公开(公告)号：US11179324B2

公开(公告)日：2021-11-23

申请号：US15419876

申请日：2017-01-30

申请人： ALZA CORPORATION

发明人： Mahmoud Ameri ,  Michel J. N. Cormier ,  Scott Sellers ,  Yuh-Fun Maa

IPC分类号： A61K9/00 ,  A61K31/716 ,  A61K38/22 ,  A61K38/29 ,  A61M37/00 ,  A61K9/70 ,  A61K48/00 ,  A61K39/00 ,  B65B31/00 ,  B65B55/00 ,  B65B7/02 ,  B65B51/10 ,  B65D81/20 ,  B65D81/26

摘要： Compositions of and methods for formulating and delivering biologically active agent formulations having enhanced physical stability, and wherein deterioration from the presence of oxygen and/or water is minimized and/or controlled, to yield a stable formulation. The compositions of and methods for formulating and delivering biologically active agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the biologically active agents.

公开(公告)号：US20210113541A1

公开(公告)日：2021-04-22

申请号：US17128293

申请日：2020-12-21

申请人： Alza Corporation

发明人： Subramanian S. VENKATRAMAN ,  Shaoling LI ,  Robert M. GALE ,  Jane STEPIC ,  William W. VAN OSDOL

IPC分类号： A61K31/4468 ,  A61K9/70 ,  A61K9/00 ,  A61K31/4535 ,  A61K47/14 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34

摘要： A method and a non-rate controlled, monolithic, subsaturated patch for transdermally administering fentanyl and analogs thereof, for analgetic purposes, to a subject through skin over an extended period of time are disclosed.

公开(公告)号：US20160374955A1

公开(公告)日：2016-12-29

申请号：US15263923

申请日：2016-09-13

申请人： ALZA Corporation

发明人： Robert M. Gale ,  Jay Audett ,  Rama V. Padmanabhan ,  Michel J.N. Cormier ,  Allison Luciano ,  Eric N. Silverberg ,  Paul B. Foreman

IPC分类号： A61K9/70 ,  C09J133/06 ,  C09J7/02 ,  A61K31/4439

CPC分类号： A61K9/7061 ,  A61K31/4439 ,  A61K31/56 ,  C09J7/255 ,  C09J7/385 ,  C09J133/06 ,  C09J2467/006

摘要： A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine salt dissolved therein provides desirable adhesive characteristics and effective transdermal therapeutic properties.

公开(公告)号：US09522122B2

公开(公告)日：2016-12-20

申请号：US14980383

申请日：2015-12-28

申请人： ALZA Corporation

发明人： Jay Douglas Audett

IPC分类号： A61K9/14 ,  A61K9/70 ,  G09F3/10 ,  A61F13/02 ,  A61K9/00 ,  A61K31/4468 ,  G09F3/02

CPC分类号： A61K9/7092 ,  A61F13/0276 ,  A61F2013/0296 ,  A61K9/0014 ,  A61K9/703 ,  A61K9/7084 ,  A61K31/4468 ,  A61M2207/00 ,  G09F3/10 ,  G09F2003/0257 ,  Y10T428/1352

摘要： A novel backing construction for a transdermal drug delivery system is disclosed. In particular, the invention relates to a system and method for labeling a transdermal drug delivery system, wherein the backing layer contains a writable medium capable of inkless printing.

公开(公告)号：US09421351B2

公开(公告)日：2016-08-23

申请号：US11477045

申请日：2006-06-27

申请人： Joseph C. Trautman ,  Lorin Olson

发明人： Joseph C. Trautman ,  Lorin Olson

IPC分类号： A61M37/00 ,  A61B17/20 ,  A61B17/92

CPC分类号： A61M37/0015 ,  A61B17/205 ,  A61B2017/925 ,  A61M2037/0023 ,  A61M2037/0038 ,  A61M2037/0046

摘要： An applicator for applying a microprojection member to the stratum corneum of a patient having a housing, a piston moveable within the housing and a cap adapted to activate the applicator. The applicator is self-setting and auto-triggering, which allows the applicator to be used by patient's having neither the strength, nor the manual dexterity to pre-set and activate other types of applicator devices.

公开(公告)号：US09095706B2

公开(公告)日：2015-08-04

申请号：US13866371

申请日：2013-04-19

申请人： Incline Therapeutics, Inc. ,  Alza Corporation

发明人： Bradley E. White ,  John Lemke ,  Paul Hayter ,  Corinna X. Chen ,  Brian W. Read ,  Jason E. Dougherty

IPC分类号： A61M31/00 ,  A61N1/18 ,  A61N1/30 ,  A61N1/32

CPC分类号： G01R19/145 ,  A61N1/025 ,  A61N1/0416 ,  A61N1/0432 ,  A61N1/08 ,  A61N1/18 ,  A61N1/303 ,  A61N1/325 ,  A61N1/327 ,  G01R19/165 ,  G08B21/182

摘要： Electrotransport drug delivery devices, system and methods of using configured to determine if a current is present between the anode and cathode when drug is not intended to be delivered by the device. These devices/systems may include an off-current module to determine that any current (e.g., which may be inferred by measuring potential difference between the anode and cathode of the device) flowing between the anode and cathode is below a threshold value when the device is not supposed to be delivering drug, thereby preventing unintended delivery of drug and/or alerting a user that unintended delivery of drug may occur.

摘要翻译： 电传送药物递送装置，使用的系统和方法被配置为确定当药物不意图由装置递送时阳极和阴极之间是否存在电流。 这些装置/系统可以包括一个截止模块，用于确定当该装置在阳极和阴极之间流动时，在阳极和阴极之间流动的任何电流（例如，可以通过测量装置的阳极和阴极之间的电位差来推断） 不应该是递送药物，从而防止药物的意外递送和/或警告用户可能发生意外的药物递送。

公开(公告)号：US20150196754A1

公开(公告)日：2015-07-16

申请号：US14406969

申请日：2013-03-05

申请人： INCLINE THERAPEUTICS, INC. ,  ALZA CORPORATION

发明人： Bradley E. White ,  Paul Hayter ,  John Lemke ,  Scot Satre ,  Corinna X. Chen ,  Brian W. Read ,  Jason E. Dougherty

IPC分类号： A61N1/32

CPC分类号： A61N1/325 ,  A61N1/025 ,  A61N1/30

摘要： Devices, systems and methods for controlling the application of current and/or voltage to deliver drug from patient contacts of an electrotransport drug delivery device by indirectly controlling and/or monitoring the applied current without directly measuring from the cathode of the patient terminal. In particular, described herein are electrotransport drug delivery systems including constant current delivery systems having a feedback current and/or voltage control module that is isolated from the patient contacts (e.g., anodes and cathodes). The feedback module may be isolated by a transistor from the patient contacts; feedback current and/or voltage control measurements may be performed at the transistor rather than at the patient contact (e.g., cathode).

摘要翻译： 用于控制电流和/或电压的应用的装置，系统和方法，以通过间接地控制和/或监测所施加的电流而不直接从患者终端的阴极测量来输送药物从电输送药物递送装置的患者接触。 特别地，本文所描述的是电传输药物递送系统，其包括具有与患者接触（例如阳极和阴极）隔离的反馈电流和/或电压控制模块的恒流输送系统。 反馈模块可以由患者接触器的晶体管隔离; 反馈电流和/或电压控制测量可以在晶体管而不是在患者接触（例如阴极）处进行。

公开(公告)号：US20140180223A1

公开(公告)日：2014-06-26

申请号：US14192811

申请日：2014-02-27

申请人： ALZA Corporation

发明人： Robert M. Gale

IPC分类号： A61K9/70 ,  A61K31/465

CPC分类号： A61K31/465 ,  A61K9/0014 ,  A61K9/7023 ,  A61K9/703 ,  A61K9/7084 ,  A61K31/4465 ,  A61K47/32 ,  A61K47/34 ,  A61K2800/262

摘要： A transparent transdermal delivery device for delivering nicotine which has an Opacity Index of less than 48.6%.

摘要翻译： 用于输送不透明度指数小于48.6％的尼古丁的透明透皮递送装置。

公开(公告)号：US08758808B2

公开(公告)日：2014-06-24

申请号：US13776452

申请日：2013-02-25

申请人： ALZA Corporation

发明人： Jay Audett ,  Jianye Wen ,  Eli J. Goldman ,  Robert M. Gale ,  Allison Luciano ,  Paul B. Foreman ,  Eric N. Silverberg

IPC分类号： A61F13/02 ,  A61K9/70 ,  A61K31/445 ,  A61K31/4468 ,  A61K31/465 ,  C07D401/04

CPC分类号： A61K9/7061 ,  A61K9/7038 ,  A61K31/4439 ,  A61K31/465 ,  A61K31/55 ,  A61K31/567 ,  A61K31/57 ,  A61K47/32 ,  C07D401/04

摘要： A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

摘要翻译： 适用于将药物递送至个体体表的聚丙烯酸酯制剂。 通过将高浓度的药物和渗透促进剂加载到对皮肤上典型的粘合剂施加具有不良粘合性能的聚丙烯酸酯粘合剂中，可以制备具有所需粘合特性和有效治疗性质的制剂。 粘合剂具有比典型的压敏粘合剂更高的玻璃化转变温度。

公开(公告)号：US08633159B2

公开(公告)日：2014-01-21

申请号：US12716184

申请日：2010-03-02

申请人： Mahmoud Ameri ,  Michel J. N. Cormier ,  Yuh-Fun Maa ,  Marika Kamberi ,  Peter E. Daddona

发明人： Mahmoud Ameri ,  Michel J. N. Cormier ,  Yuh-Fun Maa ,  Marika Kamberi ,  Peter E. Daddona

IPC分类号： A61P5/18 ,  A61M5/30 ,  C07K14/635 ,  A61K38/16

CPC分类号： A61K38/29 ,  A61K9/0021 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。