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    METHOD OF DETECTING GENOMIC ABERRATIONS FOR PRENATAL DIAGNOSIS
    3.
    发明申请
    METHOD OF DETECTING GENOMIC ABERRATIONS FOR PRENATAL DIAGNOSIS 审中-公开
    检测基因治疗对于临床诊断的方法

    公开(公告)号：US20100015619A1

    公开(公告)日：2010-01-21

    申请号：US12445516

    申请日：2007-09-21

    申请人： Hongtao Zhang ,  Ning Liu ,  Zhong Chen

    发明人： Hongtao Zhang ,  Ning Liu ,  Zhong Chen

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6883 ,  C12Q2600/16

    摘要： This invention relates to assays used to detect and confirm genomic aberrations, such as chromosomes 13, 18, 21, X and Y aneuploidy as well as 22q11.2 deletions, for prenatal diagnosis. For the detection, combined STR markers (all tetra-nucleotide repeats) are employed to cover different chromosome regions. For the confirmation step, individual chromosome specific STR markers (tetra-nucleotide repeats) are utilized. This invention particularly relates to multiplex analysis for the presence or absence of STR markers in genomic DNA isolated from peripheral blood, amniotic fluid, cultured amniocytes, chorionic villi, or fetal cells existing in maternal blood. This invention offers an efficient approach to identify chromosomal abnormalities by using STR markers.

    摘要翻译： 本发明涉及用于检测和确认基因组畸变的测定法，例如染色体13,18,21，X和Y非整倍性以及22q11.2缺失，用于产前诊断。 为了检测，使用组合的STR标记（全部四核苷酸重复）来覆盖不同的染色体区域。 对于确认步骤，使用个体染色体特异性STR标记（四核苷酸重复）。 本发明特别涉及从外周血，羊水，培养的羊膜细胞，绒毛膜绒毛或存在于母体血液中的胎儿细胞分离的基因组DNA中存在或不存在STR标记的多重分析。 本发明提供了通过使用STR标记鉴定染色体异常的有效方法。

    METHOD TO ASSESS CANCER SUSCEPTIBILITY AND DIFFERENTIAL DIAGNOSIS OF METASTASES OF UNKNOWN PRIMARY TUMORS
    5.
    发明申请
    METHOD TO ASSESS CANCER SUSCEPTIBILITY AND DIFFERENTIAL DIAGNOSIS OF METASTASES OF UNKNOWN PRIMARY TUMORS 审中-公开
    评估癌症可疑性的方法和未知原发性肿瘤的病变的差异诊断

    公开(公告)号：US20100086920A1

    公开(公告)日：2010-04-08

    申请号：US12441344

    申请日：2007-07-27

    申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

    发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： G01N33/54373 ,  G01N33/544 ,  G01N33/553 ,  G01N33/57473

    摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a serum sample, which can be used to screen for and determine susceptibility to cancer as well as for the differential diagnosis of metastases from an unknown primary tumor. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of monoclonal antibodies used for cancer susceptibility assessment and for differential diagnosis of metastases from an unknown primary tumor.

    摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同肿瘤标志物的浓度，可用于筛选和确定对癌症的易感性以及来自未知原发肿瘤的转移的鉴别诊断。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于用于癌症易感性评估的单克隆抗体的固定以及来自未知的转移的鉴别诊断是有益的 原发性肿瘤。

    METHOD FOR THE QUANTITATIVE EVALUATION OF SEX HORMONES IN A SERUM SAMPLE
    6.
    发明申请
    METHOD FOR THE QUANTITATIVE EVALUATION OF SEX HORMONES IN A SERUM SAMPLE 失效
    用于定量评估血清样品中的性别的方法

    公开(公告)号：US20100009464A1

    公开(公告)日：2010-01-14

    申请号：US12442379

    申请日：2007-09-17

    申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

    发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

    IPC分类号： G01N33/53 ,  G01N27/00

    CPC分类号： G01N33/54373 ,  G01N2800/36 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/814 ,  Y10S436/817

    摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different sex hormones in a serum sample, which can be used to evaluate different clinical situations. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative sex hormones in a serum sample.

    摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同性激素的浓度，可用于评估不同临床情况。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测血清样品中代表性性激素的相关抗体。

    METHOD FOR QUANTITATIVE MEASUREMENT OF CARDIAC BIOCHEMICAL MARKERS
    7.
    发明申请
    METHOD FOR QUANTITATIVE MEASUREMENT OF CARDIAC BIOCHEMICAL MARKERS 审中-公开
    心脏生物化学标记物定量测定方法

    公开(公告)号：US20100004872A1

    公开(公告)日：2010-01-07

    申请号：US12442378

    申请日：2007-09-07

    申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

    发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

    IPC分类号： G06F19/00 ,  G01N21/55

    CPC分类号： G01N33/6893 ,  G01N2800/32 ,  G01N2800/325

    摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different cardiac biochemical markers in a serum sample, which can be used for the early diagnosis of cardiovascular diseases and myocardial infarction. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative cardiac biochemical markers in a serum sample.

    摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同心脏生化标志物的浓度，可用于心血管疾病和心肌梗死的早期诊断。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测血清样品中代表性心脏生化标志物的相关抗体。

    METHOD FOR QUANTITATIVE DETECTION OF DIABETES RELATED IMMUNOLOGICAL MARKERS
    8.
    发明申请
    METHOD FOR QUANTITATIVE DETECTION OF DIABETES RELATED IMMUNOLOGICAL MARKERS 失效
    定量检测糖尿病相关免疫标记物的方法

    公开(公告)号：US20090325190A1

    公开(公告)日：2009-12-31

    申请号：US12441530

    申请日：2007-09-17

    申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

    发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

    IPC分类号： G01N33/53

    CPC分类号： G01N33/553 ,  G01N33/54373 ,  G01N2800/042 ,  Y10S435/808 ,  Y10S436/805

    摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the detection of respective diabetes related immunological makers in a serum sample.

    摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中糖尿病相关免疫学家的浓度，可用于诊断和/或早期诊断糖尿病，并预测一级亲属糖尿病的发病风险 。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定相关抗原和抗体，用于检测相应的糖尿病相关免疫学家 血清样品。

    METHOD OF SURFACE PLASMON RESONANCE (SPR) TECHNOLOGY TO DETECT GENOMIC DISORDERS FOR PRENATAL DIAGNOSIS
    9.
    发明申请
    METHOD OF SURFACE PLASMON RESONANCE (SPR) TECHNOLOGY TO DETECT GENOMIC DISORDERS FOR PRENATAL DIAGNOSIS 审中-公开
    表面等离子共振（SPR）技术检测基因治疗疾病进行临床诊断的方法

    公开(公告)号：US20100279422A1

    公开(公告)日：2010-11-04

    申请号：US12438333

    申请日：2007-08-14

    申请人： Zhong Chen ,  Ning Liu

    发明人： Zhong Chen ,  Ning Liu

    IPC分类号： G01N33/50 ,  G01N21/21

    CPC分类号： G01N33/54373 ,  C12Q1/6883 ,  G01N21/553 ,  G01N33/553 ,  G01N2800/385 ,  Y10T436/143333

    摘要： The present invention discloses using SPR technology to prenatally detect specific DNA loss or gain related to some genomic disorders. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of chromosome numerical abnormalities (such as chromosomes 13, 18, 21, X and Y related anomalies) and chromosome microdeletion syndromes (such as DiGeorge syndrome, etc) is also disclosed.

    摘要翻译： 本发明公开了使用SPR技术预先检测与某些基因组紊乱相关的特定DNA损失或增益。 制备混合SAM的有效配方可以大大增强金属表面在基于SPR的技术中的固定能力，这有助于固定用于鉴定染色体数值异常的DNA标记（如染色体13,18,21 ，X和Y相关异常）和染色体微缺失综合征（如DiGeorge综合征等）也被公开。

    METHOD TO DETECT TUMOR MARKERS AND DIAGNOSIS OF UNDIFFERENTIATED TUMORS
    10.
    发明申请
    METHOD TO DETECT TUMOR MARKERS AND DIAGNOSIS OF UNDIFFERENTIATED TUMORS 审中-公开
    检测肿瘤标志物和诊断不良肿瘤的方法

    公开(公告)号：US20100047815A1

    公开(公告)日：2010-02-25

    申请号：US12441357

    申请日：2007-08-07

    申请人： Zhong Chen ,  Ning Liu ,  Yancun Li

    发明人： Zhong Chen ,  Ning Liu ,  Yancun Li

    IPC分类号： G01N33/53

    CPC分类号： G01N33/57492 ,  G01N33/54373

    摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a protein sample extracted from tumor tissue, which can be used for the diagnosis of undifferentiated tumors. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of monoclonal antibodies used for detecting tumor markers in a tumor tissue sample and for the diagnosis of undifferentiated tumors.

    摘要翻译： 本发明公开了使用SPR技术同时并定量测定从肿瘤组织提取的蛋白质样品中不同肿瘤标志物的浓度，可用于诊断未分化肿瘤。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于肿瘤标志物在肿瘤组织样品中检测的单克隆抗体和诊断 的未分化肿瘤。