公开(公告)号：US12216343B2

公开(公告)日：2025-02-04

申请号：US18508894

申请日：2023-11-14

Applicant: ACUCELA INC.

Inventor： Ryo Kubota ,  Philip M. Buscemi ,  Pascal Loser ,  Ben Crook ,  Massimo Pinazza ,  Jim Niebanck ,  James Phillips ,  Stefan Bauer

IPC: G02C11/00 ,  G02C5/14 ,  G02C7/08

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US20240411155A1

公开(公告)日：2024-12-12

申请号：US18812767

申请日：2024-08-22

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Stefan BAUER ,  Benjamin CROOK ,  Julien SAUVET

IPC: G02C7/08 ,  G02C7/02 ,  G02C7/06 ,  G02C7/10 ,  G02C7/14

Abstract: An apparatus to treat refractive error of an eye comprises an optic comprising an optical zone and a peripheral defocus optical structure to form images of a plurality of stimuli anterior or posterior to a peripheral portion of a retina of the eye. In some embodiments, the peripheral defocus optical structure located outside the optical zone. In some embodiments, the peripheral defocus optical structure comprises optical power to focus light to a different depth of the eye than the optical zone. In some embodiments, the optic comprises one or more of a lens, an optically transparent substrate, a beam splitter, a prism, or an optically transmissive support.

公开(公告)号：US20240308951A1

公开(公告)日：2024-09-19

申请号：US18379142

申请日：2023-10-11

Applicant: Acucela Inc.

Inventor： Claes Olof BAVIK ,  Susan Hayes HENRY ,  Ryo KUBOTA ,  Vladimir A. KUKSA

IPC: C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

CPC classification number: C07C215/08 ,  A61K31/137 ,  A61K31/138 ,  A61K31/35 ,  A61K31/765 ,  A61K45/06 ,  C07C211/27 ,  C07C217/20 ,  C07C323/32 ,  C07D309/06

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US20240264472A1

公开(公告)日：2024-08-08

申请号：US18637705

申请日：2024-04-17

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Amitava GUPTA

IPC: G02C7/08 ,  G02F1/29

CPC classification number: G02C7/083 ,  G02F1/294 ,  G02C2202/24

Abstract: An apparatus to treat refractive error of an eye comprises an electroactive component configured to switch between a light scattering or optical power providing configuration to treat refractive error of the eye and a substantially transparent configuration to allow normal viewing. The electroactive component can be located on the lens away from a central axis of the lens to provide light to a peripheral region of the retina to decrease the progression of myopia. The electroactive component can be located on the lens away from the central axis of the lens in order for the wearer to view objects through an optical zone while the electroactive component scatters light. The electroactive component can be configured to switch to the substantially transparent configuration to allow light to pass through the electroactive component and to allow the lens to refract light to correct vision and allow normal viewing through the lens.

公开(公告)号：US20240103300A1

公开(公告)日：2024-03-28

申请号：US18508894

申请日：2023-11-14

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Philip M. BUSCEMI ,  Pascal LOSER ,  Ben CROOK ,  Massimo PINAZZA ,  Jim NIEBANCK ,  James PHILLIPS ,  Stefan BAUER

IPC: G02C7/08 ,  G02C5/14 ,  G02C11/00

CPC classification number: G02C7/083 ,  G02C5/146 ,  G02C11/10 ,  G02C2200/08

Abstract: An electronic case for electronic spectacles may include a base comprising a cavity formed therein. A first spectacle retention device may be located within the cavity. The first spectacle retention device may be configured to retain spectacles. An electrical control system may be included. An electrical connector may be configured to couple the electrical control system in electronic communication with the spectacles.

公开(公告)号：US11896308B2

公开(公告)日：2024-02-13

申请号：US18064422

申请日：2022-12-12

Applicant: ACUCELA INC.

Inventor： Christian Oggenfuss ,  Karim Haroud ,  Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota ,  Philip Buscemi

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/13

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/1005 ,  A61B3/132 ,  A61B2560/0431 ,  A61B2562/0214 ,  A61B2562/0257 ,  A61B2562/223

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US11890053B2

公开(公告)日：2024-02-06

申请号：US18177993

申请日：2023-03-03

Applicant: ACUCELA INC.

Inventor： Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B3/0025 ,  A61B3/10 ,  A61B3/1005 ,  A61B3/1225 ,  A61B5/0013 ,  G01B9/02 ,  A61B2505/07 ,  A61B2560/0425 ,  A61B2560/0431 ,  A61B2560/0456 ,  A61B2576/00

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US20230295140A1

公开(公告)日：2023-09-21

申请号：US18201715

申请日：2023-05-24

Applicant: Acucela Inc.

Inventor： Mark W. ORME ,  Edison S. ZUNIGA ,  Vladimir A. KUKSA ,  Russell Stuart CRAFT ,  Eduardo Moreno SAVEEDRA ,  Johannes Wilhelm Georg MEISSNER ,  Jacobus Antonius Joseph den HARTOG ,  Albert Cornelis DROS

IPC: C07D413/12 ,  C07D235/08 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D413/04 ,  C07D491/107

CPC classification number: C07D413/12 ,  C07D235/08 ,  C07D249/18 ,  C07D261/20 ,  C07D263/56 ,  C07D263/58 ,  C07D277/64 ,  C07D277/82 ,  C07D413/04 ,  C07D491/107

Abstract: Provided herein are compounds and methods of use thereof for the modulation of VAP-1 activity.

公开(公告)号：US20230270700A1

公开(公告)日：2023-08-31

申请号：US17934945

申请日：2022-09-23

Applicant: Acucela Inc.

Inventor： Ryo KUBOTA ,  Nancy BOMAN ,  Claes BAVIK ,  Ian L. SCOTT

IPC: A61K31/166 ,  A61K31/137 ,  A61K31/135 ,  A61K9/00 ,  A61K9/50 ,  A61K31/19 ,  A61K31/195

CPC classification number: A61K31/166 ,  A61K31/137 ,  A61K31/135 ,  A61K9/0048 ,  A61K9/5078 ,  A61K31/19 ,  A61K31/195

Abstract: Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators.

公开(公告)号：US20230241410A1

公开(公告)日：2023-08-03

申请号：US18163376

申请日：2023-02-02

Applicant: ACUCELA INC.

Inventor： Ryo KUBOTA ,  Benjamin CROOK ,  Stefan BAUER ,  Philip M. BUSCEMI ,  Amitava GUPTA ,  Jonas GERMANN

IPC: A61N5/06

CPC classification number: A61N5/0622 ,  A61N2005/0648 ,  A61N2005/0651

Abstract: A wearer adjustable apparatus is configured for a wearer to view an object and adjust stimuli projected into the eye by adjusting the location of the projection optics, for example with movement of the projection optics relative to one or more components of a support such as an eyeglass frame. In some embodiments, the projection system comprises an adjustable retainer for the wearer to adjust first active projection elements coupled to a first support in front of a first eye in relation to second projection optics coupled to a second support in front of a second eye of the wearer. In some embodiments, the apparatus comprises oculars comprising the projection optics and corrective lenses configured for the wearer to adjust positions of the lenses and projection optics in front of the wearer's eyes in order to project therapeutic spots onto a desired location relative to the wearer's retinas.