公开(公告)号：US20060213257A1

公开(公告)日：2006-09-28

申请号：US10556391

申请日：2004-05-14

申请人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

发明人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

IPC分类号： G01N30/16 ,  G01N35/10 ,  G01N1/34

CPC分类号： G01N35/1004 ,  B01L99/00 ,  G01N30/18 ,  G01N2035/00554

摘要： A sample injection apparatus and sample injection method capable of sufficiently reducing carry-over, having simple cleaning means for a short cleaning time period, a small influence of vibration of the cleaning means, and a small error in the amount of injected sample and preventing the durability of a sampling needle from being lowered, and a liquid chromatography apparatus having the sample injection apparatus are provided. The sample injection apparatus has a sampling vessel 14 into which a sample is supplied, a sampling needle 10 for aspirating and ejecting the sample, a cleaning part 17 into which a cleaning liquid for cleaning at least the sampling needle 10 is supplied, a sample injection part 15 for injecting the sample ejected from the sampling needle 10 into a moving liquid, and needle transfer means for transferring the sampling needle 10 among the sampling vessel 4, the cleaning part 17 and the sample injection part 15, wherein the cleaning part 17 has an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.

摘要翻译： 一种能够充分降低携带量的样品注射装置和样品注射方法，具有清洁时间短的简单清洁装置，清洁装置的振动的小影响，以及注射的样品量的小误差，并防止 提供采样针的耐久性降低，并且提供具有样品注射装置的液相色谱装置。 样品注射装置具有供给样品的取样容器14，用于抽吸和抽出试样的取样针10，至少提供用于清洗的清洗液的清洗部17，样品注入 用于将从采样针10喷射的样品注入到移动液体中的部分15以及用于在取样容器4，清洁部17和样品注入部15中传送采样针10的针传送装置，其中清洁部17具有 用于在清洗液中产生超声波的超声波振动器。

公开(公告)号：US20080141762A1

公开(公告)日：2008-06-19

申请号：US12068202

申请日：2008-02-04

申请人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

发明人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

IPC分类号： G01N30/16

CPC分类号： G01N35/1004 ,  B01L99/00 ,  G01N30/18 ,  G01N2035/00554

摘要： A sample injection apparatus and a liquid chromatography apparatus including the sample injection apparatus are provided. The sample injection apparatus includes a sampling vessel into which a sample is supplied, a sampling needle for aspirating and ejecting the sample, a cleaning part into which a cleaning liquid for cleaning at least the sampling needle is supplied, a sample injection part for injecting the sample ejected from the sampling needle into a moving liquid, and a needle transfer part for transferring the sampling needle among the sampling vessel, the cleaning part and the sample injection part, wherein the cleaning part includes an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.

摘要翻译： 提供了一种样品注射装置和包括样品注射装置的液相色谱装置。 样品注入装置包括：供给样品的取样容器，吸取和排出样品的取样针;至少提供采样针的清洗用清洗液的清洗部，将注射了样品的样品注入部， 从采样针喷射到移动液体中的样品和用于在采样容器，清洁部分和样品注入部分中传送采样针的针转移部分，其中清洁部分包括用于在所述采样管中产生超声波的超声波振动器 清洗液体。

公开(公告)号：US07500386B2

公开(公告)日：2009-03-10

申请号：US12068202

申请日：2008-02-04

申请人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

发明人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

IPC分类号： G01N30/16

CPC分类号： G01N35/1004 ,  B01L99/00 ,  G01N30/18 ,  G01N2035/00554

摘要： A sample injection apparatus and a liquid chromatography apparatus including the sample injection apparatus are provided. The sample injection apparatus includes a sampling vessel into which a sample is supplied, a sampling needle for aspirating and ejecting the sample, a cleaning part into which a cleaning liquid for cleaning at least the sampling needle is supplied, a sample injection part for injecting the sample ejected from the sampling needle into a moving liquid, and a needle transfer part for transferring the sampling needle among the sampling vessel, the cleaning part and the sample injection part, wherein the cleaning part includes an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.

摘要翻译： 提供了一种样品注射装置和包括样品注射装置的液相色谱装置。 样品注入装置包括：供给样品的取样容器，吸取和排出样品的取样针;至少提供采样针的清洗用清洗液的清洗部，将注射了样品的样品注入部， 从采样针喷射到移动液体中的样品和用于在采样容器，清洁部分和样品注入部分中传送采样针的针转移部分，其中清洁部分包括用于在所述采样管中产生超声波的超声波振动器 清洗液体。

公开(公告)号：US07337653B2

公开(公告)日：2008-03-04

申请号：US10556391

申请日：2004-05-14

申请人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

发明人： Yuki Togashi ,  Osamu Shirota ,  Aya Ohkubo

IPC分类号： G01N30/16

CPC分类号： G01N35/1004 ,  B01L99/00 ,  G01N30/18 ,  G01N2035/00554

摘要： A sample injection apparatus and sample injection method capable of sufficiently reducing carry-over, having simple cleaning means for a short cleaning time period, a small influence of vibration of the cleaning means, and a small error in the amount of injected sample and preventing the durability of a sampling needle from being lowered, and a liquid chromatography apparatus having the sample injection apparatus are provided. The sample injection apparatus has a sampling vessel 14 into which a sample is supplied, a sampling needle 10 for aspirating and ejecting the sample, a cleaning part 17 into which a cleaning liquid for cleaning at least the sampling needle 10 is supplied, a sample injection part 15 for injecting the sample ejected from the sampling needle 10 into a moving liquid, and needle transfer means for transferring the sampling needle 10 among the sampling vessel 4, the cleaning part 17 and the sample injection part 15, wherein the cleaning part 17 has an ultrasonic vibrator for generating an ultrasonic wave in the cleaning liquid.

摘要翻译： 一种能够充分降低携带量的样品注射装置和样品注射方法，具有清洁时间短的简单清洁装置，清洁装置的振动的小影响，以及注射的样品量的小误差，并防止 提供采样针的耐久性降低，并且提供具有样品注射装置的液相色谱装置。 样品注射装置具有供给样品的取样容器14，用于抽吸和抽出试样的取样针10，至少提供用于清洗的清洗液的清洗部17，样品注入 用于将从采样针10喷射的样品注入到移动液体中的部分15以及用于在取样容器4，清洁部17和样品注入部15中传送采样针10的针传送装置，其中清洁部17具有 用于在清洗液中产生超声波的超声波振动器。

公开(公告)号：US20100285252A1

公开(公告)日：2010-11-11

申请号：US12490531

申请日：2009-06-24

申请人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sakuma ,  Masayoshi Wada

发明人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sakuma ,  Masayoshi Wada

IPC分类号： B01D39/20 ,  B05D3/00 ,  B32B1/00 ,  B32B1/08

CPC分类号： B01J20/28019 ,  B01J20/103 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3272 ,  B01J20/3276 ,  B01J2220/54 ,  B01J2220/58 ,  C08J7/12 ,  Y10T428/139 ,  Y10T428/2991

摘要： A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.

摘要翻译： 通过将具有氨基的材料与含有通过氧化性的醛衍生物获得的醛衍生物的化合物进行处理，通过将下式（1-1）表示的磷酸胆碱基团引入到材料的表面上来对材料进行表面改性的方法 甘油磷酰胆碱开环反应。 本发明的方法提供了具有优异的生物相容性和亲水性的医疗材料等各种材料。

公开(公告)号：US20060060533A1

公开(公告)日：2006-03-23

申请号：US10536066

申请日：2003-11-20

申请人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sukuma ,  Masayoshi Wada

发明人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sukuma ,  Masayoshi Wada

IPC分类号： C02F1/28 ,  B01J20/22 ,  G01N1/28

CPC分类号： B01J20/28019 ,  B01J20/103 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3272 ,  B01J20/3276 ,  B01J2220/54 ,  B01J2220/58 ,  C08J7/12 ,  Y10T428/139 ,  Y10T428/2991

摘要： A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.

摘要翻译： 通过将具有氨基的材料与含有通过氧化性的醛衍生物获得的醛衍生物的化合物进行处理，通过将下式（1-1）表示的磷酸胆碱基团引入到材料的表面上来对材料进行表面改性的方法 甘油磷酰胆碱的开环反应。

公开(公告)号：US08673151B2

公开(公告)日：2014-03-18

申请号：US12490531

申请日：2009-06-24

申请人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sakuma ,  Masayoshi Wada

发明人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sakuma ,  Masayoshi Wada

IPC分类号： B01D15/08

CPC分类号： B01J20/28019 ,  B01J20/103 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3272 ,  B01J20/3276 ,  B01J2220/54 ,  B01J2220/58 ,  C08J7/12 ,  Y10T428/139 ,  Y10T428/2991

摘要： A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.

摘要翻译： 通过将具有氨基的材料与含有通过氧化性的醛衍生物获得的醛衍生物的化合物进行处理，通过将下式（1-1）表示的磷酸胆碱基团引入到材料的表面上来对材料进行表面改性的方法 甘油磷酰胆碱的开环反应。 本发明的方法提供了具有优异的生物相容性和亲水性的医疗材料等各种材料。

公开(公告)号：US07560023B2

公开(公告)日：2009-07-14

申请号：US10536066

申请日：2003-11-20

申请人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sakuma ,  Masayoshi Wada

发明人： Kazuyuki Miyazawa ,  Taketoshi Kanda ,  Yousuke Toujo ,  Aya Ohkubo ,  Osamu Shirota ,  Kenichi Sakuma ,  Masayoshi Wada

IPC分类号： B01D15/08

CPC分类号： B01J20/28019 ,  B01J20/103 ,  B01J20/28057 ,  B01J20/28078 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3259 ,  B01J20/3272 ,  B01J20/3276 ,  B01J2220/54 ,  B01J2220/58 ,  C08J7/12 ,  Y10T428/139 ,  Y10T428/2991

摘要： A method for surface modification of a material by means of introducing the phosphorylcholine group represented by the following formula (1-1) onto the surface of the material by treating a material having amino groups with a chemical compound containing an aldehyde derivative obtained by the oxidative ring-opening reaction of glycerophosphorylcholine. The method of the present invention provides various materials such as medical materials having superior biocompatibility and hydrophilicity.

摘要翻译： 通过将具有氨基的材料与含有通过氧化性的醛衍生物获得的醛衍生物的化合物进行处理，通过将下式（1-1）表示的磷酸胆碱基团引入到材料的表面上来对材料进行表面改性的方法 甘油磷酰胆碱的开环反应。 本发明的方法提供了具有优异的生物相容性和亲水性的医疗材料等各种材料。

公开(公告)号：US06360589B1

公开(公告)日：2002-03-26

申请号：US09180880

申请日：1998-11-25

申请人： Taketoshi Kanda ,  Aya Ohkubo ,  Yutaka Ohtsu ,  Michihiro Yamaguchi

发明人： Taketoshi Kanda ,  Aya Ohkubo ,  Yutaka Ohtsu ,  Michihiro Yamaguchi

IPC分类号： G01N3000

CPC分类号： B01J20/3261 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3219 ,  B01J39/17 ,  B01J39/26 ,  B01J2220/54 ,  G01N30/02 ,  G01N30/24 ,  G01N2030/085 ,  Y10T428/249953 ,  B01D15/36 ,  B01D15/362

摘要： A liquid chromatograph and a column packing material effectively condensing cationic specimen and exhibiting a high resolution. The liquid chromatograph includes a pre-focusing column (30, 40) having a volume of less than 2.0 milliliters and packed with a column packing material, in which a porous support is coated by a silicone polymer having a Si—R—X (R is a spacer part, X is a sulfonic group) bond and a Si—R′ (R′ is a hydrophilic group) bond, wherein the specimen to be analyzed is supplied to the pre-focusing column in the state dispersed in a solvent for condensation. The condensed specimen is then separated in a separation column (16, 43) used for separating the specimen dispersed in the solvent, and the separated specimen is analyzed by a detector (17, 41).

摘要翻译： 液相色谱仪和色谱柱填充材料有效冷凝阳离子样品并显示高分辨率。 液相色谱仪包括体积小于2.0毫升的预聚焦柱（30,40）并填充有柱填料，其中多孔载体由具有Si-RX的硅氧烷聚合物（R为 间隔部分，X是磺酸基）键和Si-R'（R'是亲水基团）键，其中待分析的试样以分散在用于冷凝的溶剂中的状态提供给预聚焦塔。 然后将冷凝的样品在用于分离分散在溶剂中的试样的分离塔（16,43）中分离，并通过检测器（17,41）分析分离的样品。