公开(公告)号：US20230039261A1

公开(公告)日：2023-02-09

申请号：US17762081

申请日：2020-08-26

Applicant: Zeteo Tech, Inc.

Inventor： WAYNE A. BRYDEN ,  Charles J. CALL ,  Michael MCLOUGHLIN ,  Dapeng CHEN ,  Scott ECELBERGER ,  Nathaniel K. JONES ,  Steven STROHL ,  Gary ANDERSON

IPC: H01J49/16 ,  H01J49/04 ,  H01J49/40 ,  G01N15/10 ,  G01N35/04 ,  G01N27/626 ,  G01N1/22

Abstract: Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of-flight mass spectrometry (TOFMS).

公开(公告)号：US20240282567A1

公开(公告)日：2024-08-22

申请号：US18642553

申请日：2024-04-22

Applicant: Zeteo Tech, Inc.

Inventor： Michael MCLOUGHLIN ,  Wayne A. BRYDEN ,  Charles J. CALL ,  Dapeng CHEN

IPC: H01J49/16 ,  G01N15/10 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40

CPC classification number: H01J49/164 ,  G01N15/10 ,  G01N27/64 ,  H01J49/0036 ,  H01J49/40 ,  G01N2015/1029 ,  G01N2015/103

Abstract: Systems are methods for identifying the composition of non-biological aerosol particles or biological aerosol particles including water bound to the surface of the particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index the aerosol particles, determine optical particle properties, and trigger an IR pulse ionization laser. Ionized fragments, and optionally photons, associated with each particle produced by ionization of the particles the IR ionization laser is analyzed using one or more detectors including a TOFMS detector and an optical detector. Unique mass spectral data and optical data associated with each indexed particle is compiled using data fusion to generate a compiled data set. The compiled optical data is compared with a training data set comprising a knowledge base of known aerosol particles to predict aerosol particle composition.

公开(公告)号：US20240148274A1

公开(公告)日：2024-05-09

申请号：US18284273

申请日：2022-03-31

Applicant: Zeteo Tech, Inc.

Inventor： Dapeng CHEN ,  Wayne A. BRYDEN ,  Michael MCLOUGHLIN

IPC: A61B5/097 ,  A61B5/00 ,  A61B5/083 ,  A61M16/08 ,  G01N1/40 ,  G01N33/68

CPC classification number: A61B5/097 ,  A61B5/0836 ,  A61B5/7203 ,  A61M16/0808 ,  G01N1/4044 ,  G01N33/6851 ,  G01N33/6893 ,  A61B2560/0431 ,  G01N2800/12 ,  G01N2800/26

Abstract: Methods and devices for capturing and analyzing aerosolized particles in exhaled breath characteristic of a respiratory disease to enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19 are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using solvents and analyzed using analytical devices including MALDI-TOFMS.

公开(公告)号：US20230245876A1

公开(公告)日：2023-08-03

申请号：US18133441

申请日：2023-04-11

Applicant: Zeteo Tech, Inc.

Inventor： Wayne A. BRYDEN ,  Charles J. CALL ,  Michael MCLOUGHLIN ,  Dapeng CHEN ,  Scott ECELBERGER ,  Nathaniel K. JONES ,  Steven STROHL

IPC: H01J49/04 ,  H01J49/00

CPC classification number: H01J49/0413 ,  H01J49/0418 ,  H01J49/0422 ,  H01J49/0036 ,  H01J49/0031

Abstract: Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.

公开(公告)号：US20230157573A1

公开(公告)日：2023-05-25

申请号：US17916649

申请日：2020-08-26

Applicant: Zeteo Tech, Inc.

Inventor： Dapeng CHEN ,  Wayne A. BRYDEN ,  Michael McLOUGHLIN

IPC: A61B5/08 ,  A61B5/097 ,  G01N33/497

CPC classification number: A61B5/082 ,  A61B5/097 ,  G01N33/497

Abstract: Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.

公开(公告)号：US20240115157A1

公开(公告)日：2024-04-11

申请号：US18532476

申请日：2023-12-07

Applicant: Zeteo Tech, Inc.

Inventor： Dapeng CHEN ,  Wayne A. BRYDEN ,  Michael McLOUGHLIN

IPC: A61B5/08 ,  A61B5/097 ,  G01N33/497

CPC classification number: A61B5/082 ,  A61B5/097 ,  G01N33/497

Abstract: Methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.