公开(公告)号：US20100025246A1

公开(公告)日：2010-02-04

申请号：US12374092

申请日：2007-07-16

申请人： Young-Ho Cho ,  Tae Yoon Kim ,  Dong Woo Lee

发明人： Young-Ho Cho ,  Tae Yoon Kim ,  Dong Woo Lee

IPC分类号： G01N27/26

CPC分类号： G01N15/1031 ,  G01N2015/1075

摘要： Disclosed herein is an apparatus and method for detecting the motion characteristics of particles in a flow channel. The apparatus of the present invention includes first and second electrode groups, each comprising a pair of electrodes, which are arranged to be spaced apart from each other in a flow channel, the pair of electrodes functioning as both a drive electrode and a sensing electrode for directly applying voltage and measuring impedance between the electrodes. An operation control unit measures variation in electrical pulses generated in the first and second electrode groups, thus detecting motion characteristics of the particles. The present invention is advantageous in that it does not require complicated optical measuring instruments or analyzing instruments, and in that it can be used to easily detect the motion characteristics of particles in a flow channel merely by analyzing variation in electrical pulses without requiring preliminary information.

摘要翻译： 本文公开了一种用于检测流动通道中的颗粒的运动特性的装置和方法。 本发明的装置包括第一和第二电极组，每个包括一对电极，它们被布置为在流动通道中彼此间隔开，该对电极用作驱动电极和用于 直接施加电压和测量电极之间的阻抗。 操作控制单元测量在第一和第二电极组中产生的电脉冲的变化，从而检测颗粒的运动特性。 本发明的优点在于它不需要复杂的光学测量仪器或分析仪器，并且其仅仅通过分析电脉冲的变化而不需要初步信息就可以用于容易地检测流动通道中的颗粒的运动特性。

公开(公告)号：US08598863B2

公开(公告)日：2013-12-03

申请号：US12374092

申请日：2007-07-16

申请人： Young-Ho Cho ,  Tae Yoon Kim ,  Dong Woo Lee

发明人： Young-Ho Cho ,  Tae Yoon Kim ,  Dong Woo Lee

IPC分类号： G01N27/00

CPC分类号： G01N15/1031 ,  G01N2015/1075

摘要： The present invention is an apparatus and method for detecting the motion characteristics of particles in a flow channel. The apparatus includes first and second electrode groups, each having a pair of electrodes, which are arranged to be spaced apart from each other in a flow channel. The pair of electrodes function as both a drive electrode and a sensing electrode for directly applying voltage and measuring impedance between the electrodes. An operation control unit measures variation in electrical pulses generated in the first and second electrode groups, thus detecting motion characteristics of the particles. The present invention is advantageous in that it does not require complicated optical measuring instruments or analyzing instruments, and in that it can be used to easily detect the motion characteristics of particles in a flow channel merely by analyzing variation in electrical pulses without requiring preliminary information.

摘要翻译： 本发明是用于检测流路中的颗粒的运动特性的装置和方法。 该装置包括第一和第二电极组，每个具有一对电极，它们被布置为在流动通道中彼此间隔开。 该对电极用作驱动电极和感测电极，用于直接施加电压并测量电极之间的阻抗。 操作控制单元测量在第一和第二电极组中产生的电脉冲的变化，从而检测颗粒的运动特性。 本发明的优点在于它不需要复杂的光学测量仪器或分析仪器，并且其仅仅通过分析电脉冲的变化而不需要初步信息就可以用于容易地检测流动通道中的颗粒的运动特性。

公开(公告)号：US08264245B2

公开(公告)日：2012-09-11

申请号：US12544098

申请日：2009-08-19

申请人： Bo Sung Ku ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Sung Koo Kang ,  Sang Jin Kim

发明人： Bo Sung Ku ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Sung Koo Kang ,  Sang Jin Kim

IPC分类号： G01R27/08

CPC分类号： G01N33/48735

摘要： According to a device and system for measuring the properties of cells, there is an advantage in that, since a cell accommodation unit having a volume is provided, the properties of three-dimensional cells can be measured. Further, the present invention is advantageous in that it enables passive measurement of multiple properties which passively measures the electrical, mechanical and/or optical properties of cells, and active measurement of multiple properties which actively applies electrical, mechanical and optical types of stimulation to cells and measures their electrical, mechanical and/or optical reactions, thus measuring the multiple properties of cells with high reliability.

摘要翻译： 根据用于测量电池性质的装置和系统，其优点在于，由于提供具有体积的电池容纳单元，因此可以测量三维电池的性质。 此外，本发明的优点在于其能够被动测量被动测量细胞的电，机械和/或光学性质的多种性质，以及主动测量多种性质，其主动地将电，机械和光学类型的刺激应用于细胞 并测量其电，机械和/或光学反应，从而以高可靠性测量电池的多重性能。

公开(公告)号：US20100321450A1

公开(公告)日：2010-12-23

申请号：US12541054

申请日：2009-08-13

申请人： Sang Jin Kim ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Bo Sung Ku ,  Sung Koo Kang

发明人： Sang Jin Kim ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Bo Sung Ku ,  Sung Koo Kang

IPC分类号： B41J2/07

CPC分类号： B01L3/50853 ,  B01L3/0268 ,  B01L3/502715 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2300/12

摘要： Disclosed herein is a droplet receiver. The droplet receiver includes an internal space formed such that its sectional area is reduced towards an input part, thus preventing the rebounding of droplets which enter a droplet receiving part, and includes an intercepting fluid layer so as to isolate the received droplets from the outside, thus preventing droplets received in the droplet receiving part from being contaminated and volatilizing.

摘要翻译： 这里公开了一种液滴接收器。 液滴接收器包括形成为使得其截面积朝向输入部分减小的内部空间，从而防止进入液滴接收部分的液滴的反弹，并且包括拦截流体层，以将接收的液滴与外部隔离， 从而防止容纳在液滴接收部中的液滴被污染和挥发。

公开(公告)号：US08251492B2

公开(公告)日：2012-08-28

申请号：US12541054

申请日：2009-08-13

申请人： Sang Jin Kim ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Bo Sung Ku ,  Sung Koo Kang

发明人： Sang Jin Kim ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Bo Sung Ku ,  Sung Koo Kang

IPC分类号： B41J2/14

CPC分类号： B01L3/50853 ,  B01L3/0268 ,  B01L3/502715 ,  B01L2200/0642 ,  B01L2200/0673 ,  B01L2200/141 ,  B01L2200/142 ,  B01L2300/12

摘要： Disclosed herein is a droplet receiver. The droplet receiver includes an internal space formed such that its sectional area is reduced towards an input part, thus preventing the rebounding of droplets which enter a droplet receiving part, and includes an intercepting fluid layer so as to isolate the received droplets from the outside, thus preventing droplets received in the droplet receiving part from being contaminated and volatilizing.

摘要翻译： 这里公开了一种液滴接收器。 液滴接收器包括形成为使得其截面积朝向输入部分减小的内部空间，从而防止进入液滴接收部分的液滴的反弹，并且包括拦截流体层，以将接收的液滴与外部隔离， 从而防止容纳在液滴接收部中的液滴被污染和挥发。

公开(公告)号：US20100321045A1

公开(公告)日：2010-12-23

申请号：US12544098

申请日：2009-08-19

申请人： Bo Sung KU ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Sung Koo Kang ,  Sang Jin Kim

发明人： Bo Sung KU ,  Tae Yoon Kim ,  Young-Ho Cho ,  Young Soo Oh ,  Sung Koo Kang ,  Sang Jin Kim

IPC分类号： G01R27/08 ,  G01N3/00 ,  G01N21/00

CPC分类号： G01N33/48735

摘要： According to a device and system for measuring the properties of cells, there is an advantage in that, since a cell accommodation unit having a volume is provided, the properties of three-dimensional cells can be measured. Further, the present invention is advantageous in that it enables passive measurement of multiple properties which passively measures the electrical, mechanical and/or optical properties of cells, and active measurement of multiple properties which actively applies electrical, mechanical and optical types of stimulation to cells and measures their electrical, mechanical and/or optical reactions, thus measuring the multiple properties of cells with high reliability.

摘要翻译： 根据用于测量电池性质的装置和系统，其优点在于，由于提供具有体积的电池容纳单元，因此可以测量三维电池的性质。 此外，本发明的优点在于其能够被动测量被动测量细胞的电，机械和/或光学性质的多种性质，以及主动测量多种性质，其主动地将电，机械和光学类型的刺激应用于细胞 并测量其电，机械和/或光学反应，从而以高可靠性测量电池的多重性能。

公开(公告)号：US6043493A

公开(公告)日：2000-03-28

申请号：US10513

申请日：1998-01-21

申请人： In Sik Kim ,  Tae Yoon Kim ,  Young Cho Shim ,  Jun Bae Lee

发明人： In Sik Kim ,  Tae Yoon Kim ,  Young Cho Shim ,  Jun Bae Lee

IPC分类号： G01J5/00 ,  G01J5/06 ,  G01J5/08 ,  G01J5/10 ,  G01J5/16

CPC分类号： G01J5/16 ,  G01J5/06 ,  G01J5/08 ,  G01J5/0815 ,  G01J5/0846 ,  G01J5/0862 ,  G01J5/0893 ,  G01J2005/068 ,  G01J5/026

摘要： Infrared sensor that can make a temperature compensation by itself, and method for compensating a temperature thereof, are disclosed. The infrared sensor preferably includes a substrate, a diaphragm formed on the substrate, and a first thermopile sensor formed on a region of the diaphragm for sensing an infrared radiation emitted from a measured object and infrared radiations emitted from regions other than the measured object. A second thermopile sensor is formed on a region of the diaphragm and connected to the first thermopile sensor for sensing the infrared radiations emitted from the regions other than the measured object. A housing protects a front face of the substrate including the first, and second thermopile sensors includes an infrared filter in the housing over the first and second thermopile sensors for transmission of infrared radiations, and a reflector reflects the infrared radiation emitted from the measured object toward the first thermopile sensor. The method for temperature compensation can include the steps of letting an infrared radiation from a measured object be directed to the first thermopile sensor and letting infrared radiations from regions other than the measured object be directed to the first and second thermopile sensors, respectively, sensing the infrared radiations in the first and second thermopile sensors directed thereto, and making a temperature compensation for the infrared radiations from regions other than the measured object using the first and second thermopile sensors to provide a temperature component of the measured object only.

摘要翻译： 公开了能够自行进行温度补偿的红外线传感器及其温度补偿方法。 红外线传感器优选地包括基板，形成在基板上的光阑和形成在光阑的区域上的第一热电堆传感器，用于感测从测量对象发射的红外辐射和从测量对象以外的区域发射的红外辐射。 第二热电堆传感器形成在隔膜的一个区域上并连接到第一热电堆传感器，用于感测从测量对象以外的区域发射的红外辐射。 壳体保护基板的前表面，包括第一和第二热电堆传感器在壳体中包括在第一和第二热电堆传感器上的红外滤光器，用于传输红外辐射，并且反射器将从测量对象发射的红外辐射反射到 第一个热电堆传感器。 用于温度补偿的方法可以包括以下步骤：将来自测量对象的红外辐射引导到第一热电堆传感器并且使来自被测物体以外的区域的红外辐射分别被引导到第一和第二热电堆传感器，感测 第一和第二热电堆传感器中的红外辐射被引导到其上，并且使用第一和第二热电堆传感器对来自除被测物体之外的区域的红外辐射进行温度补偿，以仅提供被测物体的温度分量。

公开(公告)号：US20120071424A1

公开(公告)日：2012-03-22

申请号：US13236080

申请日：2011-09-19

申请人： Dong Heon Shin ,  Tae Yoon Kim

发明人： Dong Heon Shin ,  Tae Yoon Kim

IPC分类号： A61K31/7008 ,  A61P35/00 ,  A61P17/00 ,  A61P17/12 ,  A61P17/10 ,  A61P17/08 ,  C07H5/06 ,  A61P17/06

CPC分类号： A61K31/341

摘要： Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle. Accordingly, the disclosed composition, a use, and the method can be used for preventing or treating various hyper-proliferative skin diseases such as skin cancer or psoriasis.

摘要翻译： 披露了植物鞘氨醇的新用途。 更具体地，公开了一种用于预防或治疗高增殖性皮肤疾病的组合物，其包括作为活性成分的蓬曲沙胺，用于制备高增殖性皮肤疾病的预防/治疗剂的波多沙胺或其药学上可接受的盐的方法， 用于治疗对有需要的受试者施用有效量的多沙普坦或其药学上可接受的盐的增殖性皮肤病。 帕沙星可抑制FoxO3a蛋白的降解，增加FoxO3a蛋白的表达。 因此，本发明的药物组合物通过诱导高增殖细胞的细胞凋亡和抑制细胞周期来防止治疗对增殖性疾病的作用。 因此，所公开的组合物，用途和方法可用于预防或治疗各种高增殖性皮肤疾病如皮肤癌或牛皮癣。

公开(公告)号：US12097281B1

公开(公告)日：2024-09-24

申请号：US18630703

申请日：2024-04-09

申请人： Tae Yoon Kim

发明人： Tae Yoon Kim

IPC分类号： A61K36/00 ,  A61K8/368 ,  A61K8/60 ,  A61K8/73 ,  A61K8/92 ,  A61K8/9722 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/98 ,  A61Q19/00

CPC分类号： A61K8/987 ,  A61K8/368 ,  A61K8/60 ,  A61K8/735 ,  A61K8/922 ,  A61K8/9722 ,  A61K8/9789 ,  A61K8/9794 ,  A61Q19/007 ,  A61K2800/85

摘要： A composition for improving skin moisturization of companion animals, including 10 to 20 parts by weight (“wt. parts”) of olive oil, 5 to 10 wt. parts of oleanolic acid acetate powder, 30 to 40 wt. parts of barley sprout fermented extract powder, 30 to 40 wt. parts of broccoli sprout fermented extract powder, 5 to 15 wt. parts of coconut extract fine powder, 1.5 to 2.5 wt. parts of sodium hyaluronate purified powder, 5.5 to 10 wt. parts of trehalose powder, 5 to 10 wt. parts of chlorella powder, and 5 to 10 wt. parts of green leaf mussel extract powder, based on 100 wt. parts of purified water.

公开(公告)号：US20120093796A1

公开(公告)日：2012-04-19

申请号：US12532539

申请日：2008-03-24

申请人： Dong Heon Shin ,  Tae Yoon Kim

发明人： Dong Heon Shin ,  Tae Yoon Kim

IPC分类号： A61K38/44 ,  A61P3/10 ,  A61P29/00 ,  A61P27/06 ,  A61P9/10 ,  A61P27/02 ,  A61P27/14 ,  A61P17/10 ,  A61P37/08 ,  A61P17/06 ,  A61P11/06 ,  C12N9/02 ,  C12N15/63 ,  A61K48/00 ,  A61P11/02 ,  A61P17/00 ,  A61P35/00

CPC分类号： A61K38/446 ,  A61K38/00 ,  C12N9/0089 ,  C12Y115/01001

摘要： The present invention relates to compositions for preventing or treating angiogenesis-mediated diseases or allergic diseases which contain, as an active ingredient, an EC-SOD protein or a vector having a polynucleotide encoding thereof. The EC-SOD protein or the vector having a polynucleotide encoding the EC-SOD protein has the effect on inhibiting angiogenesis by inhibiting the expression of VEGF and MMP-9 which induce angiogenesis. Therefore, the EC-SOD protein or the vector may be useful for preventing or treating angiogenesis-mediated diseases. And the EC-SOD protein or the vector having a polynucleotide encoding said EC-SOD protein also has the effect on inhibiting over-differentiation of Th2 cells which cause allergic diseases, inhibiting transcription factor (NF-κ B), and reducing degranulation of human mast cells. Accordingly, the EC-SOD protein or the vector may be useful for preventing or treating allergy diseases. In addition, the inventive method for preparing an EC-SOD protein may be used in preparing an EC-SOD protein having the activity on a large scale. Therefore, the inventive method may be useful industrially.

摘要翻译： 本发明涉及用于预防或治疗血管生成介导的疾病或过敏性疾病的组合物，其含有作为活性成分的EC-SOD蛋白或其编码多核苷酸的载体。 EC-SOD蛋白或具有编码EC-SOD蛋白的多核苷酸的载体通过抑制诱导血管发生的VEGF和MMP-9的表达，具有抑制血管发生的作用。 因此，EC-SOD蛋白或载体可用于预防或治疗血管生成介导的疾病。 并且具有编码所述EC-SOD蛋白质的多核苷酸的EC-SOD蛋白或载体也具有抑制Th2细胞过度分化的作用，所述Th2细胞引起过敏性疾病，抑制转录因子（NF-κB）和减少脱颗粒 人体肥大细胞。 因此，EC-SOD蛋白或载体可用于预防或治疗过敏性疾病。 此外，本发明的制备EC-SOD蛋白的方法可用于制备具有大规模活性的EC-SOD蛋白。 因此，本发明的方法在工业上可能是有用的。