公开(公告)号：US20210257075A1

公开(公告)日：2021-08-19

申请号：US17260423

申请日：2019-07-15

申请人： KALEO, INC.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Paul F. MEYERS ,  Michael J. ROE ,  Pawan P. SHROFF ,  John W. Quillen, JR.

IPC分类号： G16H20/17 ,  G16H40/67 ,  A61M5/315 ,  A61M5/142 ,  A61M5/172 ,  A61M5/20 ,  A61M15/00 ,  A61M15/08

摘要： A computer-implemented method includes receiving a signal associated with a characteristic of an actuation event of a medicament delivery device. The method includes establishing a communications link (e.g., via a short-range wireless protocol), between a mobile computing device and a medicament delivery device. A wireless first signal associated with a first motion profile of the medicament delivery device is then received from the medicament delivery device. A second signal associated with a second motion profile of the mobile computing device is generated. The method then includes producing a notification via the mobile computing device when A) a magnitude of the first motion profile is outside of a first threshold and B) a magnitude of the second motion profile is outside of a second threshold.

公开(公告)号：US20210093786A1

公开(公告)日：2021-04-01

申请号：US17085761

申请日：2020-10-30

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Glen L. KELLEY ,  Paul F. MEYERS

IPC分类号： A61M5/20 ,  A61M5/32 ,  A61K31/137 ,  A61M5/24

摘要： A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

公开(公告)号：US20190358399A1

公开(公告)日：2019-11-28

申请号：US16071203

申请日：2017-12-21

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Glen L. KELLEY ,  Paul F. MEYERS

IPC分类号： A61M5/20 ,  A61K31/137 ,  A61M5/24 ,  A61M5/32 ,  A61M5/315

摘要： A method of delivering epinephrine includes placing a distal end surface of a medical injector into contact with a target location of a patient. The medical injector includes a housing, an energy storage member, and a medicament container containing a dose of epinephrine effective for administration to the patient experiencing anaphylaxis and having a weight of less than 15 kg. The medicament container is coupled to a needle. The medical injector is actuated such that the energy storage member produces a force to move the needle from a first needle position to a second needle position. A distal tip of the needle extends from the distal end surface by a distance of between 7 millimeters and 8 millimeters when the needle is in the second needle position. A portion of the force is exerted to expel the dose of epinephrine when the needle is in the second position.

公开(公告)号：US20190279756A1

公开(公告)日：2019-09-12

申请号：US16421639

申请日：2019-05-24

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Paul F. MEYERS ,  Samuel Jefferson BRIGGS ,  George McGee Perkins ,  Eugene Johannes VAN WYK ,  Mitchell Frederick BURKE ,  Eric William SCAMMELL

IPC分类号： G16H20/17 ,  G16H40/67

摘要： A computer-implemented method includes establishing a communications link, via a short-range wireless protocol, between a mobile computing device and a medicament delivery device. A user input selecting a motion profile of the medicament delivery device is then received in response to an input prompt. A wireless signal is received from the medicament delivery device, the wireless signal associated with an actual motion profile of the medicament delivery device. A notification is produced to indicate a motion difference between the actual motion profile and the target motion profile. In some embodiments, the method optionally includes modifying the target motion profile based on the motion profile over a time period of at least one week, the notification indicating a motion difference between the motion profile and the modified target motion profile.

公开(公告)号：US20190030247A1

公开(公告)日：2019-01-31

申请号：US16145873

申请日：2018-09-28

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Mark J. LICATA ,  Paul F. MEYERS ,  David A. WEINZIERL ,  T. Spencer WILLIAMSON, IV

IPC分类号： A61M5/20 ,  G06F19/00 ,  A61M15/00

摘要： A system includes a medicament delivery device and a container configured to receive at least a portion of the medicament delivery device. The medicament delivery device includes an actuator and a first electronic circuit system. The actuator is configured to initiate delivery of a medicament into a body when the actuator is moved from a first position to a second position. The first electronic circuit system is configured to output a first electronic signal when the actuator is moved from the first position to the second position. The container includes a second electronic circuit system configured to receive the first electronic signal. The second electronic circuit system is configured to output a second electronic signal associated with the first electronic signal.

公开(公告)号：US20180369506A1

公开(公告)日：2018-12-27

申请号：US16119103

申请日：2018-08-31

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Mark J. LICATA ,  Paul F. MEYERS ,  David A. WEINZIERL

IPC分类号： A61M5/50 ,  G09B23/28 ,  A61M15/00 ,  G16H20/17 ,  A61M5/20 ,  A61M5/31 ,  A61M5/32 ,  A61M5/24

摘要： Medicament delivery devices are described herein. In some embodiments, an apparatus includes a medical injector and an electronic circuit system. The medical injector includes a housing, a medicament container, and a medicament delivery member. The housing defines a first region and a second region. The first region includes the medicament container and is physically isolated from the second region. The electronic circuit system is configured to be disposed within the second region defined by the housing. The electronic circuit system is configured to output an electronic output associated with a use of the medical injector.

公开(公告)号：US20170232206A1

公开(公告)日：2017-08-17

申请号：US15371515

申请日：2016-12-07

申请人： kaleo, Inc.

发明人： Frank E. BLONDINO ,  Eric S. EDWARDS ,  Evan T. EDWARDS ,  Glen L. KELLEY ,  Paul F. MEYERS

IPC分类号： A61M5/32 ,  A61K9/00 ,  A61K31/485 ,  A61M11/02 ,  A61M5/20

CPC分类号： A61M5/3234 ,  A61K9/0019 ,  A61K31/485 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/3287 ,  A61M11/02 ,  Y02A50/465

摘要： An apparatus includes a container, a needle, and an actuation assembly. The container contains a dose of a naloxone composition having a delivered volume of at least about 0.34 mL. The actuation assembly includes an energy storage member that produces a force on a movable member to move the needle and to deliver the dose of the naloxone composition. The 90% confidence interval of at least one of the relative mean maximum naloxone plasma concentration after dose delivery into the body (Cmax), time to reach the maximum naloxone plasma concentration (Tmax), area under the plasma concentration-time curve from pre-dose (time 0) extrapolated to infinity (AUC0-∞), or area under the plasma concentration-time curve from pre-dose (time 0) to the time of the last quantifiable concentration (Tlast) (AUC0-t) of the delivered dose to a delivered dose of a corresponding naloxone composition delivered via a manually-actuated syringe is within 80% to 125%.

公开(公告)号：US20160235916A1

公开(公告)日：2016-08-18

申请号：US15139826

申请日：2016-04-27

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Mark J. LICATA ,  Paul F. MEYERS ,  David A. WEINZIERL ,  T. Spencer WILLIAMSON, IV

IPC分类号： A61M5/20 ,  A61M15/00

CPC分类号： A61M5/20 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/24 ,  A61M5/2448 ,  A61M5/3129 ,  A61M5/315 ,  A61M5/3204 ,  A61M5/326 ,  A61M15/0001 ,  A61M15/008 ,  A61M15/009 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2005/314 ,  A61M2205/14 ,  A61M2205/3331 ,  A61M2205/3368 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/43 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/6018 ,  A61M2205/6036 ,  A61M2205/8206 ,  G06F19/00 ,  G06F19/3468

摘要： A system includes a medicament delivery device and a container configured to receive at least a portion of the medicament delivery device. The medicament delivery device includes an actuator and a first electronic circuit system. The actuator is configured to initiate delivery of a medicament into a body when the actuator is moved from a first position to a second position. The first electronic circuit system is configured to output a first electronic signal when the actuator is moved from the first position to the second position. The container includes a second electronic circuit system configured to receive the first electronic signal. The second electronic circuit system is configured to output a second electronic signal associated with the first electronic signal.

公开(公告)号：US20150231336A1

公开(公告)日：2015-08-20

申请号：US14605512

申请日：2015-01-26

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Mark J. LICATA ,  Paul F. MEYERS ,  Frank E. BLONDINO

IPC分类号： A61M5/31

CPC分类号： A61M5/3129 ,  A61M5/2033 ,  A61M5/2046 ,  A61M5/3204 ,  A61M5/3232 ,  A61M11/00 ,  A61M11/007 ,  A61M15/08 ,  A61M2202/048

摘要： Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH-adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.

摘要翻译： 本文描述了用于施用阿片样物质拮抗剂的药物递送装置。 在一些实施例中，一种装置包括壳体，设置在壳体内的药物容器和设置在壳体内的能量存储构件。 该药物容器充满纳洛酮组合物，其包括纳洛酮或其盐，张力调节剂和pH调节剂，由此纳洛酮组合物的重量克分子渗透浓度范围为约250-350mOsm，pH范围为约3 -5。 能量存储构件构造成产生输送纳络酮组合物的力。

公开(公告)号：US20150190591A1

公开(公告)日：2015-07-09

申请号：US14664426

申请日：2015-03-20

申请人： kaleo, Inc.

发明人： Eric S. EDWARDS ,  Evan T. EDWARDS ,  Mark J. LICATA ,  Paul F. MEYERS ,  David A. WEINZIERL

IPC分类号： A61M5/50 ,  A61M5/20 ,  A61M35/00 ,  A61M5/32 ,  A61M15/00

CPC分类号： A61M15/009 ,  A61M5/14244 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/2053 ,  A61M5/3129 ,  A61M5/3202 ,  A61M5/3204 ,  A61M5/3234 ,  A61M5/326 ,  A61M5/3287 ,  A61M5/5086 ,  A61M35/00 ,  A61M2005/206 ,  A61M2005/2073 ,  A61M2205/50 ,  A61M2205/502 ,  A61M2205/581 ,  A61M2205/582 ,  A61M2205/583 ,  A61M2205/587 ,  A61M2205/8206 ,  G06F19/00 ,  G06F19/3456

摘要： An apparatus includes a label configured to be coupled to a medicament delivery device. The label includes a first surface and a second surface. The first surface is configured to be coupled to an outer surface of the medicament delivery device. The second surface includes a textual indicia. The label further includes an electronic circuit system configured to output an electronic signal.

摘要翻译： 一种装置包括被配置为联接到药物输送装置的标签。 标签包括第一表面和第二表面。 第一表面被配置为联接到药物输送装置的外表面。 第二个表面包括文字标记。 标签还包括被配置为输出电子信号的电子电路系统。