利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

338 条记录 (耗时 0.035 秒)

    METHODS FOR DIAGNOSING OR TREATING PROSTATE CANCER
    1.
    发明申请
    METHODS FOR DIAGNOSING OR TREATING PROSTATE CANCER 失效
    用于诊断或治疗前列腺癌的方法

    公开(公告)号：US20110294123A1

    公开(公告)日：2011-12-01

    申请号：US13130284

    申请日：2009-11-18

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Takuya Tsunoda

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Takuya Tsunoda

    IPC分类号： C12Q1/68 ,  C07H21/00 ,  C07K16/18 ,  G01N33/577

    CPC分类号： C12Q1/6886 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/57434 ,  G01N2500/04

    摘要： The present invention provides methods for detecting and/or diagnosing cancer through the determination of the expression level of the STC2 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer. Moreover, the present invention provides double-stranded molecules targeting the STC2 gene, which are suggested to be useful in the treatment of cancer. The compositions and methods of the present invention find particular applicability to prostate cancer, more specifically, castration-resistant prostate cancer and aggressive prostate cancer.

    摘要翻译： 本发明提供了通过确定STC2基因的表达水平来检测和/或诊断癌症的方法。 发现该基因能够将癌细胞与正常细胞区分开来。 此外，本发明提供筛选用于治疗癌症的治疗剂的方法，用于治疗癌症的方法。 此外，本发明提供靶向STC2基因的双链分子，其被认为可用于治疗癌症。 本发明的组合物和方法特别适用于前列腺癌，更具体地说，抗阉割抗性前列腺癌和侵袭性前列腺癌。

    Methods for diagnosing or treating prostate cancer
    2.
    发明授权
    Methods for diagnosing or treating prostate cancer 失效
    诊断或治疗前列腺癌的方法

    公开(公告)号：US08420329B2

    公开(公告)日：2013-04-16

    申请号：US13130284

    申请日：2009-11-18

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Takuya Tsunoda

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Takuya Tsunoda

    IPC分类号： G01N33/53

    CPC分类号： C12Q1/6886 ,  C12N15/1136 ,  C12N2310/14 ,  C12N2310/531 ,  C12Q2600/112 ,  C12Q2600/136 ,  G01N33/57434 ,  G01N2500/04

    摘要： The present invention provides methods for detecting and/or diagnosing cancer through the determination of the expression level of the STC2 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer. Moreover, the present invention provides double-stranded molecules targeting the STC2 gene, which are suggested to be useful in the treatment of cancer. The compositions and methods of the present invention find particular applicability to prostate cancer, more specifically, castration-resistant prostate cancer and aggressive prostate cancer.

    摘要翻译： 本发明提供了通过确定STC2基因的表达水平来检测和/或诊断癌症的方法。 发现该基因能够将癌细胞与正常细胞区分开来。 此外，本发明提供筛选用于治疗癌症的治疗剂的方法，用于治疗癌症的方法。 此外，本发明提供靶向STC2基因的双链分子，其被认为可用于治疗癌症。 本发明的组合物和方法特别适用于前列腺癌，更具体地说，抗阉割抗性前列腺癌和侵袭性前列腺癌。

    Method for diagnosing pancreatic cancer
    4.
    发明申请
    Method for diagnosing pancreatic cancer 审中-公开
    诊断胰腺癌的方法

    公开(公告)号：US20050260639A1

    公开(公告)日：2005-11-24

    申请号：US11090739

    申请日：2005-03-24

    申请人： Yusuke Nakamura ,  Toyomasa Katagiri ,  Hidewaki Nakagawa

    发明人： Yusuke Nakamura ,  Toyomasa Katagiri ,  Hidewaki Nakagawa

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/136

    摘要： Objective methods for detecting and diagnosing pancreatic cancer (PNC) are described herein. In one embodiment, the diagnostic method involves determining the expression level of PNC-associated gene that discriminates between PNC cells and normal cells. The present invention further provides methods of screening for therapeutic agents useful in the treatment of pancreatic cancer, methods of treating pancreatic cancer and method of vaccinating a subject against pancreatic cancer.

    摘要翻译： 本文描述了胰腺癌（PNC）检测和诊断的客观方法。 在一个实施方案中，诊断方法涉及确定鉴别PNC细胞和正常细胞的PNC相关基因的表达水平。 本发明进一步提供筛选用于治疗胰腺癌的治疗剂的方法，胰腺癌治疗方法和疫苗接种胰腺癌的方法。

    Prostate cancer related gene STYK1
    5.
    发明授权
    Prostate cancer related gene STYK1 失效
    前列腺癌相关基因STYK1

    公开(公告)号：US08182997B2

    公开(公告)日：2012-05-22

    申请号：US12376714

    申请日：2007-08-08

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： C12Q1/6886 ,  A61K39/0011 ,  C12N9/1205 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/53 ,  C12Q2600/136 ,  C12Y207/10002

    摘要： The present invention provides methods for detecting and diagnosing cancer, which method involves the determination of the expression level of the STYK1 gene. The gene was discovered to discriminate cancer cells from normal cells. Furthermore, the present invention provides methods of screening for therapeutic agents useful in the treatment of cancer, methods for treating cancer, and methods for vaccinating a subject against cancer. Moreover, the present invention provides siRNAs targeting the STYK1 gene, which are suggested to be useful in the treatment of cancer.

    摘要翻译： 本发明提供了检测和诊断癌症的方法，该方法涉及确定STYK1基因的表达水平。 发现该基因能够将癌细胞与正常细胞区分开来。 此外，本发明提供了筛选用于治疗癌症的治疗剂的方法，用于治疗癌症的方法以及用于接种受试者接种癌症的方法。 此外，本发明提供靶向STYK1基因的siRNA，其被认为可用于治疗癌症。

    C2ORF18 AS TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS
    7.
    发明申请
    C2ORF18 AS TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
    C2ORF18作为靶基因治疗癌症和诊断

    公开(公告)号：US20110098339A1

    公开(公告)日：2011-04-28

    申请号：US12921766

    申请日：2009-03-10

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Shuichi Nakatsuru

    IPC分类号： A61K31/713 ,  G01N33/68 ,  C07H21/00 ,  C12N15/63 ,  A61P35/00

    CPC分类号： G01N33/57438 ,  A61K48/005 ,  C07K16/303 ,  C12N15/113 ,  C12N2310/14 ,  G01N2500/02

    摘要： Described herein are objective methods for detecting or diagnosing a predisposition to developing cancer, particularly pancreatic cancer. In one embodiment, the diagnostic method involves the step of determining an expression level of C2orf18 using anti-C2orf18 antibody. The present invention further provides methods of screening for therapeutic agents useful in the treatment of a C2orf18-associated disease, such as a cancer, e.g. pancreatic cancer, methods of inhibiting the cell growth and treating or alleviating their symptom. The invention also features products, such as polynucleotides, polypeptides, and vectors double-stranded molecules, antibodies, vectors and compositions composed thereof.

    摘要翻译： 本文描述了用于检测或诊断发展中的癌症，特别是胰腺癌的易感性的客观方法。 在一个实施方案中，诊断方法包括使用抗C2orf18抗体确定C2orf18的表达水平的步骤。 本发明还提供筛选用于治疗C2orf18相关疾病（例如癌症）的治疗剂的方法。 胰腺癌，抑制细胞生长和治疗或缓解其症状的方法。 本发明还包括产物，例如多核苷酸，多肽和载体双链分子，抗体，载体和由其组成的组合物。

    C12ORF48 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS
    9.
    发明申请
    C12ORF48 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS 审中-公开
    C12ORF48作为癌症治疗和诊断的靶基因

    公开(公告)号：US20110263679A1

    公开(公告)日：2011-10-27

    申请号：US13061098

    申请日：2009-08-21

    申请人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Akira Togashi

    发明人： Yusuke Nakamura ,  Hidewaki Nakagawa ,  Akira Togashi

    IPC分类号： A61K31/713 ,  G01N33/574 ,  C07H21/00 ,  C07K16/18 ,  A61P35/00 ,  C07H21/04 ,  C12N15/85 ,  G01N33/573 ,  C12Q1/48 ,  C12Q1/68 ,  C12Q1/18

    CPC分类号： C07K14/4748 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57484 ,  G01N2500/10

    摘要： Objective methods for diagnosing a predisposition to developing pancreatic cancer and prostate cancer, particularly pancreatic ductal adenocarcinoma (PDAC) and castration-resistant prostate cancer, are described herein. In one embodiment, the diagnostic method involves the step of determining an expression level of C12ORF48 using siRNAs targeting the C12ORF48 gene. The invention also features products such as siRNAs as well as to compositions containing them. The present invention further provides methods of screening for therapeutic agents useful in the treatment of C12ORF48 associated disease, such as a cancer, e.g. pancreatic cancer and prostate cancer, as well as methods of inhibiting the cell growth and treating or alleviating one or more disease symptoms. The invention also features products such as double stranded molecules, as well as vectors and compositions containing them.

    摘要翻译： 本文描述了用于诊断发展胰腺癌和前列腺癌，特别是胰腺导管腺癌（PDAC）和去势抗性前列腺癌的倾向的客观方法。 在一个实施方案中，诊断方法包括使用靶向C12ORF48基因的siRNA确定C12ORF48的表达水平的步骤。 本发明还包括诸如siRNA的产物以及含有它们的组合物。 本发明还提供筛选用于治疗C12ORF48相关疾病（例如癌症）的治疗剂的方法。 胰腺癌和前列腺癌，以及抑制细胞生长和治疗或减轻一种或多种疾病症状的方法。 本发明还包括诸如双链分子的产物，以及含有它们的载体和组合物。