公开(公告)号：US20240358735A1

公开(公告)日：2024-10-31

申请号：US18681728

申请日：2022-08-26

申请人： BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. ,  CORNELL UNIVERSITY

发明人： Frank C. SCHROEDER ,  Chester J. J. WROBEL ,  Brian J. CURTIS ,  Jingfang YU ,  Pedro RODRIGUES ,  Arnaud TAUFFENBERGER ,  Bingsen ZHANG ,  Aleksandra SKIRYCZ ,  Venkatesh Periyakavanam THIRUMALAIKUMAR

IPC分类号： A61K31/7076 ,  A61K31/7028 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/708 ,  A61K47/26 ,  C07H15/22 ,  C07H17/02

CPC分类号： A61K31/7076 ,  A61K31/7028 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/708 ,  A61K47/26 ,  C07H15/22 ,  C07H17/02

摘要： The invention relates to modular glucosides (MOGLs), therapeutic compositions containing such MOGLs and methods of using the same.

公开(公告)号：US12122844B2

公开(公告)日：2024-10-22

申请号：US16927675

申请日：2020-07-13

申请人： Cornell University ,  Memorial Sloan-Kettering Cancer Center

发明人： Ronald G. Crystal ,  Stephen M. Kaminsky ,  Martin J. Hicks ,  Viviane Tabar

IPC分类号： C07K16/30 ,  A61K39/00 ,  A61K48/00 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28

CPC分类号： C07K16/3053 ,  A61K48/005 ,  C07K16/22 ,  C07K16/24 ,  C07K16/2863 ,  A61K2039/505 ,  A61K48/00 ,  C07K2317/21 ,  C07K2317/24 ,  C12N2750/14141 ,  C12N2799/025

摘要： The invention provides methods to inhibit or treat brain cancers by locally inhibiting expression or activity of growth factors or growth factor receptors.

公开(公告)号：US20240342989A1

公开(公告)日：2024-10-17

申请号：US18637682

申请日：2024-04-17

申请人： Cornell University

发明人： ATIEH MORIDI ,  KAUSHALENDRA K. SINGH

IPC分类号： B29C64/273 ,  B22F10/22 ,  B22F10/25 ,  B22F12/43 ,  B29C64/223 ,  B29C64/236 ,  B29C64/245 ,  B29C64/321 ,  B29C64/371 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  C23C14/04

CPC分类号： B29C64/273 ,  B22F10/22 ,  B22F10/25 ,  B22F12/43 ,  B29C64/223 ,  B29C64/236 ,  B29C64/245 ,  B29C64/321 ,  B29C64/371 ,  C23C14/048 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y40/00

摘要： An additive manufacturing system includes an apparatus to facilitate production at the microscale using metal sheet as feedstock. This additive manufacturing system uses energy from a pulsed laser beam for ejection of metallic droplets to consolidate a part in a layer-by-layer manner.

公开(公告)号：US12119130B2

公开(公告)日：2024-10-15

申请号：US17095529

申请日：2020-11-11

申请人： CORNELL UNIVERSITY

发明人： Alexander Temnykh ,  Ivan Temnykh

IPC分类号： B23P19/00 ,  G21K1/093 ,  H05K13/04

CPC分类号： G21K1/093

摘要： The present technology relates to a permanent magnet insertion device that includes a frame and a plurality of single pole assemblies adjacently disposed within the frame. Each of the single pole assemblies includes a first member bearing a first permanent-magnet and a second member bearing a second permanent-magnet. The first permanent-magnet and the second permanent-magnet are spaced apart by a gap. At least one of the first member or the second member is movable relative to the other of the first member or the second member to increase or to decrease a dimensional value of the gap. A hydraulic driver is configured to move the first member relative to the second member to increase or to decrease the dimensional value of the gap. A mechanical driver is configured to move the first member relative to the second member to increase or to decrease the dimensional value of the gap.

公开(公告)号：US12116450B2

公开(公告)日：2024-10-15

申请号：US17050138

申请日：2019-04-25

申请人： Northwestern University ,  Cornell University

发明人： David J. Fortman ,  William R. Dichtel ,  Daylan T. Sheppard

IPC分类号： C08G18/82 ,  C08G18/22 ,  C08G18/42 ,  C08G18/48 ,  C08G18/73 ,  C08G18/76

CPC分类号： C08G18/7671 ,  C08G18/222 ,  C08G18/227 ,  C08G18/4247 ,  C08G18/4833 ,  C08G18/73 ,  C08G18/82

摘要： Disclosed herein are polyurethane compositions and methods for reprocessing cross-linked polyurethane compositions. The polyurethane composition comprises a network polymer and a polyurethane exchange catalyst permeated within the network polymer. The network polymer comprises a dynamic network formed from an isocyanate constitutional unit and a second constitution unit having a hydroxyl group capable of reacting with an isocyanate group of the isocyanate constitutional unit to form a urethane bond. The catalyst comprises a metal atom and a ligand coordinated to the metal atom.

公开(公告)号：US12103922B2

公开(公告)日：2024-10-01

申请号：US17678803

申请日：2022-02-23

申请人： Cornell University

发明人： John W. Babich ,  Justin Wilson ,  Nikki Thiele ,  James Kelly ,  Shashikanth Ponnala

IPC分类号： C07D413/14 ,  A61K51/04 ,  A61K51/10 ,  A61K45/06 ,  C07B59/00

CPC分类号： C07D413/14 ,  A61K51/0463 ,  A61K51/0482 ,  A61K51/1072 ,  A61K45/06 ,  C07B59/002

摘要： The present technology provides compounds as well as compositions including such compounds useful in targeted radiotherapy of cancer and/or mammalian tissue overexpressing prostate specific membrane antigen (“PSMA”) where the compounds are represented by the following:






or a pharmaceutical y acceptable salt thereof,










or a pharmaceutically acceptable salt thereof,










or a pharmaceutically acceptable salt thereof,

wherein M1 is independently at each occurrence an alpha-emitting radionuclide. Equivalents of such compounds are also disclosed.

公开(公告)号：US12084649B2

公开(公告)日：2024-09-10

申请号：US17587006

申请日：2022-01-28

申请人： CORNELL UNIVERSITY

发明人： Stephane C. Corgie ,  Xiaonan Duan ,  Emmanuel Giannelis ,  Daniel Aneshansley ,  Larry P. Walker

IPC分类号： C12N11/04 ,  A62D3/02 ,  B01J8/00 ,  B01J19/12 ,  B01J31/00 ,  B01J31/02 ,  B01J35/33 ,  B01J35/56 ,  B01J37/02 ,  C02F1/48 ,  C02F3/00 ,  C02F3/34 ,  C07C1/12 ,  C07D301/22 ,  C07G1/00 ,  C08F14/00 ,  C08F18/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/08 ,  C12N11/08 ,  C12N11/091 ,  C12N11/098 ,  C12N11/14 ,  C12N13/00 ,  C12P7/04 ,  C12P7/22 ,  C12P17/02 ,  B01J35/64 ,  C02F101/32

CPC分类号： C12N11/04 ,  A62D3/02 ,  B01J8/00 ,  B01J19/12 ,  B01J31/003 ,  B01J31/02 ,  B01J35/33 ,  B01J35/56 ,  B01J37/02 ,  C02F1/484 ,  C02F3/00 ,  C02F3/342 ,  C07C1/12 ,  C07D301/22 ,  C07G1/00 ,  C08F14/00 ,  C08F18/00 ,  C12N9/0004 ,  C12N9/0006 ,  C12N9/0061 ,  C12N9/0065 ,  C12N11/08 ,  C12N11/091 ,  C12N11/098 ,  C12N11/14 ,  C12N13/00 ,  C12P7/04 ,  C12P7/22 ,  C12P17/02 ,  B01J35/647 ,  B01J35/651 ,  B01J2208/00805 ,  B01J2219/0854 ,  B01J2219/0862 ,  C02F2101/327 ,  C02F2209/006 ,  C02F2303/04 ,  C02F2305/08 ,  C12Y101/03004 ,  C12Y111/01 ,  Y02P20/50 ,  Y02W10/40

摘要： A hierarchical catalyst composition comprising a continuous or particulate macroporous scaffold in which is incorporated mesoporous aggregates of magnetic nanoparticles, wherein an enzyme is embedded in mesopores of the mesoporous aggregates of magnetic nanoparticles. Methods for synthesizing the hierarchical catalyst composition are also described. Also described are processes that use the recoverable hierarchical catalyst composition for depolymerizing lignin, remediation of water contaminated with aromatic substances, polymerizing monomers by a free-radical mechanism, epoxidation of alkenes, halogenation of phenols, inhibiting growth and function of microorganisms in a solution, and carbon dioxide conversion to methanol. Further described are methods for increasing the space time yield and/or total turnover number of a liquid-phase chemical reaction that includes magnetic particles to facilitate the chemical reaction, the method comprising subjecting the chemical reaction to a plurality of magnetic fields of selected magnetic strength, relative position in the chemical reaction, and relative motion.

公开(公告)号：US20240290487A1

公开(公告)日：2024-08-29

申请号：US18547725

申请日：2022-03-16

申请人： CORNELL UNIVERSITY

发明人： Bobak MOSADEGH ,  Matin TORABINIA ,  Tamatha FENSTER

IPC分类号： G16H50/20 ,  G16H10/60 ,  G16H15/00 ,  G16H30/40

CPC分类号： G16H50/20 ,  G16H10/60 ,  G16H15/00 ,  G16H30/40

摘要： Embodiments described herein provide systems and methods for improving diagnosis, screening, and treatment of patients. The disclosed systems and methods generally relate to artificial intelligence (AI) based deep learning models that can help with decision making, for example, in gynecological procedures. In various embodiments, a method of generating a model for performing gynecologic procedures is described. In various embodiments, a method of determining a success rate of a minimally invasive procedure for a patient is described. In various embodiments, a method of enhancing a diagnosis of an ovarian tumor is described. In various embodiments, a method of providing a mixed reality guidance for performing gynecological procedures is described.

公开(公告)号：US20240287004A1

公开(公告)日：2024-08-29

申请号：US18411842

申请日：2024-01-12

申请人： Cornell University

发明人： Joseph P. Vacca ,  Sarah Elizabeth Bettigole

IPC分类号： C07D239/42 ,  C07D213/76 ,  C07D401/06 ,  C07D403/06

CPC分类号： C07D239/42 ,  C07D213/76 ,  C07D401/06 ,  C07D403/06

摘要： Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.

公开(公告)号：US12071424B2

公开(公告)日：2024-08-27

申请号：US18176362

申请日：2023-02-28

申请人： Cornell University

发明人： Joseph P. Vacca ,  Dansu Li ,  Sarah Elizabeth Bettigole

IPC分类号： C07D401/04 ,  A61K31/517 ,  A61P35/00 ,  C07D217/22 ,  C07D239/74 ,  C07D239/84 ,  C07D239/94 ,  C07D401/10 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D417/04

CPC分类号： C07D401/10 ,  A61P35/00 ,  C07D217/22 ,  C07D239/84 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D413/04 ,  C07D417/04

摘要： Provided herein are small molecule inhibitors for the targeting or IRE1 protein family members. Binding may be direct or indirect. Further provided herein are methods of using IRE1 small molecule inhibitors for use in treating or ameliorating cancer in a subject. Moreover, IRE1 small molecule inhibitors described herein are for the treatment of cancer, where the cancer is a solid or hematologic cancer.