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公开(公告)号:US20080287438A1
公开(公告)日:2008-11-20
申请号:US12219073
申请日:2008-07-15
申请人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
发明人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
IPC分类号: A61K31/5377 , A61K31/4196 , A61K31/4164 , A61K31/4152 , C07D403/02 , A61K31/4439 , A61P25/00 , C07D401/02 , C07D249/12 , C07D233/00 , C07D413/02
CPC分类号: C07D231/12 , A61K31/402 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4439 , A61K31/66 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/4056 , C07F9/5537 , C07F9/65031 , C07F9/6506 , C07F9/6518 , C07F9/653 , C07F9/65395 , C07F9/65586 , C07F9/657181
摘要: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.
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公开(公告)号:US07423159B2
公开(公告)日:2008-09-09
申请号:US10532667
申请日:2003-10-30
申请人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura
发明人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura
IPC分类号: C07D213/10
CPC分类号: C07D231/12 , A61K31/402 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4439 , A61K31/66 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/4056 , C07F9/5537 , C07F9/65031 , C07F9/6506 , C07F9/6518 , C07F9/653 , C07F9/65395 , C07F9/65586 , C07F9/657181
摘要: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.
摘要翻译: 本发明提供了用于预防或治疗具有优异作用和低毒性的神经病的药剂。 该试剂包括由下式表示的化合物:其中环A是含有2个或更多个氮原子的5元芳族杂环,其可进一步具有取代基; B是任选取代的烃基或任选取代的杂环基; X是二价无环烃基; Z是-O - , - S - , - NR 2 - , - CONR 2 - 或-NR 2 CO-(R SUB > 2 SUB>是氢原子或任选取代的烷基); Y是键或二价无环烃基; R 1是任选取代的环状基团,任选取代的氨基或任选取代的酰基,条件是当由环A表示的5元芳族杂环是咪唑时,则Z不应该是 - O-或其盐。
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公开(公告)号:US20060004069A1
公开(公告)日:2006-01-05
申请号:US10532667
申请日:2003-10-30
申请人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
发明人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
IPC分类号: A61K31/4196 , A61K31/4164 , A61K31/4152 , C07D43/02
CPC分类号: C07D231/12 , A61K31/402 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4439 , A61K31/66 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/4056 , C07F9/5537 , C07F9/65031 , C07F9/6506 , C07F9/6518 , C07F9/653 , C07F9/65395 , C07F9/65586 , C07F9/657181
摘要: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.
摘要翻译: 本发明提供了用于预防或治疗具有优异作用和低毒性的神经病的药剂。 该试剂包括由下式表示的化合物:其中环A是含有2个或更多个氮原子的5元芳族杂环,其可进一步具有取代基; B是任选取代的烃基或任选取代的杂环基; X是二价无环烃基; Z是-O - , - S - , - NR 2 - , - CONR 2 - 或-NR 2 CO-(R SUB > 2 SUB>是氢原子或任选取代的烷基); Y是键或二价无环烃基; R 1是任选取代的环状基团,任选取代的氨基或任选取代的酰基,条件是当由环A表示的5元芳族杂环是咪唑时,则Z不应该是 - O-或其盐。
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公开(公告)号:US07065712B2
公开(公告)日:2006-06-20
申请号:US09943601
申请日:2001-08-30
申请人: Tetsuyuki Muto , Masakazu Kanbe , Jin Hiwatashi , Katsuya Arai , Atsushi Kanai , Kaku Takeuchi , Toru Kawamura , Tomotaka Uchihashi
发明人: Tetsuyuki Muto , Masakazu Kanbe , Jin Hiwatashi , Katsuya Arai , Atsushi Kanai , Kaku Takeuchi , Toru Kawamura , Tomotaka Uchihashi
IPC分类号: G06F3/00
CPC分类号: G06Q30/02
摘要: An advertisement posting scheme utilizes a comprehensive information viewing device capable of displaying multiple Web pages on a display screen by enlarging or contracting each Web page at arbitrary magnification rate smoothly, rotating each Web page at arbitrary angle smoothly, arbitrarily varying and controlling transparency level of a plurality of Web pages that are arranged in superposition such that any overlapped hidden portion can be made visible, and three-dimensionally arranging the multiple Web pages such that the multiple Web pages can be viewed from arbitrary angle, for the purpose of displaying advertisements on the display screen at arbitrary positions, angles, sizes and transparency levels, in relation to the multiple Web pages.
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公开(公告)号:US5662348A
公开(公告)日:1997-09-02
申请号:US619888
申请日:1996-03-20
申请人: Eiichi Kusama , Toru Kawamura , Yukikazu Ueno , Hiroyuki Nishi , Yoshihisa Kato
发明人: Eiichi Kusama , Toru Kawamura , Yukikazu Ueno , Hiroyuki Nishi , Yoshihisa Kato
CPC分类号: B60G7/001 , B60G2206/124
摘要: In a suspension arm formed by press working a plate-shaped member, in a case in which, while a vehicle is traveling, a load is inputted to the suspension arm in a direction intersecting a direction in which the suspension arm swings, at least a region at which a maximum stress is generated is a non-end portion of the plate-shaped member. Accordingly, high rigidity can be ensured without an increase in weight.
摘要翻译: 在通过冲压加工板状部件形成的悬架臂中,在车辆行驶的情况下,在与悬架臂摆动方向相交的方向上,向悬架臂输入载荷,至少 产生最大应力的区域是板状构件的非端部。 因此,可以确保高刚性而不增加重量。
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公开(公告)号:US5691339A
公开(公告)日:1997-11-25
申请号:US424282
申请日:1995-04-21
IPC分类号: A61K31/44 , A61K31/4422 , A61K31/495 , A61K31/496 , C07D401/00
CPC分类号: A61K31/495 , A61K31/44 , A61K31/4422 , A61K31/496
摘要: A circulatory disorder improving agent comprising, as an active ingredient, a dihydropyridine derivative of the formula (I) ##STR1## or an acid addition salt thereof. Said circulatory disorder improving agent is particularly useful as an organ circulation disorder improving agent or peripheral circulation improving agent.
摘要翻译: PCT No.PCT / JP94 / 01412 Sec。 371日期1995年04月21日 102(e)日期1995年4月21日PCT 1994年8月25日PCT公布。 第WO95 / 05825号公报 日期:1995年3月2日循环障碍改善剂,其包含式(I)的二氢吡啶衍生物或其酸加成盐作为活性成分。 所述循环障碍改善剂特别可用作器官循环障碍改善剂或外周循环改善剂。
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公开(公告)号:US06369061B1
公开(公告)日:2002-04-09
申请号:US09786050
申请日:2001-03-21
IPC分类号: A61K31501
CPC分类号: A61K31/501 , C07D401/12
摘要: A therapeutic agent for spinal canal stenosis is provided, which contains a pyridazinone compound of the formula (I) wherein R1, R2 and R3 are each independently a hydrogen atom or a lower alkyl, X is a halogen atom, a cyano or a hydrogen atom, Y is a halogen atom, a trifluoromethyl or a hydrogen atom, and A is a C1-C8 alkylene optionally substituted with a hydroxyl, or its pharmacologically acceptable salt.
摘要翻译: 提供了一种用于椎管狭窄的治疗剂,其包含式(I)的哒嗪酮化合物,其中R 1,R 2和R 3各自独立地为氢原子或低级烷基,X为卤素原子,氰基或氢原子 Y为卤素原子,三氟甲基或氢原子,A为任选被羟基取代的C1-C8亚烷基,或其药理学上可接受的盐。
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公开(公告)号:US5856328A
公开(公告)日:1999-01-05
申请号:US915114
申请日:1997-08-20
IPC分类号: A61K31/44 , A61K31/4422 , A61K31/495 , A61K31/496 , C07D401/00
CPC分类号: A61K31/495 , A61K31/44 , A61K31/4422 , A61K31/496
摘要: A circulatory disorder improving agent comprising, as an active ingredient, a dihydropyridine derivative of the formula (I) ##STR1## or an acid addition salt thereof. Said circulatory disorder improving agent is particularly useful as an organ circulation disorder improving agent or peripheral circulation improving agent.
摘要翻译: 一种循环障碍改善剂,其包含作为活性成分的式(I)的二氢吡啶衍生物(I)或其酸加成盐。 所述循环障碍改善剂特别可用作器官循环障碍改善剂或外周循环改善剂。
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公开(公告)号:US5530001A
公开(公告)日:1996-06-25
申请号:US360705
申请日:1995-02-24
申请人: Masahide Nakajima , Norifumi Nakamura , Feng Wang , Koichi Yamanouchi , Kazutaka Hayashi , Hideaki Kido , Yoshiji Kubo , Minori Okita , Takeshi Uchida , Masahiro Watanabe , Katsumi Yamanaga , Hiroshi Shinyama , Toru Kawamura , Yuji Narita
发明人: Masahide Nakajima , Norifumi Nakamura , Feng Wang , Koichi Yamanouchi , Kazutaka Hayashi , Hideaki Kido , Yoshiji Kubo , Minori Okita , Takeshi Uchida , Masahiro Watanabe , Katsumi Yamanaga , Hiroshi Shinyama , Toru Kawamura , Yuji Narita
IPC分类号: A61K31/44 , A61K31/495
CPC分类号: A61K31/44 , A61K31/495 , Y10S514/824 , Y10S514/87 , Y10S514/925 , Y10S514/929
摘要: A novel pharmaceutical use of a dihydropyridine derivative of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is an alkyl or the like; R.sub.4 is a hydrogen atom or the like; R.sub.5 is nitro, a halogenated alkyl, cyano or the like; X is a vinylene or an azomethine; A is an alkylene; and B is --N(R.sub.6) (R.sub.7) or a group of the formula ##STR2## wherein R.sub.6 and R.sub.7 are the same or different and each is an alkyl, an aralkyl, an aryl or the like; R.sub.8 and Ar are aryl or the like; and n is 0, 1 or 2, or an acid addition salt thereof for promoting PGI.sub.2 production, and for the treatment and prevention of hyperlipemia, arteriosclerosis and cerebral diseases.
摘要翻译: PCT No.PCT / JP94 / 00460 Sec。 371日期:1995年2月24日 102(e)日期1995年2月24日PCT 1994年3月22日PCT公布。 第WO94 / 23721号公报 日期:1994年10月27日。一种式(I)的二氢吡啶衍生物(Ⅰ)的新药用途,其中R 1,R 2和R 3相同或不同,各自为烷基等; R4是氢原子等; R5是硝基,卤代烷基,氰基等; X是亚乙烯基或偶氮甲碱; A是亚烷基; 并且B是-N(R6)(R7)或下式的基团:其中R6和R7相同或不同,并且各自是烷基,芳烷基,芳基等; R8和Ar是芳基等; 和n为0,1或2,或其酸加成盐,用于促进PGI2的产生,以及用于治疗和预防高脂血症,动脉硬化和脑疾病。
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