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1.发明授权公开(公告)号：US09283542B2
公开(公告)日：2016-03-15
申请号：US12822401
申请日：2010-06-24
IPC分类号： C12N7/00 , B01J20/286 , B01J20/285 , B01D15/26 , B01J20/26 , B01J20/28 , B01J20/32
CPC分类号： B01J20/285 , B01D15/265 , B01J20/24 , B01J20/267 , B01J20/28004 , B01J20/28016 , B01J20/286 , B01J20/3042 , B01J20/3085 , B01J20/3212 , B01J20/3272 , B01J20/328 , B01J2220/44 , C12N7/00 , C12N2760/16151
摘要： A Chromatography medium having the properties of high virus adsorption and high fluidity, and a method for producing a virus vaccine using these are provided. The Chromatography medium is formed by binding a sulfated polysaccharide to porous particles having an exclusion limit molecular weight of 6000 Da or less when pure water is used as mobile phase and standard polyethylene glycol is used and an average particle size in the range of 30-200 μm.
摘要翻译： 提供具有高病毒吸附性和高流动性的色谱介质，以及使用这些技术生产病毒疫苗的方法。 当使用纯水作为流动相时，将硫酸化多糖与排斥极限分子量为6000Da或更低的多孔颗粒结合，形成色谱介质，使用标准聚乙二醇，平均粒度范围为30-200 μm。
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公开(公告)号：US08912117B2
公开(公告)日：2014-12-16
申请号：US13201647
申请日：2010-02-18
IPC分类号： A61L15/60 , B01J20/24 , A61K38/00 , C07K1/18 , C07K1/22 , B01J20/32 , B01J41/20 , B01J39/26 , C07K1/16 , B01J20/286 , B01D15/38 , B01D15/36
CPC分类号： C07K1/16 , B01D15/362 , B01D15/3804 , B01J20/286 , B01J20/328 , B01J39/26 , B01J41/20
摘要： The present invention provides a chromatography packing material having improved flow rate characteristics and adsorption characteristics. In particular, the present invention provides a chromatography packing material suitable for separation and purification of immunoglobulin in the manufacture of antibody preparations. A porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry weight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles, is used. By adding a predetermined amount of polysaccharides having a predetermined limiting viscosity to porous cellulose particles, flow rate characteristics and adsorption characteristics can be improved.
摘要翻译： 本发明提供具有改善的流速特性和吸附特性的色谱填充材料。 特别地，本发明提供了适用于制备抗体制剂中免疫球蛋白分离和纯化的色谱填充材料。 通过向多孔纤维素颗粒加入特性粘度为0.21〜0.90dL / g的多糖制成的多孔纤维素凝胶，多孔纤维素凝胶的每单位体积的干重为每单位体积的干重的1.06〜1.40倍 使用多孔纤维素颗粒。 通过向多孔纤维素颗粒添加预定量的具有预定极限粘度的多糖，可以提高流速特性和吸附特性。
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公开(公告)号：US20110301330A1
公开(公告)日：2011-12-08
申请号：US13201647
申请日：2010-02-18
CPC分类号： C07K1/16 , B01D15/362 , B01D15/3804 , B01J20/286 , B01J20/328 , B01J39/26 , B01J41/20
摘要： The present invention provides a chromatography packing material having improved flow rate characteristics and adsorption characteristics. In particular, the present invention provides a chromatography packing material suitable for separation and purification of immunoglobulin in the manufacture of antibody preparations. A porous cellulose gel, which is made by adding polysaccharides having a limiting viscosity of 0.21 to 0.90 dL/g to porous cellulose particles, the dry weight per unit volume of the porous cellulose gel being 1.06 to 1.40 times the dry weight per unit volume of the porous cellulose particles, is used. By adding a predetermined amount of polysaccharides having a predetermined limiting viscosity to porous cellulose particles, flow rate characteristics and adsorption characteristics can be improved.
摘要翻译： 本发明提供具有改善的流速特性和吸附特性的色谱填充材料。 特别地，本发明提供了适用于制备抗体制剂中免疫球蛋白分离和纯化的色谱填充材料。 通过向多孔纤维素颗粒加入特性粘度为0.21〜0.90dL / g的多糖制成的多孔纤维素凝胶，多孔纤维素凝胶的每单位体积的干重为每单位体积的干重的1.06〜1.40倍 使用多孔纤维素颗粒。 通过向多孔纤维素颗粒添加预定量的具有预定极限粘度的多糖，可以提高流速特性和吸附特性。
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公开(公告)号：US08664152B2
公开(公告)日：2014-03-04
申请号：US12199715
申请日：2008-08-27
IPC分类号： B01J20/291 , B05D5/00
CPC分类号： B01J20/291 , B01J20/26 , B01J20/262 , B01J20/265 , B01J20/267 , B01J20/285 , C08B5/14 , C08L1/16
摘要： The present invention provides a porous cellulose gel having a high mechanical strength capable of being operated at a higher flow rate, and a method for producing the same. To a suspension liquid of cellulose particles, a crosslinking agent in an amount of from 4 to 12 times the amount of the cellulose monomer in terms of moles and an alkali in an amount of from 0.1 to 1.5 times the amount of the crosslinking agent in terms of moles are added continuously dropwise or added dividedly over a prescribed period of time, whereby flow rate characteristics of a resulting porous cellulose gel can be enhanced. According to the invention, the production efficiency of a polymer substance, such as a nucleic acid and a protein can be enhanced.
摘要翻译： 本发明提供了能够以较高流量运转的机械强度高的多孔纤维素凝胶及其制造方法。 对于纤维素颗粒的悬浮液，交联剂的量为纤维素单体的摩尔数的4至12倍，碱的量为交联剂的量的0.1至1.5倍 连续滴加或分时加入规定的时间，由此可以提高所得多孔纤维素凝胶的流动速率特性。 根据本发明，可以提高聚合物物质如核酸和蛋白质的生产效率。
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公开(公告)号：US20100022755A1
公开(公告)日：2010-01-28
申请号：US12520508
申请日：2007-12-12
IPC分类号： C07K14/745
CPC分类号： C07K14/001 , C07K14/78 , Y10T428/2982
摘要： A platelet aggregation inducing substance containing as an active ingredient a polypeptide having a peptide fragment represented by formula (1) (component A): -(Pro-X-Gly)n- (1) wherein X represents Pro or Hyp; and n represents an integer of from 20 to 5,000.
摘要翻译： 含有作为活性成分的具有式（1）表示的肽片段（成分A）的多肽的血小板聚集诱导物质： - （Pro-X-Gly）n-（1）其中X表示Pro或Hyp; n表示20〜5000的整数。
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公开(公告)号：US08686117B2
公开(公告)日：2014-04-01
申请号：US12520508
申请日：2007-12-12
CPC分类号： C07K14/001 , C07K14/78 , Y10T428/2982
摘要： A platelet aggregation inducing substance containing as an active ingredient a polypeptide having a peptide fragment represented by formula (1) (component A): -(Pro-X-Gly)n- (1) wherein X represents Pro or Hyp; and n represents an integer of from 20 to 5,000.
摘要翻译： 含有作为活性成分的具有式（1）表示的肽片段（成分A）的多肽的血小板聚集诱导物质： - （Pro-X-Gly）n-（1）其中X表示Pro或Hyp; n表示20〜5000的整数。
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