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公开(公告)号：US07932245B2
公开(公告)日：2011-04-26
申请号：US10691095
申请日：2003-10-22
申请人： Youssef L. Bennani , William H. Bunnelle , Sou-Jen Chang , Sanjay R. Chemburkar , Jinhua Chen , Michael J. Dart , Dilinie P. Fernando , Yi-Yin Ku , Mark Lockwood , Lei Wang
发明人： Youssef L. Bennani , William H. Bunnelle , Sou-Jen Chang , Sanjay R. Chemburkar , Jinhua Chen , Michael J. Dart , Dilinie P. Fernando , Yi-Yin Ku , Mark Lockwood , Lei Wang
IPC分类号： A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445
CPC分类号： C07C233/58 , A61K31/397 , A61K31/445 , A61K31/537 , A61K31/54 , C07C2602/50
摘要： The present invention relates to the use of compounds of formula (I) for the treatment of epilepsy, bipolar disorder, psychiatric disorders, migraine, pain, or movement disorders, and to provide neuroprotection.
摘要翻译： 本发明涉及式（I）化合物用于治疗癫痫，双相情感障碍，精神障碍，偏头痛，疼痛或运动障碍的用途，并提供神经保护作用。
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公开(公告)号：US20090054420A1
公开(公告)日：2009-02-26
申请号：US12196124
申请日：2008-08-21
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： A61K31/541 , C07D207/09 , C07D401/02 , C07D413/02 , C07D239/02 , C07D277/02 , C07D403/02 , C07D417/02 , C07D403/14 , A61P3/00 , A61P35/00 , A61P11/06 , A61P25/00 , A61P9/00 , A61K31/4725 , A61K31/4709 , A61K31/40 , A61K31/4439 , A61K31/422 , A61K31/506 , A61K31/5377 , A61K31/426 , A61K31/501
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US20110098285A1
公开(公告)日：2011-04-28
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： A61K31/40 , C07D207/04 , C07D401/02 , C07D403/02 , C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506 , A61K31/5355 , A61K31/541 , A61K31/4709 , A61K31/501 , A61P25/28 , A61P11/06 , A61P25/00 , A61P25/16 , A61P3/00 , A61P25/08 , A61P25/18 , A61P25/24 , A61P25/30 , A61P3/10 , A61P3/04
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US08273767B2
公开(公告)日：2012-09-25
申请号：US12849697
申请日：2010-08-03
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07D413/02 , C07D417/02 , A61K31/4439 , A61K31/506
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US07153889B2
公开(公告)日：2006-12-26
申请号：US10689735
申请日：2003-10-22
申请人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
发明人： Robert J. Altenbach , Lawrence A. Black , Sou-Jen Chang , Marlon D. Cowart , Ramin Faghih , Gregory A. Gfesser , Yi-Yin Ku , Huaqing Liu , Kirill A. Lukin , Diana L. Nersesian , Yu-ming Pu , Padam N. Sharma , Youssef L. Bennani , Michael P. Curtis
IPC分类号： C07C13/465
CPC分类号： C07D207/14 , C07D207/08 , C07D207/12 , C07D207/20 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/85 , C07D215/12 , C07D215/14 , C07D215/20 , C07D217/14 , C07D237/12 , C07D237/14 , C07D237/28 , C07D239/26 , C07D239/28 , C07D239/42 , C07D239/52 , C07D241/12 , C07D241/42 , C07D263/32 , C07D277/28 , C07D295/073 , C07D295/088 , C07D295/096 , C07D295/112 , C07D295/135 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
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公开(公告)号：US09108948B2
公开(公告)日：2015-08-18
申请号：US11956816
申请日：2007-12-14
申请人： Huaqing Liu , Lawrence A. Black , Youssef L. Bennani , Marlon D. Cowart , Zhenping Tian , Paul J. Brackemeyer
发明人： Huaqing Liu , Lawrence A. Black , Youssef L. Bennani , Marlon D. Cowart , Zhenping Tian , Paul J. Brackemeyer
IPC分类号： A61K31/50 , A61K31/501 , C07D401/02 , C07D237/04 , C07D401/12 , C07D207/06 , C07D207/08 , C07D207/12 , C07D213/82 , C07D295/14 , C07D295/155 , C07D401/10 , C07D403/10 , C07D403/12 , C07D417/10 , C07D417/12 , C07D495/04
CPC分类号： C07D401/12 , C07D207/06 , C07D207/08 , C07D207/12 , C07D213/82 , C07D295/14 , C07D295/155 , C07D401/10 , C07D403/10 , C07D403/12 , C07D417/10 , C07D417/12 , C07D495/04
摘要： Compounds of formula (I) wherein R1, R2, R3, R3a, R3b, R4, and R5 are defined in the description, are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 其中R1，R2，R3，R3a，R3b，R4和R5在说明书中定义的式（I）化合物可用于治疗组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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公开(公告)号：US08829041B2
公开(公告)日：2014-09-09
申请号：US11766987
申请日：2007-06-22
IPC分类号： C07D207/09 , A61K31/409 , C07D207/06 , C07D417/10 , C07D401/10 , C07D495/04 , C07D403/10
CPC分类号： C07D207/06 , C07D401/10 , C07D403/10 , C07D417/10 , C07D495/04
摘要： Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the histamine-3 receptor ligands, methods for using such compounds and compositions, and a process for preparing compounds within the scope of formula (I).
摘要翻译： 式（I）化合物可用于治疗由组胺-3受体配体预防或改善的病症或病症。 还公开了包含组胺-3受体配体的药物组合物，使用这些化合物和组合物的方法，以及制备式（I）范围内的化合物的方法。
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8.发明申请公开(公告)号：US20120252859A1
公开(公告)日：2012-10-04
申请号：US13526249
申请日：2012-06-18
IPC分类号： A61K31/403 , C07D491/048 , A61P3/04 , A61P25/30 , A61P25/22 , A61P25/24 , C07D209/56 , A61K31/407
CPC分类号： C07D209/90 , A61K31/403 , C07D209/70 , C07D409/04 , C07D491/04
摘要： The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).
摘要翻译： 本发明一般涉及一系列化合物，含有该化合物的药物组合物，以及该化合物和组合物作为治疗剂的用途。 更具体地，本发明的化合物是三环茚并吡咯化合物。 这些化合物是5-羟色胺受体（5-HT）配体，并且可用于治疗需要调节5-羟色胺受体（5-HT）的活性的疾病，病症和状况（例如焦虑，抑郁和肥胖）。
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9.发明授权Indole acetic acids exhibiting CRTH2 receptor antagonism and uses thereof 失效表现出CRTH2受体拮抗作用的吲哚乙酸及其应用公开(公告)号：US07981912B2
公开(公告)日：2011-07-19
申请号：US12566566
申请日：2009-09-24
IPC分类号： A61K31/425 , C07D275/06 , C07D417/04
CPC分类号： C07D413/14 , C07D209/46 , C07D403/04 , C07D405/14 , C07D417/04 , C07D417/14
摘要： The invention relates to indole acetic acid compounds which function as antagonists of the CRTH2 receptor. The invention also relates to the use of these compounds to inhibit the binding of prostaglandin D2 and its metabolites or certain thromboxane metabolites to the CRTH2 receptor and to treat disorders responsive to such inhibition.
摘要翻译： 本发明涉及作为CRTH2受体拮抗剂的吲哚乙酸化合物。 本发明还涉及这些化合物用于抑制前列腺素D2及其代谢物或某些血栓烷代谢物与CRTH2受体的结合并治疗对这种抑制作用的病症的用途。
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公开(公告)号：US07981896B2
公开(公告)日：2011-07-19
申请号：US13006161
申请日：2011-01-13
IPC分类号： A61K31/496 , C07D403/10
CPC分类号： C07D231/54 , C07D231/12 , C07D231/56 , C07D401/12 , C07D403/12
摘要： This invention relates to compounds of the formula: to compositions containing these compounds, and to methods of treatment employing the compounds and compositions.
摘要翻译： 本发明涉及下式的化合物：含有这些化合物的组合物以及使用该化合物和组合物的处理方法。
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