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公开(公告)号:US20080287438A1
公开(公告)日:2008-11-20
申请号:US12219073
申请日:2008-07-15
申请人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
发明人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
IPC分类号: A61K31/5377 , A61K31/4196 , A61K31/4164 , A61K31/4152 , C07D403/02 , A61K31/4439 , A61P25/00 , C07D401/02 , C07D249/12 , C07D233/00 , C07D413/02
CPC分类号: C07D231/12 , A61K31/402 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4439 , A61K31/66 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/4056 , C07F9/5537 , C07F9/65031 , C07F9/6506 , C07F9/6518 , C07F9/653 , C07F9/65395 , C07F9/65586 , C07F9/657181
摘要: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.
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公开(公告)号:US20060004069A1
公开(公告)日:2006-01-05
申请号:US10532667
申请日:2003-10-30
申请人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
发明人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura , Misayo Sera
IPC分类号: A61K31/4196 , A61K31/4164 , A61K31/4152 , C07D43/02
CPC分类号: C07D231/12 , A61K31/402 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4439 , A61K31/66 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/4056 , C07F9/5537 , C07F9/65031 , C07F9/6506 , C07F9/6518 , C07F9/653 , C07F9/65395 , C07F9/65586 , C07F9/657181
摘要: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.
摘要翻译: 本发明提供了用于预防或治疗具有优异作用和低毒性的神经病的药剂。 该试剂包括由下式表示的化合物:其中环A是含有2个或更多个氮原子的5元芳族杂环,其可进一步具有取代基; B是任选取代的烃基或任选取代的杂环基; X是二价无环烃基; Z是-O - , - S - , - NR 2 - , - CONR 2 - 或-NR 2 CO-(R SUB > 2 SUB>是氢原子或任选取代的烷基); Y是键或二价无环烃基; R 1是任选取代的环状基团,任选取代的氨基或任选取代的酰基,条件是当由环A表示的5元芳族杂环是咪唑时,则Z不应该是 - O-或其盐。
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公开(公告)号:US07423159B2
公开(公告)日:2008-09-09
申请号:US10532667
申请日:2003-10-30
申请人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura
发明人: Yu Momose , Nozomu Sakai , Tsuyoshi Maekawa , Masatoshi Hazama , Toru Kawamura
IPC分类号: C07D213/10
CPC分类号: C07D231/12 , A61K31/402 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/4174 , A61K31/4178 , A61K31/4184 , A61K31/427 , A61K31/4439 , A61K31/66 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , C07F9/4056 , C07F9/5537 , C07F9/65031 , C07F9/6506 , C07F9/6518 , C07F9/653 , C07F9/65395 , C07F9/65586 , C07F9/657181
摘要: The present invention provides an agent for preventing or treating neuropathy having superior action and low toxicity. This agent comprises a compound represented by the formula: wherein ring A is a 5-membered aromatic heterocycle containing 2 or more nitrogen atoms, which may further have substituent(s); B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; X is a divalent acyclic hydrocarbon group; Z is —O—, —S—, —NR2—, —CONR2— or —NR2CO— (R2 is a hydrogen atom or an optionally substituted alkyl group); Y is a bond or a divalent acyclic hydrocarbon group; R1 is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, provided that when the 5-membered aromatic heterocycle represented by ring A is imidazole, then Z should not be —O—, or a salt thereof.
摘要翻译: 本发明提供了用于预防或治疗具有优异作用和低毒性的神经病的药剂。 该试剂包括由下式表示的化合物:其中环A是含有2个或更多个氮原子的5元芳族杂环,其可进一步具有取代基; B是任选取代的烃基或任选取代的杂环基; X是二价无环烃基; Z是-O - , - S - , - NR 2 - , - CONR 2 - 或-NR 2 CO-(R SUB > 2 SUB>是氢原子或任选取代的烷基); Y是键或二价无环烃基; R 1是任选取代的环状基团,任选取代的氨基或任选取代的酰基,条件是当由环A表示的5元芳族杂环是咪唑时,则Z不应该是 - O-或其盐。
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公开(公告)号:US20050090534A1
公开(公告)日:2005-04-28
申请号:US10505742
申请日:2003-02-27
申请人: Nozomu Sakai , Yu Momose , Katsuhito Murase , Masatoshi Hazama
发明人: Nozomu Sakai , Yu Momose , Katsuhito Murase , Masatoshi Hazama
IPC分类号: A61P3/10 , A61P25/00 , A61P25/24 , A61P43/00 , C07D263/32 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/28 , C07D277/30 , C07D277/40 , C07D277/46 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/653 , C07F9/6539 , C07D417/02 , A61K31/4178 , A61K31/422 , A61K31/427 , C07D413/02 , C07D43/02
CPC分类号: C07D413/04 , C07D263/32 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/30 , C07D277/40 , C07D277/46 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/653 , C07F9/6539
摘要: The present invention provides a compound represented by the formula (I) wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group, A is an optionally substituted cyclic amino group or —NR2—W-D wherein R2 is a hydrogen atom or an alkyl group, W is a bond or a divalent acyclic hydrocarbon group, and D is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom, and Y is a bond or a divalent acyclic hydrocarbon group, or a salt thereof, which is useful for the prophylaxis or treatment of diabetic neuropathy and the like.
摘要翻译: 本发明提供由式(I)表示的化合物,其中R 1为氢原子,卤素原子,任选取代的烃基,任选取代的杂环基,任选取代的羟基, 任选取代的硫醇基或任选取代的氨基,A是任选取代的环氨基或-NR 2 -WD,其中R 2是氢原子或烷基 基团,W是键或二价无环烃基,D是任选取代的环状基团,任选取代的氨基或任选取代的酰基,B是任选取代的烃基或任选取代的杂环基,X是 氧原子,硫原子或任选取代的氮原子,Y是可用于预防或治疗糖尿病性神经病变等的键或二价无环烃基或其盐。
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公开(公告)号:US07183276B2
公开(公告)日:2007-02-27
申请号:US10505742
申请日:2003-02-27
申请人: Nozomu Sakai , Yu Momose , Katsuhito Murase , Masatoshi Hazama
发明人: Nozomu Sakai , Yu Momose , Katsuhito Murase , Masatoshi Hazama
IPC分类号: A61K31/5377 , A61K31/421 , A61K31/454 , A61K31/541 , C07D413/04 , C07D279/12 , C07F9/653 , C07D211/46
CPC分类号: C07D413/04 , C07D263/32 , C07D263/38 , C07D263/46 , C07D263/48 , C07D277/30 , C07D277/40 , C07D277/46 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14 , C07F9/653 , C07F9/6539
摘要: The present invention provides a compound represented by the formula (I) wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group, A is an optionally substituted cyclic amino group or —NR2—W—D wherein R2 is a hydrogen atom or an alkyl group, W is a bond or a divalent acyclic hydrocarbon group, and D is an optionally substituted cyclic group, an optionally substituted amino group or an optionally substituted acyl group, B is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom, and Y is a bond or a divalent acyclic hydrocarbon group, or a salt thereof, which is useful for the prophylaxis or treatment of diabetic neuropathy and the like.
摘要翻译: 本发明提供由式(I)表示的化合物,其中R 1为氢原子,卤素原子,任选取代的烃基,任选取代的杂环基,任选取代的羟基, 任选取代的硫醇基或任选取代的氨基,A是任选取代的环氨基或-NR 2 -WD,其中R 2是氢原子或烷基 基团,W是键或二价无环烃基,D是任选取代的环状基团,任选取代的氨基或任选取代的酰基,B是任选取代的烃基或任选取代的杂环基,X是 氧原子,硫原子或任选取代的氮原子,Y是可用于预防或治疗糖尿病性神经病变等的键或二价无环烃基或其盐。
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公开(公告)号:US07022725B2
公开(公告)日:2006-04-04
申请号:US10416658
申请日:2001-11-16
申请人: Yu Momose , Tsuyoshi Maekawa , Tomoko Asakawa , Nozomu Sakai
发明人: Yu Momose , Tsuyoshi Maekawa , Tomoko Asakawa , Nozomu Sakai
IPC分类号: A61K31/42 , C07F261/02 , A61P3/00
CPC分类号: C07D231/12 , A61K31/42 , A61K31/427 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/675 , C07D233/56 , C07D249/08 , C07D261/08 , C07D261/12 , C07D261/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07F9/653 , C07F9/657181
摘要: A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR3 (wherein R3 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.
摘要翻译: 由式(I)表示的化合物,其中R 1和R 2中的一个是氢原子或取代基,另一个是任选取代的环状基团; W是键或二价脂族烃基; Y是下式的基团:-OR 3(其中R 3是氢原子,任选取代的烃基,任选取代的杂环基或任选取代的酰基 基团)或任选酯化或酰胺化的羧基或其盐或其前药具有优异的胰岛素分泌促进作用和降血糖作用,并且显示低毒性。 因此,该化合物可用作药剂,特别是作为预防或治疗糖尿病和糖尿病并发症的药剂等。
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公开(公告)号:US20060084690A1
公开(公告)日:2006-04-20
申请号:US11295058
申请日:2005-12-06
申请人: Yu Momose , Tsuyoshi Maekawa , Tomoko Asakawa , Nozomu Sakai
发明人: Yu Momose , Tsuyoshi Maekawa , Tomoko Asakawa , Nozomu Sakai
IPC分类号: A61K31/42 , C07D413/02 , C07D261/14 , C07F9/653
CPC分类号: C07D231/12 , A61K31/42 , A61K31/427 , A61K31/454 , A61K31/4709 , A61K31/496 , A61K31/675 , C07D233/56 , C07D249/08 , C07D261/08 , C07D261/12 , C07D261/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07F9/653 , C07F9/657181
摘要: A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR3 (wherein R is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.
摘要翻译: 由式(I)表示的化合物,其中R 1和R 2中的一个是氢原子或取代基,另一个是任选取代的环状基团; W是键或二价脂族烃基; Y是下式的基团:-OR 3(其中R是氢原子,任选取代的烃基,任选取代的杂环基或任选取代的酰基)或任选酯化或酰胺化 羧基或其盐或其前药具有优异的胰岛素分泌促进作用和降血糖作用,并且显示低毒性。 因此,该化合物可用作药剂,特别是作为预防或治疗糖尿病和糖尿病并发症的药剂等。
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公开(公告)号:US20060135578A1
公开(公告)日:2006-06-22
申请号:US10527426
申请日:2003-09-09
IPC分类号: A61K31/422 , C07D413/14
CPC分类号: C07D263/32 , C07F9/6558 , C07F9/65583
摘要: The present invention provides a compound represented by the formula: wherein R1 is an optionally substituted 5-membered heterocyclic group; X, Y and V are the same or different and each is a bond, an oxygen atom, a sulfur atom and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1- or -Z1-(CH2)n— (n is an integer of 0 to 8, Z1 is a bond, an oxygen atom, a sulfur atom and the like); ring B is a nitrogen-containing heterocycle optionally further having 1 to 3 substituents; W is a bond or a divalent hydrocarbon group having 1 to 20 carbon atoms; R2 is a hydrogen atom, a cyano group, —PO(OR9)(OR10) (R9 and R10 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, and R9 and R10 are optionally bonded to form an optionally substituted ring) and the like, or a salt thereof, which has a superior adipose tissue weight decreasing action, a hypoglycemic action and a hypolipidemic action, and which is useful as an agent for the prophylaxis or treatment of obesity, diabetes mellitus, hyperlipidemia, impaired glucose tolerance, hypertension and the like.
摘要翻译: 本发明提供由下式表示的化合物:其中R 1是任选取代的5元杂环基; X,Y和V相同或不同,各自为键,氧原子,硫原子等; Q为碳原子数为1〜20的二价烃基; 环A是任选进一步具有1至3个取代基的芳环; Z是 - (CH 2)n - - - - - - - - 1 - (CH 2) (n为0〜8的整数,Z 1为键,氧原子,硫原子等); n为0〜8的整数。 环B是任选进一步具有1至3个取代基的含氮杂环; W是碳原子数为1〜20的键或二价烃基; R 2是氢原子,氰基,-PO(OR 9)(OR 10)(R 10) SUP>和R 10相同或不同,各自为氢原子或任选取代的烃基,R 9和R 10为 任选地键合以形成任选取代的环)等,或其盐,其具有优异的脂肪组织重量减少作用,降血糖作用和降血脂作用,并且其可用作预防或治疗 肥胖症,糖尿病,高脂血症,葡萄糖耐量降低,高血压等。
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公开(公告)号:US07241785B2
公开(公告)日:2007-07-10
申请号:US10472159
申请日:2002-03-22
申请人: Yu Momose , Tsuyoshi Maekawa , Hiroshi Imoto , Hiroyuki Odaka , Hiroyuki Kimura
发明人: Yu Momose , Tsuyoshi Maekawa , Hiroshi Imoto , Hiroyuki Odaka , Hiroyuki Kimura
IPC分类号: C07D413/10 , C07D413/12 , A61K31/422
CPC分类号: C07D413/12 , C07D263/32 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention relates to a compound represented by the formula wherein R1 is an optionally substituted 5-membered heterocyclic group; X is a bond etc.; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond etc.; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n—Z1— (n is an integer of 0 to 8 and Z1 is a bond etc.) and the like; ring B is a 5-membered heterocycle optionally further having 1 to 3 substituents; W is a divalent saturated hydrocarbon group having 1 to 20 carbon atoms; R2 is —OH etc., or a salt thereof. A pharmaceutical composition containing this compound is useful as a prophylactic or therapeutic agent of diseases such as diabetes mellitus and the like.
摘要翻译: 本发明涉及由下式表示的化合物:其中R 1是任选取代的5元杂环基; X是债券等; Q为碳原子数为1〜20的二价烃基; Y是债券等; 环A是任选进一步具有1至3个取代基的芳环; Z是 - (CH 2)n - n 1 - (n是0至8的整数,Z <1) SUP>是债券等)等; 环B是任选进一步具有1至3个取代基的5元杂环; W是碳原子数为1〜20的二价饱和烃基; R 2是-OH等,或其盐。 含有该化合物的药物组合物可用作糖尿病等疾病的预防或治疗剂。
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公开(公告)号:US07238716B2
公开(公告)日:2007-07-03
申请号:US10465938
申请日:2001-12-28
申请人: Yu Momose , Tsuyoshi Maekawa , Nobuyuki Takakura , Hiroyuki Odaka , Hiroyuki Kimura , Tatsuya Ito
发明人: Yu Momose , Tsuyoshi Maekawa , Nobuyuki Takakura , Hiroyuki Odaka , Hiroyuki Kimura , Tatsuya Ito
IPC分类号: A61K31/4439 , C07D413/12
CPC分类号: C07D403/04 , C07D263/32 , C07D277/24 , C07D277/42 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要: An alkanoic acid derivative useful as a prophylactic or therapeutic agent of diabetes mellitus, hyperlipidemia, impaired glucose tolerance and the like can be provided by a compound represented by the formula wherein R1 is an optionally substituted 5-membered aromatic heterocyclic group; X is a bond and the like; Q is a divalent hydrocarbon group having 1 to 20 carbon atoms; Y is a bond and the like; ring A is an aromatic ring optionally further having 1 to 3 substituents; Z is —(CH2)n-Z1-(n is an integer of 1 to 8 and Z1 is an oxygen atom and the like) and the like; ring B is a pyridine ring optionally further having 1 to 3 substituents, and the like; U is a bond and the like; W is a divalent hydrocarbon group having 1 to 20 carbon atoms; and R3 is —OH and the like, provided that, when ring B is a benzene ring optionally further having 1 to 3 substituents, U should be a bond, or a salt thereof.
摘要翻译: 可用作糖尿病,高脂血症,葡萄糖耐量异常等的预防或治疗剂的链烷酸衍生物可由下式表示的化合物提供:其中R 1为任选取代的5元 芳香族杂环基; X是一个键等; Q为碳原子数为1〜20的二价烃基; Y是一个债券等; 环A是任选进一步具有1至3个取代基的芳环; Z是 - (CH 2)n - n 1 - (n是1至8的整数,Z <1) SUP>是氧原子等)等; 环B是任选还含有1至3个取代基的吡啶环等; U是一个债券等; W是碳原子数为1〜20的二价烃基; 且R 3为-OH等,条件是当环B为任选还含有1至3个取代基的苯环时,U应为键或其盐。
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