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1.发明授权公开(公告)号：US07087405B2
公开(公告)日：2006-08-08
申请号：US10141908
申请日：2002-05-09
IPC分类号： C12P21/06
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2319/00
摘要： This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to a human αv subunit-containing heterodimeric integrin receptors and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of disorders mediated by such receptors, such as cancer, in human patients.
摘要翻译： 本发明涉及新的人源化和其他重组或工程化抗体或含有人α亚基的异源二聚体整联蛋白受体的单克隆抗体及其编码基因的基因。 这样的抗体可用于治疗和/或预防由人类患者中由此类受体介导的疾病，例如癌症。
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2.发明授权
公开(公告)号：US6160099A
公开(公告)日：2000-12-12
申请号：US199149
申请日：1998-11-24
IPC分类号： G01N33/50 , A61K39/395 , A61K45/00 , A61P9/10 , A61P27/02 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07K14/47 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2319/00
摘要： This invention relates to novel humanized and other recombinant or engineered antibodies or monoclonal antibodies to a human .alpha..sub.v subunit-containing heterodimeric integrin receptors and to the genes encoding same. Such antibodies are useful for the therapeutic and/or prophylactic treatment of disorders mediated by such receptors, such as cancer, in human patients.
摘要翻译： 本发明涉及新的人源化和其他重组或工程化抗体或含有人αv亚基的异二聚体整联蛋白受体的单克隆抗体及其编码基因。 这样的抗体可用于治疗和/或预防由人类患者中由此类受体介导的疾病，例如癌症。
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公开(公告)号：US09085622B2
公开(公告)日：2015-07-21
申请号：US13639918
申请日：2011-09-02
申请人： Neil James Clarke , Kyung Oh Johanson , Zdenka Ludmila Jonak , Alexander H. Taylor , Christopher B. Hopson , Stephen H. Trulli , Zdenka Haskova , Judithann M. Lee , John R. White , Yu Xue
发明人： Neil James Clarke , Kyung Oh Johanson , Zdenka Ludmila Jonak , Alexander H. Taylor , Christopher B. Hopson , Stephen H. Trulli , Zdenka Haskova , Judithann M. Lee , John R. White , Yu Xue
IPC分类号： C07K16/28 , A61K39/395 , C07K16/32 , A61K39/00
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.
摘要翻译： 本公开涉及结合HER3的抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物和制备方法。 本公开还涉及这种抗原结合蛋白在治疗或预防与乳腺癌，卵巢癌，前列腺癌，膀胱癌，胰腺，胃癌，黑素瘤和其它过表达HER3的癌症相关的疾病中的用途。
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公开(公告)号：US20130156779A1
公开(公告)日：2013-06-20
申请号：US13639918
申请日：2011-09-02
申请人： Neil James Clarke , Kyung Oh Johanson , Zdenka Ludmila Jonak , Alexander H. Taylor , Christopher B. Hopson , Stephen H. Trulli , Zdenka Haskova , Judithann M. Lee , John R. White , Yu Xue
发明人： Neil James Clarke , Kyung Oh Johanson , Zdenka Ludmila Jonak , Alexander H. Taylor , Christopher B. Hopson , Stephen H. Trulli , Zdenka Haskova , Judithann M. Lee , John R. White , Yu Xue
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/32 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present disclosure relates to antigen binding proteins, such as antibodies, that bind to HER3, polynucleotides encoding such antigen binding proteins, pharmaceutical compositions comprising said antigen binding proteins and methods of manufacture. The present disclosure also concerns the use of such antigen binding proteins in the treatment or prophylaxis of diseases associated with breast cancer, ovarian cancer, prostate cancer, bladder cancer, pancreatic, gastric, melanoma and other cancers that overexpress HER3.
摘要翻译： 本公开涉及结合HER3的抗原结合蛋白，例如抗体，编码这种抗原结合蛋白的多核苷酸，包含所述抗原结合蛋白的药物组合物及其制备方法。 本公开还涉及这种抗原结合蛋白在治疗或预防与乳腺癌，卵巢癌，前列腺癌，膀胱癌，胰腺，胃癌，黑素瘤和其它过表达HER3的癌症相关的疾病中的用途。
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5.发明申请公开(公告)号：US20100196310A1
公开(公告)日：2010-08-05
申请号：US12532776
申请日：2008-03-20
CPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K39/3955 , C07K16/2887 , C07K16/3061 , A61K2300/00
摘要： The present invention relates generally to the use of human IL-18 combinations in the treatment of various forms of solid tumors and lymphomas. In particular, the present invention relates to: (1) combinations of human IL-18 with monoclonal antibodies against antigens that are expressed on the surface of cancer cells; and (2) combinations of human IL-18 with chemotherapeutic agents.
摘要翻译： 本发明一般涉及人IL-18组合在治疗各种形式的实体瘤和淋巴瘤中的用途。 特别地，本发明涉及：（1）人IL-18与针对在癌细胞表面表达的抗原的单克隆抗体的组合; 和（2）人IL-18与化学治疗剂的组合。
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公开(公告)号：US20100111945A1
公开(公告)日：2010-05-06
申请号：US12532727
申请日：2008-03-20
申请人： Zdenka Haskova , Zdenka Ludmila Jonak , Stephen H. Trulli , John F. Toso , Margaret N. Whitacre
发明人： Zdenka Haskova , Zdenka Ludmila Jonak , Stephen H. Trulli , John F. Toso , Margaret N. Whitacre
IPC分类号： A61K39/395 , A61P35/00
CPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K39/3955 , C07K16/2887 , C07K16/3061 , A61K2300/00
摘要： The present invention relates generally to the use of human IL-18 combinations in the treatment of cancers. In particular, the present invention relates to combination of human IL-18 and an anti-CD20 antibody.
摘要翻译： 本发明一般涉及人IL-18组合在癌症治疗中的应用。 特别地，本发明涉及人IL-18和抗CD20抗体的组合。
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7.发明申请公开(公告)号：US20090035258A1
公开(公告)日：2009-02-05
申请号：US12052278
申请日：2008-03-20
CPC分类号： C07K14/54 , A61K38/00 , A61K38/20 , A61K39/3955 , C07K16/2887 , C07K16/3061 , A61K2300/00
摘要： The present invention relates generally to the use of human IL-18 combinations in the treatment of various forms of solid tumors and lymphomas. In particular, the present invention relates to: (1) combinations of human IL-18 with monoclonal antibodies against antigens that are expressed on the surface of cancer cells; and (2) combinations of human IL-18 with chemotherapeutic agents.
摘要翻译： 本发明一般涉及人IL-18组合在治疗各种形式的实体瘤和淋巴瘤中的用途。 特别地，本发明涉及：（1）人IL-18与针对在癌细胞表面表达的抗原的单克隆抗体的组合; 和（2）人IL-18与化学治疗剂的组合。
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公开(公告)号：US20110229475A1
公开(公告)日：2011-09-22
申请号：US12596262
申请日：2008-04-16
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号： A61K39/395 , C07K16/24 , A61P19/02 , A61P9/10 , A61P11/06 , A61P17/06 , C12P21/08 , C12N5/10 , C12N1/00 , C12N5/12 , C12N15/63 , C12P21/02 , A61P19/06 , A61P35/00 , A61P11/00 , A61P7/00 , A61P9/00 , A61P29/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要： The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译： 本发明涉及具有多种特异性的抗体。 特别地，本发明的抗体与人IL-8，Gro-α，Gro-β，Gro-γ和ENA-78结合（交叉反应）。
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公开(公告)号：US20120315267A1
公开(公告)日：2012-12-13
申请号：US13577923
申请日：2011-02-09
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
IPC分类号： A61K39/395 , C12N15/63 , A61P19/02 , A61P11/06 , A61P9/10 , A61P1/00 , A61P1/04 , A61P37/06 , A61P35/00 , A61P11/00 , C12N5/10 , C12N1/19 , C12N1/21 , C12N1/15 , C07K16/00
CPC分类号： C07K16/244 , C07K16/24 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要： The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases
摘要翻译： 本发明涉及多种抗原特异性及其在治疗人类疾病中的应用的抗体
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公开(公告)号：US08496932B2
公开(公告)日：2013-07-30
申请号：US12596262
申请日：2008-04-16
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要： The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译： 本发明涉及具有多种特异性的抗体。 特别地，本发明的抗体与人IL-8，Gro-α，Gro-β，Gro-γ和ENA-78结合（交叉反应）。
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