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    COMPOSITIONS FOR FECAL FLORAL TRANSPLANTATION AND METHODS FOR MAKING AND USING THEM AND DEVICES FOR DELIVERING THEM
    3.
    发明申请
    COMPOSITIONS FOR FECAL FLORAL TRANSPLANTATION AND METHODS FOR MAKING AND USING THEM AND DEVICES FOR DELIVERING THEM 有权

    公开(公告)号：US20160296568A1

    公开(公告)日：2016-10-13

    申请号：US15093679

    申请日：2016-04-07

    申请人： Crestovo LLC

    发明人： Thomas Julius Borody

    IPC分类号： A61K35/74 ,  A61K9/48 ,  A61K35/742

    CPC分类号： A61K35/74 ,  A61K9/4875 ,  A61K9/4891 ,  A61K35/24 ,  A61K35/742 ,  A61K2035/115 ,  A61M5/142 ,  A61M31/00 ,  A61P1/12 ,  C12N1/00

    摘要： In alternative embodiments, the invention provides compositions, e.g., formulations, used for gastric, gastrointestinal and/or colonic treatments or lavage, e.g., orthostatic lavage, e.g., for inducing the purgation (e.g., cleansing) of a gastrointestinal (GI) tract, including a colon; and methods for making and using them. In alternative embodiments, compositions and methods of the invention are used for the stabilization, amelioration, treatment and/or prevention of constipation, for the treatment of abdominal pain, particularly non-specific abdominal pain, and diarrhea, including diarrhea caused by a drug side effect, a psychological condition, a disease or a condition such as Crohn's Disease, a poison, a toxin or an infection, e.g., a toxin-mediated traveler's diarrhea, or C. difficile or the pseudo-membranous colitis associated with this infection. In alternative embodiments, the invention provides pharmaceuticals and products (articles) of manufacture for delivering these compositions and formulations to an individual, e.g., a human or an animal. The invention also provides devices for delivering a fecal material to a patient.

    Methods for Treating Autism Spectrum Disorder and Associated Symptoms
    10.
    发明申请
    Methods for Treating Autism Spectrum Disorder and Associated Symptoms 审中-公开
    治疗自闭症谱系障碍及相关症状的方法

    公开(公告)号：US20160339065A1

    公开(公告)日：2016-11-24

    申请号：US15161654

    申请日：2016-05-23

    申请人： Arizona Board of Regents on behalf of Arizona State University ,  Regents of the University of Minnesota ,  Crestovo LLC

    发明人： James ADAMS ,  Rosa KRAJMALIK-BROWN ,  Dae-Wook KANG ,  Michael J. SADOWSKY ,  Alexander KHORUTS ,  Thomas J. BORODY

    IPC分类号： A61K35/741 ,  A61K38/08 ,  A61K45/06

    CPC分类号： A61K38/08 ,  A61K35/74 ,  A61K38/14 ,  A61K45/06 ,  A61K2035/128 ,  A61K2300/00

    摘要： The present disclosure relates to compositions and methods for treating autism spectrum disorder (ASD) by restoring an ASD patient's gut microbiota. These methods can be used with ASD patient with or without ongoing gastrointestinal symptoms. Provided here is a method for ASD treatment in a subject in need thereof comprising or consisting essentially of administering a therapeutic composition comprising a fecal microbe or a fecal microbiota preparation to the subject. Also provided here is a method comprises administering an antibiotic to a human subject; subjecting the human subject to a bowel cleanse; and administering purified fecal microbiota to the human subject. Further provided are evaluation and quantitative characterization of patient symptom improvements upon treatment described here.

    摘要翻译： 本公开涉及通过恢复ASD患者的肠道微生物群来治疗自闭症谱系障碍（ASD）的组合物和方法。 这些方法可以与ASD患者一起使用，无论是否有持续的胃肠道症状。 这里提供了一种在有需要的受试者中进行ASD治疗的方法，其包括或基本上由给予受试者的包含粪便微生物或粪便微生物群制剂的治疗组合物组成。 这里还提供了一种方法，包括向人受试者施用抗生素; 使人类受试者进行肠道清洁​​; 并向人类受试者施用纯化的粪便微生物群。 进一步提供了这里描述的治疗后患者症状改善的评估和定量表征。