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公开(公告)号：US20070172902A1
公开(公告)日：2007-07-26
申请号：US11473280
申请日：2006-06-21
申请人： Zhen Zhang , Daniel Chan , Eric Fung , Zheng Wang , Fujun Zhang
发明人： Zhen Zhang , Daniel Chan , Eric Fung , Zheng Wang , Fujun Zhang
IPC分类号： G01N33/574 , G06F19/00
CPC分类号： G01N33/57449 , G01N2333/52
摘要： The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.
摘要翻译： 本发明提供了一种可用于鉴定患者卵巢癌状态的基于蛋白质的生物标志物。 特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌或非卵巢癌。 可通过SELDI质谱法检测生物标志物。
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公开(公告)号：US20100075342A1
公开(公告)日：2010-03-25
申请号：US12384246
申请日：2009-04-02
申请人： Zhen Zhang , Daniel W. Chan , Eric T. Fung , Zheng Wang , Fujun Zhang
发明人： Zhen Zhang , Daniel W. Chan , Eric T. Fung , Zheng Wang , Fujun Zhang
IPC分类号： G01N33/50 , G01N33/53 , G01N33/573 , G01N33/543 , G01N33/574 , A61K38/16 , A61P35/00
CPC分类号： G01N33/57449 , G01N2333/52
摘要： The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarker can be detected by SELDI mass spectrometry.
摘要翻译： 本发明提供了一种可用于鉴定患者卵巢癌状态的基于蛋白质的生物标志物。 特别地，本发明的生物标志物可用于将受试者样品分类为卵巢癌或非卵巢癌。 可通过SELDI质谱法检测生物标志物。
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公开(公告)号：US20050059013A1
公开(公告)日：2005-03-17
申请号：US10635308
申请日：2003-08-05
申请人： Daniel Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
IPC分类号： A61B20060101 , C07H21/02 , C07H21/04 , C07K14/81 , C12P19/34 , C12Q1/25 , C12Q1/68 , G01N20060101 , G01N30/72 , G01N30/96 , G01N33/48 , G01N33/52 , G01N33/574 , G06F19/00
CPC分类号： G01N33/543 , G01N33/57449 , Y10S435/807 , Y10S435/967 , Y10S435/973 , Y10S436/811 , Y10S436/813 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/255
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译： 本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。 本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。
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公开(公告)号：US20050095611A1
公开(公告)日：2005-05-05
申请号：US10836649
申请日：2004-04-30
申请人： Daniel Chan , Zhen Zhang , Jens Koopmann , Michael Goggins , C. White , Eric Fung , Xiao-Ying Meng
发明人： Daniel Chan , Zhen Zhang , Jens Koopmann , Michael Goggins , C. White , Eric Fung , Xiao-Ying Meng
IPC分类号： C12Q20060101 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/57438 , C12Q1/6886 , C12Q2600/158
摘要： The present invention relates to a method of qualifying pancreatic cancer status in a subject comprising: (a) measuring at least one of the disclosed biomarkers in a sample from the subject and (b) correlating the measurement with pancreatic cancer status. The invention further relates to kits for qualifying pancreatic cancer status in a subject.
摘要翻译： 本发明涉及一种在受试者中鉴定胰腺癌状态的方法，包括：（a）测量来自受试者的样品中所公开的生物标志物中的至少一种和（b）将测量与胰腺癌状态相关联。 本发明还涉及用于在受试者中鉴定胰腺癌状态的试剂盒。
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公开(公告)号：US20070054329A1
公开(公告)日：2007-03-08
申请号：US11373833
申请日：2006-03-10
申请人： Eric Fung , Robert Bast , Daniel Chan , Jin Song , Valdimir Podust , Zhen Zhang
发明人： Eric Fung , Robert Bast , Daniel Chan , Jin Song , Valdimir Podust , Zhen Zhang
IPC分类号： G01N33/574
CPC分类号： G01N33/6851 , G01N33/57442 , G01N33/57449 , G01N33/68 , G01N33/74 , G01N2500/00
摘要： The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying ovarian cancer status as well as endometrical cancer status in a patient. In particular, it has been found that hepcidin is a biomarker for both ovarian cancer and endometrial cancer and that a panel of biomarkers, including hepcidin, transthyretin and optionally other markers are useful to classify a subject sample as ovarian cancer or non-ovarian cancer. The biomarkers can be detected by SELDI mass spectrometry.
摘要翻译： 本发明提供了可用于鉴定卵巢癌状态以及患者中子宫内膜癌状态的基于蛋白质的生物标志物和生物标志物组合。 特别地，已经发现，铁调素是卵巢癌和子宫内膜癌的生物标志物，并且一组生物标志物，包括铁调素，转甲状腺素蛋白和任选的其他标记物可用于将受试者样品分类为卵巢癌或非卵巢癌。 生物标志物可以通过SELDI质谱检测。
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公开(公告)号：US20120220476A1
公开(公告)日：2012-08-30
申请号：US13372137
申请日：2012-02-13
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
CPC分类号： G06F19/34 , G01N33/57449
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译： 本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。 本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。
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公开(公告)号：US20120046185A1
公开(公告)日：2012-02-23
申请号：US13204566
申请日：2011-08-05
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung
IPC分类号： C40B30/04 , H01J49/26 , C07K16/18 , G01N33/574 , C07K16/30
CPC分类号： G01N33/57449
摘要： The present invention provides a panel of protein-based biomarkers that are useful in diagnosing ovarian cancer in a subject. In particular, the panel of biomarkers of the invention are useful to classify a subject sample as having ovarian cancer or non-ovarian cancer.
摘要翻译： 本发明提供了一组可用于诊断受试者卵巢癌的基于蛋白质的生物标志物。 特别地，本发明的生物标志物组对于将受试者样品分类为具有卵巢癌或非卵巢癌是有用的。
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公开(公告)号：US08682591B2
公开(公告)日：2014-03-25
申请号：US13372137
申请日：2012-02-13
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
CPC分类号： G06F19/34 , G01N33/57449
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译： 本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。 本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。
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公开(公告)号：US20110033867A1
公开(公告)日：2011-02-10
申请号：US12586462
申请日：2009-09-21
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
IPC分类号： G01N33/68 , C12Q1/37 , G01N33/566 , C07K14/81
CPC分类号： G01N33/543 , G01N33/57449 , Y10S435/807 , Y10S435/967 , Y10S435/973 , Y10S436/811 , Y10S436/813 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/255
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译： 本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。 本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。
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公开(公告)号：US07605003B2
公开(公告)日：2009-10-20
申请号：US10635308
申请日：2003-08-05
申请人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
发明人： Daniel W. Chan , Zhen Zhang , Eric Fung , Xiao-Ying Meng
CPC分类号： G01N33/543 , G01N33/57449 , Y10S435/807 , Y10S435/967 , Y10S435/973 , Y10S436/811 , Y10S436/813 , Y10S436/815 , Y10S436/824 , Y10S436/825 , Y10T436/24 , Y10T436/255
摘要： The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the measurement with ovarian cancer status. The invention further relates to kits for qualifying ovarian cancer status in a subject.
摘要翻译： 本发明涉及一种在受试者中鉴定卵巢癌状态的方法，包括：（a）测量来自受试者的样品中的至少一种生物标志物，和（b）将测量与卵巢癌状态相关联。 本发明还涉及用于在受试者中鉴定卵巢癌状态的试剂盒。
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