In the normal-pressure zone, oil grooves defined in surfaces of the side blocks which face the rotor and supplied with oil from an oil sump in the vane compressor are in communication with the back-pressure chambers, to thereby maintain the oil pressure in the back-pressure chambers at a pressure level in the oil sump. In the high-pressure zone, the back-pressure chambers are out of communication with the oil grooves so that the oil fed into the back-pressure chambers is confined therein, except through a restrictor means. When the vanes move across the pump outlet, the vanes enter the high-pressure zone to trap oil in the back-pressure chambers to thereby elevate the oil pressure in the back-pressure chambers to a high level. Therefore, the vanes are prevented from being retracted deeply into vane slits in the rotor and then popping out into hitting engagement with the cylinder.

    摘要翻译: 叶片式压缩机具有叶片背压调节装置,该叶片背压调节装置包括限定在叶片支承转子中的背压室,并被固定在气缸的轴向端部的叶片和侧块包围。 背压室具有轴向端部,当转子旋转时,轴向端部设置成沿着每个侧块的路径。 该路径被分成至少一个高压区域,在该高压区域中,叶片移动通过限定在气缸中的泵出口,以及作为路径的剩余部分的至少一个正常压力区域。 在正常压力区域中,限定在面向转子并且从叶片式压缩机中的油底壳供给油的侧块的表面中的油槽与背压室连通,从而将油压保持在 在油底壳中处于压力水平的背压室。 在高压区域中,背压室与油槽不连通,除了通过限流装置之外,供给到背压室的油被限制在其中。 当叶片移动穿过泵出口时,叶片进入高压区以捕获背压室中的油,从而将背压室中的油压提升到高水平。 因此,防止叶片深深地缩回到转子中的叶片狭缝中,然后弹出与滚筒的接合。