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公开(公告)号：US20080097087A1
公开(公告)日：2008-04-24
申请号：US11578560
申请日：2005-04-14
IPC分类号： C07H21/04
CPC分类号： C08G65/329 , A61K47/543 , A61K47/60 , A61K47/6907 , A61K48/00 , C07H21/04 , C08G65/3322 , C08G65/334 , C08L2203/02
摘要： The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
摘要翻译： 本发明提供功能性寡核苷酸与聚（环氧乙烷），缀合物与阳离子聚合物的聚离子络合物及其胶束的缀合物。 胶束提高寡核苷酸在动物细胞中的稳定性及其与靶基因的特异性结合力。
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公开(公告)号：US07642343B2
公开(公告)日：2010-01-05
申请号：US11578560
申请日：2005-04-14
CPC分类号： C08G65/329 , A61K47/543 , A61K47/60 , A61K47/6907 , A61K48/00 , C07H21/04 , C08G65/3322 , C08G65/334 , C08L2203/02
摘要： The invention provides a conjugate of functional oligonucleotide with poly(ethylene oxide), polyion complex of the conjugate with cationic polymer, and micelle thereof. The micelle improves stability of the oligonucleotide in animal cells and its specific bindability to target gene.
摘要翻译： 本发明提供功能性寡核苷酸与聚（环氧乙烷），缀合物与阳离子聚合物的聚离子络合物及其胶束的缀合物。 胶束提高寡核苷酸在动物细胞中的稳定性及其与靶基因的特异性结合力。
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公开(公告)号：US20080064863A1
公开(公告)日：2008-03-13
申请号：US11661810
申请日：2005-08-24
申请人： Yukio Nagasaki , Kazunori Kataoka , Motoi Oishi
发明人： Yukio Nagasaki , Kazunori Kataoka , Motoi Oishi
IPC分类号： C07H21/02
CPC分类号： C12N15/111 , A61K47/549 , A61K47/60 , A61K47/6455 , C08G65/332 , C08G65/334 , C08L2203/02 , C12N15/88 , C12N2310/14 , C12N2310/351 , C12N2320/32
摘要： A polyion complex is provided, comprising a double stranded nucleic acid containing a poly(ethylene oxide)-modified oligo- or poly-nucleotide and a polycationic compound, which is an effective delivery means of a gene to a target cell.
摘要翻译： 提供聚阴离子配合物，其包含含有聚（环氧乙烷） - 修饰的寡聚核苷酸和多核苷酸的双链核酸和聚阳离子化合物，其是靶细胞的基因的有效递送方式。
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公开(公告)号：US20070059843A1
公开(公告)日：2007-03-15
申请号：US10575551
申请日：2004-09-06
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N33/5432
摘要： This invention provides a method to detect analyte which comprises preparing fine particles which have a chargeable group in their core and a hydrophilic polymer chain in their shell; obtaining an agglutinated matter by forming a biologically specific bond between a specific residue on the surface of fine particles and analyte, and by simultaneously forming a bond by the electrostatic interaction between impure protein and said particles; and subsequently cleaving only the latter bond by raising ionic intensity. Thus, this invention provides a method to detect analyte with rapidity and high sensitivity with use of agglutination reaction.
摘要翻译： 本发明提供一种检测分析物的方法，其包括制备在其核心中具有可带电基团的微粒和在其壳中的亲水性聚合物链; 通过在细颗粒和分析物的表面上的特定残基之间形成生物特异性键，并通过不纯蛋白与所述颗粒之间的静电相互作用同时形成粘结来获得凝集物; 并且随后通过提高离子强度来仅切割后一种键。 因此，本发明提供了使用凝集反应以快速且高灵敏度检测分析物的方法。
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公开(公告)号：US07037517B2
公开(公告)日：2006-05-02
申请号：US10470574
申请日：2003-09-01
CPC分类号： A61F2/14 , A61F2/16 , A61F2250/0056 , A61K9/0051 , A61K9/1075
摘要： The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.
摘要翻译： 本发明涉及一种涂覆的生物医学装置，所述胶束具有亲水性外壳和疏水性内芯，或疏水性外壳和亲水性内芯，所述胶束由HLB值为约1至约 医疗装置可以在其上具有一个涂层或多个涂层。 本发明还涉及胶束作为药物载体的用途。
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公开(公告)号：US06927033B2
公开(公告)日：2005-08-09
申请号：US10275904
申请日：2001-05-10
IPC分类号： C08G63/688 , G01N21/41 , G01N33/543 , G01N33/544 , G01N33/545 , G01N33/53
CPC分类号： G01N33/545 , C08G63/688 , G01N33/54353 , G01N33/544 , Y10S435/817
摘要： A polymer composition is provided, which contains a polymer or copolymer having a mercapto group at one end and functional group or ligand at the other end and also having a polyethylene glycol segment. Such a composition can form a biosensor surface of reduced non-specific adsorbability for proteins and the like.
摘要翻译： 提供一种聚合物组合物，其包含在一端具有巯基的聚合物或共聚物，另一端具有官能团或配体，并且还具有聚乙二醇部分。 这种组合物可以形成对蛋白质等降低的非特异性吸附性的生物传感器表面。
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公开(公告)号：US20050079195A1
公开(公告)日：2005-04-14
申请号：US10470574
申请日：2003-09-01
CPC分类号： A61F2/14 , A61F2/16 , A61F2250/0056 , A61K9/0051 , A61K9/1075
摘要： The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.
摘要翻译： 本发明涉及一种涂覆的生物医学装置，所述胶束具有亲水性外壳和疏水性内芯，或疏水性外壳和亲水性内芯，所述胶束由HLB值为约1至约 医疗装置可以在其上具有一个涂层或多个涂层。 本发明还涉及胶束作为药物载体的用途。
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公开(公告)号：US5929177A
公开(公告)日：1999-07-27
申请号：US11329
申请日：1998-02-05
申请人： Kazunori Kataoka , Masao Kato , Yukio Nagasaki , Teruo Okano
发明人： Kazunori Kataoka , Masao Kato , Yukio Nagasaki , Teruo Okano
IPC分类号： C08G63/06 , A61K9/107 , A61K9/51 , A61K47/34 , C08F297/00 , C08G63/664 , C08G63/676 , C08G63/91 , C08G65/26 , C08G65/329 , C08G85/00 , C08L71/02 , A61K31/765 , C08G65/32
CPC分类号： A61K9/1075 , A61K9/5153 , C08G63/664 , C08G63/676 , C08G63/912 , C08G65/2627 , C08G65/329 , C08G85/00 , C08L71/02
摘要： The present invention provides a block polymer which has functional groups on its both ends, and which comprises hydrophilic/hydrophobic segments. As for the functional groups on its both ends, the block polymer has amino group, carboxyl group or mercapto group on .alpha.-terminal, and hydroxyl group, carboxyl group, aldehyde group or vinyl group on .omega.-terminal. Hydrophilic segment comprises polyethylene oxide, while hydrophobic segment is derived from lactide, lactone or (meth)acrylic acid ester. The block polymer of this invention forms a polymeric micelle which is usable as bio-compatible materials.
摘要翻译： PCT No.PCT / JP96 / 02200 Sec。 371日期：1998年2月5日 102（e）日期1998年2月5日PCT提交1996年8月5日PCT公布。 出版物WO97 / 06202 日期1997年2月20日本发明提供了在其两端具有官能团并且包含亲水/疏水链段的嵌段聚合物。 对于其两端的官能团，嵌段聚合物在α-末端具有氨基，羧基或巯基，在ω-末端具有羟基，羧基，醛基或乙烯基。 亲水链段包括聚环氧乙烷，而疏水链段来自丙交酯，内酯或（甲基）丙烯酸酯。 本发明的嵌段聚合物形成可用作生物相容性材料的聚合胶束。
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公开(公告)号：US08841138B2
公开(公告)日：2014-09-23
申请号：US10566159
申请日：2004-07-28
申请人： Yukio Nagasaki , Tadahito Takahashi , Kazunori Kataoka , Fumiko Aboshi , Miki Kato , Tomoko Jomura , Hiroshi Kobayashi , Yoshinori Katsuyama , Masami Nakamae
发明人： Yukio Nagasaki , Tadahito Takahashi , Kazunori Kataoka , Fumiko Aboshi , Miki Kato , Tomoko Jomura , Hiroshi Kobayashi , Yoshinori Katsuyama , Masami Nakamae
IPC分类号： G01N33/553 , C12M1/40 , G01N33/543
CPC分类号： C12Q1/6837 , C12Q1/6834 , G01N27/327 , G01N27/3271 , G01N33/543 , G01N33/54366 , G01N33/54393
摘要： A substrate surface on which either a substance to detect analyte or an analyte per se is immobilized, which surface is formed by a treatment of substrate surface with a liquid which contains uncrosslinked polymer based on polyethylene glycol chain segment, said treatment conducted either simultaneously with the immobilization of said substance or analyte or after said substance or analyte has been immobilized on said surface. The non-specific adsorption of impurity protein or the like which is co-existent in sample for assay is significantly restrained.
摘要翻译： 固定有检测分析物或分析物本身的物质的底物表面，该表面是通过用含有基于聚乙二醇链段的未交联聚合物的液体处理基材表面而形成的，所述处理同时进行 所述物质或分析物的固定或所述物质或分析物已被固定在所述表面上之后。 在用于测定的样品中共存的杂质蛋白等的非特异性吸附被显着抑制。
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公开(公告)号：US07674478B2
公开(公告)日：2010-03-09
申请号：US10653626
申请日：2003-09-02
IPC分类号： A61K9/133
CPC分类号： A61F2/14 , A61F2/16 , A61F2250/0056 , A61K9/0051 , A61K9/1075
摘要： The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.
摘要翻译： 本发明涉及一种涂覆的生物医学装置，所述胶束具有亲水性外壳和疏水性内芯，或疏水性外壳和亲水性内芯，所述胶束由HLB值为约1至约 医疗装置可以在其上具有一个涂层或多个涂层。 本发明还涉及胶束作为药物载体的用途。
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