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公开(公告)号：US5902881A
公开(公告)日：1999-05-11
申请号：US811233
申请日：1997-03-03
IPC分类号： C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
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公开(公告)号：US5959099A
公开(公告)日：1999-09-28
申请号：US103399
申请日：1998-06-24
IPC分类号： C07C253/00 , C07C255/50 , C07H19/10 , C07H19/20 , C07H21/00 , C07H19/04
CPC分类号： C07H19/10 , C07C253/00 , C07H19/20 , C07H21/00 , Y02P20/55
摘要： A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.
摘要翻译： 式（1）的2-N-酰氨基保护的核苷类似物亚磷酰胺：可用于合成多种寡核苷酸类似物。 在溶液或固相寡核苷酸类似物合成中，亚磷酰胺（1）的偶联产率高，在标准条件下可以容易地除去2-N-酰氨基乙基保护基。
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公开(公告)号：US06399831B1
公开(公告)日：2002-06-04
申请号：US09451913
申请日：1999-12-01
IPC分类号： C07C32100
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
摘要翻译： 本发明涉及通过使含有磷（III）键的寡核苷酸类似物与具有制备硫化寡核苷酸类似物的二硫代碳酸二酯多硫化物反应来合成硫化寡核苷酸类似物的方法。 二酯多硫化物试剂可用于溶液和固相寡核苷酸类似物合成。
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公开(公告)号：US5783690A
公开(公告)日：1998-07-21
申请号：US933133
申请日：1997-09-18
IPC分类号： C07C253/00 , C07C255/50 , C07H19/10 , C07H19/20 , C07H21/00 , C07H1/02 , C07F9/02 , C07F9/08
CPC分类号： C07H19/10 , C07C253/00 , C07H19/20 , C07H21/00 , Y02P20/55
摘要： A 2-N-amidoethyl protected nucleoside analog phosphoramidite of formula (1): ##STR1## is useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with phosphoramidite (1) in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl protecting group can be removed easily under standard conditions.
摘要翻译： 式（1）的2-N-酰氨基保护的核苷类似亚磷酰胺：
（1）。 可用于合成多种寡核苷酸类似物。 在溶液或固相寡核苷酸类似物合成中，亚磷酰胺（1）的偶联产率高，在标准条件下可以容易地除去2-N-酰氨基乙基保护基。 -
公开(公告)号：US6040438A
公开(公告)日：2000-03-21
申请号：US104330
申请日：1998-06-25
IPC分类号： C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
摘要翻译： 本发明涉及通过使含有磷（III）键的寡核苷酸类似物与具有下式的二硫代碳酸二酯多硫化物反应产生硫化寡核苷酸类似物来合成硫化寡核苷酸类似物的方法。 二酯多硫化物试剂可用于溶液和固相寡核苷酸类似物合成。
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公开(公告)号：US5760209A
公开(公告)日：1998-06-02
申请号：US811232
申请日：1997-03-03
IPC分类号： C07C253/00 , C07C255/50 , C07H19/10 , C07H19/20 , C07H21/00 , C07H1/02 , C07H21/02 , C07H21/04
CPC分类号： C07H19/10 , C07C253/00 , C07H19/20 , C07H21/00 , Y02P20/55
摘要： Nucleoside analog phosphoramidites are provided in which the 3'-hydroxyl group is protected with an 2-N-amidoethyl group. The 2-N-amidoethyl protected nucleoside analogs are useful in the synthesis of a wide variety of oligonucleotide analogs. Coupling yields with the protected phosphoramidites in solution or solid phase oligonucleotide analog synthesis are high and the 2-N-amidoethyl group can be removed easily under standard conditions.
摘要翻译： 提供了核苷类似物亚磷酰胺，其中3'-羟基被2-N-酰氨基乙基保护。 2-N-酰氨基乙基保护的核苷类似物可用于合成多种寡核苷酸类似物。 在溶液或固相寡核苷酸类似物合成中与受保护的亚磷酰胺的偶联产率高，在标准条件下可以容易地除去2-N-酰胺基乙基。
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公开(公告)号：US07041816B2
公开(公告)日：2006-05-09
申请号：US10760940
申请日：2004-01-20
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC分类号： C07H21/00
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US07199236B2
公开(公告)日：2007-04-03
申请号：US10940360
申请日：2004-09-14
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
IPC分类号： C07H21/00
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
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公开(公告)号：US06649750B1
公开(公告)日：2003-11-18
申请号：US09477878
申请日：2000-01-05
IPC分类号： C07H2100
CPC分类号： C07H21/00 , C07B2200/11
摘要： Synthetic processes are provided wherein high purity oligomers are prepared using support bound phosphoramidite protocols starting with a nucleoside or larger synthon linked to a support media through a nucleosidic heterocyclic base moiety. Intermediates undergoing depurination at the support linkage site are removed during the wash cycle. Also provided are compositions useful in such processes.
摘要翻译： 提供了合成方法，其中使用支持结合的亚磷酰胺方案制备高纯度低聚物，起始于通过核苷酸杂环碱基部分与支持介质连接的核苷或更大的合成子。 在洗涤循环期间，在载体连接位点处经历去血的中间体被去除。 还提供了可用于这些方法的组合物。
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公开(公告)号：US06858715B2
公开(公告)日：2005-02-22
申请号：US10232881
申请日：2002-08-30
申请人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
发明人： Vasulinga T. Ravikumar , Muthiah Manoharan , Daniel C. Capaldi , Achim Krotz , Douglas L. Cole , Andrei Guzaev
摘要： Synthetic processes are provided wherein oligomeric compounds are prepared having phosphodiester, phosphorothioate, phosphorodithioate, or other covalent linkages. The oligomers have substantially reduced exocyclic adducts deriving from acrylonitrile or related contaminants.
摘要翻译： 提供合成方法，其中制备具有磷酸二酯，硫代磷酸酯，二硫代磷酸酯或其它共价键的低聚化合物。 低聚物具有显着减少的衍生自丙烯腈或相关污染物的环加成物。
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