摘要:
The invention provides a method of electrically detecting a biological analyte molecule by means of a pair of electrodes. The electrodes are arranged at a distance from one another within a sensing zone. A capture molecule, which has an affinity to the analyte molecule and which is capable of forming a complex with the analyte molecule, is immobilised on an immobilisation unit. The immobilisation unit is contacted with a solution suspected to comprise the analyte molecule. The analyte molecule is allowed to form a complex with the capture molecule. The invention also provides a probe defined by a nanoparticulate tag that comprises or consists of electrically conducting matter that is capable of chemically interacting with the analyte molecule. In the method of the invention the electrically conducting nanoparticulate tag is added. Thereby the electrically conducting nanoparticulate tag is allowed to associate to the complex formed between the capture molecule and the analyte molecule. The presence of the analyte molecule is determined based on an electrical characteristic, influenced by the electrically conducting nanoparticulate tag, of a region in the sensing zone.
摘要:
The method is performed by means of a pair of electrodes that are arranged at a distance and within a sensing zone. A nucleic acid capture molecule with an uncharged backbone and a nucleotide sequence that is at least partially complementary to at least a portion of a strand of the target nucleic acid molecule, is immobilised on an immobilisation unit. The immobilisation unit, which is arranged within the sensing zone, is contacted with a solution suspected to comprise the target nucleic acid molecule, which hybridizes to the nucleic acid capture molecule. An activation agent is added, which has an electrostatic net charge complementary to the net charge of the target nucleic acid molecule. It associates to the complex of nucleic acid capture molecule and target nucleic acid molecule. Added is a water soluble polymer with at least one polymer strand and with an electrostatic net charge that is complementary to the net charge of the activation agent. Thus the polymer associates to the activation agent. A metal salt is added, which can act as an oxidant and the metal ions of which have an electrostatic net charge complementary to the net charge of the polymer. The metal ions associate to the polymer. Upon adding a reducing agent, the latter reduces the metal ions, forming a metal wire. The presence of the analyte molecule is determined based on an electrical characteristic of a region in the sensing zone that is affected by the metal wire.
摘要:
The present invention relates to a color LCOS display chip and the drive and control method thereof. With new structure design and drive and control method, the video signal nonlinear correcting chip, display drive signal control chip and other high cost special chips which are used in conventional control and drive circuit are abandoned. Multiple systems are integrated in a single chip to save PCB required for combination of multi-system chips, which leads to a lower production cost. The weight and size of control and drive circuit are reduced due to fewer integrated circuit chips and save of PCB. Power consumption is reduced without nonlinear correcting chips and display drive signal control chips. With the finite state machine (FSM) Scheduler as the core of digital signal processing module, the voltage coding value could be adjusted as per nonlinear characteristics of different crystal materials so as to achieve an optimal nonlinear correcting performance, which enhances the universality of the chip.
摘要:
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.
摘要:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-II, Rsk1, SGK, TrkA, TrkB and TrkC kinases.
摘要:
The present invention relates to immunosuppressant, process for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction.
摘要:
The present invention relates to immunosuppressants, processes for their production, their uses and pharmaceutical compositions containing them. The invention provides a novel class of compounds useful in the treatment or prevention of diseases or disorders mediated by lymphocyte interactions, particularly diseases associated with EDG receptor mediated signal transduction. This application relates to compounds selected from Formula (Ia), (Ib), (Ic) and (Id).
摘要:
The present invention relates to a method of wirelessly transmitting and receiving audio digital signals of the type having a first plurality of blocks with each block having a second plurality of frames, with each frame having a third plurality of subframes, with each subframe having a preamble and a binary data. The method efficiently transmits and recomposes the digital audio signals by searching for the preamble associated with a subframe, which is the first subframe of a frame, with the frame being the first frame of a block, and then transmitting wirelessly only the binary data of each subframe, in each frame, in each block thereafter. In a preferred embodiment, the protocol for the transmission of data calls for each data packet that is transmitted to consist of 512 bytes. The data packet transmitted by the transmitter must be acknowledged by the transmission of an acknowledgement (ACK) packet from the receiver. In the event, the data packet is not received and/or the ACK packet is not received, and transmission must recommence, synchronization is accomplished by the retransmission of data packet immediately after the preamble of the first subframe of the first frame of a block.
摘要:
The present invention relates to a wireless data system which has a transmitter including a transmission buffer. The transmitter is configured to transmit a plurality of packets of encoded data, wherein a level of the transmission buffer is encoded in one of the packets of encoded data. The system further has a wireless receiver for receiving the plurality of packets. The receiver has at least one receiving component that receives the plurality of packets to generate a plurality of decoded signals, wherein the at least one receiving component is configured to receive one of the packets of encoded data from the transmitter to determine the level of transmission buffer. The receiving component is further configured to store the plurality of packets received in a receive buffer, to determine the level of the receive buffer, and to calculate an aggregate buffer level from the transmission buffer and the receive buffer. The receiver controls a packet output rate from the receive buffer to maintain the aggregate buffer level at a desired level.
摘要:
An antenna designing method and a data single board of a wireless terminal are disclosed. The method provided by the embodiments of the present invention includes: dividing a semi-closed area without other metal wirings on a data card single board of the wireless terminal; and arranging an antenna wiring and a metal coupling piece in the semi-closed area, where the antenna wiring and the metal coupling piece are parallel and overlap one another, a gap exists between the metal coupling piece and the data card single board, and the metal coupling piece is coupled with the data card single board via the gap. An embodiment of the present invention also provides a data card single board of a wireless terminal. According to the embodiments of the present invention, a Specific Absorption Rate (SAR) value of the antenna is reduced, and a working bandwidth of a broadband is realized.