公开(公告)号：US20120041514A1

公开(公告)日：2012-02-16

申请号：US13148461

申请日：2010-02-03

申请人： Yossi Gross ,  Shai Vaingast ,  Ra'anan Gefen

发明人： Yossi Gross ,  Shai Vaingast ,  Ra'anan Gefen

IPC分类号： A61F9/08 ,  A61N1/36

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/37217 ,  A61N1/3787 ,  H01L27/14621 ,  H01L27/14627 ,  H01L31/145

摘要： An external device (20) includes a mount (22), which is placed in front of a subject's eye. A laser (24) is coupled to the mount (22) and emits radiation (26) that is outside of 380-750 nm. A partially-transparent mirror (23) is coupled to the mount (22). An intraocular device (30) is implanted entirely in the subject's eye, and includes a plurality of stimulating electrodes (38), and an energy receiver (32), which receives the radiation (26) from the laser (24) and generates a voltage drop. A plurality of photosensors (34) detect photons (33) and generate a signal. Driving circuitry (36) is coupled to the energy receiver (32) and to the photosensors (34), and receives the signals from the photosensors (34) and utilizes the voltage drop to drive the electrodes (38) to apply currents to the retina in response to the signals from the photosensors (34). Other embodiments are also described.

摘要翻译： 外部装置（20）包括安装件（22），其安置在被检眼的前方。 激光器（24）耦合到安装件（22）并且发射在380-750nm之外的辐射（26）。 部分透明的反射镜（23）联接到安装件（22）。 将眼内装置（30）完全注入被检者的眼睛，并且包括多个刺激电极（38）和能量接收器（32），其从激光器（24）接收辐射（26）并产生电压 下降。 多个光电传感器（34）检测光子（33）并产生信号。 驱动电路（36）耦合到能量接收器（32）和光电传感器（34），并且接收来自光电传感器（34）的信号并利用电压降来驱动电极（38）以向视网膜施加电流 响应于来自光电传感器（34）的信号。 还描述了其它实施例。

公开(公告)号：US09265945B2

公开(公告)日：2016-02-23

申请号：US13148461

申请日：2010-02-03

申请人： Yossi Gross ,  Shai Vaingast ,  Ra'anan Gefen

发明人： Yossi Gross ,  Shai Vaingast ,  Ra'anan Gefen

IPC分类号： A61N1/36 ,  A61N1/372 ,  A61N1/378 ,  H01L27/146 ,  H01L31/14 ,  A61N1/05

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/37217 ,  A61N1/3787 ,  H01L27/14621 ,  H01L27/14627 ,  H01L31/145

摘要： An external device (20) includes a mount (22), which is placed in front of a subject's eye. A laser (24) is coupled to the mount (22) and emits radiation (26) that is outside of 380-750 nm. A partially-transparent mirror (23) is coupled to the mount (22). An intraocular device (30) is implanted entirely in the subject's eye, and includes a plurality of stimulating electrodes (38), and an energy receiver (32), which receives the radiation (26) from the laser (24) and generates a voltage drop. A plurality of photosensors (34) detect photons (33) and generate a signal. Driving circuitry (36) is coupled to the energy receiver (32) and to the photosensors (34), and receives the signals from the photosensors (34) and utilizes the voltage drop to drive the electrodes (38) to apply currents to the retina in response to the signals from the photosensors (34). Other embodiments are also described.

摘要翻译： 外部装置（20）包括安装件（22），其安置在被检眼的前方。 激光器（24）耦合到安装件（22）并且发射在380-750nm之外的辐射（26）。 部分透明的反射镜（23）联接到安装件（22）。 将眼内装置（30）完全注入被检者的眼睛，并且包括多个刺激电极（38）和能量接收器（32），其从激光器（24）接收辐射（26）并产生电压 下降。 多个光电传感器（34）检测光子（33）并产生信号。 驱动电路（36）耦合到能量接收器（32）和光电传感器（34），并且接收来自光电传感器（34）的信号并利用电压降来驱动电极（38）以向视网膜施加电流 响应于来自光电传感器（34）的信号。 还描述了其它实施例。

公开(公告)号：US08706243B2

公开(公告)日：2014-04-22

申请号：US13437310

申请日：2012-04-02

申请人： Ra'anan Gefen ,  Yossi Gross ,  Tuvia Liran ,  Shai Vaingast

发明人： Ra'anan Gefen ,  Yossi Gross ,  Tuvia Liran ,  Shai Vaingast

IPC分类号： A61N1/05

CPC分类号： A61N1/3787 ,  A61F2/14 ,  A61F2/148 ,  A61F2/1624 ,  A61F2/1659 ,  A61F9/00 ,  A61F9/008 ,  A61N1/0543 ,  A61N1/36046 ,  A61N1/37217

摘要： Apparatus for use with an external non-visible light source is provided. The apparatus comprises an intraocular device configured for implantation in a human eye, and comprising an energy receiver. The energy receiver is configured to receive light emitted from the external non-visible light source, and extract energy from the emitted light for powering the intraocular device. The intraocular device is configured to regulate a parameter of operation of the intraocular device based on a modulation of the light emitted by the external non-visible light source and received by the energy receiver. Other embodiments are also described.

摘要翻译： 提供了与外部不可见光源一起使用的装置。 该装置包括配置用于植入人眼中并包括能量接收器的眼内装置。 能量接收器被配置为接收从外部不可见光源发射的光，并且从发射的光提取能量以为眼内装置供电。 眼内装置被配置为基于由外部不可见光源发射并由能量接收器接收的光的调制来调节眼内装置的操作参数。 还描述了其它实施例。

公开(公告)号：US20120259410A1

公开(公告)日：2012-10-11

申请号：US13437310

申请日：2012-04-02

申请人： Ra'anan Gefen ,  Yossi Gross ,  Tuvia Liran ,  Shai Vaingast

发明人： Ra'anan Gefen ,  Yossi Gross ,  Tuvia Liran ,  Shai Vaingast

IPC分类号： A61F2/16

CPC分类号： A61N1/3787 ,  A61F2/14 ,  A61F2/148 ,  A61F2/1624 ,  A61F2/1659 ,  A61F9/00 ,  A61F9/008 ,  A61N1/0543 ,  A61N1/36046 ,  A61N1/37217

摘要： Apparatus for use with an external non-visible light source is provided. The apparatus comprises an intraocular device configured for implantation in a human eye, and comprising an energy receiver. The energy receiver is configured to receive light emitted from the external non-visible light source, and extract energy from the emitted light for powering the intraocular device. The intraocular device is configured to regulate a parameter of operation of the intraocular device based on a modulation of the light emitted by the external non-visible light source and received by the energy receiver. Other embodiments are also described.

摘要翻译： 提供了与外部不可见光源一起使用的装置。 该装置包括配置用于植入人眼中并包括能量接收器的眼内装置。 能量接收器被配置为接收从外部不可见光源发射的光，并且从发射的光提取能量以为眼内装置供电。 眼内装置被配置为基于由外部不可见光源发射并由能量接收器接收的光的调制来调节眼内装置的操作参数。 还描述了其它实施例。

公开(公告)号：US20060217588A1

公开(公告)日：2006-09-28

申请号：US10546660

申请日：2004-02-24

申请人： Yossi Gross ,  Ra'anan Gefen

发明人： Yossi Gross ,  Ra'anan Gefen

IPC分类号： A61M1/12

CPC分类号： A61M1/1055 ,  A61M1/1008 ,  A61M1/1037 ,  A61M1/1051 ,  A61M1/107 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/8243

摘要： Apparatus (20) is provided including an inflatable bladder (40), adapted to be coupled to a blood vessel (22) of a subject (18) carrying oxygenated blood, such that an interior of the bladder (40) is in fluid communication with the blood. The apparatus also includes a piston (48) in mechanical communication with the bladder (40); a motor (60), adapted to synchronize contraction and expansion of the bladder (40) with a cardiac cycle of the subject (18) by applying a motor force to the piston (48); and a spring (54), adapted to apply a spring force to the piston (48).

摘要翻译： 提供了装置（20），其包括可膨胀囊（40），其适于联接到携带有氧血液的受试者（18）的血管（22），使得囊（40）的内部与 血液。 该装置还包括与气囊（40）机械连通的活塞（48）; 电动机（60），其适于通过向所述活塞（48）施加电动力来使所述气囊（40）的收缩和膨胀与所述对象（18）的心动周期同步; 以及适于向活塞（48）施加弹簧力的弹簧（54）。

公开(公告)号：US07614998B2

公开(公告)日：2009-11-10

申请号：US10546660

申请日：2004-02-24

申请人： Yossi Gross ,  Ra'anan Gefen

发明人： Yossi Gross ,  Ra'anan Gefen

IPC分类号： A61B1/00

CPC分类号： A61M1/1055 ,  A61M1/1008 ,  A61M1/1037 ,  A61M1/1051 ,  A61M1/107 ,  A61M1/1086 ,  A61M1/122 ,  A61M1/127 ,  A61M2205/33 ,  A61M2205/3303 ,  A61M2205/8243

摘要： Apparatus (20) is provided including an inflatable bladder (40), adapted to be coupled to a blood vessel (22) of a subject (18) carrying oxygenated blood, such that an interior of the bladder (40) is in fluid communication with the blood. The apparatus also includes a piston (48) in mechanical communication with the bladder (40); a motor (60), adapted to synchronize contraction and expansion of the bladder (40) with a cardiac cycle of the subject (18) by applying a motor force to the piston (48); and a spring (54), adapted to apply a spring force to the piston (48).

摘要翻译： 提供了装置（20），其包括可膨胀囊（40），其适于联接到携带有氧血液的受试者（18）的血管（22），使得囊（40）的内部与 血液。 该装置还包括与气囊（40）机械连通的活塞（48）; 电动机（60），其适于通过向所述活塞（48）施加电动力来使所述气囊（40）的收缩和膨胀与所述对象（18）的心动周期同步; 以及适于向活塞（48）施加弹簧力的弹簧（54）。

公开(公告)号：US08150526B2

公开(公告)日：2012-04-03

申请号：US12368150

申请日：2009-02-09

申请人： Yossi Gross ,  Shai Vaingast

发明人： Yossi Gross ,  Shai Vaingast

IPC分类号： A61N1/36

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/37217 ,  A61N1/3787 ,  H01L27/14621 ,  H01L27/14627 ,  H01L31/145

摘要： Apparatus is provided, including an external device, including a mount, which is placed in front of an eye of a subject. A laser is coupled to the mount and configured to emit toward the eye radiation that is outside of 380-750 nm. A partially-transparent mirror is coupled to the mount. An intraocular device is implanted entirely in the subject's eye, and includes a plurality of stimulating electrodes, and an energy receiver, which receives the radiation from the laser and generates a voltage drop in response thereto. A plurality of photosensors detect photons and generate a signal in response thereto. Driving circuitry is coupled to the energy receiver and to the photosensors, and receives the signals from the photosensors and utilizes the voltage drop to drive the electrodes to apply currents to the retina in response to the signals from the photosensors. Other embodiments are also described.

摘要翻译： 提供了一种装置，包括外部装置，其包括安装件，该安装件放置在被检体的眼睛前方。 激光器耦合到安装座并且被配置为朝向在380-750nm之外的眼睛辐射发射。 部分透明的镜子连接到安装座。 眼内装置完全植入受试者的眼睛，并且包括多个刺激电极和能量接收器，其接收来自激光器的辐射并响应于此产生电压降。 多个光电传感器检测光子并响应于此产生信号。 驱动电路耦合到能量接收器和光电传感器，并且接收来自光电传感器的信号，并且利用电压降来驱动电极，以响应于来自光电传感器的信号而向视网膜施加电流。 还描述了其它实施例。

公开(公告)号：US20100204754A1

公开(公告)日：2010-08-12

申请号：US12368150

申请日：2009-02-09

申请人： Yossi Gross ,  Shai Vaingast

发明人： Yossi Gross ,  Shai Vaingast

IPC分类号： A61N1/36

CPC分类号： A61N1/36046 ,  A61N1/0543 ,  A61N1/37217 ,  A61N1/3787 ,  H01L27/14621 ,  H01L27/14627 ,  H01L31/145

摘要： Apparatus is provided, including an external device, including a mount, which is placed in front of an eye of a subject. A laser is coupled to the mount and configured to emit toward the eye radiation that is outside of 380-750 nm. A partially-transparent mirror is coupled to the mount. An intraocular device is implanted entirely in the subject's eye, and includes a plurality of stimulating electrodes, and an energy receiver, which receives the radiation from the laser and generates a voltage drop in response thereto. A plurality of photosensors detect photons and generate a signal in response thereto. Driving circuitry is coupled to the energy receiver and to the photosensors, and receives the signals from the photosensors and utilizes the voltage drop to drive the electrodes to apply currents to the retina in response to the signals from the photosensors. Other embodiments are also described.

摘要翻译： 提供了一种装置，包括外部装置，其包括安装件，该安装件放置在被检体的眼睛前方。 激光器耦合到安装座并且被配置为朝向在380-750nm之外的眼睛辐射发射。 部分透明的镜子连接到安装座。 眼内装置完全植入受试者的眼睛，并且包括多个刺激电极和能量接收器，其接收来自激光器的辐射并响应于此产生电压降。 多个光电传感器检测光子并响应于此产生信号。 驱动电路耦合到能量接收器和光电传感器，并且接收来自光电传感器的信号，并且利用电压降来驱动电极，以响应于来自光电传感器的信号而向视网膜施加电流。 还描述了其它实施例。

公开(公告)号：US09649487B2

公开(公告)日：2017-05-16

申请号：US13968868

申请日：2013-08-16

申请人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

发明人： Yossi Gross ,  Amir Dagan ,  Yotam Reisner ,  Offer Glasberg ,  Nitai Hanani ,  Gal Ariav

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61F2/82 ,  A61N1/365

CPC分类号： A61N1/05 ,  A61F2/82 ,  A61N1/0514 ,  A61N1/0521 ,  A61N1/056 ,  A61N1/36 ,  A61N1/36564

摘要： Apparatus and methods are described including a mechanical support element that is placed inside a first vein of a subject. At least one electrode disposed on the mechanical support element is placed inside the first vein, in a vicinity of a site upstream of a bifurcation with a second vein of the subject. A control unit enhances downstream blood flow from the first vein by driving the at least one electrode to divert blood downstream into the second vein by constricting the first vein at the upstream site, by driving the at least one electrode to apply a current to the vicinity of the site. The mechanical support element prevents the first vein from collapsing by providing mechanical support to the vein. Other embodiments are also described.

公开(公告)号：US09387078B2

公开(公告)日：2016-07-12

申请号：US14237258

申请日：2012-08-05

申请人： Yossi Gross ,  Gil Hacohen ,  Eran Miller ,  Yuval Zipory ,  Tal Reich ,  Meir Kutzik ,  Rotem Neeman

发明人： Yossi Gross ,  Gil Hacohen ,  Eran Miller ,  Yuval Zipory ,  Tal Reich ,  Meir Kutzik ,  Rotem Neeman

IPC分类号： A61F2/24 ,  A61F2/848

CPC分类号： A61F2/2442 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2466 ,  A61F2/848 ,  A61F2220/0016 ,  A61F2220/0025 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0013 ,  A61F2250/0015 ,  A61F2250/006 ,  A61F2250/0069 ,  A61F2250/0071

摘要： Apparatus is provided for use with a prosthetic valve for implantation at a native valve of a subject, the native valve including at least one native leaflet, the apparatus including (1) a prosthetic valve support, including (a) an upstream support portion, being configured to be placed against an upstream side of the native valve, and having an inner perimeter that defines an opening that is configured to receive the prosthetic valve, and (b) at least one clip (i) comprising at least two clip arms and a clip-controller interface, the clip-controller interface being coupled to at least one of the clip arms, and (ii) being configured to be coupled to a native leaflet of the native valve; and (2) at least one clip controller, reversibly couplable to the clip-controller interface, and configured to facilitate opening and closing of the clip. Other embodiments are also described.

摘要翻译： 提供了一种与用于植入受试者的天然瓣膜的人工瓣膜一起使用的装置，所述天然瓣膜包括至少一个天然小叶，该装置包括（1）假体瓣膜支撑件，其包括（a）上游支撑部分， 被配置为抵靠所述天然瓣膜的上游侧放置，并且具有限定被构造成接收所述假性瓣膜的开口的内周边，以及（b）至少一个夹子（i），其包括至少两个夹臂和 剪辑 - 控制器接口，所述剪辑 - 控制器接口耦合到所述夹臂中的至少一个，以及（ii）被配置为耦合到所述天然瓣膜的天然小叶; 和（2）至少一个剪辑控制器，可逆地联接到剪辑 - 控制器接口，并且被配置为便于剪辑的打开和关闭。 还描述了其它实施例。