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1.发明授权L-threonine importer from Corynebacterium and a preparation method of a strain producing L-threonine 有权棒状杆菌的L-苏氨酸进口商和产生L-苏氨酸的菌株的制备方法公开(公告)号：US07863435B2
公开(公告)日：2011-01-04
申请号：US10582241
申请日：2004-11-23
申请人： Young-Hoon Park , Sang-Jo Lim , Seong-Jun Kim
发明人： Young-Hoon Park , Sang-Jo Lim , Seong-Jun Kim
摘要： The present invention relates to a preparation method of an L-threonine producing strain by utilizing a novel L-threonine importer identified from Corynebacterium glutamicum. The method can be advantageously used for the production of L-threonine by increasing the fermentation concentration of Lthreonine and the yield per unit thereof.
摘要翻译： 本发明涉及利用从谷氨酸棒杆菌（Corynebacterium glutamicum）鉴定的新型L-苏氨酸进口商制备L-苏氨酸菌株的制备方法。 该方法可有利地用于通过增加L-苏氨酸的发酵浓度和每单位产量来生产L-苏氨酸。
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2.发明授权E.coli mutant containing mutant genes related with tryptophan biosynthesis and production method of tryptophan by using the same 有权含有与色氨酸生物合成相关的突变基因的大肠杆菌突变体和使用其的色氨酸的生产方法公开(公告)号：US07638312B2
公开(公告)日：2009-12-29
申请号：US10582196
申请日：2004-11-23
申请人： Young-Hoon Park , Sang-jo Lim , Byoung-Hoon Kim , Seong-Jun Kim , Ho-Soo Lim
发明人： Young-Hoon Park , Sang-jo Lim , Byoung-Hoon Kim , Seong-Jun Kim , Ho-Soo Lim
CPC分类号： C07K14/245 , C12N9/88 , C12P13/227
摘要： The present invention relates to a Tryptophan-producing E. coli mutant strain CJ285 (KCCM-10534) containing single or multi mutant genes related with Tryptophan biosynthesis and production method of Tryptophan using the same. More particularly, DNA base sequences and amino acid sequences aroF, aroG, trpR, and tyrR originated from tryptophan producing E. coli mutant strain CJ285 (KCCM-10534) and related with Tryptophan biosynthesis, are disclosed, and E. coli CJ285 containing at least one of the mutant genes is cultivated directly in a glucose-containing fermentation medium, whereby L-tryptophan can be accumulated in the culture medium.
摘要翻译： 本发明涉及含有与色氨酸生物合成相关的单个或多个突变基因的色氨酸产生大肠杆菌突变菌株CJ285（KCCM-10534）和使用其的色氨酸生产方法。 更具体地，公开了源自产生色氨酸的大肠杆菌突变菌株CJ285（KCCM-10534）并与色氨酸生物合成相关的DNA碱基序列和氨基酸序列aroF，aroG，trpR和tyrR，并且至少含有至少含有 其中一个突变基因直接在含葡萄糖的发酵培养基中培养，从而可以将L-色氨酸堆积在培养基中。
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3.发明申请Novel L-Threonine Importer From Corynebacterium And A Preparation Method Of A Strain Producing L-Threonine 有权来自棒状杆菌的新型L-苏氨酸进口者和产生L-苏氨酸的菌株的制备方法公开(公告)号：US20080026432A1
公开(公告)日：2008-01-31
申请号：US10582241
申请日：2004-11-23
申请人： Young-Hoon Park , Sang-Jo Lim , Seong-Jun Kim
发明人： Young-Hoon Park , Sang-Jo Lim , Seong-Jun Kim
摘要： The present invention relates to a preparation method of an L-threonine producing strain by utilizing a novel L-threonine importer identified from Corynebacterium glutamicum. The method can be advantageously used for the production of L-threonine by increasing the fermentation concentration of Lthreonine and the yield per unit thereof.
摘要翻译： 本发明涉及利用从谷氨酸棒杆菌（Corynebacterium glutamicum）鉴定的新型L-苏氨酸进口商制备L-苏氨酸菌株的制备方法。 该方法可有利地用于通过增加L-苏氨酸的发酵浓度和每单位产量来生产L-苏氨酸。
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4.发明申请E.Coli Mutant Containing Mutant Genes Related with Tryptophan Biosynthesis and Production Method of Tryptophan by Using the Same 有权含有色氨酸生物合成突变基因的大肠杆菌突变体及其使用色氨酸的生产方法公开(公告)号：US20080299644A1
公开(公告)日：2008-12-04
申请号：US10582196
申请日：2004-11-23
申请人： Young-Hoon Park , Sang-jo Lim , Byoung-Hoon Kim , Seong-Jun Kim , Ho-Soo Lim
发明人： Young-Hoon Park , Sang-jo Lim , Byoung-Hoon Kim , Seong-Jun Kim , Ho-Soo Lim
IPC分类号： C12N1/21
CPC分类号： C07K14/245 , C12N9/88 , C12P13/227
摘要： The present invention relates to a Tryptophan-producing E. coli mutant strain CJ285 (KCCM-10534) containing single or multi mutant genes related with Tryptophan biosynthesis and production method of Tryptophan using the same. More particularly, DNA base sequences and amino acid sequences aroF, aroG, trpR, and tyrR originated from tryptophan producing E. coli mutant strain CJ285 (KCCM-10534) and related with Tryptophan biosynthesis, are disclosed, and E. coli CJ285 containing at least one of the mutant genes is cultivated directly in a glucose-containing fermentation medium, whereby L-tryptophan can be accumulated in the culture medium.
摘要翻译： 本发明涉及含有与色氨酸生物合成相关的单个或多个突变基因的色氨酸产生大肠杆菌突变菌株CJ285（KCCM-10534）和使用其的色氨酸生产方法。 更具体地，公开了源自产生色氨酸的大肠杆菌突变菌株CJ285（KCCM-10534）并与色氨酸生物合成相关的DNA碱基序列和氨基酸序列aroF，aroG，trpR和tyrR，并且至少含有至少含有 其中一个突变基因直接在含葡萄糖的发酵培养基中培养，从而可以将L-色氨酸堆积在培养基中。
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5.发明申请CORYNEBACTERIUM GLUTAMICUM ENHANCED EXPRESSION OF MOAA GENE ENCODING MOLYBDENUM COFACTOR BIOSYNTHESIS ENZYME A AND METHOD FOR PRODUCING L-LYSINE USING THE SAME 有权木瓜淀粉酶增强表达MOAA基因编码多聚乙酸酯生物合成酶A及其生产L-赖氨酸的方法公开(公告)号：US20100273222A1
公开(公告)日：2010-10-28
申请号：US12520684
申请日：2007-12-20
申请人： Jun-Ok Moon , Jae-Woo Jang , So-Yeon Rah , Sang-Jo Lim , Jong-Soo Choi , Young-Hoon Park , Hyung-Joon Kim
发明人： Jun-Ok Moon , Jae-Woo Jang , So-Yeon Rah , Sang-Jo Lim , Jong-Soo Choi , Young-Hoon Park , Hyung-Joon Kim
CPC分类号： C12P13/08 , C12N9/0004
摘要： The present invention relates to a microorganism of Corynebacterium ssp. having enhanced expression of gene for encoding molybdenum cofactor biosynthesis enzyme A and a method for producing L-lysine using the same, which has effects on providing the production method of L-lysine using the Corynebacterium strain having enhanced productivity of L-lysine by intensifying expression of the moaA gene for encoding molybdnum cofactor biosynthesis enzyme A.
摘要翻译： 本发明涉及棒状杆菌属微生物。 具有增强的用于编码钼辅因子生物合成酶A的基因的表达和使用该辅助因子生物合成酶A的L-赖氨酸的制备方法，其具有通过增强表达来提高L-赖氨酸生产力的棒状杆菌属菌株提供L-赖氨酸的生产方法的作用 的用于编码钼辅因子生物合成酶A的moaA基因。
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6.发明申请NOVEL PROMOTER NUCLEIC ACID MOLECULE DERIVED FROM CORYNEBACTERIUM GLUTAMICUM, RECOMBINANT VECTOR COMPRISING THE PROMOTER, HOST CELL COMPRISING THE RECOMBINANT VECTOR AND METHOD OF EXPRESSING GENE USING THE HOST CELL 有权由CORYNEBACTERIUM GLUTAMICUM衍生的新型促进剂核酸分子，包含促进剂的重组载体，包含重组载体的宿主细胞和使用宿主细胞表达基因的方法公开(公告)号：US20100261256A1
公开(公告)日：2010-10-14
申请号：US12523272
申请日：2008-01-15
申请人： So-Yeon Rah , Jae-Woo Jang , Sun-Young Lee , Young-Hoon Park , Sang-Jo Lim
发明人： So-Yeon Rah , Jae-Woo Jang , Sun-Young Lee , Young-Hoon Park , Sang-Jo Lim
CPC分类号： C12N15/77
摘要： Provided are a novel promoter nucleic acid molecule having a nucleotide sequence of SEQ ID NO: 1 or 2 derived from Corynebacterium glutamicum, a recombinant vector comprising the promoter, a host cell transformed with the vector and a method of expressing genes of interest using the host cell.
摘要翻译： 提供了具有源自谷氨酸棒杆菌的SEQ ID NO：1或2的核苷酸序列的新型启动子核酸分子，包含启动子的重组载体，用载体转化的宿主细胞和使用该宿主表达感兴趣的基因的方法 细胞。
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7.发明申请MICROORGANISM PRODUCING L-THREONINE HAVING AN INACTIVATED LYSR GENE, METHOD FOR PRODUCING THE SAME AND METHOD FOR PRODUCING L-THREONINE USING THE MICROORGANISM 审中-公开生产具有灭活的LYSR基因的L-苏氨酸的微生物，其生产方法和使用微生物生产L-苏氨酸的方法公开(公告)号：US20090298138A1
公开(公告)日：2009-12-03
申请号：US11720906
申请日：2005-12-06
摘要： Provided are a microorganism having an inactivated lysR gene in its chromosome and can produce L-threonine, a method of producing the microorganism, and a method d of producing L-threonine using the method. The microorganism can produce L-threonine with a high yield.
摘要翻译： 本发明提供了一种在其染色体中具有失活的lysR基因并可产生L-苏氨酸的微生物，该微生物的生产方法和使用该方法生产L-苏氨酸的方法d。 该微生物可以高产率生产L-苏氨酸。
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8.发明授权Corynebacterium glutamicum enhanced expression of moaA gene encoding molybdenum cofactor biosynthesis enzyme A and method for producing L-lysine using the same 有权谷氨酸棒杆菌增强编码钼辅因子生物合成酶A的moaA基因的表达及其制备方法公开(公告)号：US08440433B2
公开(公告)日：2013-05-14
申请号：US12520684
申请日：2007-12-20
申请人： Jun-Ok Moon , Jae-Woo Jang , So-Yeon Rah , Sang-Jo Lim , Jong-Soo Choi , Young-Hoon Park , Hyung-Joon Kim
发明人： Jun-Ok Moon , Jae-Woo Jang , So-Yeon Rah , Sang-Jo Lim , Jong-Soo Choi , Young-Hoon Park , Hyung-Joon Kim
CPC分类号： C12P13/08 , C12N9/0004
摘要： The present invention relates to a microorganism of Corynebacterium ssp. having enhanced expression of gene for encoding molybdenum cofactor biosynthesis enzyme A and a method for producing L-lysine using the same, which has effects on providing the production method of L-lysine using the Corynebacterium strain having enhanced productivity of L-lysine by intensifying expression of the moaA gene for encoding molybdnum cofactor biosynthesis enzyme A.
摘要翻译： 本发明涉及棒状杆菌属微生物。 具有增强的用于编码钼辅因子生物合成酶A的基因的表达和使用该辅助因子生物合成酶A的L-赖氨酸的制备方法，其具有通过增强表达来提高L-赖氨酸生产力的棒状杆菌属菌株提供L-赖氨酸的生产方法的作用 的用于编码钼辅因子生物合成酶A的moaA基因。
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9.发明授权Promoter nucleic acid molecule derived from corynebacterium glutamicum, recombinant vector comprising the promoter, host cell comprising the recombinant vector and method of expressing gene using the host cell 有权衍生自谷氨酸棒杆菌的启动子核酸分子，包含启动子的重组载体，包含重组载体的宿主细胞和使用宿主细胞表达基因的方法公开(公告)号：US08426195B2
公开(公告)日：2013-04-23
申请号：US12523272
申请日：2008-01-15
申请人： So-Yeon Rah , Jae-Woo Jang , Sun-Young Lee , Young-Hoon Park , Sang-Jo Lim
发明人： So-Yeon Rah , Jae-Woo Jang , Sun-Young Lee , Young-Hoon Park , Sang-Jo Lim
CPC分类号： C12N15/77
摘要： Provided are a novel promoter nucleic acid molecule having a nucleotide sequence of SEQ ID NO: 1 or 2 derived from Corynebacterium glutamicum, a recombinant vector comprising the promoter, a host cell transformed with the vector and a method of expressing genes of interest using the host cell.
摘要翻译： 提供了具有源自谷氨酸棒杆菌的SEQ ID NO：1或2的核苷酸序列的新型启动子核酸分子，包含启动子的重组载体，用载体转化的宿主细胞和使用该宿主表达感兴趣的基因的方法 细胞。
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10.发明授权Microorganism of Escherichia Sp, or Corynebacterium Sp, comprising foreign NADP dependent glyceraldehyde-3-phosphate dehydrogenase gene and method for producing L-lysine using the same 有权含有外源NADP依赖型甘油醛-3-磷酸脱氢酶基因的Escherichia sp或Corynebacterium Sp的微生物及使用其的L-赖氨酸的制造方法公开(公告)号：US07566553B2
公开(公告)日：2009-07-28
申请号：US11722820
申请日：2005-12-29
申请人： Young-Hoon Park , So-Yeon Rah , Seong-Jun Kim , Mun-Su Rhee
发明人： Young-Hoon Park , So-Yeon Rah , Seong-Jun Kim , Mun-Su Rhee
CPC分类号： C12N9/0008 , C12P13/08 , C12Y102/01013
摘要： Provided are an Escherichia species microorganism and Corynebacterium species microorganism that are transformed with a foreign NADP dependent glyceraldehydes-3-phosphate dehydrogenase gene and have the ability to produce L-lysine and a method of producing L-lysine using the microorganisms.
摘要翻译： 本发明提供一种用外源NADP依赖性甘油醛-3-磷酸脱氢酶基因转化并具有生产L-赖氨酸能力的埃希氏菌属微生物和棒状杆菌属微生物，以及利用该微生物生产L-赖氨酸的方法。
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