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公开(公告)号:US08426403B2
公开(公告)日:2013-04-23
申请号:US12601322
申请日:2008-05-28
申请人: Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Brian A. McKittrick , John W. Clader , Mark D. McBriar , Anandan Palani
发明人: Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Brian A. McKittrick , John W. Clader , Mark D. McBriar , Anandan Palani
IPC分类号: A61K31/5365 , A61K31/5395 , C07D498/04 , A61P25/28
CPC分类号: C07D498/04 , C07D403/10 , C07D471/04 , C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的下式杂环化合物:作为γ-分泌酶的调节剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备包含一种或多种这样的化合物的药物制剂的方法 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与中枢神经系统相关的一种或多种疾病的方法。
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公开(公告)号:US20100256128A1
公开(公告)日:2010-10-07
申请号:US12601322
申请日:2008-05-28
申请人: Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Brian A. McKittrick , John W. Clader , Mark D. McBriar , Anandan Palani
发明人: Zhaoning Zhu , William J. Greenlee , Xianhai Huang , Brian A. McKittrick , John W. Clader , Mark D. McBriar , Anandan Palani
IPC分类号: A61K31/5365 , C07D498/04 , A61K31/5395 , A61P25/28
CPC分类号: C07D498/04 , C07D403/10 , C07D471/04 , C07D487/04
摘要: In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的下式杂环化合物:作为γ-分泌酶的调节剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备包含一种或多种这样的化合物的药物制剂的方法 化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与中枢神经系统相关的一种或多种疾病的方法。
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公开(公告)号:US20110257156A1
公开(公告)日:2011-10-20
申请号:US13126056
申请日:2009-11-05
申请人: Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
发明人: Zhaoning Zhu , William J. Greenlee , David James Cole , Dmitri A. Pissarnitski , Gioconda V. Gallo , Hongmei Li , Hubert B. Josien , Jun Qin , Chad E. Knutson , Mihirbaran Mandal , Monica L. Vicarel , Murali Rajagopalan , Pawan Kumar Dhondi , Ruo Xu , Zhong-Yue Sun , Thomas A. Bara , Xianhai Huang , Xiaohong Zhu , Zhiqiang Zhao , John W. Clader , Anandan Palani , Theodros Asberom , Troy McCracken , Chad E. Bennett
IPC分类号: A61K31/55 , A61K31/5383 , A61K31/5377 , A61K31/501 , A61K31/497 , A61K31/506 , A61K31/438 , A61K31/437 , C07D413/10 , C07D498/20 , C07D498/04 , A61P25/00 , A61P25/28 , A61K31/4245 , A61K31/5386
CPC分类号: C07D471/04 , C07D413/10 , C07D498/04 , C07D498/20 , C07F7/0812
摘要: In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了新颖的杂环化合物作为γ-分泌酶的调节剂,制备这些化合物的方法,含有一种或多种这样的化合物的药物组合物,制备包含一种或多种此类化合物的药物制剂的方法,以及治疗方法, 使用这种化合物或药物组合物预防,抑制或改善与中枢神经系统相关的一种或多种疾病。
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公开(公告)号:US07345042B2
公开(公告)日:2008-03-18
申请号:US10878788
申请日:2004-06-28
申请人: Anandan Palani , Sherry A. Shapiro , Hubert B. Josien , Thomas A. Bara , John W. Clader , Pradeep B. Pushpavanam , Shengjian Li , Mark D. McBriar
发明人: Anandan Palani , Sherry A. Shapiro , Hubert B. Josien , Thomas A. Bara , John W. Clader , Pradeep B. Pushpavanam , Shengjian Li , Mark D. McBriar
IPC分类号: A61K31/496 , C07D409/14
CPC分类号: C07D409/14
摘要: The present invention discloses methods of using antagonists for melanin-concentrating hormone (MCH), to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes, as well as novel compounds which are antagonists for melanin-concentrating hormone (MCH). In other aspects, the invention is directed to pharmaceutical compositions comprising such MCH antagonists as well as methods for preparing such compounds. Compounds of the invention generally have the structure: where the substituents are as defined herein.
摘要翻译: 本发明公开了使用拮抗剂用于黑色素浓缩激素(MCH),治疗肥胖症,代谢紊乱,进食障碍如食欲过盛和糖尿病的方法,以及作为黑色素浓缩激素(MCH)拮抗剂的新化合物。 在其它方面,本发明涉及包含这种MCH拮抗剂的药物组合物以及制备这些化合物的方法。 本发明的化合物通常具有以下结构:其中取代基如本文所定义。
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公开(公告)号:US07348328B2
公开(公告)日:2008-03-25
申请号:US10308782
申请日:2002-12-03
申请人: John W. Clader , Anandan Palani , Ruo Xu , Mark D. McBriar , Jing Su , Haiqun Tang
发明人: John W. Clader , Anandan Palani , Ruo Xu , Mark D. McBriar , Jing Su , Haiqun Tang
IPC分类号: A61K31/497 , C07D237/02 , C07D265/30
CPC分类号: C07D207/08 , C07C275/30 , C07C2601/14 , C07C2602/18 , C07C2602/20 , C07D205/04 , C07D207/06 , C07D207/10 , C07D207/12 , C07D207/14 , C07D209/52 , C07D211/26 , C07D211/34 , C07D211/96 , C07D213/75 , C07D213/89 , C07D233/24 , C07D295/13 , C07D333/36 , C07D401/12 , C07D405/04 , C07D405/06 , C07D409/04 , C07D413/06
摘要: The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such MCH antagonists as well as methods of using them to treat obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
摘要翻译: 本发明公开了作为黑色素浓缩激素(MCH)的新型拮抗剂的化合物以及这些化合物的制备方法。 在另一个实施方案中,本发明公开了包含这样的MCH拮抗剂的药物组合物以及使用它们治疗肥胖,代谢紊乱,进食障碍如食欲过盛和糖尿病的方法。
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公开(公告)号:US06391865B1
公开(公告)日:2002-05-21
申请号:US09562814
申请日:2000-05-01
申请人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Eric Gilbert , Marc A. Labroli
发明人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Eric Gilbert , Marc A. Labroli
IPC分类号: A01N5500
CPC分类号: A61K31/496 , A61K45/06 , C07D211/58 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/06 , C07D413/06 , A61K2300/00
摘要: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
摘要翻译: 使用式5的CCR5拮抗剂或其药学上可接受的盐,其中R是任选取代的苯基,吡啶基,噻吩基或萘基; R 1是氢或烷基; R 2是取代的苯基,取代的杂芳基,萘基,芴基,二苯基甲基或任选取代的苯基 - R 4是氢或烷基; R 6是氢,烷基或链烯基; R 4是氢或烷基; R 3是氢,烷基或烷氧基烷基, 公开了用于治疗HIV,实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎症性肠病,特应性皮炎,牛皮癣,哮喘,过敏或多发性硬化的新型化合物,以及包含它们的药物组合物 ,以及本发明的CCR5拮抗剂与可用于治疗HIV的抗病毒剂或可用于治疗炎性疾病的药剂的组合。
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公开(公告)号:US06387930B1
公开(公告)日:2002-05-14
申请号:US09562815
申请日:2000-05-01
申请人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin
发明人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin
IPC分类号: C07D40104
CPC分类号: C07D401/14 , C07D211/58 , C07D413/14 , C07D417/14
摘要: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein X is —C(R13)2—, —C(R13)(R19)—, —C(O)—, —O—, —NH—, —N(alkyl)—, R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is H, alkyl or alkenyl; R2 is optionally substituted phenyl, phenylalkyl, heteroaryl or heteroarylalkyl, naphthyl, fluorenyl or diphenylmethyl; R3 is optionally substituted phenyl, heteroaryl or naphthyl; R4 is H, alkyl, fluoro-alkyl, cyclopropylmethyl, —CH2CH2OH, —CH2CH2—O-alkyl, —CH2C(O)—O-alkyl, —CH2C(O)NH2, —CH2C(O)—NHalkyl or —CH2C(O)—N(alkyl)2; R19 is optionally substituted phenyl, heteroaryl or naphthyl, cycloalkyl, cycloalkylalkyl or alkoxyalkyl; and R5, R13, R14, R15 and R16 are hydrogen or alkyl for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
摘要翻译: 使用下式的CCR5拮抗剂或其药学上可接受的盐,其中X是-C(R 13)2 - , - C(R 13)(R 19) - , - C(O) - , - O - N(烷基) - ,R是任选取代的苯基,吡啶基,噻吩基或萘基; R1是H,烷基或烯基; R2是任选取代的苯基,苯基烷基,杂芳基或杂芳基烷基,萘基,芴基或二苯基甲基; R 3是任选取代的苯基, 杂芳基或萘基; R4是H,烷基,氟代烷基,环丙基甲基,-CH2CH2OH,-CH2CH2-O-烷基,-CH2C(O)-O-烷基,-CH2C(O)NH2,-CH2C(O) 或-CH 2 C(O)-N(烷基)2; R 19是任选取代的苯基,杂芳基或萘基,环烷基,环烷基烷基或烷氧基烷基; 和R 5,R 13,R 14,R 15和R 16是氢或烷基,用于治疗HIV,实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎性肠病,特应性皮炎,牛皮癣,哮喘,过敏或多发性硬化 以及新化合物,包含它们的药物组合物,以及本发明的CCR5拮抗剂与可用于治疗HIV的抗病毒剂或可用于治疗炎性疾病的药剂的组合。
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公开(公告)号:US07384944B2
公开(公告)日:2008-06-10
申请号:US10668862
申请日:2003-09-23
申请人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin , Eric Gilbert , Marc A. Labroli
发明人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin , Eric Gilbert , Marc A. Labroli
IPC分类号: A61K31/497
CPC分类号: C07D401/06 , A61K31/496 , A61K45/06 , C07D211/58 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/06 , C07D413/06 , A61K2300/00
摘要: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
摘要翻译: 使用下式的CCR5拮抗剂或其药学上可接受的盐,其中R是任选取代的苯基,吡啶基,噻吩基或萘基; R 1是氢或烷基; R 2是取代的苯基,取代的杂芳基,萘基,芴基,二苯基甲基或任选取代的苯基或杂芳基 - 烷基; R 3是氢,烷基,烷氧基烷基,环烷基,环烷基烷基或任选取代的苯基,苯基烷基,萘基,萘基烷基,杂芳基或杂芳基烷基; R 4,R 5和R 7是氢或烷基; R 6是氢,烷基或链烯基; 公开了用于治疗HIV,实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎症性肠病,特应性皮炎,牛皮癣,哮喘,过敏或多发性硬化的新型化合物,以及包含它们的药物组合物 ,以及本发明的CCR5拮抗剂与可用于治疗HIV的抗病毒剂或可用于治疗炎性疾病的药剂的组合。
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公开(公告)号:US20080188485A1
公开(公告)日:2008-08-07
申请号:US12055900
申请日:2008-03-26
申请人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin , Eric Gilbert , Marc A. Labroli
发明人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin , Eric Gilbert , Marc A. Labroli
IPC分类号: A61K31/496 , A61P1/00 , A61P19/02
CPC分类号: C07D401/06 , A61K31/496 , A61K45/06 , C07D211/58 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/06 , C07D413/06 , A61K2300/00
摘要: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroarylalkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
摘要翻译: 使用下式的CCR5拮抗剂或其药学上可接受的盐,其中R是任选取代的苯基,吡啶基,噻吩基或萘基; R 1是氢或烷基; R 2是取代的苯基,取代的杂芳基,芴基,二苯甲基或任选取代的苯基或杂芳基烷基; R 3是氢,烷基,烷氧基烷基,环烷基,环烷基烷基或任选取代的苯基,苯基烷基,萘基,萘基烷基,杂芳基或杂芳基烷基; R 4,R 5和R 7是氢或烷基; R 6是氢,烷基或链烯基; 公开了用于治疗HIV,实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎症性肠病,特应性皮炎,牛皮癣,哮喘,过敏或多发性硬化的新型化合物,以及包含它们的药物组合物 ,以及本发明的CCR5拮抗剂与可用于治疗HIV的抗病毒剂或可用于治疗炎性疾病的药剂的组合。
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公开(公告)号:US08114879B2
公开(公告)日:2012-02-14
申请号:US12055900
申请日:2008-03-26
申请人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin , Eric Gilbert , Marc A. Labroli
发明人: Bahige M. Baroudy , John W. Clader , Hubert B. Josien , Stuart W. McCombie , Brian A. McKittrick , Michael W. Miller , Bernard R. Neustadt , Anandan Palani , Elizabeth M. Smith , Ruo Steensma , Jayaram R. Tagat , Susan F. Vice , Mark A. Laughlin , Eric Gilbert , Marc A. Labroli
IPC分类号: A61K31/497 , C07D403/00
CPC分类号: C07D401/06 , A61K31/496 , A61K45/06 , C07D211/58 , C07D401/10 , C07D401/12 , C07D405/12 , C07D409/06 , C07D413/06 , A61K2300/00
摘要: The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1 is hydrogen or alkyl; R2 is substituted phenyl, substituted heteroaryl, naphthyl fluorenyl, diphenylmethyl or optionally substituted phenyl- or heteroaryl-alkyl; R3 is hydrogen, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, or optionally substituted phenyl, phenylalkyl, naphthyl, naphthylalkyl, heteroaryl or heteroarylalkyl; R4, R5 and R7 are hydrogen or alkyl; R6 is hydrogen, alkyl or alkenyl; for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis is disclosed, as well as novel compounds, pharmaceutical compositions comprising them, and the combination of CCR5 antagonists of the invention in combination with antiviral agents useful in the treatment of HIV or agents useful in the treatment of inflammatory diseases.
摘要翻译: 使用下式的CCR5拮抗剂或其药学上可接受的盐,其中R是任选取代的苯基,吡啶基,噻吩基或萘基; R1是氢或烷基; R 2是取代的苯基,取代的杂芳基,芴基,二苯基甲基或任选取代的苯基或杂芳基 - 烷基; R 3是氢,烷基,烷氧基烷基,环烷基,环烷基烷基或任选取代的苯基,苯基烷基,萘基,萘基烷基,杂芳基或杂芳基烷基; R4,R5和R7是氢或烷基; R6是氢,烷基或烯基; 公开了用于治疗HIV,实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎症性肠病,特应性皮炎,牛皮癣,哮喘,过敏或多发性硬化的新型化合物,以及包含它们的药物组合物 ,以及本发明的CCR5拮抗剂与可用于治疗HIV的抗病毒剂或可用于治疗炎性疾病的药剂的组合。
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