公开(公告)号：US5609881A

公开(公告)日：1997-03-11

申请号：US548138

申请日：1995-10-25

申请人： Yoshito Ikada ,  Shokyu Gen ,  Takao Kubota ,  Ikuo Kyotani

发明人： Yoshito Ikada ,  Shokyu Gen ,  Takao Kubota ,  Ikuo Kyotani

IPC分类号： A61L31/04 ,  A61L31/06 ,  A61L31/08 ,  A61L31/14 ,  A61L31/00 ,  A61L33/00 ,  A61K9/70

CPC分类号： A61L31/148 ,  A61L31/044 ,  A61L31/06 ,  A61L31/08

摘要： A bio-degradable/absorbable barrier membrane is coated thereon with sucrose esters of fatty acids. The sucrose esters of fatty acids is one or more members selected from the group consisting of monoester, diester, and polyester. The fatty acid is one or more members selected from the group consisting of stearic acid, palmitic acid, lauric acid, and myristic acid. These higher fatty acids may be mixed with a lower fatty acid.

摘要翻译： 生物可降解/可吸收的阻隔膜上涂覆有脂肪酸的蔗糖酯。 脂肪酸的蔗糖酯是选自单酯，二酯和聚酯中的一种或多种。 脂肪酸是选自硬脂酸，棕榈酸，月桂酸和肉豆蔻酸的一种或多种。 这些高级脂肪酸可以与低级脂肪酸混合。

公开(公告)号：US5250584A

公开(公告)日：1993-10-05

申请号：US915770

申请日：1992-07-21

申请人： Yoshito Ikada ,  Shokyu Gen

发明人： Yoshito Ikada ,  Shokyu Gen

IPC分类号： A61K6/00 ,  A61K9/00 ,  A61K31/765 ,  A61L27/18 ,  A61L27/58 ,  A61F2/00 ,  C08G63/08

CPC分类号： A61L27/58 ,  A61K31/765 ,  A61K6/0032 ,  A61K9/0063 ,  A61L27/18 ,  Y10S623/924

摘要： A periodontium-regenerating material for the regenerative treatment of the periodontium consists of bio-degradable/absorable copolymers of lactide/.epsilon.-caprolactone or lactide/glycolide having a weight-average molecular weight of 40,000 to 500,000 as well as a dynamic modulus of 5.times.10.sup.7 to 5.times.10.sup.9 dynes/cm.sup.2 and a elongation rate of 100 to 2,000 %, both measured at room temperature (25.degree. C.). Those copolymers may be used in the form of a sheet or film which may or may not be porous.

摘要翻译： 用于牙周组织的再生治疗的牙周膜再生材料由重均分子量为40,000至500,000的丙交酯/ε-己内酯或丙交酯/乙交酯的生物降解/吸收共聚物以及5×10 7至 5×10 9达因/ cm2，伸长率为100〜2000％，均在室温（25℃）下测定。 这些共聚物可以以可以是或不是多孔的片或薄膜的形式使用。

公开(公告)号：US4994281A

公开(公告)日：1991-02-19

申请号：US119361

申请日：1987-11-10

申请人： Shozo Muranishi ,  Yoshito Ikada ,  Hiroshi Yoshikawa ,  Shokyu Gen

发明人： Shozo Muranishi ,  Yoshito Ikada ,  Hiroshi Yoshikawa ,  Shokyu Gen

IPC分类号： A61K9/58 ,  A61K9/16 ,  A61K9/22 ,  A61K9/51

CPC分类号： A61K9/5153 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5192

摘要： Polylactic acid microspheres having an average particle diameter of about 0.1 to 10 .mu.m which are produced from solution containing a physiologically active substance by the solvent-evaporation drying process. The microspheres are produced by emulsifying the solution in a non-solvent by the aid of ultrasonic wave. The microspheres produce a sustained release effect of the physiologically active substance.

公开(公告)号：US4882162A

公开(公告)日：1989-11-21

申请号：US242085

申请日：1988-09-08

申请人： Yoshito Ikada ,  Shokyu Gen ,  Shigeo Ohi ,  Yosuke Urabe ,  Hiroyuki Kawashima

发明人： Yoshito Ikada ,  Shokyu Gen ,  Shigeo Ohi ,  Yosuke Urabe ,  Hiroyuki Kawashima

IPC分类号： A61L27/00 ,  A61F2/10 ,  A61F13/00 ,  A61L15/16 ,  A61L27/18 ,  A61L27/58 ,  A61L27/60 ,  A61L15/04

CPC分类号： A61L27/60 ,  A61F2/105 ,  A61L27/18 ,  A61L27/58 ,  A61F2013/00157 ,  A61F2013/00221 ,  A61F2013/00259 ,  A61F2013/00263

摘要： An artificial skin or bandage is formed from an elastomeric layer which is surfaced by a fibrous wound contacting layer which is first formed into a fabric and subsequently degraded by heat hydrolysis or other degradative treatment into a form which could no longer be formed into a fabric but which forms an ideal bioabsorbable wound contact surface in which damage to the newly formed, fragile epidermus is minimized.

公开(公告)号：US5458643A

公开(公告)日：1995-10-17

申请号：US189603

申请日：1994-02-01

申请人： Masanori Oka ,  Shokyu Gen ,  Yoshito Ikada ,  Hideaki Okimatsu

发明人： Masanori Oka ,  Shokyu Gen ,  Yoshito Ikada ,  Hideaki Okimatsu

IPC分类号： A61F2/00 ,  A61F2/28 ,  A61F2/30 ,  A61F2/36 ,  A61F2/44 ,  A61L27/00 ,  A61L27/16 ,  A61L27/52

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3603 ,  A61F2/442 ,  A61L27/16 ,  A61L27/52 ,  A61F2/30965 ,  A61F2002/30113 ,  A61F2002/30125 ,  A61F2002/30133 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30156 ,  A61F2002/30224 ,  A61F2002/30261 ,  A61F2002/30263 ,  A61F2002/3028 ,  A61F2002/30563 ,  A61F2002/30673 ,  A61F2002/30915 ,  A61F2002/30971 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0015 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0023 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2230/0084 ,  A61F2310/00023 ,  A61F2310/00203

摘要： A prosthesis used for a damaged bone, an artificial articular cartilage or an artificial intervertebral disc being characterized in that the prosthesis is a composite body comprising polyvinyl alcohol hydrogel and ceramic or metallic porous body. With this prosthesis, PVA hydrogel enhances lubrication and shock absorbing functions, and the porous body allows the ingrowth and ossification of the bone tissue of a living body therein to affinitively connect said hydrogel to the bones of the living body.

摘要翻译： 用于损伤的骨，人造关节软骨或人造椎间盘的假体的特征在于，假体是包含聚乙烯醇水凝胶和陶瓷或金属多孔体的复合体。 通过该假体，PVA水凝胶增强润滑和冲击吸收功能，多孔体能够使活体的骨组织向内生长和骨化，将所述水凝胶亲和地连接到生物体的骨骼上。

公开(公告)号：US5314478A

公开(公告)日：1994-05-24

申请号：US692202

申请日：1991-04-26

申请人： Masanori Oka ,  Shokyu Gen ,  Yoshito Ikada ,  Hideaki Okimatsu

发明人： Masanori Oka ,  Shokyu Gen ,  Yoshito Ikada ,  Hideaki Okimatsu

IPC分类号： A61F2/00 ,  A61F2/28 ,  A61F2/30 ,  A61F2/36 ,  A61F2/44 ,  A61L27/00 ,  A61L27/16 ,  A61L27/52 ,  A61F2/02

CPC分类号： A61F2/28 ,  A61F2/30756 ,  A61F2/3603 ,  A61F2/442 ,  A61L27/16 ,  A61L27/52 ,  A61F2/30965 ,  A61F2002/30113 ,  A61F2002/30125 ,  A61F2002/30133 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30156 ,  A61F2002/30224 ,  A61F2002/30261 ,  A61F2002/30263 ,  A61F2002/3028 ,  A61F2002/30563 ,  A61F2002/30673 ,  A61F2002/30915 ,  A61F2002/30971 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/0015 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0023 ,  A61F2230/0063 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2230/0084 ,  A61F2310/00023 ,  A61F2310/00203

摘要： A prosthesis used for a damaged bone, an artificial articular cartilage or an artificial intervertebral disc being characterized in that the prosthesis is a composite body comprising polyvinyl alcohol hydrogel and ceramic or metallic porous body. With this prosthesis, PVA hydrogel enhances lubrication and shock absorbing functions, and the porous body allows the ingrowth and ossification of the bone tissue of a living body therein to affinitively connect said hydrogel to the bones of the living body.

摘要翻译： 用于损伤的骨，人造关节软骨或人造椎间盘的假体的特征在于，假体是包含聚乙烯醇水凝胶和陶瓷或金属多孔体的复合体。 通过该假体，PVA水凝胶增强润滑和冲击吸收功能，多孔体能够使活体的骨组织向内生长和骨化，将所述水凝胶亲和地连接到生物体的骨骼上。

公开(公告)号：US5010145A

公开(公告)日：1991-04-23

申请号：US182184

申请日：1988-04-15

申请人： Yoshito Ikada ,  Shokyu Gen

发明人： Yoshito Ikada ,  Shokyu Gen

IPC分类号： A61L17/00 ,  D01F6/62 ,  D01F6/84 ,  D01F6/92

CPC分类号： D01F6/92

摘要： A polylactic acid fiber comprises a blend of poly-L-lactic acid and poly-D-lactic acid and is improved by spinning and then drawing.

公开(公告)号：US4988761A

公开(公告)日：1991-01-29

申请号：US343468

申请日：1989-04-26

申请人： Yoshito Ikada ,  Shokyu Gen

发明人： Yoshito Ikada ,  Shokyu Gen

IPC分类号： C08J3/00 ,  A61L27/16 ,  B01J13/00 ,  C08F6/00 ,  C08F16/02 ,  C08F16/06 ,  C08F116/06 ,  C08J3/03 ,  C08J3/09

CPC分类号： C08J3/03 ,  A61L27/16 ,  C08J3/09 ,  C08J2329/04

摘要： The present invention relates to a method of producing polyvinyl alcohol hydrogel characterized by the following features: the production process consists of a low-temperature processing stage in which the solution of polyvinyl alcohol with a polymerization degree over 1200 is processed at a low temperature so that polyvinyl alcohol is gelated, and a high-temperature processing stage in which the polyvinyl alcohol gelated int he low-temperature processing stage is dried, then processed at higher than 100.degree. C.; in this way, polyvinyl alcohol hydrogel with a saturated water content lower than 40 wt % is obtained. The hydrogels of this invention are useful for providing improved artificial articular cartilage for replacement of cartilage in the human body.

公开(公告)号：US4844067A

公开(公告)日：1989-07-04

申请号：US153996

申请日：1988-02-09

申请人： Yoshito Ikada ,  Shokyu Gen ,  Tatsuya Kawai ,  Takashi Matsuda

发明人： Yoshito Ikada ,  Shokyu Gen ,  Tatsuya Kawai ,  Takashi Matsuda

IPC分类号： A61L17/00 ,  A61L17/14

CPC分类号： A61L17/145

摘要： A suture coating composition comprising a sucrose fatty acid ester and sutures coated therewith whereby said sutures exhibit improved smoothness in tie-down properties and knotting can be readily accomplished using said suture.

公开(公告)号：US4603695A

公开(公告)日：1986-08-05

申请号：US626545

申请日：1984-06-29

申请人： Yoshito Ikada ,  Shokyu Gen ,  Yasuhiko Shimizu ,  Koichi Tamura ,  Tatsuo Nakamura ,  Sosuke Kimura ,  Tsuneo Cho ,  Hideki Tadokoro ,  Kazuaki Hori

发明人： Yoshito Ikada ,  Shokyu Gen ,  Yasuhiko Shimizu ,  Koichi Tamura ,  Tatsuo Nakamura ,  Sosuke Kimura ,  Tsuneo Cho ,  Hideki Tadokoro ,  Kazuaki Hori

IPC分类号： C08G63/00 ,  A61B19/00 ,  A61F2/00 ,  A61F2/02 ,  A61L27/58 ,  A61L31/00 ,  C08G63/06 ,  C08G63/08 ,  A61B17/04

CPC分类号： A61F2/0063 ,  A61L27/58 ,  A61B2090/0816 ,  A61F2210/0004

摘要： An adhesion preventive for preventing adhesion between vital tissues is provided. The present adhesion preventive is a molded material consisting essentially of a biodegradable and absorbable polymer. It has an advantage of requiring no reoperation for its removal since it would be degraded and absorbed after completing its function in vivo.

摘要翻译： 提供了一种用于防止生物组织之间粘附的粘合防止剂。 本发明的粘合防止剂是基本上由可生物降解和可吸收的聚合物组成的模制材料。 它具有不需要再次手术去除的优点，因为它在体内完成其功能之后将被降解和吸收。